NO20045487L - Anvendelse av fluor NMR for hoy gjennomlopsscreening - Google Patents

Anvendelse av fluor NMR for hoy gjennomlopsscreening

Info

Publication number
NO20045487L
NO20045487L NO20045487A NO20045487A NO20045487L NO 20045487 L NO20045487 L NO 20045487L NO 20045487 A NO20045487 A NO 20045487A NO 20045487 A NO20045487 A NO 20045487A NO 20045487 L NO20045487 L NO 20045487L
Authority
NO
Norway
Prior art keywords
high throughput
throughput screening
fluorine nmr
nmr
fluorine
Prior art date
Application number
NO20045487A
Other languages
English (en)
Norwegian (no)
Inventor
Claudio Dalvit
Brian J Stockman
Maria Flocco
Marina Veronesi
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of NO20045487L publication Critical patent/NO20045487L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/465NMR spectroscopy applied to biological material, e.g. in vitro testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/4625Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Vehicle Body Suspensions (AREA)
  • Polyesters Or Polycarbonates (AREA)
NO20045487A 2002-06-05 2004-12-16 Anvendelse av fluor NMR for hoy gjennomlopsscreening NO20045487L (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38689702P 2002-06-05 2002-06-05
US38925202P 2002-06-17 2002-06-17
US39887502P 2002-07-26 2002-07-26
US45476603P 2003-03-14 2003-03-14
US45476503P 2003-03-14 2003-03-14
PCT/US2003/017729 WO2004051214A2 (en) 2002-06-05 2003-06-05 Use of fluorine nmr for high throughput screening

Publications (1)

Publication Number Publication Date
NO20045487L true NO20045487L (no) 2005-02-07

Family

ID=32475841

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045487A NO20045487L (no) 2002-06-05 2004-12-16 Anvendelse av fluor NMR for hoy gjennomlopsscreening

Country Status (12)

Country Link
US (1) US20040091937A1 (da)
EP (1) EP1511852B1 (da)
JP (1) JP2005536763A (da)
KR (1) KR20050008788A (da)
CN (1) CN1668757A (da)
AT (1) ATE469238T1 (da)
AU (1) AU2003243406A1 (da)
CA (1) CA2488473C (da)
DE (1) DE60332727D1 (da)
IL (1) IL165527A0 (da)
NO (1) NO20045487L (da)
WO (1) WO2004051214A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529328A (ja) 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー 競合的結合1hnmr実験を用いたリガンドの同定方法
US20040072211A1 (en) * 2002-06-05 2004-04-15 Pharmacia & Upjohn Company Methods for identifying ligands using waterlogsy NMR
WO2006042120A2 (en) * 2004-10-06 2006-04-20 Regents Of The University Of Minnesota Contrast from rotating frame relaxation by adiabatic pulses
EP1923397B1 (en) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorinated amino acids and peptides
CN102507627B (zh) * 2011-11-14 2014-10-01 中国科学院武汉物理与数学研究所 一种高通量筛选药物的核磁共振方法
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN103760184A (zh) * 2014-01-16 2014-04-30 江南大学 一种测定铅离子的磁共振成像传感器的构建方法
EP3472433A4 (en) 2016-09-20 2019-07-24 Halliburton Energy Services, Inc. ANALYSIS OF LIQUIDS IN CORE SAMPLES CONTAINED IN PRESSURE NMR CORE HOLDERS, WITH 1H AND 19F NMR
CN107831094B (zh) * 2017-10-30 2020-04-07 中国人民解放军国防科技大学 基于碱金属原子弛豫率变化测量气体扩散常数的方法
CN108303440A (zh) * 2018-04-04 2018-07-20 山东大学 一种基于19f-nmr技术快速检测利奥西呱与蛋白相互作用的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US6110660A (en) * 1995-08-20 2000-08-29 The European Institute Of Science Ab Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability
US6897028B1 (en) * 1997-07-07 2005-05-24 Florida State University Identification of molecular targets
WO2000017360A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
US6677160B1 (en) * 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
WO2001023889A1 (en) * 1999-09-29 2001-04-05 Smithkline Beecham Corporation Method of using one-dimensional and multi-dimensional nuclear magnetic resonance to identify compounds that interact with target biomolecules
US6593341B2 (en) * 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
EP1483295B1 (en) * 2002-03-01 2008-12-10 Immunomedics, Inc. Rs7 antibodies
JP2005529328A (ja) * 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー 競合的結合1hnmr実験を用いたリガンドの同定方法
US20040072211A1 (en) * 2002-06-05 2004-04-15 Pharmacia & Upjohn Company Methods for identifying ligands using waterlogsy NMR

Also Published As

Publication number Publication date
CN1668757A (zh) 2005-09-14
JP2005536763A (ja) 2005-12-02
EP1511852A4 (en) 2008-07-16
KR20050008788A (ko) 2005-01-21
ATE469238T1 (de) 2010-06-15
AU2003243406A1 (en) 2004-06-23
CA2488473C (en) 2013-02-05
CA2488473A1 (en) 2004-06-17
IL165527A0 (en) 2006-01-15
DE60332727D1 (de) 2010-07-08
US20040091937A1 (en) 2004-05-13
EP1511852A2 (en) 2005-03-09
WO2004051214A2 (en) 2004-06-17
WO2004051214A3 (en) 2004-09-10
EP1511852B1 (en) 2010-05-26

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