ATE469238T1 - Verwendung von fluor-nmr zum screening mit hohem durchsatz - Google Patents

Verwendung von fluor-nmr zum screening mit hohem durchsatz

Info

Publication number
ATE469238T1
ATE469238T1 AT03812412T AT03812412T ATE469238T1 AT E469238 T1 ATE469238 T1 AT E469238T1 AT 03812412 T AT03812412 T AT 03812412T AT 03812412 T AT03812412 T AT 03812412T AT E469238 T1 ATE469238 T1 AT E469238T1
Authority
AT
Austria
Prior art keywords
nmr
fluorine
throughput screening
throughput
detection
Prior art date
Application number
AT03812412T
Other languages
English (en)
Inventor
Claudio Dalvit
Brian Stockman
Maria Flocco
Marina Veronesi
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Application granted granted Critical
Publication of ATE469238T1 publication Critical patent/ATE469238T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Vehicle Body Suspensions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT03812412T 2002-06-05 2003-06-05 Verwendung von fluor-nmr zum screening mit hohem durchsatz ATE469238T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38689702P 2002-06-05 2002-06-05
US38925202P 2002-06-17 2002-06-17
US39887502P 2002-07-26 2002-07-26
US45476603P 2003-03-14 2003-03-14
US45476503P 2003-03-14 2003-03-14
PCT/US2003/017729 WO2004051214A2 (en) 2002-06-05 2003-06-05 Use of fluorine nmr for high throughput screening

Publications (1)

Publication Number Publication Date
ATE469238T1 true ATE469238T1 (de) 2010-06-15

Family

ID=32475841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03812412T ATE469238T1 (de) 2002-06-05 2003-06-05 Verwendung von fluor-nmr zum screening mit hohem durchsatz

Country Status (12)

Country Link
US (1) US20040091937A1 (de)
EP (1) EP1511852B1 (de)
JP (1) JP2005536763A (de)
KR (1) KR20050008788A (de)
CN (1) CN1668757A (de)
AT (1) ATE469238T1 (de)
AU (1) AU2003243406A1 (de)
CA (1) CA2488473C (de)
DE (1) DE60332727D1 (de)
IL (1) IL165527A0 (de)
NO (1) NO20045487L (de)
WO (1) WO2004051214A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470543B2 (en) 2002-06-05 2008-12-30 Nerviano Medical Sciences S.R.L. Methods for identifying ligands using competitive binding 1H NMR experiments
WO2003104824A2 (en) * 2002-06-05 2003-12-18 Pharmacia & Upjohn Company Methods for identifying ligands using waterlogsy nmr
WO2006042120A2 (en) * 2004-10-06 2006-04-20 Regents Of The University Of Minnesota Contrast from rotating frame relaxation by adiabatic pulses
EP1923397B1 (de) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorierte Aminosäuren und Peptide
CN102507627B (zh) * 2011-11-14 2014-10-01 中国科学院武汉物理与数学研究所 一种高通量筛选药物的核磁共振方法
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN103760184A (zh) * 2014-01-16 2014-04-30 江南大学 一种测定铅离子的磁共振成像传感器的构建方法
EP3472433A4 (de) 2016-09-20 2019-07-24 Halliburton Energy Services, Inc. Analyse von flüssigkeiten in kernproben, die in unter druck stehenden nmr-kernhaltern enthalten sind, mit 1h und 19f nmr
CN107831094B (zh) * 2017-10-30 2020-04-07 中国人民解放军国防科技大学 基于碱金属原子弛豫率变化测量气体扩散常数的方法
CN108303440A (zh) * 2018-04-04 2018-07-20 山东大学 一种基于19f-nmr技术快速检测利奥西呱与蛋白相互作用的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US6110660A (en) * 1995-08-20 2000-08-29 The European Institute Of Science Ab Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability
US6897028B1 (en) * 1997-07-07 2005-05-24 Florida State University Identification of molecular targets
JP2003524381A (ja) * 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド，ボルチモア システインノット成長因子ミュータント
WO2001023889A1 (en) * 1999-09-29 2001-04-05 Smithkline Beecham Corporation Method of using one-dimensional and multi-dimensional nuclear magnetic resonance to identify compounds that interact with target biomolecules
US6677160B1 (en) * 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6593341B2 (en) * 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
CA2478047C (en) * 2002-03-01 2014-01-21 Immunomedics, Inc. Rs7 antibodies
US7470543B2 (en) * 2002-06-05 2008-12-30 Nerviano Medical Sciences S.R.L. Methods for identifying ligands using competitive binding 1H NMR experiments
WO2003104824A2 (en) * 2002-06-05 2003-12-18 Pharmacia & Upjohn Company Methods for identifying ligands using waterlogsy nmr

Also Published As

Publication number Publication date
JP2005536763A (ja) 2005-12-02
IL165527A0 (en) 2006-01-15
WO2004051214A3 (en) 2004-09-10
WO2004051214A2 (en) 2004-06-17
CN1668757A (zh) 2005-09-14
NO20045487L (no) 2005-02-07
EP1511852B1 (de) 2010-05-26
EP1511852A4 (de) 2008-07-16
DE60332727D1 (de) 2010-07-08
EP1511852A2 (de) 2005-03-09
KR20050008788A (ko) 2005-01-21
US20040091937A1 (en) 2004-05-13
CA2488473C (en) 2013-02-05
CA2488473A1 (en) 2004-06-17
AU2003243406A1 (en) 2004-06-23

Similar Documents

Publication Publication Date Title
DE60300734D1 (de) Anordnungen zur Vorbehandlung von Proben
DE60331738D1 (de) Nmr-probenkopf mit probenbehälter
DE60319475D1 (de) Parallele Magnetresonanzbildgebung unter Verwendung von Navigator-Echosignalen
ATE381334T1 (de) 2,5-substituiertetetrahydroisochinoline zur verwendung als 5-ht6 modulatoren
DE60133785D1 (de) Verbesserte gewebeerzeugte harmonische Bilddarstellung mit Verwendung von kodierter Anregung
AU2003293704A8 (en) Methods and kits for assays of rapid screening of diabetes
DE60143301D1 (de) Polyarylcarboxamide zur verwendung als lipidsenker
IS7576A (is) And-mýelíntengd glýkóprótín (MAG) mótefni
DE60332320D1 (de) Neues screening-verfahren
DE50212455D1 (de) Verwendung von Dimerdiolen
DE50210488D1 (de) System zum Steuern von Lichtsignalgebern an Kreuzungen
DK1531689T3 (da) Komplet måltidserstatning
DE60306646D1 (de) Anbringen von ladeleisten
DE60332727D1 (de) Verwendung von fluor-nmr zum screening mit hohem durchsatz
EP1552003A4 (de) Verfahren zur beurteilung der qualität von mikroarrays
DE69928250D1 (de) Analytisches verfahren unter verwendung von multipelviren-markierung
DE60304884D1 (de) Segmentierte reifenform zur verringerung von grat
DE60322052D1 (de) N-acylaminoacetonitril-derivate und ihre verwendung zur kontrolle von parasiten
DE602004024622D1 (de) Ladesystem unter Verwendung von Gitterelementen mit differenzierten Mustern
DE69930064D1 (de) Vorrichtung zum Befestigen von Ringen
ATE481117T1 (de) Verwendung von n-isopropylacrylamide zur aufbewahrung von kontaktlinsen
NO20031033L (no) Reseptor i EDb-fibronectindomene
EA200500878A1 (ru) Кальцилитические соединения
ATE497947T1 (de) Neue 1,3-disubstituierte azetidinderivate zur verwendung als liganden des 5ht2a-rezeptors
ATE455770T1 (de) N-alkynyl-2-heteroaryloxyalkylamide zur verwendung als fungizide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1511852

Country of ref document: EP