DE60332727D1 - Verwendung von fluor-nmr zum screening mit hohem durchsatz - Google Patents

Verwendung von fluor-nmr zum screening mit hohem durchsatz

Info

Publication number
DE60332727D1
DE60332727D1 DE60332727T DE60332727T DE60332727D1 DE 60332727 D1 DE60332727 D1 DE 60332727D1 DE 60332727 T DE60332727 T DE 60332727T DE 60332727 T DE60332727 T DE 60332727T DE 60332727 D1 DE60332727 D1 DE 60332727D1
Authority
DE
Germany
Prior art keywords
fluor
nmr
performance screening
screening
performance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332727T
Other languages
English (en)
Inventor
Claudio Dalvit
Brian J Stockman
Maria Flocco
Marina Veronesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Original Assignee
Nerviano Medical Sciences SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences SRL filed Critical Nerviano Medical Sciences SRL
Application granted granted Critical
Publication of DE60332727D1 publication Critical patent/DE60332727D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Vehicle Body Suspensions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE60332727T 2002-06-05 2003-06-05 Verwendung von fluor-nmr zum screening mit hohem durchsatz Expired - Lifetime DE60332727D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38689702P 2002-06-05 2002-06-05
US38925202P 2002-06-17 2002-06-17
US39887502P 2002-07-26 2002-07-26
US45476503P 2003-03-14 2003-03-14
US45476603P 2003-03-14 2003-03-14
PCT/US2003/017729 WO2004051214A2 (en) 2002-06-05 2003-06-05 Use of fluorine nmr for high throughput screening

Publications (1)

Publication Number Publication Date
DE60332727D1 true DE60332727D1 (de) 2010-07-08

Family

ID=32475841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60332727T Expired - Lifetime DE60332727D1 (de) 2002-06-05 2003-06-05 Verwendung von fluor-nmr zum screening mit hohem durchsatz

Country Status (12)

Country Link
US (1) US20040091937A1 (de)
EP (1) EP1511852B1 (de)
JP (1) JP2005536763A (de)
KR (1) KR20050008788A (de)
CN (1) CN1668757A (de)
AT (1) ATE469238T1 (de)
AU (1) AU2003243406A1 (de)
CA (1) CA2488473C (de)
DE (1) DE60332727D1 (de)
IL (1) IL165527A0 (de)
NO (1) NO20045487L (de)
WO (1) WO2004051214A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1514108A4 (de) * 2002-06-05 2007-08-01 Pharmacia & Upjohn Co Llc Verfahren zur identifizierung von liganden mittels waterlogsy-nmr
JP2005529328A (ja) 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー 競合的結合１ｈｎｍｒ実験を用いたリガンドの同定方法
WO2006042120A2 (en) * 2004-10-06 2006-04-20 Regents Of The University Of Minnesota Contrast from rotating frame relaxation by adiabatic pulses
EP1923397B1 (de) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorierte Aminosäuren und Peptide
CN102507627B (zh) * 2011-11-14 2014-10-01 中国科学院武汉物理与数学研究所 一种高通量筛选药物的核磁共振方法
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN103760184A (zh) * 2014-01-16 2014-04-30 江南大学 一种测定铅离子的磁共振成像传感器的构建方法
US10761157B2 (en) 2016-09-20 2020-09-01 Halliburton Energy Services, Inc. Analyzing fluids in core samples contained in pressurized NMR core holders with 1H and 19F NMR
CN107831094B (zh) * 2017-10-30 2020-04-07 中国人民解放军国防科技大学 基于碱金属原子弛豫率变化测量气体扩散常数的方法
CN108303440A (zh) * 2018-04-04 2018-07-20 山东大学 一种基于19f-nmr技术快速检测利奥西呱与蛋白相互作用的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US6110660A (en) * 1995-08-20 2000-08-29 The European Institute Of Science Ab Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability
US6897028B1 (en) * 1997-07-07 2005-05-24 Florida State University Identification of molecular targets
CA2344277A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
US6677160B1 (en) * 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
JP2003510608A (ja) * 1999-09-29 2003-03-18 スミスクライン・ビーチャム・コーポレイション 標的生体分子と相互作用する化合物を同定するための一次元および多次元核磁気共鳴の使用法
US6593341B2 (en) * 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
KR101002443B1 (ko) * 2002-03-01 2010-12-17 이뮤노메딕스, 인코오포레이티드 Ｒｓ7 항체
EP1514108A4 (de) * 2002-06-05 2007-08-01 Pharmacia & Upjohn Co Llc Verfahren zur identifizierung von liganden mittels waterlogsy-nmr
JP2005529328A (ja) * 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー 競合的結合１ｈｎｍｒ実験を用いたリガンドの同定方法

Also Published As

Publication number Publication date
EP1511852B1 (de) 2010-05-26
US20040091937A1 (en) 2004-05-13
CA2488473A1 (en) 2004-06-17
EP1511852A2 (de) 2005-03-09
WO2004051214A3 (en) 2004-09-10
CN1668757A (zh) 2005-09-14
NO20045487L (no) 2005-02-07
CA2488473C (en) 2013-02-05
JP2005536763A (ja) 2005-12-02
IL165527A0 (en) 2006-01-15
EP1511852A4 (de) 2008-07-16
ATE469238T1 (de) 2010-06-15
KR20050008788A (ko) 2005-01-21
WO2004051214A2 (en) 2004-06-17
AU2003243406A1 (en) 2004-06-23

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