NO20074438L - Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon - Google Patents

Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon

Info

Publication number
NO20074438L
NO20074438L NO20074438A NO20074438A NO20074438L NO 20074438 L NO20074438 L NO 20074438L NO 20074438 A NO20074438 A NO 20074438A NO 20074438 A NO20074438 A NO 20074438A NO 20074438 L NO20074438 L NO 20074438L
Authority
NO
Norway
Prior art keywords
formula
thio
substituted aryl
single enantiomers
enantioselective synthesis
Prior art date
Application number
NO20074438A
Other languages
English (en)
Inventor
Laurence Prat
Olivier Neckebrock
Dominique Schweizer
Philippe Louvet
Original Assignee
Cephalon France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon France filed Critical Cephalon France
Publication of NO20074438L publication Critical patent/NO20074438L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår en fremgangsmåte for fremstilling av sulfoksidforbindelser med formel (I) enten som en enkel enantiomer eller en enantiomert anriket form omfattende a) reagering av et pro-kiralt sulfid med formel (II) med et kiralt metallkompleks, en base og et oksidasjonsmiddel i et organisk løsningsmiddel; eventuelt b) isolering av det fremstilte sulfoksidet med formel (I), hvor Ar, Y og R1 er definert som i patentkrav 1. Formel (I) Formel (II)
NO20074438A 2005-03-14 2007-09-03 Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon NO20074438L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05290560A EP1702915A1 (en) 2005-03-14 2005-03-14 Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
US11/374,227 US7893111B2 (en) 2005-03-14 2006-03-13 Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
PCT/IB2006/000552 WO2006097814A1 (en) 2005-03-14 2006-03-14 Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation

Publications (1)

Publication Number Publication Date
NO20074438L true NO20074438L (no) 2007-10-15

Family

ID=34942003

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074438A NO20074438L (no) 2005-03-14 2007-09-03 Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon

Country Status (22)

Country Link
US (2) US7893111B2 (no)
EP (2) EP1702915A1 (no)
JP (2) JP5192370B2 (no)
KR (1) KR101256881B1 (no)
CN (1) CN101142176B (no)
AR (1) AR053167A1 (no)
AU (1) AU2006224292B2 (no)
BR (1) BRPI0607968A2 (no)
CA (1) CA2599690C (no)
DK (1) DK1863760T3 (no)
ES (1) ES2392452T3 (no)
HK (1) HK1105950A1 (no)
HR (1) HRP20120939T1 (no)
IL (1) IL185585A (no)
MX (1) MX2007011159A (no)
MY (1) MY157717A (no)
NO (1) NO20074438L (no)
NZ (1) NZ560986A (no)
SI (1) SI1863760T1 (no)
TW (1) TWI364412B (no)
WO (1) WO2006097814A1 (no)
ZA (1) ZA200707267B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2009172A3 (cs) * 2009-03-17 2010-09-29 Zentiva, K.S. Zpusob výroby (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolu
CN104447440B (zh) * 2013-09-12 2016-05-18 中国科学院大连化学物理研究所 一种催化不对称氧化硫醚的方法
HUE066335T2 (hu) 2018-10-05 2024-07-28 Annapurna Bio Inc Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127722A (en) 1975-10-02 1978-11-28 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
DE2708449C3 (de) 1977-02-26 1981-01-08 Hoechst Ag, 6000 Frankfurt Verfahren zum gleichmäßigen Färben von bahnförmigen Textilien aus modifizierten Polyesterfasern auf Baumfärbeapparaten
GB1584462A (en) 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
DE10224722C1 (de) 2002-05-30 2003-08-14 Leibniz Inst Fuer Festkoerper Hochfeste, plastisch verformbare Formkörper aus Titanlegierungen
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (en) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
EP1477476B1 (en) 2003-05-16 2009-09-09 Cephalon France Modafinil synthesis process
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7297817B2 (en) * 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
EP1634861A1 (en) 2004-09-13 2006-03-15 Cephalon, Inc. Methods for the separation of modafinil
US20060086667A1 (en) 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides

Also Published As

Publication number Publication date
MX2007011159A (es) 2007-10-17
US20060205706A1 (en) 2006-09-14
JP2013018782A (ja) 2013-01-31
CN101142176A (zh) 2008-03-12
JP5698201B2 (ja) 2015-04-08
US20110098505A1 (en) 2011-04-28
WO2006097814A1 (en) 2006-09-21
HRP20120939T1 (hr) 2013-01-31
US8183294B2 (en) 2012-05-22
MY157717A (en) 2016-07-15
EP1863760B1 (en) 2012-10-03
KR101256881B1 (ko) 2013-04-22
EP1702915A1 (en) 2006-09-20
TW200700369A (en) 2007-01-01
CN101142176B (zh) 2012-06-06
AU2006224292B2 (en) 2011-08-11
NZ560986A (en) 2010-11-26
IL185585A (en) 2013-05-30
IL185585A0 (en) 2008-01-06
EP1863760A1 (en) 2007-12-12
CA2599690A1 (en) 2006-09-21
CA2599690C (en) 2015-02-03
ZA200707267B (en) 2008-09-25
AU2006224292A1 (en) 2006-09-21
SI1863760T1 (sl) 2013-02-28
TWI364412B (en) 2012-05-21
DK1863760T3 (da) 2012-12-03
US7893111B2 (en) 2011-02-22
BRPI0607968A2 (pt) 2009-10-27
HK1105950A1 (en) 2008-02-29
ES2392452T3 (es) 2012-12-10
JP2008537934A (ja) 2008-10-02
AR053167A1 (es) 2007-04-25
JP5192370B2 (ja) 2013-05-08
KR20070111555A (ko) 2007-11-21

Similar Documents

Publication Publication Date Title
PL1663963T3 (pl) Proces enancjoselektywnej syntezy pojedynczych enancjomerów modafinilu przez asymetryczne utlenianie
TW200510381A (en) Novel 2-pyridinecarboxamide derivatives
ATE496044T1 (de) Indolylmaleimidderivate
WO2009069537A1 (ja) 発光素子材料および発光素子
NO20074438L (no) Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon
MY148301A (en) Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
DE602005016705D1 (de) Verfahren zur herstellung substituierter sulfoxide
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
HRP20080510T3 (en) Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol
WO2008052379A3 (en) Organic compounds
GB0411929D0 (en) Organic compounds
UA92050C2 (ru) Энантиоселективное получение производных бензимидазола и их солей
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
ATE526312T1 (de) Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren
ATE471312T1 (de) Diaryltriazolmethylamin-derivate sowie ihre herstellung und therapeutische verwendung
CN101323609B (zh) 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法
TW200706529A (en) A process for preparing an alkenylether compound
NO20061350L (no) Fremgangsmate for enantioselektiv syntese av enkelt enantiomerer av modafinil ved assymetrisk oksidasjon
ATE473989T1 (de) Eine phosphorylcholingruppe enthaltende verbindung, und verfahren zu ihrer herstellung
SE0400410D0 (sv) New compounds
ATE415388T1 (de) Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten
IL180571A0 (en) Method for producing enantiomeric from of 2,3-diaminopropionic acid derivatives
TH79588A (th) การสังเคราะห์แบบไม่สมมาตรของอนุพันธ์ไดไฮโดรเบนโซฟิวราน
WO2008111414A1 (ja) 触媒組成物及びそれを用いたクロスカップリング化合物の製造方法
DE602005004278D1 (de) Arylpyrrol mit antitubulinwirkung, arylfulran- und arylthiopenderivate, verfahren zur herstellung und verwendung als antimitotikum

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application