NO20051155L - Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelse - Google Patents
Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelseInfo
- Publication number
- NO20051155L NO20051155L NO20051155A NO20051155A NO20051155L NO 20051155 L NO20051155 L NO 20051155L NO 20051155 A NO20051155 A NO 20051155A NO 20051155 A NO20051155 A NO 20051155A NO 20051155 L NO20051155 L NO 20051155L
- Authority
- NO
- Norway
- Prior art keywords
- give
- rizatriptan
- reaction
- preparation
- hydrazone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Oppfinnelsen angår rizatriptan eller et farmasøytisk akseptabelt derivat derav som inkluderer a) fremstilling av diazoniumsaltet av anilinhydrokloridet (II); etterfulgt av reduksjon og surgjøring, noe som gir hydrazinet (III); b) in situ omsetting av hydrazinhydrokloridet (III) med a-keto-d-valerolakton, noe som gir hydrazonet (IV); c) Fisher-indolomsetting av hydrazonet (IV), noe som gir pyranoindolonet. (V), eventuelt etterfulgt av en hydrolysereaksjon, noe som gir (VI); d) transesterifisering av (V) eller esterifisering av dens hydrolyseprodukt (VI), noe som gir (VII), hvor R betyr rett eller forgrenet C1 -C4-alkylkjede; e) omdanning av hydroksylgruppen i (VII) til dimetylamin, noe som gir indolkarboksylatet (VIII), hvor R har betydningen som definert ovenfor; f) saponifisering av 2-karboalkoksygruppen (VIII), noe som gir indolkarboksylsyren (IX); og g) dekarboksylering av indolkarboksylsyren (IX), noe som gir rizatriptan og eventuelt oppnåelsen av et farmasøytisk akseptabelt salt derav. Oppfinnelsen angår også syntesemellomprodukter for oppnåelsen av rizatriptan.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201874A ES2204303B2 (es) | 2002-08-07 | 2002-08-07 | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
PCT/IB2003/003540 WO2004014877A1 (en) | 2002-08-07 | 2003-08-05 | Process for preparing rizatriptan |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20051155L true NO20051155L (no) | 2005-03-03 |
Family
ID=31502894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051155A NO20051155L (no) | 2002-08-07 | 2005-03-03 | Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelse |
Country Status (11)
Country | Link |
---|---|
US (1) | US7279581B2 (no) |
EP (1) | EP1527053B8 (no) |
KR (1) | KR20050039749A (no) |
AT (1) | ATE312084T1 (no) |
AU (1) | AU2003250478A1 (no) |
DE (1) | DE60302671D1 (no) |
ES (2) | ES2204303B2 (no) |
IS (1) | IS7702A (no) |
NO (1) | NO20051155L (no) |
TW (1) | TW200404798A (no) |
WO (1) | WO2004014877A1 (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103288714A (zh) * | 2002-06-27 | 2013-09-11 | 史密斯克莱.比奇曼(科克)有限公司 | 卡维地洛磷酸盐和/或其溶剂合物相应的组合物和/或治疗方法 |
ES2204302B2 (es) * | 2002-08-07 | 2005-03-01 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
WO2005068453A2 (en) | 2004-01-09 | 2005-07-28 | Ratiopharm Gmbh | Crystalline forms of rizatriptan benzoate |
ATE461916T1 (de) * | 2004-01-28 | 2010-04-15 | Ratiopharm Gmbh | Syntheseverfahren und zwischenprodukte zur herstellung von rizatriptan |
EP1951713A1 (en) * | 2005-11-14 | 2008-08-06 | Matrix Laboratories Ltd | Process for the large scale production of rizatriptan benzoate |
ATE510836T1 (de) * | 2006-01-19 | 2011-06-15 | Matrix Lab Ltd | Umwandlung eines aromatischen diazoniumsalzes in ein arylhydrazin |
EP3407869A1 (en) | 2016-01-27 | 2018-12-05 | Instar Technologies A.S. | Oromucosal nanofiber carriers for therapeutic treatment |
CN115353492A (zh) * | 2022-08-26 | 2022-11-18 | 浙江野风药业股份有限公司 | 一种连续合成1-(4-肼基苯基)甲基-1,2,4-三氮唑的方法 |
CN115417859B (zh) * | 2022-09-19 | 2024-02-02 | 陕西师范大学 | 一种苯甲酸利扎曲坦的合成方法 |
CN116283924A (zh) * | 2023-01-16 | 2023-06-23 | 四川效佳科技有限公司 | 一种药用级纯度的苯甲酸利扎曲普坦的重结晶方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
ES2033578B1 (es) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida. |
ES2033577B1 (es) | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores. |
GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
US5567824A (en) * | 1994-05-24 | 1996-10-22 | Merck & Co., Inc. | Palladium catalyzed ring closure of triazolyltryptamine |
CN1084751C (zh) | 1996-08-13 | 2002-05-15 | 麦克公司 | 钯催化的吲哚化反应 |
US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
GB9926250D0 (en) * | 1999-11-06 | 2000-01-12 | Knoll Ag | Chemical process |
-
2002
- 2002-08-07 ES ES200201874A patent/ES2204303B2/es not_active Expired - Fee Related
-
2003
- 2003-08-05 AU AU2003250478A patent/AU2003250478A1/en not_active Abandoned
- 2003-08-05 US US10/509,918 patent/US7279581B2/en active Active
- 2003-08-05 DE DE60302671T patent/DE60302671D1/de not_active Expired - Lifetime
- 2003-08-05 WO PCT/IB2003/003540 patent/WO2004014877A1/en not_active Application Discontinuation
- 2003-08-05 EP EP03784405A patent/EP1527053B8/en not_active Expired - Lifetime
- 2003-08-05 KR KR1020047012028A patent/KR20050039749A/ko not_active Application Discontinuation
- 2003-08-05 ES ES03784405T patent/ES2254982T3/es not_active Expired - Lifetime
- 2003-08-05 TW TW092121365A patent/TW200404798A/zh unknown
- 2003-08-05 AT AT03784405T patent/ATE312084T1/de not_active IP Right Cessation
-
2005
- 2005-02-21 IS IS7702A patent/IS7702A/is unknown
- 2005-03-03 NO NO20051155A patent/NO20051155L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2003250478A1 (en) | 2004-02-25 |
TW200404798A (en) | 2004-04-01 |
DE60302671D1 (de) | 2006-01-12 |
ES2204303B2 (es) | 2004-12-16 |
KR20050039749A (ko) | 2005-04-29 |
EP1527053B1 (en) | 2005-12-07 |
US20050148778A1 (en) | 2005-07-07 |
EP1527053B8 (en) | 2006-03-08 |
WO2004014877A1 (en) | 2004-02-19 |
ATE312084T1 (de) | 2005-12-15 |
ES2254982T3 (es) | 2006-06-16 |
EP1527053A1 (en) | 2005-05-04 |
US7279581B2 (en) | 2007-10-09 |
IS7702A (is) | 2005-02-21 |
ES2204303A1 (es) | 2004-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20051155L (no) | Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelse | |
NO20051178L (no) | Fremgangsmate til fremstilling av zolmitriptanforbindelser | |
TW425382B (en) | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders | |
TNSN05140A1 (en) | Perindopril | |
HK1109628A1 (en) | 1-acetic acid-indole derivatives with pgd2 antagonist activity | |
US20080214646A1 (en) | Novel Nsaids Possessing a Nitric Oxide Donor Diazen-1-Ium-1,2-Diolate Moiety | |
DK1966118T3 (da) | Forbedret fremgangsmåde til fremstilling af ramipril | |
MX9801044A (es) | Sintesis en un solo recipiente de derivados de 2-oxazolidinona. | |
FR2678618A1 (fr) | Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. | |
Chen et al. | P3 cap modified Phe*-Ala series BACE inhibitors | |
Duan et al. | Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl) acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) | |
CO4700300A1 (es) | Procedimiento para preparar olanzapina | |
IL179871A0 (en) | Process for the preparation of gabapentin | |
Ma et al. | Efficient asymmetric synthesis of important tryptophan analogs for biological research via the Schöllkopf chiral auxiliary | |
ES2386989T3 (es) | Derivados de ácido fenilacético como inhibidores de COX-2 | |
AR026362A1 (es) | Procedimiento quimico | |
WO2008056378A3 (en) | Novel process for the preparation of naratriptan hydrochloride | |
Bishnoi et al. | Relative role of cyclooxygenase-2 (COX-2) inhibitors and lipoxygenase (LOX) inhibitors in aging induced dementia and oxidative damage | |
WO2009074524A3 (de) | Verfahren zur enzymatischen reduktion von alpha-dehydroaminosäuren unter verwendung von enoat dehydrogenasen | |
Grigorenko et al. | A new synthesis of α-methylspermidine | |
EP1148783A4 (en) | CONVERSION OF COX INHIBITING, NON COX-2 SELECTIVE INHIBITORS TO DERIVATIVES OF COX-2 SELECTIVE INHIBITORS | |
AR051933A1 (es) | Proceso para la preparacion de n-(3,5 dicloropirid-4-ilo)-4-difluormetoxi-8-metano sulfonamido-dibenzo[b,d] furano-1-carboxamida | |
WO2009131493A3 (ru) | Производные 5-гидpoкcи-4-aминoмeтил-l-циклoгeкcил (или циклoгeптил)--3-aлкoкcикapбoнилиндoлoв, их фармацевтически приемлемые соли, обладающие противовирусной активностью, и способ их получения | |
FR2723317A1 (fr) | Utilisation d'antagonistes de la neurotensine pour la preparation de medicaments diuretiques | |
García-Reynaga et al. | Biomimetic synthesis of Cbz-(S)-dolaphenine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |