NO169525C - Diagnostisk preparat - Google Patents
Diagnostisk preparatInfo
- Publication number
- NO169525C NO169525C NO854349A NO854349A NO169525C NO 169525 C NO169525 C NO 169525C NO 854349 A NO854349 A NO 854349A NO 854349 A NO854349 A NO 854349A NO 169525 C NO169525 C NO 169525C
- Authority
- NO
- Norway
- Prior art keywords
- diagnostic preparation
- diagnostic
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8405500A SE465908B (sv) | 1984-11-01 | 1984-11-01 | Diagnosticeringspartiklar innehaallande en paramagnetisk metall |
SE8405501A SE465909B (sv) | 1984-11-01 | 1984-11-01 | Partikelformat diagnosticeringsmedel innehaallande en paramagnetisk metall |
Publications (3)
Publication Number | Publication Date |
---|---|
NO854349L NO854349L (no) | 1986-05-02 |
NO169525B NO169525B (no) | 1992-03-30 |
NO169525C true NO169525C (no) | 1992-07-08 |
Family
ID=26658808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO854349A NO169525C (no) | 1984-11-01 | 1985-10-31 | Diagnostisk preparat |
Country Status (6)
Country | Link |
---|---|
US (1) | US4985233A (no) |
EP (1) | EP0184899B1 (no) |
JP (1) | JPH0678246B2 (no) |
DE (1) | DE3577185D1 (no) |
DK (1) | DK164486C (no) |
NO (1) | NO169525C (no) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735796A (en) * | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
EP0330801A1 (en) * | 1983-02-08 | 1989-09-06 | Schering Aktiengesellschaft | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
US6203777B1 (en) * | 1983-12-21 | 2001-03-20 | Nycomed Imaging As | Method of contrast enhanced magnetic resonance imaging using carbohydrate particles |
SE463651B (sv) * | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
US5336762A (en) * | 1985-11-18 | 1994-08-09 | Access Pharmaceuticals, Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
EP0247156B1 (en) * | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
US5342607A (en) * | 1986-07-03 | 1994-08-30 | Advanced Magnetics, Inc. | Receptor mediated endocytosis type magnetic resonance imaging contrast agents |
US5219554A (en) | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
US5679323A (en) * | 1986-07-03 | 1997-10-21 | Advanced Magnetics, Inc. | Hepatocyte-specific receptor-mediated endocytosis-type compositions |
US4951675A (en) * | 1986-07-03 | 1990-08-28 | Advanced Magnetics, Incorporated | Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging |
US4770183A (en) * | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
US5284646A (en) * | 1986-07-03 | 1994-02-08 | Advanced Magnetics Inc. | Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents |
US5352432A (en) * | 1986-07-03 | 1994-10-04 | Advanced Magnetics, Inc. | Hepatocyte specific composition and their use as diagnostic imaging agents |
FR2612400A1 (fr) * | 1987-03-16 | 1988-09-23 | Centre Nat Rech Scient | Microcapsules contenant un marqueur radioactif et/ou paramagnetique sous forme de chelate, et leur utilisation dans le domaine de l'imagerie medicale |
DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5049667A (en) * | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
US5154179A (en) * | 1987-07-02 | 1992-10-13 | Medical Magnetics, Inc. | Device construction and method facilitating magnetic resonance imaging of foreign objects in a body |
DE3724188C2 (de) * | 1987-07-17 | 1995-05-18 | Heinz Dr Gries | Metallhaltige Oligosaccharid-Polysulfate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel |
US6013531A (en) * | 1987-10-26 | 2000-01-11 | Dade International Inc. | Method to use fluorescent magnetic polymer particles as markers in an immunoassay |
GB8801646D0 (en) * | 1988-01-26 | 1988-02-24 | Nycomed As | Chemical compounds |
GB8813144D0 (en) * | 1988-06-03 | 1988-07-06 | Nycomed As | Compositions |
WO1990001295A1 (en) | 1988-08-04 | 1990-02-22 | Advanced Magnetics, Incorporated | Receptor mediated endocytosis type mri contrast agents |
US5213788A (en) * | 1988-09-29 | 1993-05-25 | Ranney David F | Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement |
US5314681A (en) * | 1988-12-23 | 1994-05-24 | Nycomed Innovation Ab | Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging |
US5393525A (en) * | 1989-07-21 | 1995-02-28 | Nycomed Imaging As | Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration |
GB8916780D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
GB8916782D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
US5358702A (en) * | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
JPH05506227A (ja) * | 1990-04-10 | 1993-09-16 | イマルクス ファーマシューティカル コーポレーション | 磁気共鳴画像用造影剤としてのポリマー |
US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
US5268165A (en) * | 1990-10-16 | 1993-12-07 | Biomedical Frontiers, Inc. | Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging |
US5236693A (en) * | 1990-11-14 | 1993-08-17 | Brigham And Women's Hospital | Medical ultrasound contrast agent and method of using same |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5310539A (en) * | 1991-04-15 | 1994-05-10 | Board Of Regents, The University Of Texas System | Melanin-based agents for image enhancement |
DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
ATE151992T1 (de) * | 1991-06-03 | 1997-05-15 | Nycomed Imaging As | Verbesserungen im bezug auf kontrastmittel |
JP2939336B2 (ja) * | 1991-06-11 | 1999-08-25 | 名糖産業株式会社 | 水溶性カルボキシ多糖−磁性酸化鉄酸化複合体 |
EP0543988B1 (en) * | 1991-06-17 | 1995-06-21 | Dade International Inc. | Process for producing magnetically responsive polymer particles and application thereof |
US5250284A (en) * | 1991-10-15 | 1993-10-05 | Arnon Krongrad | Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc |
CA2121681A1 (en) * | 1991-11-19 | 1993-05-27 | Evan C. Unger | Gel particle contrast media for improved diagnostic imaging |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
JP2911674B2 (ja) * | 1992-02-20 | 1999-06-23 | 明治乳業株式会社 | 消化管造影用組成物 |
KR930019648A (ko) * | 1992-03-27 | 1993-10-18 | 도키 가츠유키 | 테트라아자시클로도덴칸 유도체 및 그의 용도 |
DE69207589T2 (de) * | 1992-06-01 | 1996-05-23 | Basf Ag | Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln |
EP0654973A4 (en) * | 1992-07-21 | 1995-08-09 | Gen Hospital Corp | LYPHATIC TISSUE DRUG ADMINISTRATION SYSTEM. |
ES2105332T3 (es) * | 1992-10-14 | 1997-10-16 | Nycomed Imaging As | Polimeros quelantes. |
WO1994008624A2 (en) * | 1992-10-14 | 1994-04-28 | Sterling Winthrop Inc. | Therapeutic and diagnostic imaging compositions and methods |
US5817292A (en) * | 1992-10-14 | 1998-10-06 | Nycomed Imaging As | MR imaging compositions and methods |
US5401492A (en) * | 1992-12-17 | 1995-03-28 | Sterling Winthrop, Inc. | Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents |
CA2154667A1 (en) * | 1993-02-02 | 1994-08-18 | Linda M. Gustavson | Directed biodistribution of small molecules |
US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
US6122540A (en) * | 1994-06-08 | 2000-09-19 | The Regents Of The University Of California | Noninvasive measurement of renal hemodynamic functions using magnetic resonance imaging |
DE4428851C2 (de) * | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
US5863518A (en) * | 1994-10-21 | 1999-01-26 | Nihon Medi-Physics Co., Ltd. | Diagnostic imaging agent with backbone with modified sugar chain end |
DK81095A (da) * | 1995-07-11 | 1997-01-12 | Henrik S Thomsen | Peroralt MR-kontraststof til lever og øvre tarmkanal |
FR2749082B1 (fr) * | 1996-05-24 | 1998-06-26 | Bio Merieux | Particules superparamagnetiques et monodispersees |
NL1003776C2 (nl) * | 1996-08-09 | 1998-02-20 | Cooperatie Cosun U A | Milieuvriendelijke complexanten voor zware metalen |
AU7104598A (en) | 1997-04-09 | 1998-10-30 | Philipp Lang | New technique to monitor drug delivery noninvasively (in vivo) |
JP4927302B2 (ja) * | 2000-09-21 | 2012-05-09 | グラステク インコーポレイテッド | ガラス板用関節成形型 |
US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US20040143180A1 (en) * | 2001-11-27 | 2004-07-22 | Sheng-Ping Zhong | Medical devices visible under magnetic resonance imaging |
WO2004004786A1 (en) * | 2002-07-02 | 2004-01-15 | Universitair Medisch Centrum Utrecht | Scanning suspension comprising a particle with a diameter of at least 1 micrometer |
ATE400302T1 (de) * | 2002-07-22 | 2008-07-15 | Bracco Imaging Spa | Zellmarkierungsverfahren mit paramagnetischen komplexen für mrt-anwendungen |
US8620406B2 (en) * | 2004-01-23 | 2013-12-31 | Boston Scientific Scimed, Inc. | Medical devices visible by magnetic resonance imaging |
US7761138B2 (en) | 2004-03-12 | 2010-07-20 | Boston Scientific Scimed, Inc. | MRI and X-ray visualization |
US7483732B2 (en) * | 2004-04-15 | 2009-01-27 | Boston Scientific Scimed, Inc. | Magnetic resonance imaging of a medical device and proximate body tissue |
EP1793860B1 (en) | 2004-07-15 | 2009-08-05 | GynaecologIQ B.V. | Composition and method for medical imaging of body cavities |
US7778684B2 (en) * | 2005-08-08 | 2010-08-17 | Boston Scientific Scimed, Inc. | MRI resonator system with stent implant |
US20070239256A1 (en) * | 2006-03-22 | 2007-10-11 | Jan Weber | Medical devices having electrical circuits with multilayer regions |
US10996218B2 (en) | 2008-03-11 | 2021-05-04 | Ournextbaby Llc | Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles |
NL2003660C2 (en) | 2009-10-16 | 2011-04-19 | Giskit B V | Composition and method for medical imaging of body cavities. |
WO2012036691A1 (en) | 2010-09-16 | 2012-03-22 | Urobiologics Llc | Use of female mammal's urine for determination of fetal gender related characteristics |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2862920A (en) * | 1956-06-07 | 1958-12-02 | Ohio Commw Eng Co | Ferrous carboxymethyl dextran |
GB1175834A (en) * | 1966-04-07 | 1969-12-23 | Atomic Energy Authority Uk | Improvements in or relating to the Chemical Production of Metal-Containing Materials as Particles and other Configurations |
US3563978A (en) * | 1968-05-15 | 1971-02-16 | Irving L Ochs | Polyvalent metal complexes of natural polymers |
US3928581A (en) * | 1972-09-13 | 1975-12-23 | Astra Laekemedel Ab | Certain polymer-iron complexes for treatment of iron deficiency |
SE431214B (sv) * | 1977-06-02 | 1984-01-23 | Klaus H Mosbach | Sett att framstella magnetiska polymerpartiklar som berare av en foretredesvis biologiskt aktiv substans |
SE409694B (sv) | 1978-01-02 | 1979-09-03 | Odlund Bjorn Alf Ingemar | Lastningsmaskin |
US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
HU186077B (en) * | 1982-06-16 | 1985-05-28 | Afit Iv Autojavito Vallalat | Device for blocking the hand brake lever |
CA1244082A (en) * | 1983-01-10 | 1988-11-01 | Robert T. Gordon | Method for enhancing nmr imaging; and diagnostic use |
US4731239A (en) * | 1983-01-10 | 1988-03-15 | Gordon Robert T | Method for enhancing NMR imaging; and diagnostic use |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
DK148251C (da) | 1983-02-18 | 1985-10-14 | Dansk Gartneri Tek As | Lukkemekanisme til under et tag paa raekke ophaengte gardinparter |
FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
CA1242643A (en) * | 1983-08-12 | 1988-10-04 | Eric T. Fossel | Nmr imaging utilizing chemical shift reagents |
CA1243602A (en) * | 1983-08-25 | 1988-10-25 | Hong-Ning Yeung | Methods for enhancing the contrast in nmr imaging |
US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
SE463651B (sv) * | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
US4728575A (en) * | 1984-04-27 | 1988-03-01 | Vestar, Inc. | Contrast agents for NMR imaging |
GB8413849D0 (en) * | 1984-05-31 | 1984-07-04 | Amersham Int Plc | Nmr contrast agents |
JPS6162785A (ja) | 1984-09-04 | 1986-03-31 | 日本プライブリコ株式会社 | 耐摩耗・耐火材ライニング用アンカ− |
US4675173A (en) * | 1985-05-08 | 1987-06-23 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging of the liver and spleen |
US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
-
1985
- 1985-10-25 EP EP85307738A patent/EP0184899B1/en not_active Expired - Lifetime
- 1985-10-25 DE DE8585307738T patent/DE3577185D1/de not_active Expired - Lifetime
- 1985-10-31 NO NO854349A patent/NO169525C/no unknown
- 1985-10-31 DK DK500085A patent/DK164486C/da active
- 1985-11-01 US US06/793,899 patent/US4985233A/en not_active Expired - Fee Related
- 1985-11-01 JP JP60244240A patent/JPH0678246B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3577185D1 (de) | 1990-05-23 |
EP0184899B1 (en) | 1990-04-18 |
JPS61155338A (ja) | 1986-07-15 |
NO169525B (no) | 1992-03-30 |
EP0184899A1 (en) | 1986-06-18 |
US4985233A (en) | 1991-01-15 |
DK164486B (da) | 1992-07-06 |
DK500085D0 (da) | 1985-10-31 |
DK164486C (da) | 1992-11-23 |
JPH0678246B2 (ja) | 1994-10-05 |
DK500085A (da) | 1986-05-02 |
NO854349L (no) | 1986-05-02 |
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