NO20063186L - Inhibitorer av cyklinavhengige kinaser, preparater og anvendelser derav - Google Patents
Inhibitorer av cyklinavhengige kinaser, preparater og anvendelser deravInfo
- Publication number
- NO20063186L NO20063186L NO20063186A NO20063186A NO20063186L NO 20063186 L NO20063186 L NO 20063186L NO 20063186 A NO20063186 A NO 20063186A NO 20063186 A NO20063186 A NO 20063186A NO 20063186 L NO20063186 L NO 20063186L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- cyclin
- dependent kinases
- preparations
- applications
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 108091007914 CDKs Proteins 0.000 title abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title abstract 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 102000016736 Cyclin Human genes 0.000 abstract 1
- 108050006400 Cyclin Proteins 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000006369 cell cycle progression Effects 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår nye inhibitorer av syklinavhengige kinaser (cdk) i følge formel I, hvori substituentene er som definert i kravene, og nærmere bestemt, men ikke utelukkende, som inhibitorer av cdk/syklinkomplekser. Som beskrevet heri kan inhibitorene ifølge foreliggende oppfinnelse hemme cellesyklusmaskineriet og vil følgelig være anvendbare for modulering av cellesyklusprogresjonen og til syvende og sist kontrollere cellevekst og differensiering. Slike forbindelser vil være anvendelige for behandling av individer med forstyrrelser forbundet med overdreven celleproliferasjon.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53187203P | 2003-12-23 | 2003-12-23 | |
US56013804P | 2004-04-06 | 2004-04-06 | |
US61648004P | 2004-10-06 | 2004-10-06 | |
PCT/US2004/043492 WO2005063765A1 (en) | 2003-12-23 | 2004-12-21 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20063186L true NO20063186L (no) | 2006-09-20 |
Family
ID=34743691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063186A NO20063186L (no) | 2003-12-23 | 2006-07-10 | Inhibitorer av cyklinavhengige kinaser, preparater og anvendelser derav |
Country Status (13)
Country | Link |
---|---|
US (1) | US8097619B2 (no) |
EP (1) | EP1709051A1 (no) |
JP (1) | JP4791975B2 (no) |
KR (1) | KR101155883B1 (no) |
AU (1) | AU2004309415B2 (no) |
BR (1) | BRPI0418095A (no) |
CA (1) | CA2551640C (no) |
EA (1) | EA013117B1 (no) |
HK (1) | HK1101399A1 (no) |
IL (1) | IL176543A0 (no) |
MX (1) | MXPA06007399A (no) |
NO (1) | NO20063186L (no) |
WO (1) | WO2005063765A1 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2584493A1 (en) * | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Kinase inhibitors for treating cancers |
EP2019101A1 (en) | 2007-07-26 | 2009-01-28 | GPC Biotech AG | Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor |
US8822447B2 (en) | 2010-04-22 | 2014-09-02 | Janssen Pharmaceutica Nv | Indazole compounds useful as ketohexokinase inhibitors |
BRPI1107312B1 (pt) | 2011-11-25 | 2021-09-08 | Universidade Federal De Santa Catarina | Composto de acil-hidrazona |
EP3548488A1 (en) | 2016-11-30 | 2019-10-09 | Oncotyrol Center for Personalized Cancer Medicine GmbH | 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3211732A (en) | 1965-10-12 | Pyrazolob:x-d]pyrlil/hdines | ||
CH398626A (de) | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
JPS60130521A (ja) | 1983-12-19 | 1985-07-12 | Morishita Seiyaku Kk | 抗癌剤 |
US4678499A (en) | 1985-03-11 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
