NO20044775L - Diazabicykloalkanderivater med NK1 antagonistisk aktivitet - Google Patents

Diazabicykloalkanderivater med NK1 antagonistisk aktivitet

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Publication number
NO20044775L
NO20044775L NO20044775A NO20044775A NO20044775L NO 20044775 L NO20044775 L NO 20044775L NO 20044775 A NO20044775 A NO 20044775A NO 20044775 A NO20044775 A NO 20044775A NO 20044775 L NO20044775 L NO 20044775L
Authority
NO
Norway
Prior art keywords
morpholin
antagonistic activity
indolyl
halogen
substituted
Prior art date
Application number
NO20044775A
Other languages
English (en)
Inventor
Gustaaf Johan Mar Scharrenburg
Andrew C Mccreary
Jan H Van Maarseveen
Wouter I Iwema Bakker
Hein K A C Coolen
Dirk De Boer
Mayke B Hesselink
Gijsbert D Kuil
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20044775L publication Critical patent/NO20044775L/no

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører en gruppe unike diazabicykloalkanderivater med intressant neurokinin-NKi reseptorantagonistisk aktivitet representert ved den generelle formelen (1): (1) der: R' står for fenyl, 2-indolyl, 3-indolyl, 3-indazolyl eller benzo[b]tiofen-3-yl, der gruppene kan være substituert med halogen eller alkyl (1-3C), R^ og B? står uavhengig av hverandre for halogen, H, OCH3, CH3 og CF3, R\ R' og R* står uavhengig av hverandre for H, OH, 0-alkyl(l-4C), CH2OH, NH2, dialkyl(l-3C)N, pyrrolidin-1-yl, piperidin-1-yl, morfolin-4-yl eller niorfolin-4-yl substituert med en eller to metyl- eller metoksymetylgmpper, morfolin-4-ylamino, morfolin-4-ylmetyl, imidazolyl-1-yl, tiomorfolin-4-yl, l,l-dioksotiomorfolin-4-yl eller 3-okBa-8-azabicyklo[3.2.I]okt-8-yl; R'* og R^ kan sammen stå for en keto-, en l,3-dioksan-2-yl- eller en l,3-dioksolan-2-yl gruppe, X står for enten O eller S, n har verdien 1,2 eller 3, a er et asymmetriske kaibonatomet 8a, 9a eller 1 Oa når n henholdsvis er lik 1,2 eller 3. Oppfinnelsen vedrører en fremgangsmåte til fiemstilling av de nye forbindelsene og føimasciytiske sairnnensetninger som inneholder minst en av disse forbindelsene som en aktiv ingrediens.
NO20044775A 2002-04-04 2004-11-03 Diazabicykloalkanderivater med NK1 antagonistisk aktivitet NO20044775L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076405 2002-04-04
PCT/EP2003/050086 WO2003084955A1 (en) 2002-04-04 2003-04-02 Diazabicyclo alkane derivatives with nk1 antagonistic activity

Publications (1)

Publication Number Publication Date
NO20044775L true NO20044775L (no) 2004-12-16

Family

ID=28685940

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044775A NO20044775L (no) 2002-04-04 2004-11-03 Diazabicykloalkanderivater med NK1 antagonistisk aktivitet

Country Status (21)

