UA85405C2 - Производные 1,1'-(1,2-этиндиил)бис-бензола как ингибиторы ртр-1в - Google Patents
Производные 1,1'-(1,2-этиндиил)бис-бензола как ингибиторы ртр-1вInfo
- Publication number
- UA85405C2 UA85405C2 UAA200610431A UAA200610431A UA85405C2 UA 85405 C2 UA85405 C2 UA 85405C2 UA A200610431 A UAA200610431 A UA A200610431A UA A200610431 A UAA200610431 A UA A200610431A UA 85405 C2 UA85405 C2 UA 85405C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ethynediyl
- ptp
- inhibitors
- bis
- benzene derivatives
- Prior art date
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- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
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- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Это изобретение касается карбоновых кислот формулы (І) и их применение для лечения и/или профилактики ожирения и/или метаболических расстройств, опосредованных резистентностью к инсулину или гипергликемией, в том числе диабета типа І и/или диабета типа II, неадекватной толерантности к глюкозе, резистентности к инсулину, гиперлипидемии, гипертриглицеридемии, гиперхолестеринемии, синдрома поликистозного яичника (PCOS).В частности, это изобретение касается применения карбоновых кислот формулы (І) для модулирования, особенно для ингибирования, активности РТР.(I)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP04101445 | 2004-04-07 |
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UA85405C2 true UA85405C2 (ru) | 2009-01-26 |
Family
ID=34928943
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UAA200610431A UA85405C2 (ru) | 2004-04-07 | 2005-03-29 | Производные 1,1'-(1,2-этиндиил)бис-бензола как ингибиторы ртр-1в |
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US (1) | US7947851B2 (ru) |
EP (1) | EP1756081A1 (ru) |
JP (1) | JP5043645B2 (ru) |
KR (1) | KR101194968B1 (ru) |
CN (1) | CN1997638B (ru) |
AR (1) | AR048465A1 (ru) |
AU (1) | AU2005231980B2 (ru) |
BR (1) | BRPI0508790A (ru) |
CA (1) | CA2560648C (ru) |
EA (1) | EA011930B1 (ru) |
HK (1) | HK1102597A1 (ru) |
IL (1) | IL178425A (ru) |
MX (1) | MXPA06011678A (ru) |
NO (1) | NO20065122L (ru) |
UA (1) | UA85405C2 (ru) |
WO (1) | WO2005097773A1 (ru) |
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UA94049C2 (ru) * | 2005-07-15 | 2011-04-11 | Лаборатуар Сероно С.А. | Применение ингибиторов glepp-1 для лечения аутоиммунных и/или воспалительных расстройств |
AU2015210454B2 (en) * | 2005-12-23 | 2016-10-27 | Ariad Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
CN103044432B (zh) | 2005-12-23 | 2016-08-03 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
KR20090010186A (ko) * | 2006-04-13 | 2009-01-29 | 주식회사 뉴로테크 | 살리실산 유도체 화합물 및 이를 포함하는 약학 조성물 |
KR20090018104A (ko) * | 2006-05-08 | 2009-02-19 | 어리어드 파마슈티칼스, 인코포레이티드 | 아세틸렌계 헤테로아릴 화합물 |
MX2008014290A (es) | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos monociclicos. |
US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
JP2009108036A (ja) * | 2007-09-28 | 2009-05-21 | Fujifilm Corp | 新規アセチレン化合物、その製造方法、それを構成単位として含むポリマー、該化合物及び/又は該ポリマーを含む組成物、該組成物を硬化させてなる硬化物 |
WO2009120783A1 (en) * | 2008-03-25 | 2009-10-01 | The Johns Hopkins University | High affinity inhibitors of hepatitis c virus ns3/4a protease |
WO2010056311A1 (en) | 2008-11-12 | 2010-05-20 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
EP2358658A4 (en) * | 2008-11-20 | 2012-11-14 | Reddys Lab Ltd Dr | PREPARATION OF RASAGILIN AND ITS SALTS |
WO2013029555A1 (zh) * | 2011-09-01 | 2013-03-07 | 天津医科大学附属肿瘤医院 | 熏草菌素a衍生物及其制备方法与应用 |
CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
WO2016001452A1 (en) | 2014-07-04 | 2016-01-07 | Universität Zürich | Compounds, in particular for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated |
WO2018155260A1 (ja) * | 2017-02-23 | 2018-08-30 | 株式会社Ihi | Ohラジカル検出プローブ、ohラジカル測定装置、および、ohラジカル測定方法 |
WO2020040831A1 (en) * | 2018-08-20 | 2020-02-27 | Perlara Pbc | Methods for treating congenital disorders of glycosylation |
JP2023542178A (ja) | 2020-09-18 | 2023-10-05 | アイユーシーエフ-エイチワイユー(インダストリー-ユニバーシティ コーオペレーション ファウンデーション ハンヤン ユニバーシティ) | PTPsigma-Fc融合タンパク質およびそれを含む薬学組成物 |
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CA1176269A (en) * | 1981-03-02 | 1984-10-16 | Kazimir Sestanj | N-naphthoylglycine derivatives |
US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
NZ335028A (en) | 1996-10-16 | 2000-09-29 | American Cyanamid Co | Ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase (MMP) and TACE (TNF-alpha converting enzyme) inhibitors |
AU5647099A (en) | 1998-09-11 | 2000-04-03 | Shionogi & Co., Ltd. | Remedal or preventive agent for congestive heart failure |
CA2353151A1 (en) * | 1998-12-16 | 2000-06-22 | Boehringer Ingelheim Pharma Kg | Substituted aryl and heteroaryl derivatives, the preparation thereof and their use as medicaments |
ATE321052T1 (de) | 2000-07-07 | 2006-04-15 | Novo Nordisk As | Modulatoren von protein tyrosin phosphatasen (ptpasen) |
JP4164028B2 (ja) * | 2001-10-12 | 2008-10-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アルキンマトリックスメタロプロテイナーゼ阻害剤 |
CN100410236C (zh) | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
ATE455772T1 (de) * | 2003-07-21 | 2010-02-15 | Merck Serono Sa | Alkinylarylcarbonsäureamide |
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2005
- 2005-03-29 WO PCT/EP2005/051426 patent/WO2005097773A1/en active Application Filing
- 2005-03-29 EA EA200601869A patent/EA011930B1/ru not_active IP Right Cessation
- 2005-03-29 CN CN2005800182403A patent/CN1997638B/zh not_active Expired - Fee Related
- 2005-03-29 CA CA2560648A patent/CA2560648C/en not_active Expired - Fee Related
- 2005-03-29 UA UAA200610431A patent/UA85405C2/ru unknown
- 2005-03-29 KR KR1020067022922A patent/KR101194968B1/ko not_active IP Right Cessation
- 2005-03-29 US US11/547,861 patent/US7947851B2/en not_active Expired - Fee Related
- 2005-03-29 JP JP2007506765A patent/JP5043645B2/ja not_active Expired - Fee Related
- 2005-03-29 EP EP05717158A patent/EP1756081A1/en not_active Withdrawn
- 2005-03-29 MX MXPA06011678A patent/MXPA06011678A/es active IP Right Grant
- 2005-03-29 BR BRPI0508790-2A patent/BRPI0508790A/pt not_active Application Discontinuation
- 2005-03-29 AU AU2005231980A patent/AU2005231980B2/en not_active Ceased
- 2005-04-06 AR ARP050101353A patent/AR048465A1/es not_active Application Discontinuation
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2006
- 2006-10-03 IL IL178425A patent/IL178425A/en not_active IP Right Cessation
- 2006-11-07 NO NO20065122A patent/NO20065122L/no not_active Application Discontinuation
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2007
- 2007-10-09 HK HK07110898.5A patent/HK1102597A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA06011678A (es) | 2007-01-23 |
EA200601869A1 (ru) | 2007-04-27 |
JP5043645B2 (ja) | 2012-10-10 |
IL178425A (en) | 2012-02-29 |
EA011930B1 (ru) | 2009-06-30 |
KR101194968B1 (ko) | 2012-10-25 |
IL178425A0 (en) | 2007-02-11 |
CN1997638B (zh) | 2011-07-06 |
BRPI0508790A (pt) | 2007-09-04 |
JP2007532514A (ja) | 2007-11-15 |
CA2560648A1 (en) | 2005-10-20 |
AR048465A1 (es) | 2006-04-26 |
HK1102597A1 (en) | 2007-11-30 |
CN1997638A (zh) | 2007-07-11 |
AU2005231980A1 (en) | 2005-10-20 |
EP1756081A1 (en) | 2007-02-28 |
AU2005231980B2 (en) | 2011-09-08 |
WO2005097773A1 (en) | 2005-10-20 |
KR20070008675A (ko) | 2007-01-17 |
NO20065122L (no) | 2006-11-07 |
US20090029903A1 (en) | 2009-01-29 |
CA2560648C (en) | 2013-01-22 |
US7947851B2 (en) | 2011-05-24 |
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