NO176550C - Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse - Google Patents

Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse

Info

Publication number
NO176550C
NO176550C NO885213A NO885213A NO176550C NO 176550 C NO176550 C NO 176550C NO 885213 A NO885213 A NO 885213A NO 885213 A NO885213 A NO 885213A NO 176550 C NO176550 C NO 176550C
Authority
NO
Norway
Prior art keywords
preparation
stable
compound
pharmaceutical formulations
formulations containing
Prior art date
Application number
NO885213A
Other languages
English (en)
Norwegian (no)
Other versions
NO885213D0 (no
NO176550B (no
NO885213L (no
Inventor
Werner Fulberth
Richard Leeb
Manfred Radau
Willi Stammberger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO885213D0 publication Critical patent/NO885213D0/no
Publication of NO885213L publication Critical patent/NO885213L/no
Publication of NO176550B publication Critical patent/NO176550B/no
Publication of NO176550C publication Critical patent/NO176550C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO885213A 1987-11-24 1988-11-23 Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse NO176550C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739690 DE3739690A1 (de) 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen

Publications (4)

Publication Number Publication Date
NO885213D0 NO885213D0 (no) 1988-11-23
NO885213L NO885213L (no) 1989-05-25
NO176550B NO176550B (no) 1995-01-16
NO176550C true NO176550C (no) 1995-04-26

Family

ID=6341084

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885213A NO176550C (no) 1987-11-24 1988-11-23 Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse

Country Status (21)

Country Link
US (2) US5151433A (sv)
EP (1) EP0317878B1 (sv)
JP (1) JPH0768140B2 (sv)
KR (1) KR970004908B1 (sv)
CN (1) CN1028962C (sv)
AT (1) ATE74513T1 (sv)
AU (1) AU615495B2 (sv)
CA (1) CA1338344C (sv)
DE (2) DE3739690A1 (sv)
DK (1) DK168423B1 (sv)
ES (1) ES2033400T3 (sv)
FI (1) FI93693C (sv)
GR (1) GR3004925T3 (sv)
HU (1) HU202100B (sv)
IE (1) IE61173B1 (sv)
IL (1) IL88460A0 (sv)
NO (1) NO176550C (sv)
NZ (1) NZ227032A (sv)
PH (1) PH27416A (sv)
PT (1) PT89061B (sv)
ZA (1) ZA888734B (sv)

