NO167577C - Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering. - Google Patents

Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering.

Info

Publication number
NO167577C
NO167577C NO871784A NO871784A NO167577C NO 167577 C NO167577 C NO 167577C NO 871784 A NO871784 A NO 871784A NO 871784 A NO871784 A NO 871784A NO 167577 C NO167577 C NO 167577C
Authority
NO
Norway
Prior art keywords
heparin
lmw
molecular weight
depolymerization
polydispersity
Prior art date
Application number
NO871784A
Other languages
English (en)
Other versions
NO167577B (no
NO871784L (no
NO871784D0 (no
Inventor
Joergen Ilum Nielsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO871784D0 publication Critical patent/NO871784D0/no
Publication of NO871784L publication Critical patent/NO871784L/no
Publication of NO167577B publication Critical patent/NO167577B/no
Publication of NO167577C publication Critical patent/NO167577C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO871784A 1986-04-30 1987-04-29 Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering. NO167577C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK196886A DK196886D0 (da) 1986-04-30 1986-04-30 Fremstilling af polysaccharider

Publications (4)

Publication Number Publication Date
NO871784D0 NO871784D0 (no) 1987-04-29
NO871784L NO871784L (no) 1987-11-02
NO167577B NO167577B (no) 1991-08-12
NO167577C true NO167577C (no) 1991-11-20

Family

ID=8109192

Family Applications (1)

Application Number Title Priority Date Filing Date
NO871784A NO167577C (no) 1986-04-30 1987-04-29 Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering.

Country Status (12)

Country Link
EP (1) EP0244235B1 (no)
JP (1) JPS62283102A (no)
AT (1) ATE84801T1 (no)
AU (1) AU585709B2 (no)
CA (1) CA1334080C (no)
DE (1) DE3783644T2 (no)
DK (1) DK196886D0 (no)
ES (1) ES2052559T3 (no)
FI (1) FI89943C (no)
GR (1) GR3006929T3 (no)
IE (1) IE60409B1 (no)
NO (1) NO167577C (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
FR2675806B1 (fr) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
SK286024B6 (sk) * 1996-11-27 2008-01-07 Aventis Pharmaceuticals Inc. Farmaceutický prostriedok a použitie tohto prostriedku na prípravu liečiva
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2526122B1 (en) 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102690862B (zh) * 2012-06-08 2015-01-28 上海太阳生物技术有限公司 抗凝血酶ⅲ(at-ⅲ)测定试剂盒(发色底物法)
EP3997238A1 (en) 2019-07-09 2022-05-18 Optimvia, LLC Methods for synthesizing anticoagulant polysaccharides
CN111763702A (zh) * 2020-07-13 2020-10-13 福州大学 一种制备硫酸乙酰肝素寡糖的方法
EP4182452A4 (en) 2020-07-14 2024-07-31 Optimvia Llc METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider

Also Published As

Publication number Publication date
FI871909A0 (fi) 1987-04-29
FI89943B (fi) 1993-08-31
AU7225387A (en) 1987-11-05
JPH0542918B2 (no) 1993-06-30
DK196886D0 (da) 1986-04-30
NO167577B (no) 1991-08-12
ATE84801T1 (de) 1993-02-15
NO871784L (no) 1987-11-02
CA1334080C (en) 1995-01-24
IE871152L (en) 1987-10-30
EP0244235B1 (en) 1993-01-20
FI89943C (fi) 1993-12-10
AU585709B2 (en) 1989-06-22
DE3783644T2 (de) 1993-05-13
EP0244235A2 (en) 1987-11-04
JPS62283102A (ja) 1987-12-09
NO871784D0 (no) 1987-04-29
EP0244235A3 (en) 1988-09-28
GR3006929T3 (no) 1993-06-30
FI871909A (fi) 1987-10-31
ES2052559T3 (es) 1994-07-16
DE3783644D1 (de) 1993-03-04
IE60409B1 (en) 1994-07-13

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