NO20056093L - Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav og fremgangsmate for fremstilling av den samme - Google Patents
Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav og fremgangsmate for fremstilling av den sammeInfo
- Publication number
- NO20056093L NO20056093L NO20056093A NO20056093A NO20056093L NO 20056093 L NO20056093 L NO 20056093L NO 20056093 A NO20056093 A NO 20056093A NO 20056093 A NO20056093 A NO 20056093A NO 20056093 L NO20056093 L NO 20056093L
- Authority
- NO
- Norway
- Prior art keywords
- crystal
- preparing
- same
- acid salt
- methanesulfonic acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
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- Obesity (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
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Abstract
8-(3-pentylamino)-2-metyl-3-(2-klor-4-metoksyfenyl)-6,7-dihydro-5H-cyklopenta[d]pyrazolo[1,5-a]pyrimidinmetansulfonat, som er ny, og en fremgangsmåte for fremstilling av et mellomprodukt for forbindelsen. 8-(3-pentylamino)-2metyl-3-(2-klor-4-metoksyfenyl)-6,7-dihydro-5H-cyklopenta[d]pyrazolo[1,5-a]pyrimidinmetansulfonat er en forbindelse som har en svært utmerket termisk stabilitet. Den nye fremstillingsprosessen gjør det mulig å effektivt produsere en forbindelse representert ved den generelle formel (I): hvori Ar representerer en eventuelt substituert benzenring, osv.; og R1 representerer C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl osv., som er et mellomprodukt, i et høyt utbytte.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003181908 | 2003-06-25 | ||
PCT/JP2004/009263 WO2004113344A1 (ja) | 2003-06-25 | 2004-06-24 | ピラゾロピリミジン化合物のメタンスルホン酸塩、その結晶およびその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20056093L true NO20056093L (no) | 2006-03-24 |
NO332186B1 NO332186B1 (no) | 2012-07-23 |
Family
ID=33535237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20056093A NO332186B1 (no) | 2003-06-25 | 2005-12-21 | Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav, fremgangsmate for fremstilling av det samme, farmasoytisk preparat samt anvendelse derav |
Country Status (19)
Country | Link |
---|---|
US (1) | US7947697B1 (no) |
EP (1) | EP1637531B1 (no) |
JP (1) | JP4655276B2 (no) |
KR (1) | KR101082227B1 (no) |
CN (1) | CN100422186C (no) |
AT (1) | ATE478873T1 (no) |
AU (1) | AU2004249629B2 (no) |
BR (1) | BRPI0411923A (no) |
CA (1) | CA2529561C (no) |
DE (1) | DE602004028820D1 (no) |
ES (1) | ES2349393T3 (no) |
IL (1) | IL172697A (no) |
MX (1) | MXPA05013917A (no) |
NO (1) | NO332186B1 (no) |
NZ (1) | NZ544301A (no) |
RU (1) | RU2345995C2 (no) |
TW (1) | TWI356058B (no) |
WO (1) | WO2004113344A1 (no) |
ZA (1) | ZA200510450B (no) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2005061508A1 (ja) * | 2003-12-22 | 2007-07-12 | 小野薬品工業株式会社 | 三環式複素環化合物およびその化合物を有効成分とする医薬 |
WO2005087775A1 (ja) * | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物 |
CN112225732B (zh) * | 2019-07-15 | 2024-01-09 | 四川科瑞德制药股份有限公司 | 一种盐酸哌罗匹隆水合物晶型及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1030768C (zh) * | 1990-10-09 | 1996-01-24 | 大塚制药株式会社 | 嘧啶衍生物或其药用盐的制备方法 |
US5420128A (en) | 1990-10-09 | 1995-05-30 | Otsuka Pharmaceutical Co., Ltd. | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor |
JPH05112571A (ja) | 1990-10-19 | 1993-05-07 | Otsuka Pharmaceut Co Ltd | ピリミジン誘導体 |
EP0795555A4 (en) | 1995-09-28 | 1998-01-07 | Otsuka Pharma Co Ltd | ANALGETICS |
WO1999064422A1 (en) | 1998-06-09 | 1999-12-16 | Neurogen Corporation | Pyrido[2,3-b]indolizine derivatives and aza analogues thereof; crf1 specific ligands |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
WO2000027850A2 (en) | 1998-11-12 | 2000-05-18 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
PT1129091E (pt) | 1998-11-12 | 2003-02-28 | Neurocrine Biosciences Inc | Antagonistas de receptor de crf e metodos relacionados |
CA2432148C (en) | 2000-12-28 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient |
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- 2004-06-24 EP EP04746732A patent/EP1637531B1/en not_active Expired - Lifetime
- 2004-06-24 JP JP2005507336A patent/JP4655276B2/ja not_active Expired - Fee Related
- 2004-06-24 CN CNB2004800243652A patent/CN100422186C/zh not_active Expired - Fee Related
- 2004-06-24 DE DE602004028820T patent/DE602004028820D1/de not_active Expired - Lifetime
- 2004-06-24 CA CA2529561A patent/CA2529561C/en not_active Expired - Fee Related
- 2004-06-24 ES ES04746732T patent/ES2349393T3/es not_active Expired - Lifetime
- 2004-06-24 TW TW093118239A patent/TWI356058B/zh not_active IP Right Cessation
- 2004-06-24 NZ NZ544301A patent/NZ544301A/en not_active IP Right Cessation
- 2004-06-24 RU RU2006101986/04A patent/RU2345995C2/ru not_active IP Right Cessation
- 2004-06-24 WO PCT/JP2004/009263 patent/WO2004113344A1/ja active Application Filing
- 2004-06-24 US US10/561,214 patent/US7947697B1/en not_active Expired - Fee Related
- 2004-06-24 AU AU2004249629A patent/AU2004249629B2/en not_active Ceased
- 2004-06-24 MX MXPA05013917A patent/MXPA05013917A/es active IP Right Grant
-
2005
- 2005-12-20 IL IL172697A patent/IL172697A/en not_active IP Right Cessation
- 2005-12-21 NO NO20056093A patent/NO332186B1/no not_active IP Right Cessation
- 2005-12-22 ZA ZA200510450A patent/ZA200510450B/en unknown
- 2005-12-23 KR KR1020057024807A patent/KR101082227B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ544301A (en) | 2008-08-29 |
TWI356058B (en) | 2012-01-11 |
KR20060026060A (ko) | 2006-03-22 |
KR101082227B1 (ko) | 2011-11-09 |
RU2006101986A (ru) | 2006-07-27 |
ATE478873T1 (de) | 2010-09-15 |
CA2529561A1 (en) | 2004-12-29 |
MXPA05013917A (es) | 2006-03-09 |
ES2349393T3 (es) | 2010-12-30 |
IL172697A (en) | 2013-05-30 |
CN1842530A (zh) | 2006-10-04 |
WO2004113344A1 (ja) | 2004-12-29 |
US7947697B1 (en) | 2011-05-24 |
CN100422186C (zh) | 2008-10-01 |
NO332186B1 (no) | 2012-07-23 |
EP1637531A1 (en) | 2006-03-22 |
JPWO2004113344A1 (ja) | 2006-07-27 |
ZA200510450B (en) | 2006-12-27 |
CA2529561C (en) | 2012-05-29 |
AU2004249629B2 (en) | 2009-07-30 |
EP1637531A4 (en) | 2008-09-03 |
RU2345995C2 (ru) | 2009-02-10 |
EP1637531B1 (en) | 2010-08-25 |
TW200504064A (en) | 2005-02-01 |
IL172697A0 (en) | 2006-04-10 |
JP4655276B2 (ja) | 2011-03-23 |
AU2004249629A1 (en) | 2004-12-29 |
BRPI0411923A (pt) | 2006-08-15 |
DE602004028820D1 (de) | 2010-10-07 |
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