JPS6299361A (ja) | 1985-10-25 | 1987-05-08 | Morishita Seiyaku Kk | インデノ〔1,2−c〕ピラゾ−ル誘導体 |
TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
US5593997A (en) | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
US6407103B2 (en) * | 1998-04-21 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Indeno [1,2-c] pyrazol-4-ones and their uses |
CN1297442A (zh) | 1998-04-21 | 2001-05-30 | 杜邦药品公司 | 用作抗癌剂和抗增殖剂的5-氨基茚并[1,2-c]吡唑-4-酮类化合物 |
US6531477B1 (en) | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
US6559152B2 (en) | 1998-10-13 | 2003-05-06 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
US6291504B1 (en) | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
JP2004524277A (ja) | 2000-10-20 | 2004-08-12 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | アシルセミカルバジド及びサイクリン依存性キナーゼ(cdk)阻害剤としてのその使用 |
US6491971B2 (en) | 2000-11-15 | 2002-12-10 | G.T. Equipment Technologies, Inc | Release coating system for crucibles |
US6706718B2 (en) | 2000-12-01 | 2004-03-16 | Bristol-Myers Squibb Company | 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-one derivatives and their uses |
CA2439263C (en) | 2001-03-02 | 2012-10-23 | Frank Becker | Three hybrid assay system |
US7605175B2 (en) * | 2001-03-02 | 2009-10-20 | Gpc Biotech Ag | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
EP1404670A4 (en) | 2001-07-06 | 2004-11-24 | Bristol Myers Squibb Pharma Co | SEMICARBAZIDES AND THEIR USE |
US20040248905A1 (en) | 2001-07-10 | 2004-12-09 | Markwalder Jay A | 6-Substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
PL369742A1 (en) * | 2001-10-15 | 2005-05-02 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
US6753329B2 (en) | 2001-12-03 | 2004-06-22 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
-
2004
- 2004-12-21 AU AU2004309415A patent/AU2004309415B2/en not_active Ceased
- 2004-12-21 BR BRPI0418095-0A patent/BRPI0418095A/pt not_active IP Right Cessation
- 2004-12-21 KR KR1020067014820A patent/KR101155883B1/ko not_active IP Right Cessation
- 2004-12-21 MX MXPA06007399A patent/MXPA06007399A/es active IP Right Grant
- 2004-12-21 EP EP04815554A patent/EP1709051A1/en not_active Withdrawn
- 2004-12-21 JP JP2006547427A patent/JP4791975B2/ja not_active Expired - Fee Related
- 2004-12-21 WO PCT/US2004/043492 patent/WO2005063765A1/en active Application Filing
- 2004-12-21 EA EA200601216A patent/EA013117B1/ru not_active IP Right Cessation
- 2004-12-21 CA CA2551640A patent/CA2551640C/en not_active Expired - Fee Related
- 2004-12-21 US US10/584,485 patent/US8097619B2/en not_active Expired - Fee Related
-
2006
- 2006-06-25 IL IL176543A patent/IL176543A0/en unknown
- 2006-07-10 NO NO20063186A patent/NO20063186L/no not_active Application Discontinuation
-
2007
- 2007-08-27 HK HK07109307.2A patent/HK1101399A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US8097619B2 (en) | 2012-01-17 |
HK1101399A1 (en) | 2007-10-18 |
KR20060130624A (ko) | 2006-12-19 |
AU2004309415A1 (en) | 2005-07-14 |
CA2551640A1 (en) | 2005-07-14 |
US20090209530A1 (en) | 2009-08-20 |
AU2004309415B2 (en) | 2010-08-26 |
BRPI0418095A (pt) | 2007-04-17 |
JP2007516296A (ja) | 2007-06-21 |
WO2005063765A1 (en) | 2005-07-14 |
JP4791975B2 (ja) | 2011-10-12 |
EA200601216A1 (ru) | 2006-12-29 |
KR101155883B1 (ko) | 2012-06-20 |
MXPA06007399A (es) | 2007-01-26 |
CA2551640C (en) | 2012-09-11 |
EP1709051A1 (en) | 2006-10-11 |
EA013117B1 (ru) | 2010-02-26 |
IL176543A0 (en) | 2006-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |