NO20065122L - 1,1'-(1,2-etyndiyl)bis-benzenderivater som PTP 1-B-hemmere - Google Patents

1,1'-(1,2-etyndiyl)bis-benzenderivater som PTP 1-B-hemmere

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Publication number
NO20065122L
NO20065122L NO20065122A NO20065122A NO20065122L NO 20065122 L NO20065122 L NO 20065122L NO 20065122 A NO20065122 A NO 20065122A NO 20065122 A NO20065122 A NO 20065122A NO 20065122 L NO20065122 L NO 20065122L
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NO
Norway
Prior art keywords
ptp
ethynthyl
inhibitors
bis
benzene derivatives
Prior art date
Application number
NO20065122A
Other languages
English (en)
Inventor
Agnes Bombrun
Dominique Swinnen
Jerome Gonzalez
Catherine Jorand-Lebrun
Patrick Gerber
Original Assignee
Applied Research Systems
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Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20065122L publication Critical patent/NO20065122L/no

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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen angår karboksylsyrer med formel (I) og deres anvendelse for behandling og/eller forebygging av overvekt og/eller metabolske hdelser mediert av insulinresistens eller hyperglykemi som omfatter diabetes type I og/eller II, utilstrekkelig glukosetoleranse, insulinresistens, hyperlipidemi, hypertriglyseridemi, hyperkolesterolemi og polycystisk eggstokksyndrom (PCOS). Oppfinnelsen angår spesielt bruken av karboksylsyrer med formel (I) for å modulere, da spesielt å hemme, aktiviteten til PTP.
NO20065122A 2004-04-07 2006-11-07 1,1'-(1,2-etyndiyl)bis-benzenderivater som PTP 1-B-hemmere NO20065122L (no)

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US56628004P 2004-04-29 2004-04-29
PCT/EP2005/051426 WO2005097773A1 (en) 2004-04-07 2005-03-29 1,1’-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b inhibitors

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US20090029903A1 (en) 2009-01-29
UA85405C2 (ru) 2009-01-26
EP1756081A1 (en) 2007-02-28
CN1997638B (zh) 2011-07-06
WO2005097773A1 (en) 2005-10-20
EA011930B1 (ru) 2009-06-30
JP2007532514A (ja) 2007-11-15
AU2005231980A1 (en) 2005-10-20
HK1102597A1 (en) 2007-11-30
IL178425A (en) 2012-02-29
KR101194968B1 (ko) 2012-10-25
CN1997638A (zh) 2007-07-11
US7947851B2 (en) 2011-05-24
AR048465A1 (es) 2006-04-26
JP5043645B2 (ja) 2012-10-10
AU2005231980B2 (en) 2011-09-08
KR20070008675A (ko) 2007-01-17
EA200601869A1 (ru) 2007-04-27
BRPI0508790A (pt) 2007-09-04
MXPA06011678A (es) 2007-01-23
CA2560648C (en) 2013-01-22
IL178425A0 (en) 2007-02-11
CA2560648A1 (en) 2005-10-20

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