NO20013456L - Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer - Google Patents

Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer

Info

Publication number
NO20013456L
NO20013456L NO20013456A NO20013456A NO20013456L NO 20013456 L NO20013456 L NO 20013456L NO 20013456 A NO20013456 A NO 20013456A NO 20013456 A NO20013456 A NO 20013456A NO 20013456 L NO20013456 L NO 20013456L
Authority
NO
Norway
Prior art keywords
chemokine receptor
receptor modulators
useful
modulators
final products
Prior art date
Application number
NO20013456A
Other languages
English (en)
Norwegian (no)
Other versions
NO20013456D0 (no
Inventor
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Original Assignee
Millenium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millenium Pharmaceuticals Inc filed Critical Millenium Pharmaceuticals Inc
Publication of NO20013456D0 publication Critical patent/NO20013456D0/no
Publication of NO20013456L publication Critical patent/NO20013456L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20013456A 1999-01-13 2001-07-12 Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer NO20013456L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11565499P 1999-01-13 1999-01-13
PCT/US1999/030434 WO2000042045A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Publications (2)

Publication Number Publication Date
NO20013456D0 NO20013456D0 (no) 2001-07-12
NO20013456L true NO20013456L (no) 2001-09-12

Family

ID=22362668

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013456A NO20013456L (no) 1999-01-13 2001-07-12 Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer

Country Status (20)

Country Link
EP (1) EP1144415A2 (ru)
JP (1) JP2002534526A (ru)
KR (1) KR20010086166A (ru)
CN (1) CN1344270A (ru)
AP (1) AP2001002228A0 (ru)
AU (1) AU1940900A (ru)
BR (1) BR9916905A (ru)
CA (1) CA2372197A1 (ru)
CZ (1) CZ20012502A3 (ru)
EA (1) EA200100774A1 (ru)
HK (1) HK1044539A1 (ru)
HU (1) HUP0202932A3 (ru)
IL (1) IL144289A0 (ru)
MX (1) MXPA01007033A (ru)
NO (1) NO20013456L (ru)
OA (1) OA11820A (ru)
PL (1) PL349348A1 (ru)
SK (1) SK9972001A3 (ru)
WO (1) WO2000042045A2 (ru)
ZA (1) ZA200106592B (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1377549A1 (en) * 2001-03-12 2004-01-07 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
EA007493B1 (ru) 2001-03-29 2006-10-27 Эли Лилли Энд Компани N-(2-арилэтил)бензиламины в качестве антагонистов 5-ht-рецептора
WO2003035650A1 (fr) * 2001-09-25 2003-05-01 Takeda Chemical Industries, Ltd. Inhibiteur d'entree
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
EP1619193A4 (en) 2003-04-18 2010-08-11 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
NZ553696A (en) 2004-09-13 2010-02-26 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
WO2006129679A1 (ja) 2005-05-31 2006-12-07 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
PT1942108E (pt) 2005-10-28 2013-10-24 Ono Pharmaceutical Co Composto com um grupo básico e a sua utilização
ES2407115T3 (es) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
CA2642668C (en) * 2006-02-15 2013-01-08 Allergan, Inc. Indole-3-carboxylic acid amide and ester compounds bearing phenyl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
AU2007225836A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
EP2042503B1 (en) 2006-05-16 2013-01-30 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
EA016633B1 (ru) 2006-05-23 2012-06-29 Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" Замещенные индолы, способ их получения и применения
WO2008016006A1 (en) 2006-07-31 2008-02-07 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
CA2674946A1 (en) * 2007-01-11 2008-07-24 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
US8524917B2 (en) 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
US8293738B2 (en) 2010-05-12 2012-10-23 Abbott Laboratories Indazole inhibitors of kinase
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
CN104193669B (zh) * 2014-08-01 2016-12-07 大连理工大学 一类阿比朵尔类似物或其盐、其制备方法及应用
WO2016112088A1 (en) * 2015-01-06 2016-07-14 Spero Therapeutics, Inc. Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors
CN110256324A (zh) * 2019-06-13 2019-09-20 苏州莱安医药化学技术有限公司 一种2-甲基-5-羟基吲哚的制备方法
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
HRP960352A2 (en) * 1996-07-26 1998-08-31 Pliva Pharm & Chem Works Novel coumarin quinoline carboxylic acids
KR100447553B1 (ko) * 1997-02-26 2004-09-08 화이자 인코포레이티드 헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도
EP1052992A1 (en) * 1998-02-02 2000-11-22 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
HK1044539A1 (zh) 2002-10-25
MXPA01007033A (es) 2003-07-21
HUP0202932A3 (en) 2003-07-28
PL349348A1 (en) 2002-07-15
SK9972001A3 (en) 2002-03-05
JP2002534526A (ja) 2002-10-15
HUP0202932A2 (hu) 2002-12-28
NO20013456D0 (no) 2001-07-12
AP2001002228A0 (en) 2001-09-30
CN1344270A (zh) 2002-04-10
OA11820A (en) 2005-08-17
WO2000042045A3 (en) 2000-11-09
IL144289A0 (en) 2002-05-23
KR20010086166A (ko) 2001-09-08
WO2000042045A2 (en) 2000-07-20
CA2372197A1 (en) 2000-07-20
EA200100774A1 (ru) 2002-02-28
CZ20012502A3 (cs) 2002-03-13
EP1144415A2 (en) 2001-10-17
AU1940900A (en) 2000-08-01
ZA200106592B (en) 2002-08-12
BR9916905A (pt) 2002-01-29

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