NO177498C - Fremgangsmåte for fremstilling av et protein med biologisk FSH-aktivitet - Google Patents

Fremgangsmåte for fremstilling av et protein med biologisk FSH-aktivitet

Info

Publication number
NO177498C
NO177498C NO890805A NO890805A NO177498C NO 177498 C NO177498 C NO 177498C NO 890805 A NO890805 A NO 890805A NO 890805 A NO890805 A NO 890805A NO 177498 C NO177498 C NO 177498C
Authority
NO
Norway
Prior art keywords
biological
protein
producing
fsh activity
fsh
Prior art date
Application number
NO890805A
Other languages
English (en)
Norwegian (no)
Other versions
NO890805D0 (no
NO177498B (no
NO890805L (no
Inventor
Giuseppe Arpaia
Serenella Serani
Antonino Sirna
Stefano Villa
Original Assignee
Serono Cesare Ist Ricerca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11264576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO177498(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Serono Cesare Ist Ricerca filed Critical Serono Cesare Ist Ricerca
Publication of NO890805D0 publication Critical patent/NO890805D0/no
Publication of NO890805L publication Critical patent/NO890805L/no
Publication of NO177498B publication Critical patent/NO177498B/no
Publication of NO177498C publication Critical patent/NO177498C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
NO890805A 1987-06-26 1989-02-24 Fremgangsmåte for fremstilling av et protein med biologisk FSH-aktivitet NO177498C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8748110A IT1206302B (it) 1987-06-26 1987-06-26 Ormone follicolo-stimolante urinario
PCT/IT1988/000048 WO1988010270A1 (en) 1987-06-26 1988-06-24 Urinary follicle stimulating hormone

Publications (4)

Publication Number Publication Date
NO890805D0 NO890805D0 (no) 1989-02-24
NO890805L NO890805L (no) 1989-02-24
NO177498B NO177498B (no) 1995-06-19
NO177498C true NO177498C (no) 1995-09-27

Family

ID=11264576

Family Applications (1)

Application Number Title Priority Date Filing Date
NO890805A NO177498C (no) 1987-06-26 1989-02-24 Fremgangsmåte for fremstilling av et protein med biologisk FSH-aktivitet

Country Status (26)

Country Link
US (3) US5128453A (de)
EP (1) EP0322438B1 (de)
JP (1) JP2523843B2 (de)
KR (1) KR0156565B1 (de)
CN (2) CN1031714C (de)
AR (1) AR243241A1 (de)
AT (1) ATE115148T1 (de)
AU (1) AU615930B2 (de)
CA (1) CA1340649C (de)
DE (1) DE3852383T2 (de)
DK (1) DK173349B1 (de)
ES (1) ES2009948A6 (de)
FI (1) FI96608C (de)
GE (2) GEP19971042B (de)
GR (1) GR1003186B (de)
HK (1) HK143195A (de)
IL (1) IL86847A (de)
IT (1) IT1206302B (de)
LT (2) LT3999B (de)
LV (2) LV10628B (de)
MX (1) MX9203471A (de)
NO (1) NO177498C (de)
RU (2) RU2105012C1 (de)
UA (1) UA19101A (de)
WO (1) WO1988010270A1 (de)
ZA (1) ZA884492B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
US6737515B2 (en) * 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
CN1309567A (zh) * 1998-07-23 2001-08-22 伊莱利利公司 Fsh和fsh变体制剂,产品和方法
EP1169053A1 (de) 1999-04-13 2002-01-09 Inhale Therapeutic Systems, Inc. Verabreichung von trockenpulverformulierungen über die lungen zur behandlung der unfruchtbarkeit
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
AU6469401A (en) * 2000-05-19 2001-11-26 Serono Reproductive Biology In Pharmaceutically active compounds and methods of use
DE60127175T2 (de) * 2000-12-21 2007-11-08 Nektar Therapeutics, San Carlos Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor
WO2004050679A2 (en) 2001-10-22 2004-06-17 Applied Research Systems Ars Holding N.V. Mutant glycoproteins
ES2261740T3 (es) * 2001-10-22 2006-11-16 Applied Research Systems Ars Holding N.V. Composiciones de fsh con alto grado de sialilacion y su uso para la preparacion de medicamentos.
ES2399047T3 (es) * 2002-09-20 2013-03-25 Merck Serono Sa Derivados de piperazina y procedimiento de uso
MXPA05010373A (es) * 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
CA2518903C (en) * 2003-04-02 2013-02-05 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
WO2004112826A1 (en) * 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
CA2544333A1 (en) 2003-12-22 2005-07-14 Ares Trading S.A. Method for purifying fsh
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
AU2005303818B2 (en) * 2004-11-09 2011-06-23 Ares Trading S.A. Method for purifying FSH
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
SG155183A1 (en) 2005-08-26 2009-09-30 Ares Trading Sa Process for the preparation of glycosylated interferon beta
AU2006287767B2 (en) 2005-09-07 2010-05-13 Merck Serono Sa IKK inhibitors for the treatment of endometriosis
EP1951395B1 (de) * 2005-09-14 2012-02-29 Ares Trading S.A. Verfahren zur quantitativen bestimmung von poloxameren
EP1960419B1 (de) 2005-12-09 2016-03-16 Ares Trading S.A. Verfahren zur aufreinigung von fsh oder einer fsh-mutante
WO2009014782A2 (en) * 2007-04-27 2009-01-29 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
RS52976B (sr) 2007-06-28 2014-02-28 Biogenerix Ag Ćelijski klon koji proizvodi fsh
EP2249869B1 (de) 2008-02-08 2011-09-07 BioGeneriX AG Flüssige formulierung von fsh
TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
MX2011010480A (es) 2009-04-01 2012-09-07 Biogenerix Ag Metodo para purificar una fsh recombinante.
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
RU2438680C1 (ru) * 2010-10-07 2012-01-10 Федеральное государственное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения препарата фолликулостимулирующего гормона из аденогипофизов животных
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
JP6712224B2 (ja) 2014-09-11 2020-06-17 久光製薬株式会社 マイクロニードルデバイス
WO2016067956A1 (ja) 2014-10-27 2016-05-06 久光製薬株式会社 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス
KR102636093B1 (ko) * 2016-10-11 2024-02-13 온코그린 테라퓨틱스 에스아 종양의 진단 및 치료에서 fsh 호르몬 수용체의 리간드
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
KR102752765B1 (ko) * 2019-12-26 2025-01-14 주식회사 엘지화학 여포 자극 호르몬의 정제 방법
CN113583125B (zh) * 2021-07-09 2022-09-20 苏州晟济药业有限公司 抗体以及包含其的结合剂、免疫吸附材料及其应用

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US3852422A (en) * 1971-06-26 1974-12-03 Serono Ist Farm Long-active gonadotropins
SU618113A1 (ru) * 1976-11-19 1978-08-05 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Способ получени фолликулостимулирующего гормона
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
DE3583528D1 (de) * 1984-04-03 1991-08-29 Serono Lab Verfahren zur herbeifuehrung der ovulation.
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
GB8510177D0 (en) * 1985-04-22 1985-05-30 Public Health Laborotory Servi Isolating pituitary glycoprotein hormones
GB2174600B (en) * 1985-05-10 1989-12-20 Univ Melbourne Induction of ovulation in mares
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario

Also Published As

Publication number Publication date
EP0322438B1 (de) 1994-12-07
FI890893A0 (fi) 1989-02-24
FI890893L (fi) 1989-02-24
FI96608C (fi) 1996-07-25
ES2009948A6 (es) 1989-10-16
CN1069062C (zh) 2001-08-01
US5128453A (en) 1992-07-07
CN1031714C (zh) 1996-05-01
JP2523843B2 (ja) 1996-08-14
FI96608B (fi) 1996-04-15
LT4018B (en) 1996-08-26
AR243241A1 (es) 1993-07-30
GR880100418A (el) 1989-03-08
DE3852383T2 (de) 1995-04-20
NO890805D0 (no) 1989-02-24
RU2059412C1 (ru) 1996-05-10
HK143195A (en) 1995-09-15
DK89989D0 (da) 1989-02-24
LT3999B (en) 1996-06-25
AU615930B2 (en) 1988-06-24
WO1988010270A1 (en) 1988-12-29
LTIP1654A (en) 1995-08-25
CN1030589A (zh) 1989-01-25
IT1206302B (it) 1989-04-14
CA1340649C (en) 1999-07-13
EP0322438A1 (de) 1989-07-05
DK173349B1 (da) 2000-08-07
LV10628A (lv) 1995-04-20
MX9203471A (es) 1992-09-01
NO177498B (no) 1995-06-19
US5840857A (en) 1998-11-24
GR1003186B (el) 1999-09-01
CN1117873A (zh) 1996-03-06
IT8748110A0 (it) 1987-06-26
GEP19981274B (en) 1998-05-06
IL86847A (en) 1997-11-20
AU1962088A (en) 1989-01-19
LV10196A (lv) 1994-10-20
LTIP1652A (en) 1995-08-25
IL86847A0 (en) 1988-11-30
ZA884492B (en) 1989-05-30
GEP19971042B (en) 1997-06-13
DE3852383D1 (de) 1995-01-19
KR0156565B1 (ko) 1998-10-15
NO890805L (no) 1989-02-24
LV10196B (en) 1995-04-20
UA19101A (uk) 1997-12-25
ATE115148T1 (de) 1994-12-15
US5767067A (en) 1998-06-16
LV10628B (en) 1995-10-20
KR890701626A (ko) 1989-12-21
DK89989A (da) 1989-02-24
RU2105012C1 (ru) 1998-02-20
JPH02500840A (ja) 1990-03-22

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