NO20072542L - Pyrimidinderivat kondensert med ikke-aromatisk ring - Google Patents
Pyrimidinderivat kondensert med ikke-aromatisk ringInfo
- Publication number
- NO20072542L NO20072542L NO20072542A NO20072542A NO20072542L NO 20072542 L NO20072542 L NO 20072542L NO 20072542 A NO20072542 A NO 20072542A NO 20072542 A NO20072542 A NO 20072542A NO 20072542 L NO20072542 L NO 20072542L
- Authority
- NO
- Norway
- Prior art keywords
- insulin
- aromatic ring
- pyrimidine derivative
- diabetes
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004305374 | 2004-10-20 | ||
PCT/JP2005/019000 WO2006043490A1 (ja) | 2004-10-20 | 2005-10-17 | 非芳香環縮合ピリミジン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072542L true NO20072542L (no) | 2007-07-18 |
Family
ID=36202906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072542A NO20072542L (no) | 2004-10-20 | 2007-05-18 | Pyrimidinderivat kondensert med ikke-aromatisk ring |
Country Status (15)
Country | Link |
---|---|
US (1) | US7947690B2 (es) |
EP (1) | EP1803710A4 (es) |
JP (1) | JP4775767B2 (es) |
KR (1) | KR20070084035A (es) |
CN (1) | CN101044123B (es) |
AU (1) | AU2005297743A1 (es) |
BR (1) | BRPI0516237A (es) |
CA (1) | CA2584666C (es) |
IL (1) | IL182641A0 (es) |
MX (1) | MX2007004769A (es) |
NO (1) | NO20072542L (es) |
RU (1) | RU2007118653A (es) |
TW (1) | TW200621257A (es) |
WO (1) | WO2006043490A1 (es) |
ZA (1) | ZA200703947B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1693804B1 (en) * | 1996-09-04 | 2009-11-11 | Intertrust Technologies Corp. | Trusted infrastructure support systems, methods and techniques for secure electronic commerce, electronic transactions, commerce process control and automation, distributed computing and rights management |
EA011009B1 (ru) | 2003-01-14 | 2008-12-30 | Арена Фармасьютикалз Инк. | 1,2,3-тризамещённые арильные и гетероарильные производные в качестве модуляторов метаболизма и профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия |
EP2181994B1 (en) * | 2006-03-31 | 2014-05-28 | Research Foundation Itsuu Laboratory | Antimicrobial compounds |
PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
MX2008013120A (es) | 2006-04-11 | 2008-10-27 | Arena Pharm Inc | Metodos para utilizar el receptor gpr119 para identificar compuestos utiles para incrementar la masa osea en un individuo. |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
NZ573979A (en) | 2006-07-06 | 2012-02-24 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
DK2054418T3 (da) * | 2006-07-06 | 2012-02-27 | Array Biopharma Inc | Dihydrothieno-pyrimidiner som AKT-proteinkinase-inhibitorer |
WO2008006025A1 (en) * | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
EP2170883A1 (en) * | 2007-06-28 | 2010-04-07 | Merck Frosst Canada Ltd. | Substituted fused pyrimidines as antagonists of gpr105 activity |
JP5628028B2 (ja) * | 2007-07-05 | 2014-11-19 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2009089453A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
EP2247578B1 (en) | 2008-01-09 | 2013-05-22 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
AR073354A1 (es) * | 2008-07-31 | 2010-11-03 | Genentech Inc | Compuestos de pirimidina, composiciones farmaceuticas y su uso en el tratamiento del cancer. |
CA2766151A1 (en) * | 2009-06-24 | 2010-12-29 | Genentech, Inc. | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
US20110021515A1 (en) * | 2009-07-24 | 2011-01-27 | Takeda Pharmaceutical Company Limited | Dihyrofuropyrmindine compounds |
CN102020657A (zh) * | 2009-09-11 | 2011-04-20 | 上海艾力斯医药科技有限公司 | 稠合杂芳基衍生物、制备方法及其应用 |
KR101469334B1 (ko) * | 2009-11-12 | 2014-12-04 | 에프. 호프만-라 로슈 아게 | N-9-치환된 퓨린 화합물, 조성물 및 사용 방법 |
KR101447789B1 (ko) * | 2009-11-12 | 2014-10-06 | 에프. 호프만-라 로슈 아게 | N-7 치환된 퓨린 및 피라졸로피리미딘 화합물, 조성물 및 사용 방법 |
JP5858917B2 (ja) | 2010-08-26 | 2016-02-10 | 興和株式会社 | イソキノリン誘導体又はその塩の新規製造方法 |
BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
WO2012099581A1 (en) | 2011-01-19 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Dihydrofuropyrimidine compounds |
LT2694072T (lt) | 2011-04-01 | 2018-02-12 | Genentech, Inc. | Akt slopinančio junginio ir abiraterono derinys, skirtas naudoti terapiniam gydymui |
RU2013148817A (ru) | 2011-04-01 | 2015-05-10 | Дженентек, Инк. | Комбинации соединений-ингибиторов акт и мек и способы их применения |
CN102875567B (zh) * | 2011-07-15 | 2015-03-11 | 天津药物研究院 | 一类含哌嗪化合物、制备及用途 |
WO2014124860A1 (en) * | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
TW201512189A (zh) | 2013-04-16 | 2015-04-01 | Gruenenthal Chemie | 新型被取代之嘧啶縮合化合物 |
US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
EP3939965A1 (en) | 2015-06-22 | 2022-01-19 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders |
EP3582772A1 (en) | 2017-02-16 | 2019-12-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
BR112019024300A2 (pt) | 2017-05-22 | 2020-06-16 | Topadur Pharma Ag | Ativadores de guanilato ciclase solúvel com modo duplo de ação e inibidores da fosfodiesterase e usos dos mesmos |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1470336A1 (de) * | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
US4871739A (en) * | 1987-01-21 | 1989-10-03 | Merck & Co., Inc. | Substituted 6H-7,8-dihydrothiapyrano(3,2-D)-pyrimidines as hyopglycemic agents |
EP0276057B1 (en) | 1987-01-21 | 1994-03-09 | Merck & Co. Inc. | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents |
US4889856A (en) * | 1987-08-31 | 1989-12-26 | Merck & Co., Inc. | 7,8-dihydro-4-(1-pierazinyl)-6H-thiopyrano-[3,2-d] pyrimidines as β-blockers |
JPH04224580A (ja) | 1990-12-25 | 1992-08-13 | Nippon Soda Co Ltd | ピリミジン誘導体、その製造方法及び農園芸用殺菌剤 |
DE19853278A1 (de) | 1998-11-19 | 2000-05-25 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19904710A1 (de) | 1999-02-05 | 2000-08-10 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
ES2266259T3 (es) | 2000-09-15 | 2007-03-01 | Vertex Pharmaceuticals Incorporated | Compuestos de pirazol utiles como inhibidores de proteina cinasas. |
JPWO2002026745A1 (ja) * | 2000-09-29 | 2004-02-05 | 日本曹達株式会社 | チエノピリミジン化合物とその塩並びに製造方法 |
EP1474147B1 (en) | 2001-12-07 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Pyrimidine-based compounds useful as gsk-3 inhibitors |
US7423044B2 (en) * | 2002-09-05 | 2008-09-09 | Wyeth | Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia |
ES2217956B1 (es) | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
JP4224580B2 (ja) | 2003-02-28 | 2009-02-18 | 独立行政法人産業技術総合研究所 | 層状オルガノシリカナノ複合体およびその製造方法 |
CA2520465A1 (en) | 2003-03-28 | 2004-10-14 | Scios Inc. | Bi-cyclic pyrimidine inhibitors of tgf.beta. |
RU2006106710A (ru) * | 2003-08-05 | 2007-09-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Конденсированные пиримидиновые соединения в качестве ингибиторов потенциалозависимых ионных каналов |
TW200626157A (en) * | 2004-09-30 | 2006-08-01 | Tibotec Pharm Ltd | HCV inhibiting bi-cyclic pyrimidines |
-
2005
- 2005-10-14 TW TW094135952A patent/TW200621257A/zh unknown
- 2005-10-17 EP EP05793361A patent/EP1803710A4/en not_active Withdrawn
- 2005-10-17 RU RU2007118653/04A patent/RU2007118653A/ru not_active Application Discontinuation
- 2005-10-17 WO PCT/JP2005/019000 patent/WO2006043490A1/ja active Application Filing
- 2005-10-17 ZA ZA200703947A patent/ZA200703947B/xx unknown
- 2005-10-17 BR BRPI0516237-8A patent/BRPI0516237A/pt not_active IP Right Cessation
- 2005-10-17 JP JP2006542955A patent/JP4775767B2/ja not_active Expired - Fee Related
- 2005-10-17 AU AU2005297743A patent/AU2005297743A1/en not_active Abandoned
- 2005-10-17 CA CA2584666A patent/CA2584666C/en not_active Expired - Fee Related
- 2005-10-17 US US11/577,648 patent/US7947690B2/en not_active Expired - Fee Related
- 2005-10-17 MX MX2007004769A patent/MX2007004769A/es not_active Application Discontinuation
- 2005-10-17 KR KR1020077010353A patent/KR20070084035A/ko not_active Application Discontinuation
- 2005-10-17 CN CN2005800357323A patent/CN101044123B/zh not_active Expired - Fee Related
-
2007
- 2007-04-18 IL IL182641A patent/IL182641A0/en unknown
- 2007-05-18 NO NO20072542A patent/NO20072542L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101044123B (zh) | 2010-09-08 |
CN101044123A (zh) | 2007-09-26 |
MX2007004769A (es) | 2007-06-25 |
KR20070084035A (ko) | 2007-08-24 |
US7947690B2 (en) | 2011-05-24 |
EP1803710A4 (en) | 2009-08-26 |
JP4775767B2 (ja) | 2011-09-21 |
ZA200703947B (en) | 2008-08-27 |
CA2584666A1 (en) | 2006-04-27 |
BRPI0516237A (pt) | 2008-08-26 |
RU2007118653A (ru) | 2008-11-27 |
IL182641A0 (en) | 2007-07-24 |
US20080070896A1 (en) | 2008-03-20 |
WO2006043490A1 (ja) | 2006-04-27 |
CA2584666C (en) | 2011-12-06 |
AU2005297743A1 (en) | 2006-04-27 |
EP1803710A1 (en) | 2007-07-04 |
JPWO2006043490A1 (ja) | 2008-05-22 |
TW200621257A (en) | 2006-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |