NO20076084L - Fremgangsmate for fremstilling av sulfonsyresalts av oksabispidiner - Google Patents

Fremgangsmate for fremstilling av sulfonsyresalts av oksabispidiner

Info

Publication number
NO20076084L
NO20076084L NO20076084A NO20076084A NO20076084L NO 20076084 L NO20076084 L NO 20076084L NO 20076084 A NO20076084 A NO 20076084A NO 20076084 A NO20076084 A NO 20076084A NO 20076084 L NO20076084 L NO 20076084L
Authority
NO
Norway
Prior art keywords
formula
compound
iii
sulfonic acid
acid salt
Prior art date
Application number
NO20076084A
Other languages
English (en)
Inventor
Lal Cheema
David Cladingboel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20076084L publication Critical patent/NO20076084L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Det tilveiebringes en fremgangsmåte for å isolere et sulfonsyresalt med formel I, eller et solvat derav, fra en blanding omfattende: (i) den tilsvarende frie basen; og (ii) en forbindelse med formel III eller et salt og/eller solvat derav, der fremgangsmåten omfatter å tilveiebringe en vandig dispersjon av forbindelsene med formlene II og III og en kilde for R3SO3--anioner og deretter, hvis nødvendig, regulere pH i den vandige dispersjonen til hvilken som helst verdi fra 3 til 8. Det er videre gitt fremgangsmåter hvor blandingen av forbindelser med formlene II og III er gitt ved ufullstendig reaksjon, for eksempel i nærvær av base og en vandig fase, mellom en forbindelse med formel III og en forbindelse med formel IV I slike fremgangsmåter kan RSO3--anionene av det resulterende saltet med formel I avledes fra forbindelsen med formel IV. For alle disse fremgangsmåtene har også D, R1, R2 og R3 betydninger gitt i beskrivelsen.
NO20076084A 2005-06-20 2007-11-27 Fremgangsmate for fremstilling av sulfonsyresalts av oksabispidiner NO20076084L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0501426 2005-06-20
SE0502773 2005-12-15
PCT/SE2006/000691 WO2006137771A1 (en) 2005-06-20 2006-06-12 Process for the preparation of sulfonic acid salts of oxabispidines

Publications (1)

Publication Number Publication Date
NO20076084L true NO20076084L (no) 2008-01-18

Family

ID=37570713

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076084A NO20076084L (no) 2005-06-20 2007-11-27 Fremgangsmate for fremstilling av sulfonsyresalts av oksabispidiner

Country Status (13)

Country Link
US (1) US20080200673A1 (no)
EP (1) EP1896487A4 (no)
JP (1) JP2008546764A (no)
KR (1) KR20080019245A (no)
AR (1) AR054284A1 (no)
AU (1) AU2006259938B2 (no)
BR (1) BRPI0611841A2 (no)
CA (1) CA2610093A1 (no)
IL (1) IL187660A0 (no)
MX (1) MX2007016492A (no)
NO (1) NO20076084L (no)
TW (1) TW200734341A (no)
WO (1) WO2006137771A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate

Also Published As

Publication number Publication date
WO2006137771A1 (en) 2006-12-28
AU2006259938A1 (en) 2006-12-28
IL187660A0 (en) 2008-08-07
AU2006259938B2 (en) 2010-07-01
TW200734341A (en) 2007-09-16
AR054284A1 (es) 2007-06-13
BRPI0611841A2 (pt) 2016-08-30
US20080200673A1 (en) 2008-08-21
JP2008546764A (ja) 2008-12-25
MX2007016492A (es) 2008-03-07
CA2610093A1 (en) 2006-12-28
EP1896487A1 (en) 2008-03-12
EP1896487A4 (en) 2010-03-31
KR20080019245A (ko) 2008-03-03

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