NO20063322L - Morfolinylinneholdende benzimidazoler som inhibitorer av respiratorisk syncytialvirusreplikasjon - Google Patents
Morfolinylinneholdende benzimidazoler som inhibitorer av respiratorisk syncytialvirusreplikasjonInfo
- Publication number
- NO20063322L NO20063322L NO20063322A NO20063322A NO20063322L NO 20063322 L NO20063322 L NO 20063322L NO 20063322 A NO20063322 A NO 20063322A NO 20063322 A NO20063322 A NO 20063322A NO 20063322 L NO20063322 L NO 20063322L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- substituted
- r4ar4b
- alkyl
- morpholinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører morfolinylinneholdende benzimidazoler med inhibitoraktivitet på replikasjonen til det respiratoriske syncytialviruset og med formelen en prodrog, TV-oksid, addisjonssalt, kvaternært amin, metallkompleks eller stereokjemisk isomer form derav hvori G er en direktebinding eller valgfritt substituert Ci-ioalkandiyl; R1 er Ar1 eller en monocyklisk eller bicyklisk heterocykel, Q er R7, pyrrolidinyl substituert med R7, piperidinyl substituert med R7 eller homopiperidinyl substituert med R7; én av R2a og R3a er valgt fra halo, valgfritt mono- eller polysubstituert Ci^alkyl, valgfritt mono- eller polysubstituert C2-6alkenyl, nitro, hydroksy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)karbonyl, C1-6alkyloksy, Ar2oksy, Ar2C1-6alkyloksy, karboksyl, C1-6alkyloksykarbonyl eller -C(=Z)Ar2; og den andre ene av R2a og R3a er hydrogen; hvis R2a er forskjellig fra hydrogen så er R2b hydrogen, C1-6alkyl eller halogen og R3b er hydrogen; hvis R3a er forskjellig fra hydrogen så er R hydrogen, C1-6alkyl eller halogen og R er hydrogen. Den vedrører ytterligere fremstillingen derav og sammensetninger omfattende disse forbindelsene, så vel som anvendelsen derav som en medisin.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104810 | 2003-12-18 | ||
US56718204P | 2004-04-30 | 2004-04-30 | |
EP04105312 | 2004-10-26 | ||
PCT/EP2004/053620 WO2005058871A1 (en) | 2003-12-18 | 2004-12-20 | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20063322L true NO20063322L (no) | 2006-09-18 |
NO339314B1 NO339314B1 (no) | 2016-11-28 |
Family
ID=34704695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063322A NO339314B1 (no) | 2003-12-18 | 2006-07-18 | Morfolinylinneholdende benzimidazoler som inhibitorer av respiratorisk syncytialvirusreplikasjon |
Country Status (33)
Country | Link |
---|---|
US (2) | US7449463B2 (no) |
EP (1) | EP1697345B1 (no) |
JP (1) | JP4951348B2 (no) |
KR (1) | KR100967406B1 (no) |
CN (2) | CN1894237A (no) |
AP (1) | AP2150A (no) |
AR (1) | AR046959A1 (no) |
AT (1) | ATE388950T1 (no) |
AU (1) | AU2004298460B2 (no) |
BR (1) | BRPI0417268B8 (no) |
CA (1) | CA2548668C (no) |
CY (1) | CY1108142T1 (no) |
DE (1) | DE602004012448T2 (no) |
DK (1) | DK1697345T3 (no) |
EA (1) | EA009876B1 (no) |
EG (1) | EG25799A (no) |
ES (1) | ES2303653T3 (no) |
HK (1) | HK1130799A1 (no) |
HR (1) | HRP20080245T3 (no) |
IL (1) | IL175910A (no) |
ME (1) | ME01042B (no) |
MX (1) | MXPA06007112A (no) |
MY (1) | MY143573A (no) |
NO (1) | NO339314B1 (no) |
NZ (1) | NZ547479A (no) |
PL (1) | PL1697345T3 (no) |
PT (1) | PT1697345E (no) |
RS (1) | RS50584B (no) |
SI (1) | SI1697345T1 (no) |
TW (1) | TWI351401B (no) |
UA (1) | UA84718C2 (no) |
WO (1) | WO2005058871A1 (no) |
ZA (1) | ZA200605894B (no) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
AU2006260969B2 (en) * | 2005-06-20 | 2011-11-17 | Janssen Sciences Ireland Uc | 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
CA2612264C (en) * | 2005-06-20 | 2014-09-23 | Tibotec Pharmaceuticals Ltd. | Heterocyclylaminoalkyl substituted benzimidazoles |
US20120148678A1 (en) | 2010-12-08 | 2012-06-14 | Advanced Technologies And Regenerative Medicine, Llc. | Sustained release of poorly water soluble active compounds |
PT2766359T (pt) | 2011-10-14 | 2016-07-14 | Ambit Biosciences Corp | Compostos heterocíclicos e utilização dos mesmos como moduladores de recetores tirosina-cinase de tipo iii |
UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
JO3637B1 (ar) * | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
CN109562160B (zh) * | 2016-05-10 | 2022-07-29 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗rsv的双环稠合的吡唑衍生物 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
RS60209B1 (sr) | 2017-03-20 | 2020-06-30 | Forma Therapeutics Inc | Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr) |
TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
JP7305658B2 (ja) | 2018-01-31 | 2023-07-10 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | 抗rsv活性を有するシクロアルキル置換ピラゾロピリミジン |
WO2019206828A1 (en) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against rsv |
WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
GB201820751D0 (en) * | 2018-12-19 | 2019-01-30 | Bp Oil Int | Methods for preparing intermediates |
BR112022001125A2 (pt) | 2019-07-22 | 2022-03-15 | Lupin Ltd | Compostos macrocíclicos como agonistas de sting, seus métodos e seus usos |
JP7329239B2 (ja) | 2019-09-20 | 2023-08-18 | 株式会社タマディック | フライトシミュレーター |
WO2023018560A1 (en) * | 2021-08-13 | 2023-02-16 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20014574A3 (cs) * | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
DE60033859T2 (de) * | 1999-06-28 | 2007-11-08 | Janssen Pharmaceutica N.V. | Hemmer des Respiratorischen Syncytial Virus |
AU778218B2 (en) * | 1999-06-28 | 2004-11-25 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
AR046971A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
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2004
- 2004-12-17 AR ARP040104755A patent/AR046959A1/es active IP Right Grant
- 2004-12-20 AP AP2006003640A patent/AP2150A/xx active
- 2004-12-20 AU AU2004298460A patent/AU2004298460B2/en not_active Ceased
- 2004-12-20 EP EP04817576A patent/EP1697345B1/en active Active
- 2004-12-20 AT AT04817576T patent/ATE388950T1/de active
- 2004-12-20 ME MEP-2008-207A patent/ME01042B/me unknown
- 2004-12-20 RS RSP-2008/0266A patent/RS50584B/sr unknown
- 2004-12-20 UA UAA200606224A patent/UA84718C2/ru unknown
- 2004-12-20 PL PL04817576T patent/PL1697345T3/pl unknown
- 2004-12-20 CN CNA2004800378255A patent/CN1894237A/zh active Pending
- 2004-12-20 MX MXPA06007112A patent/MXPA06007112A/es active IP Right Grant
- 2004-12-20 NZ NZ547479A patent/NZ547479A/en not_active IP Right Cessation
- 2004-12-20 PT PT04817576T patent/PT1697345E/pt unknown
- 2004-12-20 CN CN200810166056.9A patent/CN101412709B/zh active Active
- 2004-12-20 ES ES04817576T patent/ES2303653T3/es active Active
- 2004-12-20 WO PCT/EP2004/053620 patent/WO2005058871A1/en active Application Filing
- 2004-12-20 DK DK04817576T patent/DK1697345T3/da active
- 2004-12-20 EA EA200601178A patent/EA009876B1/ru unknown
- 2004-12-20 KR KR1020067014047A patent/KR100967406B1/ko active IP Right Grant
- 2004-12-20 JP JP2006544467A patent/JP4951348B2/ja active Active
- 2004-12-20 MY MYPI20045259A patent/MY143573A/en unknown
- 2004-12-20 BR BRPI0417268A patent/BRPI0417268B8/pt not_active IP Right Cessation
- 2004-12-20 CA CA2548668A patent/CA2548668C/en active Active
- 2004-12-20 SI SI200430732T patent/SI1697345T1/sl unknown
- 2004-12-20 DE DE602004012448T patent/DE602004012448T2/de active Active
- 2004-12-20 TW TW093139923A patent/TWI351401B/zh not_active IP Right Cessation
- 2004-12-20 US US10/563,691 patent/US7449463B2/en active Active
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2006
- 2006-05-25 IL IL175910A patent/IL175910A/en active IP Right Grant
- 2006-06-14 EG EGNA2006000561 patent/EG25799A/xx active
- 2006-07-17 ZA ZA2006/05894A patent/ZA200605894B/en unknown
- 2006-07-18 NO NO20063322A patent/NO339314B1/no not_active IP Right Cessation
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2008
- 2008-06-03 HR HR20080245T patent/HRP20080245T3/xx unknown
- 2008-06-12 CY CY20081100633T patent/CY1108142T1/el unknown
- 2008-06-17 US US12/140,686 patent/US8883837B2/en active Active
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2009
- 2009-10-13 HK HK09109448.0A patent/HK1130799A1/xx not_active IP Right Cessation
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CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: JANSSEN SCIENCES IRELAND UC, IE |
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MM1K | Lapsed by not paying the annual fees |