NO20051155L - Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelse - Google Patents
Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelseInfo
- Publication number
- NO20051155L NO20051155L NO20051155A NO20051155A NO20051155L NO 20051155 L NO20051155 L NO 20051155L NO 20051155 A NO20051155 A NO 20051155A NO 20051155 A NO20051155 A NO 20051155A NO 20051155 L NO20051155 L NO 20051155L
- Authority
- NO
- Norway
- Prior art keywords
- give
- rizatriptan
- reaction
- preparation
- hydrazone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Oppfinnelsen angår rizatriptan eller et farmasøytisk akseptabelt derivat derav som inkluderer a) fremstilling av diazoniumsaltet av anilinhydrokloridet (II); etterfulgt av reduksjon og surgjøring, noe som gir hydrazinet (III); b) in situ omsetting av hydrazinhydrokloridet (III) med a-keto-d-valerolakton, noe som gir hydrazonet (IV); c) Fisher-indolomsetting av hydrazonet (IV), noe som gir pyranoindolonet. (V), eventuelt etterfulgt av en hydrolysereaksjon, noe som gir (VI); d) transesterifisering av (V) eller esterifisering av dens hydrolyseprodukt (VI), noe som gir (VII), hvor R betyr rett eller forgrenet C1 -C4-alkylkjede; e) omdanning av hydroksylgruppen i (VII) til dimetylamin, noe som gir indolkarboksylatet (VIII), hvor R har betydningen som definert ovenfor; f) saponifisering av 2-karboalkoksygruppen (VIII), noe som gir indolkarboksylsyren (IX); og g) dekarboksylering av indolkarboksylsyren (IX), noe som gir rizatriptan og eventuelt oppnåelsen av et farmasøytisk akseptabelt salt derav. Oppfinnelsen angår også syntesemellomprodukter for oppnåelsen av rizatriptan.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201874A ES2204303B2 (es) | 2002-08-07 | 2002-08-07 | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
PCT/IB2003/003540 WO2004014877A1 (en) | 2002-08-07 | 2003-08-05 | Process for preparing rizatriptan |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20051155L true NO20051155L (no) | 2005-03-03 |
Family
ID=31502894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051155A NO20051155L (no) | 2002-08-07 | 2005-03-03 | Fremgangsmate for fremstilling av en farmasoytisk aktiv forbindelse |
Country Status (11)
Country | Link |
---|---|
US (1) | US7279581B2 (no) |
EP (1) | EP1527053B8 (no) |
KR (1) | KR20050039749A (no) |
AT (1) | ATE312084T1 (no) |
AU (1) | AU2003250478A1 (no) |
DE (1) | DE60302671D1 (no) |
ES (2) | ES2204303B2 (no) |
IS (1) | IS7702A (no) |
NO (1) | NO20051155L (no) |
TW (1) | TW200404798A (no) |
WO (1) | WO2004014877A1 (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1678305A (zh) * | 2002-06-27 | 2005-10-05 | Sb药物波多黎各公司 | 卡维地洛磷酸盐和/或其溶剂合物和/或相应组合物和/或治疗方法 |
ES2204302B2 (es) * | 2002-08-07 | 2005-03-01 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
US7777049B2 (en) | 2004-01-09 | 2010-08-17 | Ratiopharm Gmbh | Crystalline forms of Rizatriptan benzoate |
EP1751104B1 (en) * | 2004-01-28 | 2010-03-24 | ratiopharm GmbH | Synthesis methods and intermediates for the manufacture of rizatriptan |
WO2007054979A1 (en) * | 2005-11-14 | 2007-05-18 | Matrix Laboratories Ltd | Process for the large scale production of rizatriptan benzoate |
ATE510836T1 (de) * | 2006-01-19 | 2011-06-15 | Matrix Lab Ltd | Umwandlung eines aromatischen diazoniumsalzes in ein arylhydrazin |
JP7126260B2 (ja) | 2016-01-27 | 2022-08-26 | インスター テクノロジーズ アクチオヴァ スプルチュノスト | 治療処置用の口腔粘膜ナノファイバ担体 |
CN115353492A (zh) * | 2022-08-26 | 2022-11-18 | 浙江野风药业股份有限公司 | 一种连续合成1-(4-肼基苯基)甲基-1,2,4-三氮唑的方法 |
CN115417859B (zh) * | 2022-09-19 | 2024-02-02 | 陕西师范大学 | 一种苯甲酸利扎曲坦的合成方法 |
CN116283924A (zh) * | 2023-01-16 | 2023-06-23 | 四川效佳科技有限公司 | 一种药用级纯度的苯甲酸利扎曲普坦的重结晶方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
ES2033578B1 (es) * | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida. |
ES2033577B1 (es) | 1991-06-06 | 1995-01-16 | Quimica Sint S A Con El 50 | Procedimiento para la obtencion de la 2-carboxi-3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida y sus esteres alquilicos inferiores. |
GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
US5567824A (en) * | 1994-05-24 | 1996-10-22 | Merck & Co., Inc. | Palladium catalyzed ring closure of triazolyltryptamine |
DE69717287T2 (de) | 1996-08-13 | 2003-09-11 | Merck & Co Inc | Palladiumkatalysierte indolisierung |
US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
GB9926250D0 (en) | 1999-11-06 | 2000-01-12 | Knoll Ag | Chemical process |
-
2002
- 2002-08-07 ES ES200201874A patent/ES2204303B2/es not_active Expired - Fee Related
-
2003
- 2003-08-05 US US10/509,918 patent/US7279581B2/en active Active
- 2003-08-05 ES ES03784405T patent/ES2254982T3/es not_active Expired - Lifetime
- 2003-08-05 AU AU2003250478A patent/AU2003250478A1/en not_active Abandoned
- 2003-08-05 DE DE60302671T patent/DE60302671D1/de not_active Expired - Lifetime
- 2003-08-05 EP EP03784405A patent/EP1527053B8/en not_active Expired - Lifetime
- 2003-08-05 KR KR1020047012028A patent/KR20050039749A/ko not_active Application Discontinuation
- 2003-08-05 WO PCT/IB2003/003540 patent/WO2004014877A1/en not_active Application Discontinuation
- 2003-08-05 AT AT03784405T patent/ATE312084T1/de not_active IP Right Cessation
- 2003-08-05 TW TW092121365A patent/TW200404798A/zh unknown
-
2005
- 2005-02-21 IS IS7702A patent/IS7702A/is unknown
- 2005-03-03 NO NO20051155A patent/NO20051155L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200404798A (en) | 2004-04-01 |
IS7702A (is) | 2005-02-21 |
EP1527053B8 (en) | 2006-03-08 |
DE60302671D1 (de) | 2006-01-12 |
ES2204303A1 (es) | 2004-04-16 |
US7279581B2 (en) | 2007-10-09 |
WO2004014877A1 (en) | 2004-02-19 |
AU2003250478A1 (en) | 2004-02-25 |
US20050148778A1 (en) | 2005-07-07 |
EP1527053B1 (en) | 2005-12-07 |
ES2254982T3 (es) | 2006-06-16 |
ES2204303B2 (es) | 2004-12-16 |
ATE312084T1 (de) | 2005-12-15 |
KR20050039749A (ko) | 2005-04-29 |
EP1527053A1 (en) | 2005-05-04 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |