NO20061797L - Trombinreseptorantagonister - Google Patents
TrombinreseptorantagonisterInfo
- Publication number
- NO20061797L NO20061797L NO20061797A NO20061797A NO20061797L NO 20061797 L NO20061797 L NO 20061797L NO 20061797 A NO20061797 A NO 20061797A NO 20061797 A NO20061797 A NO 20061797A NO 20061797 L NO20061797 L NO 20061797L
- Authority
- NO
- Norway
- Prior art keywords
- thrombin
- polymorphs
- solvates
- binders
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/671,216 US7488742B2 (en) | 2000-06-15 | 2003-09-25 | Thrombin receptor antagonists |
| PCT/US2004/031495 WO2005030712A2 (en) | 2003-09-25 | 2004-09-23 | Thrombin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20061797L true NO20061797L (no) | 2006-05-19 |
Family
ID=34393462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20061797A NO20061797L (no) | 2003-09-25 | 2006-04-24 | Trombinreseptorantagonister |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7488742B2 (ru) |
| EP (1) | EP1663965B1 (ru) |
| JP (1) | JP4694490B2 (ru) |
| KR (1) | KR20060128848A (ru) |
| CN (1) | CN101128457A (ru) |
| AR (1) | AR045809A1 (ru) |
| AU (1) | AU2004276327B2 (ru) |
| BR (1) | BRPI0414592A (ru) |
| CA (1) | CA2540163C (ru) |
| CO (1) | CO5680428A2 (ru) |
| EC (1) | ECSP066455A (ru) |
| IL (1) | IL174538A0 (ru) |
| MX (1) | MXPA06003379A (ru) |
| MY (1) | MY143834A (ru) |
| NO (1) | NO20061797L (ru) |
| PE (1) | PE20050471A1 (ru) |
| RU (1) | RU2367660C9 (ru) |
| SG (1) | SG147466A1 (ru) |
| TW (1) | TWI331608B (ru) |
| WO (1) | WO2005030712A2 (ru) |
| ZA (1) | ZA200602448B (ru) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
| ES2357876T3 (es) * | 2002-04-16 | 2011-05-03 | Schering Corporation | Antagonistas triciclicos del receptor de trombina. |
| EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
| CA2567981C (en) * | 2004-05-28 | 2010-08-31 | Schering Corporation | Constrained himbacine analogs as thrombin receptor antagonists |
| US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| EP1799243B1 (en) * | 2004-10-06 | 2015-07-15 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| CA2582639A1 (en) * | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
| DK1829874T3 (da) | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co | Tricyklisk forbindelse og anvendelse deraf |
| DK1848705T3 (da) | 2005-01-14 | 2010-06-14 | Schering Corp | EXO- og diastereoselektive synteser af himbacin-analoger |
| TWI316937B (en) * | 2005-03-31 | 2009-11-11 | Schering Corp | Spirocyclic thrombin receptor antagonists |
| WO2007075808A2 (en) * | 2005-12-20 | 2007-07-05 | Schering Corporation | Methods for preventing and/or treating a cell proliferative disorder |
| CN101384590A (zh) * | 2005-12-22 | 2009-03-11 | 先灵公司 | 作为凝血酶受体拮抗剂的唑并异喹啉 |
| AU2006331583A1 (en) * | 2005-12-22 | 2007-07-05 | Schering Corporation | Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery |
| CN101460463A (zh) * | 2006-03-29 | 2009-06-17 | 先灵公司 | 可作为凝血酶受体拮抗剂的单环和双环喜巴辛衍生物 |
| TW200812619A (en) * | 2006-04-06 | 2008-03-16 | Schering Corp | TRA combination therapies |
| EP2007755B1 (en) * | 2006-04-13 | 2012-06-27 | Schering Corporation | Fused ring thrombin receptor antagonists |
| JP2009542662A (ja) * | 2006-06-29 | 2009-12-03 | シェーリング コーポレイション | 置換二環系および置換三環系トロンビン受容体アンタゴニスト |
| TWI367112B (en) | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
| DE102006036023A1 (de) * | 2006-08-02 | 2008-02-07 | Sanofi-Aventis | Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität |
| TWI343262B (en) * | 2006-09-26 | 2011-06-11 | Schering Corp | Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist |
| JP2010505842A (ja) | 2006-10-04 | 2010-02-25 | シェーリング コーポレイション | トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体 |
| US20080194560A1 (en) * | 2006-12-22 | 2008-08-14 | Zhi Yun Wang | Disintegration promoters in solid dose wet granulation formulations |
| JP2010522169A (ja) * | 2007-03-23 | 2010-07-01 | シェーリング コーポレイション | トロンビン受容体アンタゴニストの使用による、経皮的インターベンション後の有害事象の低減 |
| WO2009097971A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Triazoliumsalze als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
| PL2240487T3 (pl) | 2008-02-05 | 2012-05-31 | Sanofi Sa | Triazolopirydazyny jako inhibitory PAR1, ich otrzymywanie i zastosowanie jako leków |
| DK2242740T3 (da) | 2008-02-05 | 2013-03-25 | Sanofi Sa | SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler |
| WO2010141525A1 (en) | 2009-06-04 | 2010-12-09 | Schering Corporation | Active metabolite of a thrombin receptor antagonist |
| JP2012529431A (ja) | 2009-06-08 | 2012-11-22 | メルク・シャープ・アンド・ドーム・コーポレーション | トロンビン受容体アンタゴニストおよびクロピドグレルの固定用量錠剤 |
| EP2558465B1 (de) | 2010-04-16 | 2014-12-17 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
| ES2527535T3 (es) | 2010-04-16 | 2015-01-26 | Sanofi | Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1 |
| US9340530B2 (en) | 2012-03-06 | 2016-05-17 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists |
| WO2015013083A1 (en) | 2013-07-22 | 2015-01-29 | Merck Sharp & Dohme Corp. | Co-crystal of the par-1 receptor antagonist vorapaxar and aspirin |
| US20160200715A1 (en) * | 2013-08-22 | 2016-07-14 | Merck Sharp & Dohme Corp. | Preparation and use of 7a-heterocycle substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
| US9701669B2 (en) | 2013-08-22 | 2017-07-11 | Merck Sharp & Dohme Corp. | Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists |
| US9808473B2 (en) | 2013-08-22 | 2017-11-07 | Merck Sharp & Dohme Corp. | Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
| WO2016114386A1 (ja) * | 2015-01-15 | 2016-07-21 | 国立研究開発法人国立精神・神経医療研究センター | 進行型免疫性脱髄疾患治療剤 |
| CN110407819B (zh) * | 2019-08-02 | 2020-06-26 | 牡丹江医学院 | 一种作为预防外科手术并发症的凝血酶受体拮抗剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000229961A (ja) * | 1998-12-11 | 2000-08-22 | Sagami Chem Res Center | ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法 |
| US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| PT1294714E (pt) | 2000-06-15 | 2007-11-06 | Schering Corp | Antagonistas do receptor de trombina |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
| WO2003033501A1 (en) * | 2001-10-18 | 2003-04-24 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
| ES2357876T3 (es) * | 2002-04-16 | 2011-05-03 | Schering Corporation | Antagonistas triciclicos del receptor de trombina. |
| CA2567981C (en) * | 2004-05-28 | 2010-08-31 | Schering Corporation | Constrained himbacine analogs as thrombin receptor antagonists |
| US7541471B2 (en) * | 2005-01-14 | 2009-06-02 | Schering Corporation | Synthesis of himbacine analogs |
| DK1848705T3 (da) * | 2005-01-14 | 2010-06-14 | Schering Corp | EXO- og diastereoselektive synteser af himbacin-analoger |
| WO2006076565A2 (en) * | 2005-01-14 | 2006-07-20 | Schering Corporation | Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs |
| EP2399912B1 (en) * | 2005-01-14 | 2015-02-25 | Merck Sharp & Dohme Corp. | An exo-selective synthesis of himbacine analogs |
-
2003
- 2003-09-25 US US10/671,216 patent/US7488742B2/en not_active Expired - Lifetime
-
2004
- 2004-09-23 AU AU2004276327A patent/AU2004276327B2/en not_active Ceased
- 2004-09-23 TW TW093128874A patent/TWI331608B/zh not_active IP Right Cessation
- 2004-09-23 SG SG200807889-1A patent/SG147466A1/en unknown
- 2004-09-23 MX MXPA06003379A patent/MXPA06003379A/es active IP Right Grant
- 2004-09-23 RU RU2006113638/04A patent/RU2367660C9/ru not_active IP Right Cessation
- 2004-09-23 CA CA2540163A patent/CA2540163C/en not_active Expired - Fee Related
- 2004-09-23 PE PE2004000927A patent/PE20050471A1/es not_active Application Discontinuation
- 2004-09-23 EP EP04789042.1A patent/EP1663965B1/en not_active Expired - Lifetime
- 2004-09-23 AR ARP040103439A patent/AR045809A1/es unknown
- 2004-09-23 BR BRPI0414592-5A patent/BRPI0414592A/pt not_active IP Right Cessation
- 2004-09-23 CN CNA2004800278261A patent/CN101128457A/zh active Pending
- 2004-09-23 JP JP2006528258A patent/JP4694490B2/ja not_active Expired - Fee Related
- 2004-09-23 WO PCT/US2004/031495 patent/WO2005030712A2/en active Application Filing
- 2004-09-23 KR KR1020067005753A patent/KR20060128848A/ko not_active Application Discontinuation
- 2004-09-24 MY MYPI20043931A patent/MY143834A/en unknown
-
2006
- 2006-03-23 CO CO06029040A patent/CO5680428A2/es not_active Application Discontinuation
- 2006-03-23 IL IL174538A patent/IL174538A0/en unknown
- 2006-03-24 EC EC2006006455A patent/ECSP066455A/es unknown
- 2006-03-24 ZA ZA200602448A patent/ZA200602448B/en unknown
- 2006-04-24 NO NO20061797A patent/NO20061797L/no not_active Application Discontinuation
-
2008
- 2008-10-30 US US12/261,514 patent/US20090076088A1/en not_active Abandoned
- 2008-10-30 US US12/261,545 patent/US20090069383A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2540163C (en) | 2012-06-05 |
| MXPA06003379A (es) | 2006-06-08 |
| AU2004276327A1 (en) | 2005-04-07 |
| US20040152736A1 (en) | 2004-08-05 |
| US7488742B2 (en) | 2009-02-10 |
| PE20050471A1 (es) | 2005-08-24 |
| AU2004276327B2 (en) | 2010-10-07 |
| WO2005030712A8 (en) | 2007-12-21 |
| IL174538A0 (en) | 2006-08-01 |
| US20090076088A1 (en) | 2009-03-19 |
| ECSP066455A (es) | 2006-09-18 |
| US20090069383A1 (en) | 2009-03-12 |
| CA2540163A1 (en) | 2005-04-07 |
| BRPI0414592A (pt) | 2006-11-07 |
| AR045809A1 (es) | 2005-11-16 |
| SG147466A1 (en) | 2008-11-28 |
| JP4694490B2 (ja) | 2011-06-08 |
| RU2367660C2 (ru) | 2009-09-20 |
| RU2006113638A (ru) | 2007-11-10 |
| JP2007523051A (ja) | 2007-08-16 |
| CN101128457A (zh) | 2008-02-20 |
| EP1663965A2 (en) | 2006-06-07 |
| MY143834A (en) | 2011-07-15 |
| WO2005030712A3 (en) | 2007-09-20 |
| RU2367660C9 (ru) | 2010-08-10 |
| ZA200602448B (en) | 2007-09-26 |
| CO5680428A2 (es) | 2006-09-29 |
| TW200524914A (en) | 2005-08-01 |
| WO2005030712A2 (en) | 2005-04-07 |
| EP1663965B1 (en) | 2014-04-09 |
| KR20060128848A (ko) | 2006-12-14 |
| TWI331608B (en) | 2010-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20061797L (no) | Trombinreseptorantagonister | |
| NO20064579L (no) | Bifenylforbindelser anvendelige som muskariniske receptorantagonister | |
| DE60335869D1 (de) | 1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren | |
| NO20081001L (no) | Derivater av karboksamid som antagonister for muskarinisk reseptor | |
| EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
| NO20071108L (no) | Nye 4-benzylidenpiperidinderivater | |
| NO20082330L (no) | Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav | |
| NO20060195L (no) | Kinolylamidderivater som CCR-5-antagonister | |
| NO20041504L (no) | Lactamderivater som antagonister for humane 11CBY reseptorer. | |
| NO20080243L (no) | Substituerte arylpyrazoler til anvendelse mot parasitter | |
| EA200970585A1 (ru) | Бензамидные производные как агонисты ер-рецепторов | |
| NO20063501L (no) | Kinolinintermediater av reseptor-Tyrosin-Kinase-inhibitorer og deres syntese | |
| SE0400284D0 (sv) | Novel compounds | |
| TW200800943A (en) | Indane derivatives as MCH receptor antagonists | |
| DK1506185T3 (da) | Forbindelser og deres anvendelse som 5-HT-inhibitorer | |
| NO20071159L (no) | Prodmedikamentsubstituerte benzoksazoler som ostrogene midler | |
| WO2005060959A8 (en) | Pyrazole derivatives and use thereof as orexin receptor antagonists | |
| EA200702612A1 (ru) | Соединения бензимидазолкарбоксамида в качестве агонистов рецепторов 5-нт | |
| CY1109694T1 (el) | Παραγωγα πυρρολιδινης ως ανταγωνιστες υποδοχεα η3 ισταμινης | |
| DK1893589T3 (da) | Substituerede N-benzo[d]isoxazol-3-yl-amin-derivater som inhibitorer af mGluR5-, serotonin-(5-HT) og noradrenalinreceptorer og deres anvendelse til fremstilling af lægemidler | |
| NO20080669L (no) | Acetylenpiperaziner som metabotrofiske glutamatreseptorantagonister | |
| DK1673354T3 (da) | Arylindenopyridiner og arylindenopyrimidiner og deres anvendelse som adenosin-A2a-receptorantagonister | |
| ATE447575T1 (de) | Selektive spirocyclische glucocorticoid-rezeptor- modulatoren | |
| NO20062249L (no) | 1H-imidazolderivater som cannabionidreseptor modulatorer | |
| WO2007004041A3 (en) | New compounds and their pharmaceutical use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |