NO20053114L - Astma og allergisk inflammasjonsmodulatorer. - Google Patents
Astma og allergisk inflammasjonsmodulatorer.Info
- Publication number
- NO20053114L NO20053114L NO20053114A NO20053114A NO20053114L NO 20053114 L NO20053114 L NO 20053114L NO 20053114 A NO20053114 A NO 20053114A NO 20053114 A NO20053114 A NO 20053114A NO 20053114 L NO20053114 L NO 20053114L
- Authority
- NO
- Norway
- Prior art keywords
- asthma
- allergic inflammatory
- inflammatory modulators
- inflammatory
- conditions
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 230000000172 allergic effect Effects 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000012657 Atopic disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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PCT/US2003/040617 WO2004058164A2 (fr) | 2002-12-20 | 2003-12-19 | Modulateurs de l'asthme et de l'inflammation allergique |
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US (2) | US7321001B2 (fr) |
EP (1) | EP1585511B1 (fr) |
JP (1) | JP4457017B2 (fr) |
KR (1) | KR20050111314A (fr) |
CN (1) | CN100406007C (fr) |
AU (1) | AU2003297398B2 (fr) |
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CA (1) | CA2511214C (fr) |
EA (1) | EA011087B1 (fr) |
ES (1) | ES2401079T3 (fr) |
IS (1) | IS7907A (fr) |
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NZ (1) | NZ541234A (fr) |
PL (1) | PL377314A1 (fr) |
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Families Citing this family (145)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ536504A (en) | 2002-05-24 | 2008-04-30 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
JP4457017B2 (ja) | 2002-12-20 | 2010-04-28 | アムジエン・インコーポレーテツド | 喘息及びアレルギー性炎症モジュレーター |
CN1511828A (zh) * | 2002-12-31 | 2004-07-14 | �й������ž�����ҽѧ��ѧԺ����ҽ | 磺酰苯胺类衍生物及其医药用途 |
GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
US20080254053A1 (en) * | 2003-04-09 | 2008-10-16 | Mullally John P | Protocol for treatment of diabetes |
EP1471057B1 (fr) | 2003-04-25 | 2006-01-18 | Actimis Pharmaceuticals, Inc. | Derivés de l'acid pyrimidinylacétique pour le traitment des maladies associées au CRTH2 |
SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
WO2005054176A1 (fr) * | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | Modulateurs des recepteurs actives par les proliferateurs de peroxysomes |
MXPA06007172A (es) * | 2003-12-23 | 2006-08-23 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri. |
EP1718649B1 (fr) * | 2004-01-31 | 2009-06-10 | Actimis Pharmaceuticals, Inc., | Derives d'acide imidazo 1,2-c¨pyrimidinylacetique |
DK1725553T3 (da) | 2004-03-11 | 2008-08-18 | Actelion Pharmaceuticals Ltd | Tetrahydropyridoindolderivater |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
WO2006056752A1 (fr) | 2004-11-23 | 2006-06-01 | Astrazeneca Ab | Derives d'acide phenoxyacetique utiles pour le traitement des maladies respiratoires |
EP1819673A2 (fr) | 2004-11-30 | 2007-08-22 | Plexxikon, Inc. | Derivés indole utiles comme des composés actifs sur les ppar |
US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
ES2348920T3 (es) * | 2005-04-13 | 2010-12-17 | Astion Development A/S | Agonistas de adrenoceptores beta-2 para el tratamiento de enfermedades del tejido conectivo de la piel. |
CA2601979C (fr) * | 2005-04-21 | 2014-06-17 | Laboratoires Serono S.A. | Pyrazine sulfonamides 2,3 substituees |
GB0510584D0 (en) * | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
WO2007014008A2 (fr) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2 |
JP5155171B2 (ja) * | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
JP2009514935A (ja) * | 2005-11-05 | 2009-04-09 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
GB0525141D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
ES2380683T3 (es) * | 2005-12-15 | 2012-05-17 | Astrazeneca Ab | Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria |
JP2009536313A (ja) * | 2006-01-11 | 2009-10-08 | レインダンス テクノロジーズ, インコーポレイテッド | ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法 |
WO2007110876A2 (fr) * | 2006-03-24 | 2007-10-04 | Panacea Biotec Ltd. | Dérives innovants du sulfonanilide, compositions pharmaceutiques qui les contiennent et procédés qui les concernent |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20080014589A1 (en) | 2006-05-11 | 2008-01-17 | Link Darren R | Microfluidic devices and methods of use thereof |
WO2007146838A2 (fr) * | 2006-06-09 | 2007-12-21 | Icos Corporation | Acides phénylacétiques substitués utilisés en tant qu'antagonistes de dp-2 |
CN101490024A (zh) * | 2006-06-09 | 2009-07-22 | Icos股份有限公司 | 用作dp-2拮抗剂的取代的苯乙酸 |
WO2008008374A2 (fr) * | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Inhibiteurs de ccr2 et leurs procédés d'utilisation |
US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
RU2458918C2 (ru) | 2006-07-22 | 2012-08-20 | Оксаген Лимитед | Соединения, обладающие антагонистической активностью по отношению к crth2 |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
SI2057115T1 (sl) | 2006-08-21 | 2013-02-28 | Array Biopharma, Inc. | Derivati 4-substituirane fenoksifenilocetne kisline |
ATE509925T1 (de) | 2006-11-17 | 2011-06-15 | Pfizer | Substituierte bicyclocarbonsäureamidverbindungen |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
WO2008127893A1 (fr) * | 2007-04-04 | 2008-10-23 | Hight H Thomas | Compositions pharmaceutiques à base de niacine |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
UA100983C2 (ru) * | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
CA2692761C (fr) | 2007-07-12 | 2013-04-30 | Chemocentryx, Inc. | Heteroaryl-pyridyl- et phenyl-benzenesulfonamides condenses en tant que modulateurs du ccr2 pour le traitement de l'inflammation |
EP2205570B1 (fr) | 2007-09-25 | 2013-09-11 | Actimis Pharmaceuticals, Inc., | Pyrimidines à substitution 2-s-benzyle en tant qu'antagonistes de crth2 |
AU2008305632B2 (en) | 2007-09-25 | 2014-01-30 | Actimis Pharmaceuticals, Inc. | Alkylthio pyrimidines as CRTH2 antagonists |
US20100298368A1 (en) * | 2007-11-06 | 2010-11-25 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
WO2009061676A2 (fr) * | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc. | Antagonistes de récepteurs pgd2 |
DK2229358T3 (da) | 2007-12-14 | 2011-07-04 | Pulmagen Therapeutics Asthma Ltd | Indoler og deres terapeutiske anvendelse |
ES2471919T3 (es) * | 2007-12-19 | 2014-06-27 | Amgen, Inc | Derivados de ácido fenilac�tico como moduladores de inflamación |
US20110060026A1 (en) * | 2008-01-18 | 2011-03-10 | George Hynd | Indoles Active on CRTH2 Receptor |
RU2503672C2 (ru) | 2008-01-18 | 2014-01-10 | Оксаген Лимитед | Соединения, обладающие активностью антагонистов crth2 |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
WO2009093029A1 (fr) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Composés présentant une activité antagoniste de crth2 |
EP2265581A1 (fr) | 2008-01-22 | 2010-12-29 | Oxagen Limited | Composés présentant une activité antagoniste du récepteur crth2 |
CA2713139C (fr) | 2008-02-01 | 2013-04-23 | Amira Pharmaceuticals, Inc. | Antagonistes aminoalkylbiphenyle disubstitues par n,n des recepteurs de la prostaglandine d2 |
EP2245002A4 (fr) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | Antagonistes aminoalkylbiphényle n, n' disubstitués des récepteurs d2 de la prostaglandine |
WO2009102893A2 (fr) * | 2008-02-14 | 2009-08-20 | Amira Pharmaceuticals, Inc. | Composés diaryliques cycliques en tant qu'antagonistes de récepteurs de prostaglandine d2 |
ES2494366T3 (es) | 2008-02-22 | 2014-09-15 | Otsuka Pharmaceutical Co., Ltd. | Compuesto de benzodiacepina y composición farmacéutica |
JP2011513242A (ja) * | 2008-02-25 | 2011-04-28 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体アンタゴニスト |
JP2011518130A (ja) * | 2008-04-02 | 2011-06-23 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト |
WO2010008864A2 (fr) | 2008-06-24 | 2010-01-21 | Amira Pharmaceuticals, Inc. | Antagonistes de cycloalcane[b]indole de récepteurs de prostaglandine d2 |
WO2009158426A1 (fr) * | 2008-06-25 | 2009-12-30 | Array Biopharma Inc. | Dérivés de l’acide carboxylique phénoxychromane substitués en 6 |
JP5531370B2 (ja) | 2008-07-03 | 2014-06-25 | パンミラ ファーマシューティカルズ,エルエルシー. | プロスタグランジンd2受容体のアンタゴニスト |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
WO2010009365A1 (fr) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Bibliothèque de gouttelettes |
GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
WO2010042652A2 (fr) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Antagonistes hétéroalkyl biphényle des récepteurs de la prostaglandine d2 |
GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
WO2010057118A2 (fr) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Antagonistes hétérocycliques des récepteurs de la prostaglandine d2 |
KR101322496B1 (ko) | 2008-11-17 | 2013-10-29 | 에프. 호프만-라 로슈 아게 | 나프틸아세트산 |
EP2379535B1 (fr) | 2008-12-22 | 2016-06-15 | Array Biopharma Inc. | Dérivés d'acide 7-phénoxychromanecarboxylique |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
WO2011002814A2 (fr) * | 2009-06-30 | 2011-01-06 | Ligand Pharmaceuticals Inc. | Composés d'acide biaryl oxyacétique |
SG177736A1 (en) * | 2009-07-31 | 2012-02-28 | Panmira Pharmaceuticals Llc | Dermal formulations of dp2 receptor antagonists |
CA2768492A1 (fr) | 2009-07-31 | 2011-02-03 | Panmira Pharmaceuticals, Llc | Compositions pharmaceutiques ophtalmiques d'antagonsites du recepteur dp2 |
CN102596902A (zh) * | 2009-08-05 | 2012-07-18 | 潘米拉制药公司 | Dp2拮抗剂及其用途 |
RU2553676C2 (ru) | 2009-08-21 | 2015-06-20 | Оцука Фармасьютикал Ко., Лтд. | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА |
TWI481601B (zh) * | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
WO2011042564A1 (fr) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
AR079492A1 (es) | 2009-12-23 | 2012-02-01 | Ironwood Pharmaceuticals Inc | Moduladores de crth2 |
MX2012007927A (es) | 2010-01-06 | 2012-08-15 | Panmira Pharmaceuticals Llc | Antagonistas de dp2 y usos del mismo. |
WO2011100604A2 (fr) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Analyse numérique d'analytes |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
JP5860459B2 (ja) | 2010-06-30 | 2016-02-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激薬 |
RU2013104506A (ru) | 2010-07-05 | 2014-08-10 | Актелион Фармасьютиклз Лтд | 1-фенилзамещенные производные гетероциклила и их применение в качестве модуляторов рецептора простагландина d2 |
US20130216552A1 (en) | 2010-07-12 | 2013-08-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
WO2012009134A1 (fr) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Modulateurs de crth2 |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
WO2012061926A1 (fr) * | 2010-11-08 | 2012-05-18 | Zalicus Pharmaceuticals Ltd. | Composés de bisarylsulfone et de dialkylarylsulfone en tant que bloquants du canal calcique |
CN103402515B (zh) | 2010-11-09 | 2017-05-17 | 铁木医药有限公司 | sGC刺激剂 |
EP2457900A1 (fr) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | Nouveaux dérivés de pyrazole présentant un comportement antagoniste CRTH2 |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
EP3736281A1 (fr) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions et méthodes de marquage moléculaire |
EP2526945A1 (fr) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
EP2714970B1 (fr) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Quantification d'enzyme |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
EP2548863A1 (fr) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
EP2548876A1 (fr) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | Nouveaux antagonistes de CRTH2 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US20140328861A1 (en) | 2011-12-16 | 2014-11-06 | Atopix Therapeutics Limited | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis |
KR20140107550A (ko) | 2011-12-21 | 2014-09-04 | 액테리온 파마슈티칼 리미티드 | 헤테로시클릴 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 그의 용도 |
WO2013101830A1 (fr) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | Pyrazoles 2-benzyle, 3-(pyrimidin-2-yle)-substitués utiles comme stimulateurs de scg |
CA2876808A1 (fr) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | Derives heterocyclyles 1-phenyl-substitues et leur utilisation en tant que modulateurs du recepteur de la prostaglandine d2 |
WO2014047111A1 (fr) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de la sgc |
EP2897953B8 (fr) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Stimulateurs de sgc |
RS59981B1 (sr) | 2013-03-15 | 2020-03-31 | Cyclerion Therapeutics Inc | Sgc stimulatori |
CN104341307B (zh) * | 2013-08-05 | 2016-12-28 | 北京京朋汇药业研究发展有限公司 | 苯乙酸衍生物及其抗肿瘤用途 |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
JP2016540017A (ja) | 2013-12-11 | 2016-12-22 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激物質 |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
EP3094327A1 (fr) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
CN107406421A (zh) | 2014-09-17 | 2017-11-28 | 铁木医药有限公司 | sGC刺激物 |
AU2015317824A1 (en) | 2014-09-17 | 2017-03-23 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sGC stimulators |
WO2016044445A2 (fr) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Stimulateurs de sgc |
EP4420734A2 (fr) | 2015-02-13 | 2024-08-28 | Institut National de la Santé et de la Recherche Médicale | Antagonistes de ptgdr-1 et/ou ptgdr-2 pour la prévention et/ou le traitement du lupus érythémateux systémique |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
AU2017291826B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Phosphorus prodrugs of sGC stimulators |
KR20230074840A (ko) | 2016-07-07 | 2023-05-31 | 사이클리온 테라퓨틱스, 인크. | sGC 자극제의 고체 형태 |
BR112019010375A2 (pt) | 2016-11-23 | 2019-08-27 | Chemocentryx Inc | método de tratamento de glomeruloesclerose segmental focal |
SG11202002975YA (en) | 2017-10-11 | 2020-04-29 | Chemocentryx Inc | Treatment of focal segmental glomerulosclerosis with ccr2 antagonists |
CN114258391A (zh) | 2019-04-03 | 2022-03-29 | 阿里戈斯治疗公司 | 吡咯化合物 |
CN112500281A (zh) * | 2020-12-07 | 2021-03-16 | 唐山师范学院 | 丁香酸的制备方法 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8704158D0 (en) | 1987-02-23 | 1987-04-01 | Wellcome Found | Substituted hydantoin compounds |
DE4041780A1 (de) * | 1990-12-24 | 1992-06-25 | Boehringer Mannheim Gmbh | Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel |
HUT73813A (en) | 1993-06-30 | 1996-09-30 | Wellcome Found | Anti-athero-sclerotic diaryl compounds, process to prepare them and pharmaceutical compositions contg. them |
US5545669A (en) | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
DK0799206T3 (da) | 1994-12-20 | 2003-01-27 | Hoffmann La Roche | Aryl- og heteroaryl-sulfonamidderivater, fremstillingen deraf og anvendelsen deraf som endothelinantagonister |
US6008234A (en) | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
JP3565864B2 (ja) | 1996-09-12 | 2004-09-15 | シエーリング アクチエンゲゼルシヤフト | 環式アミノ酸または環式ヒドロキシ酸誘導体により置換されたベンズアミジン誘導体および抗擬固薬としてのこれらの使用 |
TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
JPH11202458A (ja) | 1998-01-16 | 1999-07-30 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
JP2002512997A (ja) | 1998-04-29 | 2002-05-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Impdh酵素のインヒビター |
JP2000007646A (ja) * | 1998-06-16 | 2000-01-11 | Ono Pharmaceut Co Ltd | スルフォンアミド誘導体およびそれらを有効成分と して含有する薬剤 |
AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
JP3828364B2 (ja) | 1999-03-10 | 2006-10-04 | 塩野義製薬株式会社 | [2.2.1]および[3.1.1]ビシクロ骨格を有するpgd2/txa2両受容体拮抗性医薬組成物 |
JP3486408B2 (ja) | 1999-08-23 | 2004-01-13 | 株式会社ビー・エム・エル | 物質のヒトプロスタグランジンd2受容体に対する性質の同定方法 |
US6531291B1 (en) | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
US7084136B2 (en) | 2000-06-02 | 2006-08-01 | Shionogi & Co., Ltd. | Drug composition antagonistic to both PGD2/TXA2 receptors |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
AU2002229611A1 (en) | 2000-12-08 | 2002-06-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of active compounds capable of modulating the intracellular pathway triggered by the dp receptor in langerhans cells |
DE60215000T2 (de) | 2001-05-23 | 2007-08-09 | Merck Frosst Canada & Co, Kirkland | Dihydropyrroloil[1,2-a]indol- und Tetrahydropyridol[1,2-a]indol-Derivate als Prostaglandin-D2-Rezeptor-Antagonisten |
JP4529119B2 (ja) | 2001-08-09 | 2010-08-25 | 小野薬品工業株式会社 | カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤 |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
WO2003078409A1 (fr) | 2002-03-19 | 2003-09-25 | Ono Pharmaceutical Co., Ltd. | Composes d'acide carboxylique et medicaments renfermant les composes comme principe actif |
AU2003231513A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Pgd2 receptor antagonist |
AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
JP4457017B2 (ja) | 2002-12-20 | 2010-04-28 | アムジエン・インコーポレーテツド | 喘息及びアレルギー性炎症モジュレーター |
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- 2003-12-19 WO PCT/US2003/040617 patent/WO2004058164A2/fr active Application Filing
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Also Published As
Publication number | Publication date |
---|---|
EA011087B1 (ru) | 2008-12-30 |
WO2004058164A2 (fr) | 2004-07-15 |
US20080085891A1 (en) | 2008-04-10 |
NO20053114D0 (no) | 2005-06-24 |
CA2511214C (fr) | 2012-12-18 |
CN100406007C (zh) | 2008-07-30 |
AU2003297398B2 (en) | 2009-09-24 |
ES2401079T3 (es) | 2013-04-16 |
EP1585511A4 (fr) | 2007-08-29 |
MXPA05006701A (es) | 2006-03-30 |
JP4457017B2 (ja) | 2010-04-28 |
EP1585511A2 (fr) | 2005-10-19 |
US20040220237A1 (en) | 2004-11-04 |
JP2006516143A (ja) | 2006-06-22 |
BR0317591A (pt) | 2005-11-22 |
CN1767823A (zh) | 2006-05-03 |
EP1585511B1 (fr) | 2013-01-23 |
ZA200505523B (en) | 2006-09-27 |
CA2511214A1 (fr) | 2004-07-15 |
NZ541234A (en) | 2008-06-30 |
KR20050111314A (ko) | 2005-11-24 |
US7321001B2 (en) | 2008-01-22 |
WO2004058164A3 (fr) | 2004-08-26 |
EA200501017A1 (ru) | 2006-02-24 |
AU2003297398A1 (en) | 2004-07-22 |
US7541383B2 (en) | 2009-06-02 |
IS7907A (is) | 2005-06-22 |
PL377314A1 (pl) | 2006-01-23 |
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