NO168304C - Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater

Info

Publication number
NO168304C
NO168304C NO891364A NO891364A NO168304C NO 168304 C NO168304 C NO 168304C NO 891364 A NO891364 A NO 891364A NO 891364 A NO891364 A NO 891364A NO 168304 C NO168304 C NO 168304C
Authority
NO
Norway
Prior art keywords
hydrogen
carboxy
formula
alkyl
alkanoyl
Prior art date
Application number
NO891364A
Other languages
English (en)
Norwegian (no)
Other versions
NO168304B (no
NO891364D0 (no
NO891364L (no
Inventor
Isao Kawamoto
Teruo Tanaka
Rokuro Endo
Masao Miyauchi
Masayuki Iwata
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO891364D0 publication Critical patent/NO891364D0/no
Publication of NO891364L publication Critical patent/NO891364L/no
Publication of NO168304B publication Critical patent/NO168304B/no
Publication of NO168304C publication Critical patent/NO168304C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO891364A 1988-04-01 1989-03-31 Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater NO168304C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8097488 1988-04-01
JP11164088 1988-05-10

Publications (4)

Publication Number Publication Date
NO891364D0 NO891364D0 (no) 1989-03-31
NO891364L NO891364L (no) 1990-02-08
NO168304B NO168304B (no) 1991-10-28
NO168304C true NO168304C (no) 1992-02-05

Family

ID=26421941

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891364A NO168304C (no) 1988-04-01 1989-03-31 Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater

Country Status (16)

Country Link
US (1) US5104867A (fi)
EP (2) EP0337637B1 (fi)
KR (2) KR0133071B1 (fi)
AT (1) ATE114654T1 (fi)
AU (1) AU615729B2 (fi)
CA (1) CA1336092C (fi)
DE (1) DE68919508T2 (fi)
DK (2) DK175029B1 (fi)
ES (1) ES2067534T3 (fi)
FI (1) FI91258C (fi)
GR (1) GR3015128T3 (fi)
HK (1) HK1005733A1 (fi)
HU (2) HU204275B (fi)
IE (2) IE66711B1 (fi)
NO (1) NO168304C (fi)
NZ (1) NZ228589A (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5227376A (en) * 1990-02-14 1993-07-13 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds and their production
US5208348A (en) * 1990-09-07 1993-05-04 Tanabe Seiyaku Co., Ltd. Mercaptan compound
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
CA2093778A1 (en) * 1992-04-10 1993-10-11 George R. Brown Heterocyclic compounds
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
DK0599512T3 (da) * 1992-11-17 1999-10-11 Sankyo Co Krystallinsk carbapenemderivat
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
JP2701685B2 (ja) * 1992-12-28 1998-01-21 田辺製薬株式会社 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法
US5495012A (en) * 1992-12-28 1996-02-27 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
JP2969616B2 (ja) 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
JPH09143156A (ja) 1995-11-17 1997-06-03 Tanabe Seiyaku Co Ltd アセトキシアゼチジノン誘導体の製法及びその合成中間体
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
ES2180977T3 (es) * 1996-04-26 2003-02-16 Sankyo Co Un derivado de 1-metilcarbapenem.
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
BR9910098A (pt) 1998-05-01 2000-12-26 Kyoto Pharma Ind Derivados de carbapenem, utilização dos mesmos e compostos intermediários dos mesmos
CA2331586A1 (en) 1998-05-08 1999-11-18 Sumitomo Pharmaceuticals Company, Limited Novel .beta.-lactam compounds and process for producing the same
AU2003000A (en) * 1999-01-13 2000-08-01 Sankyo Company Limited Carbapenem ester compounds
WO2001012622A1 (en) * 1999-08-18 2001-02-22 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
SK15822003A3 (sk) * 2001-05-21 2004-06-08 Kyoto Pharmaceutical Industries, Ltd. Karbapenémový derivát
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1612211A4 (en) * 2003-04-08 2008-07-02 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUNDS
WO2006025475A1 (ja) * 2004-09-03 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK165280A (da) * 1979-04-19 1980-10-20 Merck & Co Inc Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden
FR2508440B1 (fr) * 1981-06-25 1985-11-08 Saint Gobain Isover Procede de preparation d'alcools orthohydroxybenzyliques
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
CA1272719A (en) * 1986-03-06 1990-08-14 Pierre Dextraze Carbapenem antibiotics

Also Published As

Publication number Publication date
DK175029B1 (da) 2004-05-03
HUT50178A (en) 1989-12-28
HU211836A9 (en) 1995-12-28
NO168304B (no) 1991-10-28
KR890016045A (ko) 1989-11-28
NO891364D0 (no) 1989-03-31
EP0597821A1 (en) 1994-05-18
HK1005733A1 (en) 1999-01-22
AU615729B2 (en) 1991-10-10
DK158089D0 (da) 1989-03-31
DK158089A (da) 1989-10-02
GR3015128T3 (en) 1995-05-31
FI91258B (fi) 1994-02-28
DE68919508T2 (de) 1995-07-20
ES2067534T3 (es) 1995-04-01
FI91258C (fi) 1994-06-10
FI891572A (fi) 1989-10-02
NO891364L (no) 1990-02-08
CA1336092C (en) 1995-06-27
KR0132907B1 (ko) 1998-04-17
KR0133071B1 (ko) 1998-04-17
NZ228589A (en) 1991-06-25
EP0337637A1 (en) 1989-10-18
IE66711B1 (en) 1996-01-24
DK199801576A (da) 1998-11-30
HU204275B (en) 1991-12-30
IE891035L (en) 1989-10-01
IE950607L (en) 1989-10-01
FI891572A0 (fi) 1989-03-31
US5104867A (en) 1992-04-14
ATE114654T1 (de) 1994-12-15
DE68919508D1 (de) 1995-01-12
AU3238689A (en) 1989-10-05
EP0337637B1 (en) 1994-11-30

Similar Documents

Publication Publication Date Title
NO168304C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater
FI885594A (fi) Tiazolidindioner anvaendbara foer saenkande av blodsockerhalten samt atherosklerosis hindrande medel.
NO173139C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-aminopyrimidinonderivater
ES8703881A1 (es) Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico
NO171365C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO160076C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoksazol- og benzotianolaminderivater.
AU626740B2 (en) Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
AU582642B2 (en) Substituted N-``(4-piperidinyl)alkyl`` bicyclic condensed oxazol- and thiazolamines
IL57324A (en) 3-substituted-6-alkanoylamino-1,3,5-triazine-2,4-diones,process for their preparation and pharmaceutical compositions containing them
AU3181789A (en) 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion
NO158379C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nitroalifatiske forbindelser.
AU1507888A (en) New bicyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same
NO161068C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-((z)-2-2-aminothiazol-4-yl)-2-oxyimino-ace-tamido)-3-cefem-4-carboxylsyreforbindelser.
EP0188254A3 (en) New cephem compounds, processes for preparation thereof and pharmaceutical compositions containing them
NZ216334A (en) Spiro imidazolone derivatives and pharmaceutical composition
AU657423B2 (en) Novel piperidine derivatives and process for preparation thereof

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees