NO20002837L - Nye arylpiperazinylalkyl-3(2H)-pyridazinoner - Google Patents

Nye arylpiperazinylalkyl-3(2H)-pyridazinoner

Info

Publication number
NO20002837L
NO20002837L NO20002837A NO20002837A NO20002837L NO 20002837 L NO20002837 L NO 20002837L NO 20002837 A NO20002837 A NO 20002837A NO 20002837 A NO20002837 A NO 20002837A NO 20002837 L NO20002837 L NO 20002837L
Authority
NO
Norway
Prior art keywords
radical
arylpiperazinylalkyl
pyridazinones
receptors
new
Prior art date
Application number
NO20002837A
Other languages
English (en)
Other versions
NO20002837D0 (no
Inventor
Aurelio Orjales Venero
Neftali Garcia-Dominguez
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of NO20002837D0 publication Critical patent/NO20002837D0/no
Publication of NO20002837L publication Critical patent/NO20002837L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye arylpiperazinylalkyl-3(2H)-pyridazinoner av generell formel (I) og deres fremstilling og deres addisjonssalter med farmasøytisk akseptable syrer N¿N /¿s d! hvori R, er et metyl- eller fenylradikal, R2 er et hydrogenatom eller et metylradikal, n har verdier mellom 2 og 4, og Ra er et naftylfadikal eller et fenylradikal som er substituert med et radikal slik som metoksyl, trifluormetyl og klor, er beskrevet. Forbindelsene utviser affinitet for serotonin 5HTIA- og 5HT2-reseptorer og for dopamin D2-reseptorer, og kan være anvendbare som antipsykotiske midler.
NO20002837A 1999-06-04 2000-06-02 Nye arylpiperazinylalkyl-3(2H)-pyridazinoner NO20002837L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901239A ES2162731B1 (es) 1999-06-04 1999-06-04 Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Publications (2)

Publication Number Publication Date
NO20002837D0 NO20002837D0 (no) 2000-06-02
NO20002837L true NO20002837L (no) 2000-12-05

Family

ID=8308721

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002837A NO20002837L (no) 1999-06-04 2000-06-02 Nye arylpiperazinylalkyl-3(2H)-pyridazinoner

Country Status (15)

Country Link
US (1) US6413966B1 (no)
EP (1) EP1057820A1 (no)
JP (1) JP2001002659A (no)
KR (1) KR20010049474A (no)
AU (1) AU3780100A (no)
BR (1) BR0002578A (no)
CA (1) CA2310873A1 (no)
ES (1) ES2162731B1 (no)
HR (1) HRP20000370A2 (no)
HU (1) HUP0002132A2 (no)
IL (1) IL136507A0 (no)
MX (1) MXPA00005428A (no)
NO (1) NO20002837L (no)
PL (1) PL340490A1 (no)
TR (1) TR200001621A3 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
ES2323451T7 (es) 2001-07-20 2011-08-01 Psychogenics Inc. Tratamiento para el trastorno de hiperactividad con deficit de atencion.
WO2021123174A1 (en) * 2019-12-19 2021-06-24 Universite De Strasbourg Sigma-1 receptor ligands and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
JP3670690B2 (ja) * 1993-10-04 2005-07-13 トーアエイヨー株式会社 ３−ピリダジノン誘導体、その製造法およびそれを含有する循環器官用剤
EP0875512A3 (en) * 1997-04-16 1999-04-07 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New naphthylpiperazine derivatives with antipsychotic activity
RU2209813C2 (ru) * 1997-11-19 2003-08-10 Кова Ко., Лтд. Производные пиридазина, лекарственные средства на их основе и способ лечения артрита

Also Published As

Publication number Publication date
EP1057820A1 (en) 2000-12-06
TR200001621A2 (tr) 2001-07-23
HUP0002132A2 (hu) 2002-11-28
PL340490A1 (en) 2000-12-18
US6413966B1 (en) 2002-07-02
HRP20000370A2 (en) 2001-06-30
HU0002132D0 (en) 2000-08-28
KR20010049474A (ko) 2001-06-15
JP2001002659A (ja) 2001-01-09
ES2162731A1 (es) 2002-01-01
TR200001621A3 (tr) 2001-07-23
NO20002837D0 (no) 2000-06-02
ES2162731B1 (es) 2003-02-16
IL136507A0 (en) 2001-06-14
BR0002578A (pt) 2001-01-02
MXPA00005428A (es) 2002-06-04
AU3780100A (en) 2000-12-07
CA2310873A1 (en) 2000-12-04

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