NO20075726L - Fremgangsmate for syntese av 6-alkylaminokinolinderivater - Google Patents
Fremgangsmate for syntese av 6-alkylaminokinolinderivaterInfo
- Publication number
- NO20075726L NO20075726L NO20075726A NO20075726A NO20075726L NO 20075726 L NO20075726 L NO 20075726L NO 20075726 A NO20075726 A NO 20075726A NO 20075726 A NO20075726 A NO 20075726A NO 20075726 L NO20075726 L NO 20075726L
- Authority
- NO
- Norway
- Prior art keywords
- present
- alkylaminoquinoline
- synthesis
- derivatives
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68504005P | 2005-05-25 | 2005-05-25 | |
| PCT/US2006/015931 WO2006127203A2 (en) | 2005-05-25 | 2006-04-26 | Methods of synthesizing 6-alkylaminoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075726L true NO20075726L (no) | 2008-02-04 |
Family
ID=36794434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075726A NO20075726L (no) | 2005-05-25 | 2007-11-09 | Fremgangsmate for syntese av 6-alkylaminokinolinderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060270670A1 (zh) |
| EP (1) | EP1883630A2 (zh) |
| JP (1) | JP2008542266A (zh) |
| KR (1) | KR20080016604A (zh) |
| CN (1) | CN101180273A (zh) |
| AR (1) | AR054192A1 (zh) |
| AU (1) | AU2006249596A1 (zh) |
| BR (1) | BRPI0610142A2 (zh) |
| CA (1) | CA2608589A1 (zh) |
| CR (1) | CR9545A (zh) |
| GT (1) | GT200600215A (zh) |
| IL (1) | IL187301A0 (zh) |
| MX (1) | MX2007014774A (zh) |
| NO (1) | NO20075726L (zh) |
| PA (1) | PA8676301A1 (zh) |
| PE (1) | PE20070007A1 (zh) |
| RU (1) | RU2007140957A (zh) |
| TW (1) | TW200716556A (zh) |
| WO (1) | WO2006127203A2 (zh) |
| ZA (1) | ZA200710143B (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070135499A1 (en) * | 2005-07-11 | 2007-06-14 | Aerie Pharmaceuticals, Inc. | Hydrazide compounds |
| US7470787B2 (en) * | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2672624T3 (es) * | 2009-05-01 | 2018-06-15 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| JP5622842B2 (ja) | 2009-05-14 | 2014-11-12 | コーロン ライフ サイエンス インク | アルキルアミン誘導体の製造方法 |
| KR101916481B1 (ko) | 2010-09-29 | 2018-11-07 | 인터벳 인터내셔널 비.브이. | Ｎ-헤테로아릴 화합물 |
| WO2012041872A1 (en) | 2010-09-29 | 2012-04-05 | Intervet International B.V. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
| CN102649778A (zh) * | 2011-02-23 | 2012-08-29 | 苏州波锐生物医药科技有限公司 | 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| EP2833886B1 (en) * | 2012-04-04 | 2020-08-12 | HangzhouDeRenYuCheng Biotechnology Ltd. | Substituted quinolines as bruton's tyrosine kinase inhibitors |
| PL3811943T3 (pl) | 2013-03-15 | 2023-06-12 | Aerie Pharmaceuticals, Inc. | Związek do stosowania w leczeniu zaburzeń oczu |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| EP3376870B1 (en) | 2015-11-17 | 2021-08-11 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| PL3447051T3 (pl) * | 2016-04-28 | 2022-03-14 | Jiangsu Hengrui Medicine Co., Ltd. | Sposób otrzymywania inhibitora kinazy tyrozynowej i jego pochodnej |
| JP6907319B2 (ja) | 2016-08-31 | 2021-07-21 | アエリエ ファーマシューティカルズ インコーポレイテッド | 眼科用組成物 |
| CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| MXPA02008836A (es) * | 2000-03-13 | 2003-02-10 | American Cyanamid Co | Uso de cianoquinolinas para tratar o inhibir los polipos colonicos. |
| UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
| JP4361375B2 (ja) * | 2002-02-05 | 2009-11-11 | ワイス | Ｎ−アシル−２−アミノ−４−アルコキシ−５−ニトロ安息香酸の合成方法 |
| CL2004000016A1 (es) * | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
| RU2345069C2 (ru) * | 2003-08-19 | 2009-01-27 | Уайт Холдингз Корпорейшн | Способ получения 4-амино-3-хинолинкарбонитрилов |
| RU2006127414A (ru) * | 2004-01-16 | 2008-02-27 | Вайет (Us) | Хинолиновые промежуточные соединения ингибиторов рецептора тирозинкиназы и их синтез |
-
2006
- 2006-04-26 KR KR1020077028377A patent/KR20080016604A/ko not_active Application Discontinuation
- 2006-04-26 CN CNA2006800177664A patent/CN101180273A/zh active Pending
- 2006-04-26 MX MX2007014774A patent/MX2007014774A/es unknown
- 2006-04-26 CA CA002608589A patent/CA2608589A1/en not_active Abandoned
- 2006-04-26 BR BRPI0610142-9A patent/BRPI0610142A2/pt not_active IP Right Cessation
- 2006-04-26 JP JP2008513496A patent/JP2008542266A/ja not_active Withdrawn
- 2006-04-26 WO PCT/US2006/015931 patent/WO2006127203A2/en active Application Filing
- 2006-04-26 RU RU2007140957/04A patent/RU2007140957A/ru not_active Application Discontinuation
- 2006-04-26 AU AU2006249596A patent/AU2006249596A1/en not_active Abandoned
- 2006-04-26 EP EP06751575A patent/EP1883630A2/en not_active Withdrawn
- 2006-05-04 TW TW095115892A patent/TW200716556A/zh unknown
- 2006-05-18 AR ARP060102011A patent/AR054192A1/es unknown
- 2006-05-22 PE PE2006000538A patent/PE20070007A1/es not_active Application Discontinuation
- 2006-05-24 GT GT200600215A patent/GT200600215A/es unknown
- 2006-05-25 PA PA20068676301A patent/PA8676301A1/es unknown
- 2006-05-25 US US11/442,562 patent/US20060270670A1/en not_active Abandoned
-
2007
- 2007-11-09 NO NO20075726A patent/NO20075726L/no not_active Application Discontinuation
- 2007-11-11 IL IL187301A patent/IL187301A0/en unknown
- 2007-11-23 CR CR9545A patent/CR9545A/es not_active Application Discontinuation
- 2007-11-26 ZA ZA200710143A patent/ZA200710143B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PA8676301A1 (es) | 2009-03-31 |
| CR9545A (es) | 2008-01-10 |
| ZA200710143B (en) | 2008-11-26 |
| TW200716556A (en) | 2007-05-01 |
| RU2007140957A (ru) | 2009-06-27 |
| IL187301A0 (en) | 2008-04-13 |
| BRPI0610142A2 (pt) | 2011-01-04 |
| KR20080016604A (ko) | 2008-02-21 |
| US20060270670A1 (en) | 2006-11-30 |
| AU2006249596A1 (en) | 2006-11-30 |
| PE20070007A1 (es) | 2007-02-12 |
| MX2007014774A (es) | 2008-02-19 |
| WO2006127203A2 (en) | 2006-11-30 |
| JP2008542266A (ja) | 2008-11-27 |
| EP1883630A2 (en) | 2008-02-06 |
| WO2006127203A3 (en) | 2007-05-03 |
| GT200600215A (es) | 2006-12-26 |
| AR054192A1 (es) | 2007-06-06 |
| CN101180273A (zh) | 2008-05-14 |
| CA2608589A1 (en) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |