NO20072700L - Anti-ADDL antistoffer og anvendelser derav - Google Patents
Anti-ADDL antistoffer og anvendelser deravInfo
- Publication number
- NO20072700L NO20072700L NO20072700A NO20072700A NO20072700L NO 20072700 L NO20072700 L NO 20072700L NO 20072700 A NO20072700 A NO 20072700A NO 20072700 A NO20072700 A NO 20072700A NO 20072700 L NO20072700 L NO 20072700L
- Authority
- NO
- Norway
- Prior art keywords
- addls
- antibodies
- disease
- useful
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62177604P | 2004-10-25 | 2004-10-25 | |
US65253805P | 2005-02-14 | 2005-02-14 | |
PCT/US2005/038125 WO2006055178A2 (fr) | 2004-10-25 | 2005-10-21 | Anticorps anti-addl et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072700L true NO20072700L (no) | 2007-07-25 |
Family
ID=36407593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072700A NO20072700L (no) | 2004-10-25 | 2007-05-25 | Anti-ADDL antistoffer og anvendelser derav |
Country Status (12)
Country | Link |
---|---|
US (5) | US7811563B2 (fr) |
EP (2) | EP1812062B1 (fr) |
JP (4) | JP5173426B2 (fr) |
KR (1) | KR20070094890A (fr) |
AU (1) | AU2005306997B2 (fr) |
BR (2) | BRPI0516962A (fr) |
CA (1) | CA2584859C (fr) |
IL (2) | IL182554A0 (fr) |
NO (1) | NO20072700L (fr) |
NZ (1) | NZ554725A (fr) |
RU (1) | RU2007119382A (fr) |
WO (1) | WO2006055178A2 (fr) |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002003911A2 (fr) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention et traitement de la maladie d'alzheimer |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
JP5137053B2 (ja) | 2004-02-10 | 2013-02-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト | 抗b因子抗体もしくはその抗原結合性フラグメント、それを含む組成物、抗原結合性ポリペプチド、および治療薬 |
SE0401601D0 (sv) * | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
CA2584859C (fr) * | 2004-10-25 | 2017-11-07 | Merck & Co., Inc. | Anticorps anti-addl et leurs utilisations |
US20060134098A1 (en) | 2004-11-16 | 2006-06-22 | Kalobios, Inc. | Immunoglobulin variable region cassette exchange |
CA2589860A1 (fr) * | 2005-01-24 | 2006-08-03 | Amgen Inc. | Anticorps anti-amyloide humanise |
CA2610340C (fr) | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition de la voie de complement alternative pour le traitement de lesions traumatiques du cerveau, de lesions de la moelle epiniere et de conditions apparentees |
CA2620936A1 (fr) * | 2005-09-01 | 2007-03-08 | Precision Therapeutics, Inc. | Tests de chimiosensibilite faisant appel a des cellules tumorales presentant des caracteristiques phenotypiques persistantes |
CN101291692A (zh) * | 2005-10-21 | 2008-10-22 | 默克制药公司 | 抗addl单克隆抗体及其应用 |
WO2007062088A1 (fr) * | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Traitement par anticorps de la maladie d'alzheimer et des maladies connexes |
AU2006319358B2 (en) | 2005-11-30 | 2012-01-19 | AbbVie Deutschland GmbH & Co. KG | Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
KR20140087058A (ko) | 2005-11-30 | 2014-07-08 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
CN101325972B (zh) * | 2005-12-12 | 2020-06-16 | Ac免疫有限公司 | 具有治疗性质的Aβ1-42特异性单克隆抗体 |
SG10201404801YA (en) | 2005-12-12 | 2014-09-26 | Ac Immune Sa | Monoclonal antibody |
KR20080097188A (ko) * | 2006-02-24 | 2008-11-04 | 키에시 파르마슈티시 엣스. 피. 에이. | 항아밀로이드 면역성성분, 그 제조방법 및 용도 |
NZ567888A (en) * | 2006-03-23 | 2010-08-27 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
SI2468770T1 (en) * | 2006-07-14 | 2018-05-31 | Ac Immune S.A. | A humanized antibody against amyloid beta. |
