IL165527A0 - Use of fluorine NMR for high throughput screening - Google Patents

Use of fluorine NMR for high throughput screening

Info

Publication number
IL165527A0
IL165527A0 IL16552704A IL16552704A IL165527A0 IL 165527 A0 IL165527 A0 IL 165527A0 IL 16552704 A IL16552704 A IL 16552704A IL 16552704 A IL16552704 A IL 16552704A IL 165527 A0 IL165527 A0 IL 165527A0
Authority
IL
Israel
Prior art keywords
high throughput
throughput screening
fluorine nmr
nmr
fluorine
Prior art date
Application number
IL16552704A
Other languages
English (en)
Original Assignee
Pharmacia Ind
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ind, Upjohn Co filed Critical Pharmacia Ind
Publication of IL165527A0 publication Critical patent/IL165527A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Vehicle Body Suspensions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
IL16552704A 2002-06-05 2004-12-02 Use of fluorine NMR for high throughput screening IL165527A0 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38689702P 2002-06-05 2002-06-05
US38925202P 2002-06-17 2002-06-17
US39887502P 2002-07-26 2002-07-26
US45476503P 2003-03-14 2003-03-14
US45476603P 2003-03-14 2003-03-14
PCT/US2003/017729 WO2004051214A2 (en) 2002-06-05 2003-06-05 Use of fluorine nmr for high throughput screening

Publications (1)

Publication Number Publication Date
IL165527A0 true IL165527A0 (en) 2006-01-15

Family

ID=32475841

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16552704A IL165527A0 (en) 2002-06-05 2004-12-02 Use of fluorine NMR for high throughput screening

Country Status (12)

Country Link
US (1) US20040091937A1 (da)
EP (1) EP1511852B1 (da)
JP (1) JP2005536763A (da)
KR (1) KR20050008788A (da)
CN (1) CN1668757A (da)
AT (1) ATE469238T1 (da)
AU (1) AU2003243406A1 (da)
CA (1) CA2488473C (da)
DE (1) DE60332727D1 (da)
IL (1) IL165527A0 (da)
NO (1) NO20045487L (da)
WO (1) WO2004051214A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529337A (ja) * 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー ＷａｔｅｒＬＯＧＳＹＮＭＲを使用してリガンドを同定する方法
AU2003240546A1 (en) 2002-06-05 2003-12-22 Pharmacia And Upjohn Company Methods for identifying ligands using competitive binding 1h nmr experiments
US7279899B2 (en) * 2004-10-06 2007-10-09 Regents Of The University Of Minnesota Contrast from rotating frame relaxation by adiabatic pulses
EP1923397B1 (en) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorinated amino acids and peptides
CN102507627B (zh) * 2011-11-14 2014-10-01 中国科学院武汉物理与数学研究所 一种高通量筛选药物的核磁共振方法
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN103760184A (zh) * 2014-01-16 2014-04-30 江南大学 一种测定铅离子的磁共振成像传感器的构建方法
EP3472433A4 (en) 2016-09-20 2019-07-24 Halliburton Energy Services, Inc. ANALYSIS OF LIQUIDS IN CORE SAMPLES CONTAINED IN PRESSURE NMR CORE HOLDERS, WITH 1H AND 19F NMR
CN107831094B (zh) * 2017-10-30 2020-04-07 中国人民解放军国防科技大学 基于碱金属原子弛豫率变化测量气体扩散常数的方法
CN108303440A (zh) * 2018-04-04 2018-07-20 山东大学 一种基于19f-nmr技术快速检测利奥西呱与蛋白相互作用的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US6110660A (en) * 1995-08-20 2000-08-29 The European Institute Of Science Ab Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability
US6897028B1 (en) * 1997-07-07 2005-05-24 Florida State University Identification of molecular targets
JP2003524381A (ja) * 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド，ボルチモア システインノット成長因子ミュータント
US6677160B1 (en) * 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
EP1221048A4 (en) * 1999-09-29 2005-01-05 Smithkline Beecham Corp METHOD FOR USING ONE-DIMENSIONAL AND MULTIDIMENSIONAL NUCLEAR MAGNETIC RESONANCE FOR IDENTIFYING COMPOUNDS THAT INTERACT WITH TARGET BIOMOLECULARS
US6593341B2 (en) * 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
PT3483183T (pt) * 2002-03-01 2021-06-02 Immunomedics Inc Imunoconjugado compreendendo anticorpos rs7 humanizados
JP2005529337A (ja) * 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー ＷａｔｅｒＬＯＧＳＹＮＭＲを使用してリガンドを同定する方法
AU2003240546A1 (en) * 2002-06-05 2003-12-22 Pharmacia And Upjohn Company Methods for identifying ligands using competitive binding 1h nmr experiments

Also Published As

Publication number Publication date
CA2488473C (en) 2013-02-05
WO2004051214A2 (en) 2004-06-17
US20040091937A1 (en) 2004-05-13
DE60332727D1 (de) 2010-07-08
CN1668757A (zh) 2005-09-14
EP1511852B1 (en) 2010-05-26
EP1511852A2 (en) 2005-03-09
NO20045487L (no) 2005-02-07
ATE469238T1 (de) 2010-06-15
EP1511852A4 (en) 2008-07-16
CA2488473A1 (en) 2004-06-17
WO2004051214A3 (en) 2004-09-10
AU2003243406A1 (en) 2004-06-23
KR20050008788A (ko) 2005-01-21
JP2005536763A (ja) 2005-12-02

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