Country Link
US (1) US7202238B2 (no)
EP (1) EP1495022B1 (no)
JP (1) JP2005525395A (no)
KR (1) KR20040095361A (no)
CN (1) CN1279041C (no)
AR (1) AR039192A1 (no)
AT (1) ATE435863T1 (no)
AU (1) AU2003224162B2 (no)
BR (1) BR0306148A (no)
CA (1) CA2462708A1 (no)
DE (1) DE60328272D1 (no)
HK (1) HK1070356A1 (no)
HR (1) HRP20040273A2 (no)
IL (2) IL160943A0 (no)
MX (1) MXPA04004812A (no)
NO (1) NO20044775L (no)
PL (1) PL371378A1 (no)
RU (1) RU2310656C2 (no)
UA (1) UA77515C2 (no)
WO (1) WO2003084955A1 (no)
ZA (1) ZA200404744B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101459A1 (en) * 2002-05-29 2003-12-11 The Regents Of The University Of California Antagonizing nk1 receptors inhibits consumption of substances of abuse
AR045796A1 (es) * 2003-09-26 2005-11-16 Solvay Pharm Bv Derivados de hexa y octahidro - pirido (1,2-a) pirazina con actividad antagonista de nk1. composiciones farmaceuticas.
WO2006013205A1 (en) * 2004-08-04 2006-02-09 Solvay Pharmaceuticals B.V. Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation
DE102006049452A1 (de) 2006-10-17 2008-05-08 Grünenthal GmbH Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln
WO2010011912A1 (en) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Trpv4 antagonists
US8450484B2 (en) * 2008-07-25 2013-05-28 GlaxoSmithKline, LLC TRPV4 antagonists
AR088064A1 (es) 2011-09-29 2014-05-07 Abbvie Inc Octahidropirrolo[1,2-a]pirazina sulfonamidas sustituidas como bloqueadores de canales de calcio
WO2013049164A1 (en) * 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
RU2631319C2 (ru) * 2012-02-22 2017-09-21 Лео Фарма А/С Новые соединения - антагонисты рецептора нейрокинина 1
CN105008361A (zh) 2012-12-12 2015-10-28 艾伯维公司 作为钙通道阻滞剂用于治疗疼痛的的二氮杂*衍生物
SI3024463T1 (sl) * 2013-07-25 2020-08-31 Neuren Pharmaceuticals Limited Nevroprotektivne biciklične spojine in postopki za njihovo uporabo pri zdravljenju motenj avtističnega spektra in nevrorazvojnih motenj
WO2015024203A1 (en) * 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii
SG11201908691PA (en) 2017-03-20 2019-10-30 Broad Inst Inc Compounds and methods for the treatment of parasitic diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1125112A (en) * 1966-01-07 1968-08-28 Science Union & Cie New derivatives of diazabicyclo-decane and process for preparing them
IL111730A (en) 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
ATE208766T1 (de) * 1995-05-23 2001-11-15 Janssen Pharmaceutica Nv (2-morpholinylmethyl)benzamid-derivate
KR19990021857A (ko) 1995-05-25 1999-03-25 후지야마 아키라 뉴로키닌 수용체 길항물질로서 1-벤조일-2-(인돌일-3-알킬)-피페라진 유도체
GB9510600D0 (en) 1995-05-25 1995-07-19 Fujisawa Pharmaceutical Co Piperazine derivatives
CA2240835A1 (en) 1995-12-18 1997-06-26 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as tachykinin antagonists
AUPO735997A0 (en) 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
ATE396187T1 (de) 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
EP0982030A3 (en) * 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
TR200101649T2 (tr) 1998-12-14 2001-10-22 Fujisawa Pharmaceutical Co., Ltd. Piperazin türevleri.
DE10036818A1 (de) 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Also Published As

Publication number Publication date
RU2310656C2 (ru) 2007-11-20
BR0306148A (pt) 2004-10-19
KR20040095361A (ko) 2004-11-12
JP2005525395A (ja) 2005-08-25
US7202238B2 (en) 2007-04-10
ZA200404744B (en) 2005-09-21
IL160943A (en) 2008-11-03
HRP20040273A2 (en) 2005-02-28
US20050119267A1 (en) 2005-06-02
EP1495022B1 (en) 2009-07-08
PL371378A1 (en) 2005-06-13
CA2462708A1 (en) 2003-10-16
ATE435863T1 (de) 2009-07-15
AU2003224162A1 (en) 2003-10-20
HK1070356A1 (en) 2005-06-17
CN1279041C (zh) 2006-10-11
EP1495022A1 (en) 2005-01-12
MXPA04004812A (es) 2004-08-11
IL160943A0 (en) 2004-08-31
UA77515C2 (en) 2006-12-15
RU2004112415A (ru) 2005-03-27
WO2003084955A1 (en) 2003-10-16
DE60328272D1 (de) 2009-08-20
CN1592747A (zh) 2005-03-09
AR039192A1 (es) 2005-02-09
AU2003224162B2 (en) 2008-06-12

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