NO20062791L - 1-benzyl-5-piperazin-1-yl-34 4 dihydro-lH-kinazolin-2-on derivater og de respektive 1H-benzo(1,2,6) tiadiazin-2,2-dioksid og 1, 4-dihydro-benzo (D) (1,3)oksazin-2-on derivater som modulatorer av 5-hydroksytryptamin reseptor (5-HT) for behandling av sykdom - Google Patents

1-benzyl-5-piperazin-1-yl-34 4 dihydro-lH-kinazolin-2-on derivater og de respektive 1H-benzo(1,2,6) tiadiazin-2,2-dioksid og 1, 4-dihydro-benzo (D) (1,3)oksazin-2-on derivater som modulatorer av 5-hydroksytryptamin reseptor (5-HT) for behandling av sykdom

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Publication number
NO20062791L
NO20062791L NO20062791A NO20062791A NO20062791L NO 20062791 L NO20062791 L NO 20062791L NO 20062791 A NO20062791 A NO 20062791A NO 20062791 A NO20062791 A NO 20062791A NO 20062791 L NO20062791 L NO 20062791L
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Norway
Prior art keywords
disease
benzo
dihydro
derivatives
alkyl
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NO20062791A
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English (en)
Norwegian (no)
Inventor
Meng Sui
Shu-Hai Zhao
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Hoffmann La Roche
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Publication of NO20062791L publication Critical patent/NO20062791L/no

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/181,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15Six-membered rings
    • C07D285/16Thiadiazines; Hydrogenated thiadiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20062791A 2004-01-16 2006-06-15 1-benzyl-5-piperazin-1-yl-34 4 dihydro-lH-kinazolin-2-on derivater og de respektive 1H-benzo(1,2,6) tiadiazin-2,2-dioksid og 1, 4-dihydro-benzo (D) (1,3)oksazin-2-on derivater som modulatorer av 5-hydroksytryptamin reseptor (5-HT) for behandling av sykdom NO20062791L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53708004P 2004-01-16 2004-01-16
PCT/EP2005/000095 WO2005067933A1 (en) 2004-01-16 2005-01-07 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1h-quinazolin-2-one derivatives and the respective 1h-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(d) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-ht) for the treatment of diseases of the central nervous system

Publications (1)

Publication Number Publication Date
NO20062791L true NO20062791L (no) 2006-08-01

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NO20062791A NO20062791L (no) 2004-01-16 2006-06-15 1-benzyl-5-piperazin-1-yl-34 4 dihydro-lH-kinazolin-2-on derivater og de respektive 1H-benzo(1,2,6) tiadiazin-2,2-dioksid og 1, 4-dihydro-benzo (D) (1,3)oksazin-2-on derivater som modulatorer av 5-hydroksytryptamin reseptor (5-HT) for behandling av sykdom

Country Status (19)

Country Link
US (2) US7196087B2 (enExample)
EP (1) EP1708713B1 (enExample)
JP (1) JP4533391B2 (enExample)
KR (1) KR100843053B1 (enExample)
CN (1) CN1909909B (enExample)
AR (1) AR047958A1 (enExample)
AT (1) ATE388712T1 (enExample)
AU (1) AU2005205016B2 (enExample)
BR (1) BRPI0506909A (enExample)
CA (1) CA2552681A1 (enExample)
CO (1) CO5700763A2 (enExample)
DE (1) DE602005005298T2 (enExample)
ES (1) ES2302174T3 (enExample)
IL (1) IL176631A0 (enExample)
NO (1) NO20062791L (enExample)
RU (1) RU2006129464A (enExample)
TW (1) TW200530222A (enExample)
WO (1) WO2005067933A1 (enExample)
ZA (1) ZA200605434B (enExample)

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MX2007007103A (es) * 2004-12-13 2008-03-10 Lilly Co Eli Derivados espiro como inhibidores de lipoxigenasa.
BRPI0613430A2 (pt) * 2005-07-13 2011-01-11 Hoffmann La Roche compostos derivados de benzimidazol, uso dos mesmos, método para a preparação destes e composição farmacêutica
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―1h―퀴나졸린―2,4―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
WO2008033764A2 (en) * 2006-09-11 2008-03-20 N.V. Organon Quinazolinone and isoquinolinone acetamide derivatives
WO2008073958A2 (en) 2006-12-12 2008-06-19 Wyeth Substituted benzothiadiazinedioxide derivatives and methods of their use
KR20110036583A (ko) * 2008-06-20 2011-04-07 로타팜 에스.피.에이. 6-1h-이미다조-퀴나졸린 및 퀴놀린 유도체, 신규 mao 억제제 및 이미다졸린 수용체 리간드
KR20110038180A (ko) * 2008-09-08 2011-04-13 에프. 호프만-라 로슈 아게 5-치환된 벤즈옥사진
AU2011255169A1 (en) 2010-05-21 2013-01-17 Shanghai Institute Of Pharmaceutical Industry Fused quinazoline derivatives and uses thereof
KR102900157B1 (ko) 2016-11-15 2025-12-12 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법
CN114072393B (zh) 2019-04-29 2025-05-27 索伦特治疗有限责任公司 作为mrgx2抑制剂的3-氨基-4h-苯并[e][1,2,4]噻二嗪1,1-二氧化物衍生物
BR112022007503A2 (pt) * 2019-10-21 2022-07-12 Alairion Inc Derivados de ácido 3-(4-(11h-dibenzo[b,e][1,4]azepin-6-il)piperazin-1-il)- e 3-(4-(11h-dibenzo[b,f][1,4]oxazepin/tiazepin/diazepin-11-il)piperazin-1-il)-propanoico como moduladores de receptor de h1 e 5-ht2a para o tratamento de distúrbios do sono

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Also Published As

Publication number Publication date
US7365063B2 (en) 2008-04-29
US20070149510A1 (en) 2007-06-28
WO2005067933A1 (en) 2005-07-28
JP4533391B2 (ja) 2010-09-01
RU2006129464A (ru) 2008-02-27
ES2302174T3 (es) 2008-07-01
ATE388712T1 (de) 2008-03-15
CN1909909A (zh) 2007-02-07
AR047958A1 (es) 2006-03-15
KR100843053B1 (ko) 2008-07-01
AU2005205016A1 (en) 2005-07-28
JP2007517826A (ja) 2007-07-05
AU2005205016B2 (en) 2010-07-15
CN1909909B (zh) 2010-12-15
BRPI0506909A (pt) 2007-05-29
EP1708713A1 (en) 2006-10-11
US20050165001A1 (en) 2005-07-28
CO5700763A2 (es) 2006-11-30
EP1708713B1 (en) 2008-03-12
DE602005005298D1 (de) 2008-04-24
KR20060126720A (ko) 2006-12-08
US7196087B2 (en) 2007-03-27
TW200530222A (en) 2005-09-16
DE602005005298T2 (de) 2009-03-12
IL176631A0 (en) 2006-10-31
CA2552681A1 (en) 2005-07-28
ZA200605434B (en) 2008-02-27

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