EP3988566A1 (fr) * | 2006-07-14 | 2022-04-27 | AC Immune SA | Anticorps humanisés contre le peptide amyloïde-bêta |
WO2008011348A2 (fr) * | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Anticorps humanisé |
PL2074145T3 (pl) * | 2006-10-02 | 2017-11-30 | Ac Immune S.A. | Humanizowane przeciwciało przeciw amyloidowi beta |
US8207304B2 (en) | 2006-10-19 | 2012-06-26 | Csl Limited | Antibody antagonists of interleukin-13 receptor α1 |
EP2530090A3 (fr) * | 2006-10-19 | 2013-01-23 | CSL Limited | Anticorps anti-IL-13R alpha 1 et leurs utilisations |
US7754213B2 (en) * | 2006-10-19 | 2010-07-13 | Merck & Co., Inc. | High affinity antibody antagonists of interleukin-13 receptor alpha 1 |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
JP2010515717A (ja) * | 2007-01-11 | 2010-05-13 | フィリップス−ウニベルジテート・マールブルク | アルツハイマーおよび他の神経性認知症疾患の診断ならびに処置 |
EP2124952A2 (fr) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Méthode de traitement d'amyloïdoses |
EP2481408A3 (fr) | 2007-03-01 | 2013-01-09 | Probiodrug AG | Nouvelle utilisation d'inhibiteurs glutaminyle cyclase |
EP2118142A2 (fr) * | 2007-03-14 | 2009-11-18 | Taligen Therapeutics, Inc. | Anticorps anti-facteur b humanisé |
EP2865670B1 (fr) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
WO2008148751A1 (fr) * | 2007-06-04 | 2008-12-11 | Vib Vzw | Induction ciblée de l'agrégation de protéines avec des structures bêta croisées |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
EP2009445A1 (fr) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Utilisation d'anticorps à domaine simple de chaînes pour détecter une formule oligomérique d'un peptide amyloide bêta et ses applications |
US9006283B2 (en) | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
US8962677B2 (en) | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
RU2538709C2 (ru) * | 2007-10-05 | 2015-01-10 | Дженентек, Инк. | Гуманизированное антитело |
RU2482876C2 (ru) | 2007-10-05 | 2013-05-27 | Дженентек, Инк. | Применение антитела против амилоида-бета при глазных заболеваниях |
US20090104210A1 (en) * | 2007-10-17 | 2009-04-23 | Tota Michael R | Peptide compounds for treating obesity and insulin resistance |
WO2009051220A1 (fr) * | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Anticorps capable de se lier spécifiquement à un oligomère aβ, et son utilisation |
SI3002298T1 (sl) | 2007-11-21 | 2019-12-31 | Oregon Health & Science University | Monoklonska protitelesa proti faktorju XI in postopki njihove uporabe |
WO2009079566A2 (fr) | 2007-12-18 | 2009-06-25 | Acumen Pharmaceuticals, Inc. | Nouveaux polypeptides du récepteur de l'addl, polynucléotides et cellules hôtes pour une production recombinante |
US8414893B2 (en) | 2007-12-21 | 2013-04-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
ES2617604T3 (es) * | 2008-02-08 | 2017-06-19 | Immunas Pharma, Inc. | Anticuerpos capaces de unirse específicamente a oligómeros de beta amiloides, y su utilización |
AT506819B1 (de) | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
US9085614B2 (en) | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
CN102171237A (zh) * | 2008-08-14 | 2011-08-31 | 默沙东公司 | 使用蛋白a亲和色谱法纯化抗体的方法 |
DK2419447T3 (en) | 2009-04-17 | 2017-09-25 | Immunas Pharma Inc | ANTIBODIES THAT SPECIFICALLY BIND TO A BETA OLIGOMER AND USE THEREOF |
CA2767105A1 (fr) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Procedes de stimulation de la regeneration du foie |
US8858949B2 (en) | 2009-08-06 | 2014-10-14 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
DK2462162T3 (en) | 2009-08-06 | 2017-01-16 | Immunas Pharma Inc | Antibodies that specifically bind to A-beta oligomers and their use |
CN102597233B (zh) | 2009-08-07 | 2014-10-29 | 协和发酵麒麟株式会社 | 人源化抗淀粉样-b寡聚体抗体 |
SG177679A1 (en) | 2009-08-07 | 2012-02-28 | Kyowa Hakko Kirin Co Ltd | Humanized anti-amyloid-b oligomer antibody |
BR112012004823B1 (pt) * | 2009-09-03 | 2021-11-30 | Merck Sharp & Dohme Corp | Anticorpo ou fragmento de ligação de antígeno do mesmo, uso de um anticorpo ou um fragmento de ligação de antígeno do mesmo, e composição farmacêutica |
EP2475428B1 (fr) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Dérivés hétérocycliques en tant qu'inhibiteurs de glutaminyle cyclase |
JP5106688B2 (ja) * | 2009-11-24 | 2012-12-26 | 楽天株式会社 | 情報処理装置、情報処理方法、プログラム及び記憶媒体 |
US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
RS55460B1 (sr) | 2009-11-30 | 2017-04-28 | Janssen Biotech Inc | Mutirana fc antitela sa uklonjenom efektorskom funkcijom |
KR101637138B1 (ko) | 2010-02-24 | 2016-07-06 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
EP2560953B1 (fr) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibiteurs de glutaminyl cyclase |
WO2011149461A1 (fr) | 2010-05-27 | 2011-12-01 | Medtronic, Inc. | Anticorps anti-amyloïde bêta conjugués à des molécules contenant de l'acide sialique |
US9320793B2 (en) | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
US9176151B2 (en) | 2010-07-14 | 2015-11-03 | Acumen Pharmaceuticals, Inc. | Antibodies, kit and method for detecting amyloid beta oligomers |
JP5934203B2 (ja) * | 2010-07-14 | 2016-06-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗addlモノクローナル抗体およびこの使用 |
WO2012016173A2 (fr) | 2010-07-30 | 2012-02-02 | Ac Immune S.A. | Anticorps humanisés sûrs et fonctionnels |
WO2012024187A1 (fr) | 2010-08-14 | 2012-02-23 | Abbott Laboratories | Protéines de liaison bêta-amyloïdes |
US20130164288A1 (en) | 2010-09-07 | 2013-06-27 | Protalix Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
CA2812644A1 (fr) * | 2010-09-27 | 2012-04-05 | Zestagen, S.A. | Compositions et methodes de traitement d'une neoplasie |
AU2011311516B2 (en) * | 2010-10-07 | 2015-06-11 | Ac Immune S.A. | Phosphospecific antibodies recognising Tau |
KR101919170B1 (ko) | 2010-11-19 | 2018-11-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 중화 항-ccl20 항체 |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
BR112013025415B1 (pt) | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
DK2732289T3 (en) | 2011-07-13 | 2018-05-22 | Acumen Pharmaceuticals Inc | ANTIBODIES, KIT AND IN VITRO METHOD FOR DETECTING BETA AMYLOID OLIGOMERS |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
EA201490644A1 (ru) | 2011-09-30 | 2014-09-30 | Дана-Фарбер Кэнсер Инститьют, Инк. | Терапевтические пептиды |
US9579358B2 (en) * | 2011-10-10 | 2017-02-28 | Lancaster University Business Enterprises Limited | Compositions for binding to amyloid proteins |
SG10201604104PA (en) | 2011-10-25 | 2016-07-28 | Prothena Therapeutics Ltd | Antibody formulations and methods |
DE102011057019A1 (de) * | 2011-12-23 | 2013-06-27 | Forschungszentrum Jülich GmbH | Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen |
US9377472B2 (en) | 2012-04-30 | 2016-06-28 | Amoneta Diagnostics | Biological complex specific for Alzheimer's disease detection in vitro and use thereof |
EP2846819B1 (fr) | 2012-05-09 | 2017-05-03 | Yeda Research and Development Co. Ltd. | Variants de pro-domaine tace en tant qu'inhibiteur de tnf-a et leur utilisation médicale |
EP2855529A4 (fr) | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | Anticorps anti-facteur b humaneered |
RU2668824C2 (ru) | 2012-08-31 | 2018-10-02 | Иммьюноджен Инк. | Диагностические анализы и наборы для детекции фолатного рецептора 1 |
US10745483B2 (en) | 2013-03-15 | 2020-08-18 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
MX371496B (es) | 2013-08-30 | 2020-01-31 | Immunogen Inc | Anticuerpos y ensayos para la detección del receptor 1 de folato. |
DK3083680T3 (da) | 2013-12-20 | 2020-03-16 | Hoffmann La Roche | Humaniserede anti-Tau(pS422)-antistoffer og fremgangsmåder til anvendelse |
JP2017510631A (ja) | 2014-03-14 | 2017-04-13 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 癌に対しnkg2d経路機能を回復させるためのワクチン組成物および方法 |
AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
LT3166970T (lt) * | 2014-07-10 | 2021-05-10 | Bioarctic Ab | Patobulinti a-beta protofibriles surišantys antikūnai |
EP3273994B1 (fr) | 2015-03-27 | 2021-12-01 | University of Southern California | Thérapie à base de lymphocytes t car dirigés contre le récepteur lhr pour le traitement des tumeurs solides |
AU2016243126A1 (en) * | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cells for the treatment of B7-H4 expressing solid tumors |
CN107810196B (zh) | 2015-06-24 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 人源化的抗-Tau(pS422)抗体和使用方法 |
CA2994888A1 (fr) | 2015-09-17 | 2017-03-23 | Immunogen, Inc. | Combinaisons therapeutiques comprenant des immunoconjugues anti-folr1 |
JP2017132742A (ja) * | 2016-01-29 | 2017-08-03 | 国立大学法人 大分大学 | Aβオリゴマー特異的抗体の新規薬理用途 |
WO2017172733A1 (fr) * | 2016-03-28 | 2017-10-05 | The Regents Of The University Of California | Anticorps anti-ryk et leurs procédés d'utilisation |
WO2018084712A1 (fr) | 2016-11-07 | 2018-05-11 | Crossbeta Biosciences B.V. | Nouvelle molécule de liaison spécifique d'oligomère bêta-amyloïde |
US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
BR112019013463A2 (pt) | 2016-12-29 | 2020-01-07 | University Of Miami | Método para a modulação da atividade de inflamassoma e da inflamação nos pulmões |
EP3574020B1 (fr) * | 2017-07-18 | 2024-05-15 | The University of British Columbia | Anticorps anti-bêta-amyloïde |
AU2018306321A1 (en) * | 2017-07-28 | 2020-02-13 | Phanes Therapeutics, Inc. | Anti-TIM-3 antibodies and uses thereof |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
EP3749689A1 (fr) | 2018-02-08 | 2020-12-16 | Yeda Research and Development Co. Ltd | Inhibiteurs du protéasome 20s |
EP3818081A4 (fr) * | 2018-07-03 | 2022-06-22 | University of Miami | Compositions et méthodes pour le traitement de maladies ou de troubles liés aux inflammasomes |
CN111217912B (zh) * | 2018-11-26 | 2022-11-08 | 东莞市朋志生物科技有限公司 | 一种抗pgⅱ的抗体及其应用 |
US20220041697A1 (en) * | 2018-12-10 | 2022-02-10 | New York University | Monoclonal antibodies targeting c-terminal region of phosphorylated tau |
IL266433B (en) | 2019-05-02 | 2020-11-30 | Sagi Irit | Compositions comprising the propeptide of lysyl oxidase and uses thereof |
EP3995505A4 (fr) * | 2019-07-05 | 2023-07-26 | Shimadzu Corporation | Anticorps monoclonal dirigé contre l'amyloïde bêta, et procédé de mesure d'un peptide apparenté à l'amyloïde bêta utilisant ledit anticorps |
AU2020347483A1 (en) * | 2019-09-10 | 2022-03-31 | Ac Immune Sa | Novel molecules for diagnosis |
EP4121108A4 (fr) * | 2020-03-18 | 2024-04-03 | Elanco Us Inc | Anticorps dirigés contre le récepteur à l'il4 à usage vétérinaire |
CN112480250B (zh) * | 2020-12-23 | 2022-03-15 | 上海交通大学 | 一种抗人骨桥蛋白的抗体及其应用 |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
WO2022251048A1 (fr) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anticorps anti-amyloïde bêta et leurs utilisations |
WO2023081766A2 (fr) * | 2021-11-03 | 2023-05-11 | Rutgers, The State University Of New Jersey | Conjugués anticorps-médicament dirigés contre le récepteur tyrosine kinase epha5 |
WO2023156999A1 (fr) | 2022-02-17 | 2023-08-24 | Yeda Research And Development Co. Ltd. | Propeptide de lysyl oxydase pour le traitement du cancer |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4493825A (en) | 1982-10-05 | 1985-01-15 | Iowa State University Research Foundation | Purified and antigenically selective vaccines for domestic animals |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
CA2017507C (fr) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant constitue d'une emulsion de gouttelettes submicron d'huile |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
EP0519596B1 (fr) * | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | Procédé pour réduire l'immunogénicité des domaines variables d'anticorps |
EP0746609A4 (fr) | 1991-12-17 | 1997-12-17 | Genpharm Int | Animaux transgeniques non humains capables de produire des anticorps heterologues |
GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
CA2115900A1 (fr) * | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Cribles pharmaceutiques et anticorps |
FR2702049B1 (fr) | 1993-02-24 | 1995-03-31 | Imra Europe Sa | Procédé et dispositif pour déterminer un risque de condensation d'eau sur une surface se trouvant au contact d'un volume d'air humide. |
AU7378096A (en) | 1995-09-28 | 1997-04-17 | Alexion Pharmaceuticals, Inc. | Porcine cell interaction proteins |
US20030068316A1 (en) * | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
US6218506B1 (en) * | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
IL138608A0 (en) * | 1998-04-02 | 2001-10-31 | Genentech Inc | Antibody variants and fragments thereof |
GB9809951D0 (en) * | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
WO2005011599A2 (fr) * | 2003-08-01 | 2005-02-10 | Northwestern University | Anticorps specifiques des oligomeres a proteines beta amyloides toxiques |
EP1660533A4 (fr) | 2003-09-12 | 2009-10-21 | Univ California | Anticorps monoclonaux specifiques a des intermediaires d'agregation de poids moleculaire eleve communs a des amyloides formes a partir de proteines de sequence differente |
CA2584859C (fr) * | 2004-10-25 | 2017-11-07 | Merck & Co., Inc. | Anticorps anti-addl et leurs utilisations |
-
2005
- 2005-10-21 CA CA2584859A patent/CA2584859C/fr active Active
- 2005-10-21 RU RU2007119382/15A patent/RU2007119382A/ru not_active Application Discontinuation
- 2005-10-21 AU AU2005306997A patent/AU2005306997B2/en active Active
- 2005-10-21 NZ NZ554725A patent/NZ554725A/en unknown
- 2005-10-21 EP EP05820737.4A patent/EP1812062B1/fr active Active
- 2005-10-21 US US11/577,426 patent/US7811563B2/en active Active
- 2005-10-21 US US11/256,332 patent/US7780963B2/en active Active
- 2005-10-21 KR KR1020077011785A patent/KR20070094890A/ko not_active Application Discontinuation
- 2005-10-21 WO PCT/US2005/038125 patent/WO2006055178A2/fr active Application Filing
- 2005-10-21 EP EP12157990A patent/EP2465872A3/fr not_active Withdrawn
- 2005-10-21 JP JP2007538122A patent/JP5173426B2/ja active Active
- 2005-10-21 BR BRPI0516962-3A patent/BRPI0516962A/pt not_active IP Right Cessation
-
2006
- 2006-10-17 BR BRPI0617480A patent/BRPI0617480A2/pt not_active IP Right Cessation
-
2007
- 2007-04-15 IL IL182554A patent/IL182554A0/en unknown
- 2007-05-25 NO NO20072700A patent/NO20072700L/no not_active Application Discontinuation
-
2008
- 2008-03-27 IL IL190502A patent/IL190502A0/en unknown
-
2010
- 2010-07-01 US US12/828,411 patent/US8128930B2/en active Active
- 2010-10-11 US US12/901,738 patent/US8889138B2/en active Active
-
2011
- 2011-12-07 JP JP2011268315A patent/JP5634975B2/ja active Active
- 2011-12-07 JP JP2011268314A patent/JP2012087139A/ja active Pending
-
2012
- 2012-02-08 US US13/368,742 patent/US8383113B2/en active Active
- 2012-08-29 JP JP2012189197A patent/JP2013035843A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20072700L (no) | Anti-ADDL antistoffer og anvendelser derav | |
NO20082288L (no) | Monoklonalt anti-ADDL-antistoff og anvendelse derav | |
WO2007011834A3 (fr) | Composes et procede pour diagnostiquer et traiter les maladies associees aux amyloides | |
WO2010115843A3 (fr) | Composition pharmaceutique | |
Jhamandas et al. | β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor | |
WO2006118959A3 (fr) | Anticorps diriges contre un peptide amyloide-beta et procedes d'utilisation de ceux-ci | |
ATE539745T1 (de) | Zusammensetzungen zur behandlung von amyloid- assoziierten erkrankungen | |
WO2007064972A3 (fr) | Anticorps monoclonaux et utilisation de ceux-ci | |
WO2008150946A8 (fr) | Anticorps humanisés qui se lient au globulomère aβ(1-42) et leurs utilisations | |
WO2010065077A3 (fr) | Antagonistes d'il-6 pour prévenir ou traiter la thrombose | |
WO2005018424A3 (fr) | Anticorps specifiques de la proteine amyloide fibrillaire et procedure permettant de detecter des depots de proteines amyloides fibrillaires | |
MX338640B (es) | Anticuerpo monoclonal anti-ligando difundible derivado de amiloide beta y usos de los mismos. | |
WO2008051326A3 (fr) | Identification de contactines et de cams l1 en tant que ligands pour la protéine précurseur amyloïde | |
Yu et al. | Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model | |
Yang et al. | Acute exercise and brain BACE 1 protein content: A time course study | |
Ohsawa et al. | Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice | |
WO2003083046A3 (fr) | Nouvelles proteines et acides nucleiques codant pour de telles proteines | |
WO2003064628A3 (fr) | Mandrin a vide faisant intervenir un materiau fritte et procede de fabrication | |
WO2003102159A3 (fr) | Nouvelles proteines et nouveaux acides nucleiques codant pour ces proteines | |
WO2004047854A3 (fr) | Procedes de traitement de la maladie d'alzheimer et compositions afferentes | |
DE602004024992D1 (de) | Verwendung von pyrazolopyridinen zur behandlung von kognitiven defiziten | |
Zhang et al. | Novel histone modifications in microglia derived from a mouse model of chronic pain | |
ATE391915T1 (de) | Verwendung des proteins grf-1 zur auswahl von molekülen | |
WO2005005471A3 (fr) | Utilisation de produits des proteines dg153 ou dg177 secretees pour la prevention et le traitement de maladies du pancreas et/ou de l'obesite et/ou du syndrome metabolique | |
WO2003057854A3 (fr) | Nouvelles proteines et acides nucleiques codant ces dernieres |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |