NO20023175L - Kamptotecin beta-alaninestere med topoisomerase I inhibering - Google Patents
Kamptotecin beta-alaninestere med topoisomerase I inhiberingInfo
- Publication number
- NO20023175L NO20023175L NO20023175A NO20023175A NO20023175L NO 20023175 L NO20023175 L NO 20023175L NO 20023175 A NO20023175 A NO 20023175A NO 20023175 A NO20023175 A NO 20023175A NO 20023175 L NO20023175 L NO 20023175L
- Authority
- NO
- Norway
- Prior art keywords
- topoisomerase
- beta
- camptotecin
- inhibition
- alanine esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/474,099 US6288072B1 (en) | 1999-12-29 | 1999-12-29 | Camptothecin β-alanine esters with topoisomerase I inhibition |
PCT/US2000/015033 WO2001049691A1 (en) | 1999-12-29 | 2000-06-14 | CAMPTOTHECIN β-ALANINE ESTERS WITH TOPOISOMERASE I INIBHITION |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20023175D0 NO20023175D0 (no) | 2002-06-28 |
NO20023175L true NO20023175L (no) | 2002-08-29 |
Family
ID=23882177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20023175A NO20023175L (no) | 1999-12-29 | 2002-06-28 | Kamptotecin beta-alaninestere med topoisomerase I inhibering |
Country Status (11)
Country | Link |
---|---|
US (1) | US6288072B1 (ko) |
EP (1) | EP1254141B1 (ko) |
JP (1) | JP4704648B2 (ko) |
KR (1) | KR100762556B1 (ko) |
AT (1) | ATE302204T1 (ko) |
AU (1) | AU784602B2 (ko) |
CA (1) | CA2396030C (ko) |
DE (1) | DE60022095T2 (ko) |
ES (1) | ES2246864T3 (ko) |
NO (1) | NO20023175L (ko) |
WO (1) | WO2001049691A1 (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
AU2002366100A1 (en) * | 2001-11-20 | 2003-06-10 | University Of Kentucky Research Foundation | Engineered liposomal particles containing core-loaded pro-drugs for the controlled release of camptothecins |
US7071202B2 (en) * | 2002-02-21 | 2006-07-04 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
ITRM20020306A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
US7071204B2 (en) | 2003-06-30 | 2006-07-04 | Research Triangle Institute | Camptothecin analogs having an E-ring ketone |
RU2015120074A (ru) | 2012-10-30 | 2016-12-20 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Функционализированные производные 9-бром-камптотецина |
US11254773B2 (en) | 2017-05-11 | 2022-02-22 | The Regents Of The University Of California | Nanoscale multiple emulsions and nanoparticles |
CN111171041B (zh) * | 2018-11-12 | 2021-07-27 | 中国海洋大学 | 20位取代的喜树碱衍生物及其制备方法和应用 |
CN111484501A (zh) * | 2020-04-22 | 2020-08-04 | 沈阳药科大学 | 羟基喜树碱亚油酸酯小分子前药及其自组装纳米粒的构建 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US564619A (en) * | 1896-07-28 | Apparatus for dyeing | ||
US5053512A (en) | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
US4981968A (en) | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5227380A (en) | 1987-03-31 | 1993-07-13 | Research Triangle Institute | Pharmaceutical compositions and methods employing camptothecins |
US4894456A (en) | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5106742A (en) | 1987-03-31 | 1992-04-21 | Wall Monroe E | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5364858A (en) | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5122526A (en) | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
US5122606A (en) | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
US5180722A (en) | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
US5340817A (en) | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
US5049668A (en) | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
DE4119981C1 (ko) | 1991-06-18 | 1993-01-21 | Fa. Carl Freudenberg, 6940 Weinheim, De | |
DE69209969T2 (de) * | 1991-10-29 | 1996-09-12 | Glaxo Wellcome Inc | Wasserlösliche Camptothecinderivate |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
IS4152A (is) * | 1993-04-29 | 1994-10-30 | Glaxo Inc. | Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra |
US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
US5496830A (en) | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
US5614529A (en) | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
GB9510716D0 (en) | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
JPH08333370A (ja) | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
IL124287A (en) * | 1995-11-02 | 2004-06-01 | Osi Pharm Inc | Method for preparing camptothecin derivatives and some novel intermediates thereof |
WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
-
1999
- 1999-12-29 US US09/474,099 patent/US6288072B1/en not_active Expired - Lifetime
-
2000
- 2000-06-14 EP EP00939454A patent/EP1254141B1/en not_active Expired - Lifetime
- 2000-06-14 ES ES00939454T patent/ES2246864T3/es not_active Expired - Lifetime
- 2000-06-14 AU AU54538/00A patent/AU784602B2/en not_active Ceased
- 2000-06-14 WO PCT/US2000/015033 patent/WO2001049691A1/en active IP Right Grant
- 2000-06-14 KR KR1020027008491A patent/KR100762556B1/ko not_active IP Right Cessation
- 2000-06-14 JP JP2001550231A patent/JP4704648B2/ja not_active Expired - Fee Related
- 2000-06-14 DE DE60022095T patent/DE60022095T2/de not_active Expired - Lifetime
- 2000-06-14 CA CA2396030A patent/CA2396030C/en not_active Expired - Fee Related
- 2000-06-14 AT AT00939454T patent/ATE302204T1/de not_active IP Right Cessation
-
2002
- 2002-06-28 NO NO20023175A patent/NO20023175L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2396030C (en) | 2011-03-15 |
ATE302204T1 (de) | 2005-09-15 |
NO20023175D0 (no) | 2002-06-28 |
KR20020081682A (ko) | 2002-10-30 |
US6288072B1 (en) | 2001-09-11 |
WO2001049691A1 (en) | 2001-07-12 |
JP4704648B2 (ja) | 2011-06-15 |
AU5453800A (en) | 2001-07-16 |
JP2003519234A (ja) | 2003-06-17 |
CA2396030A1 (en) | 2001-07-12 |
KR100762556B1 (ko) | 2007-10-04 |
EP1254141B1 (en) | 2005-08-17 |
DE60022095D1 (en) | 2005-09-22 |
ES2246864T3 (es) | 2006-03-01 |
EP1254141A4 (en) | 2003-05-02 |
DE60022095T2 (de) | 2006-06-08 |
EP1254141A1 (en) | 2002-11-06 |
AU784602B2 (en) | 2006-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |