NO20076553L - RAF-inhibitorforbindelser og fremgangsmater for anvendelse derav - Google Patents

RAF-inhibitorforbindelser og fremgangsmater for anvendelse derav

Info

Publication number
NO20076553L
NO20076553L NO20076553A NO20076553A NO20076553L NO 20076553 L NO20076553 L NO 20076553L NO 20076553 A NO20076553 A NO 20076553A NO 20076553 A NO20076553 A NO 20076553A NO 20076553 L NO20076553 L NO 20076553L
Authority
NO
Norway
Prior art keywords
methods
inhibitor compounds
raf inhibitor
compounds
formula
Prior art date
Application number
NO20076553A
Other languages
English (en)
Norwegian (no)
Inventor
George Topalov
Ellen Laird
Joseph P Lyssikatos
Mike Welch
Jonas Grina
Josh Hansen
Brad Newhouse
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of NO20076553L publication Critical patent/NO20076553L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20076553A 2005-05-20 2007-12-19 RAF-inhibitorforbindelser og fremgangsmater for anvendelse derav NO20076553L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68317505P 2005-05-20 2005-05-20
PCT/US2006/019280 WO2006125101A2 (en) 2005-05-20 2006-05-18 Raf inhibitor compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
NO20076553L true NO20076553L (no) 2008-02-19

Family

ID=37432152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076553A NO20076553L (no) 2005-05-20 2007-12-19 RAF-inhibitorforbindelser og fremgangsmater for anvendelse derav

Country Status (14)

Country Link
US (1) US7566716B2 (cg-RX-API-DMAC10.html)
EP (1) EP1902056A2 (cg-RX-API-DMAC10.html)
JP (1) JP2008540674A (cg-RX-API-DMAC10.html)
KR (1) KR20080038278A (cg-RX-API-DMAC10.html)
CN (1) CN101263142A (cg-RX-API-DMAC10.html)
AU (1) AU2006247118A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0610863A2 (cg-RX-API-DMAC10.html)
CA (1) CA2609299A1 (cg-RX-API-DMAC10.html)
IL (1) IL187509A0 (cg-RX-API-DMAC10.html)
MX (1) MX2007014510A (cg-RX-API-DMAC10.html)
NO (1) NO20076553L (cg-RX-API-DMAC10.html)
RU (1) RU2007147382A (cg-RX-API-DMAC10.html)
WO (1) WO2006125101A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200710969B (cg-RX-API-DMAC10.html)

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WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
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SG178854A1 (en) 2009-08-28 2012-04-27 Array Biopharma Inc Raf inhibitor compounds and methods of use thereof
EP2470538A1 (en) 2009-08-28 2012-07-04 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
CN102858754A (zh) 2009-08-28 2013-01-02 阵列生物制药公司 Raf抑制剂化合物及其使用方法
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KR20130088116A (ko) 2010-06-04 2013-08-07 아브락시스 바이오사이언스, 엘엘씨 췌장암의 치료 방법
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MX336865B (es) 2011-04-07 2016-02-04 Bayer Pharma AG Imidazopiridazinas como inhibidores de quinasa akt.
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
DK2797888T3 (en) 2011-12-31 2016-09-19 Beigene Ltd Fused tricyclic compounds as RAF kinase inhibitors
WO2014206344A1 (en) 2013-06-28 2014-12-31 Beigene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
US9629851B2 (en) 2013-09-20 2017-04-25 Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis ROCK in combination with MAPK pathway
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
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EP3464279B1 (en) 2016-05-26 2021-11-24 Incyte Corporation Heterocyclic compounds as immunomodulators
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US20220033396A1 (en) * 2018-11-26 2022-02-03 Janssen Sciences Ireland Unlimited Company Further heteroaromatic compounds having activity against rsv
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JP7559059B2 (ja) 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物
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US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
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Also Published As

Publication number Publication date
AU2006247118A1 (en) 2006-11-23
WO2006125101A2 (en) 2006-11-23
MX2007014510A (es) 2008-02-05
KR20080038278A (ko) 2008-05-06
IL187509A0 (en) 2008-03-20
BRPI0610863A2 (pt) 2010-08-03
RU2007147382A (ru) 2009-06-27
JP2008540674A (ja) 2008-11-20
US7566716B2 (en) 2009-07-28
CN101263142A (zh) 2008-09-10
CA2609299A1 (en) 2006-11-23
US20060281751A1 (en) 2006-12-14
EP1902056A2 (en) 2008-03-26
WO2006125101A3 (en) 2007-03-29
ZA200710969B (en) 2009-03-25

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