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US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
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DK0869772T3 (da) * 1995-12-27 2002-01-21 Janssen Pharmaceutica Nv Bioadhæsiv fast doseringsform
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
WO2001015674A2 (en) * 1999-08-30 2001-03-08 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
FR2824477B1 (fr) * 2001-05-09 2005-09-09 Ethypharm Lab Prod Ethiques Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes
CA2357982A1 (en) * 2001-09-28 2003-03-28 Bernard Charles Sherman Solid compositions comprising ramipril
US20050202081A1 (en) * 2002-01-15 2005-09-15 Deepak Bahl Stable pharmaceutical compositions comprising ace inhibitor(s)
US20060177498A1 (en) * 2003-01-22 2006-08-10 Ramaswami Bharatrajan Solid pharmaceutical composition comprising ramipril
GB0301471D0 (en) * 2003-01-22 2003-02-19 Biochemie Gmbh Organic compounds
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US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
AU2003300692A1 (en) * 2003-10-30 2005-05-19 Lupin Ltd. Stable formulations of ace inhibitors and methods for preparation thereof
GB2394660A (en) * 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
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US20080234353A1 (en) * 2004-03-24 2008-09-25 Reynir Eyjolfsson Formulations of Ramipril
US20060045911A1 (en) * 2004-08-27 2006-03-02 Sun Pharmaceutical Industries Ltd. Stable pharmaceutical formulations
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GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
KR100679166B1 (ko) 2005-10-04 2007-02-06 신풍제약주식회사 안정성이 증진된 약제학적 조성물 및 그의 제조방법
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
CA2646066A1 (en) * 2006-03-28 2007-10-04 Gelesis, Inc. Use of polymeric materials with other substances for improved performance
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
MX2008013374A (es) * 2006-04-19 2008-11-12 Teva Pharma Composiciones farmaceuticas estables de derivados del acido 2-aza-biciclo[3.3.0]-octano-3-carboxilico.
DE602006000402T8 (de) * 2006-06-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
JP2009538905A (ja) * 2006-06-02 2009-11-12 テバ ファーマシューティカル インダストリーズ リミティド 感湿性薬物を含んで成る安定性製剤及びその製造方法
US20100035955A1 (en) * 2006-06-30 2010-02-11 Panagiotis Keramidas Stabilised Composition Comprising ACE Inhibitors
MX2009002091A (es) * 2006-08-28 2009-03-09 Sanofi Aventis Deutschland Metodos para reducir las concentraciones de glucosa.
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
PL382311A1 (pl) * 2007-04-27 2008-11-10 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Kompozycja farmaceutyczna o polepszonej stabilności zawierająca inhibitor acetylocholinoesterazy lub farmaceutycznie dopuszczalną jego sól oraz sposób jej wytwarzania
EP2273985B1 (en) 2008-03-28 2016-02-17 Ferrer Internacional, S.A. Capsule for the prevention of cardiovascular diseases
WO2010030735A2 (en) * 2008-09-11 2010-03-18 Aethos Pharmaceuticals, Inc. Stabilized coating for pharmaceutical formulations
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
EP2814465B1 (en) 2012-02-17 2019-07-03 Egis Gyógyszergyár Zrt. Pharmaceutical formulation having improved stability
PL227900B1 (pl) 2012-11-15 2018-01-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
TWI668285B (zh) * 2015-12-31 2019-08-11 長興材料工業股份有限公司 可熱聚合之組合物、由此形成之組成液及其用途
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WO2021162562A2 (en) 2020-02-10 2021-08-19 Adamed Pharma S.A. Stable ramipril composition and fixed dose composition comprising thereof
CN115068434B (zh) * 2022-08-03 2023-05-09 昆山龙灯瑞迪制药有限公司 一种雷米普利片的制备方法

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Also Published As

Publication number Publication date
JPH0768140B2 (ja) 1995-07-26
EP0317878B1 (de) 1992-04-08
FI93693C (sv) 1995-05-26
HU202100B (en) 1991-02-28
DE3739690A1 (de) 1989-06-08
US5442008A (en) 1995-08-15
US5151433A (en) 1992-09-29
ZA888734B (en) 1989-07-26
FI885398A0 (sv) 1988-11-22
NO885213D0 (no) 1988-11-23
ES2033400T3 (es) 1993-03-16
DK168423B1 (da) 1994-03-28
DK653688D0 (da) 1988-11-23
AU615495B2 (en) 1991-10-03
ATE74513T1 (de) 1992-04-15
AU2581888A (en) 1989-05-25
DE3869919D1 (de) 1992-05-14
KR890007739A (ko) 1989-07-05
IE883505L (en) 1989-05-24
NZ227032A (en) 1991-05-28
IL88460A0 (en) 1989-06-30
PH27416A (en) 1993-06-21
NO176550B (no) 1995-01-16
NO885213L (no) 1989-05-25
JPH01165596A (ja) 1989-06-29
DK653688A (da) 1989-05-25
CN1028962C (zh) 1995-06-21
PT89061A (pt) 1988-12-01
EP0317878A1 (de) 1989-05-31
PT89061B (pt) 1993-03-31
HUT48455A (en) 1989-06-28
FI93693B (sv) 1995-02-15
IE61173B1 (en) 1994-10-05
FI885398A (sv) 1989-05-25
CA1338344C (en) 1996-05-21
CN1042917A (zh) 1990-06-13
KR970004908B1 (ko) 1997-04-08
GR3004925T3 (sv) 1993-04-28

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