NO166184C - Analogifremgangsmaate for fremstilling av terapeutisk aktive n9-cyklopentyl-substituerte adeninderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive n9-cyklopentyl-substituerte adeninderivater.

Info

Publication number
NO166184C
NO166184C NO874749A NO874749A NO166184C NO 166184 C NO166184 C NO 166184C NO 874749 A NO874749 A NO 874749A NO 874749 A NO874749 A NO 874749A NO 166184 C NO166184 C NO 166184C
Authority
NO
Norway
Prior art keywords
adenin
cyclopentyl
derivatives
substituted
preparation
Prior art date
Application number
NO874749A
Other languages
English (en)
Other versions
NO874749L (no
NO166184B (no
NO874749D0 (no
Inventor
Jen Chen
Alan J Hutchison
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO874749D0 publication Critical patent/NO874749D0/no
Publication of NO874749L publication Critical patent/NO874749L/no
Publication of NO166184B publication Critical patent/NO166184B/no
Publication of NO166184C publication Critical patent/NO166184C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO874749A 1986-11-14 1987-11-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive n9-cyklopentyl-substituerte adeninderivater. NO166184C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93132786A 1986-11-14 1986-11-14

Publications (4)

Publication Number Publication Date
NO874749D0 NO874749D0 (no) 1987-11-13
NO874749L NO874749L (no) 1988-05-16
NO166184B NO166184B (no) 1991-03-04
NO166184C true NO166184C (no) 1991-06-12

Family

ID=25460605

Family Applications (1)

Application Number Title Priority Date Filing Date
NO874749A NO166184C (no) 1986-11-14 1987-11-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive n9-cyklopentyl-substituerte adeninderivater.

Country Status (15)

Country Link
EP (1) EP0267878A1 (no)
JP (1) JPS63135384A (no)
KR (1) KR880006241A (no)
AU (1) AU608258B2 (no)
CA (1) CA1288431C (no)
DD (1) DD273833A5 (no)
DK (1) DK596087A (no)
FI (1) FI874982A (no)
HU (1) HU198489B (no)
IL (1) IL84414A0 (no)
NO (1) NO166184C (no)
NZ (1) NZ222527A (no)
PH (1) PH25044A (no)
PT (1) PT86120B (no)
ZA (1) ZA878527B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164556B (no) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US5015739A (en) * 1988-04-22 1991-05-14 Schering Corporation Processes for preparation of cyclopentyl purine derivatives
GB8813148D0 (en) * 1988-06-03 1988-07-06 Glaxo Group Ltd Chemical compounds
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
US5312961A (en) * 1989-02-14 1994-05-17 Elf Sanofi 2-amino-7-hydroxytetralin carboxylalkyl ethers
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
US5470857A (en) * 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
US5514688A (en) * 1990-09-14 1996-05-07 Merrell Dow Pharmaceuticals Inc. Carbocyclic adenosine analogs useful as immunosuppressants
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
US5817661A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
FR2685918B1 (fr) * 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5840923A (en) * 1992-04-21 1998-11-24 Chiroscience Limited Chiral cyclopentene derivatives and their preparation
EP0638077B1 (en) * 1992-04-21 2001-09-19 Chirotech Technology Limited Chiral cyclopentene derivatives and their preparation
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
EP0577558A2 (de) * 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
WO1996019478A1 (en) * 1994-12-19 1996-06-27 Novartis Ag 6'-substituted carbocyclic nucleosides
WO2000063703A1 (en) 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
WO2001060383A1 (en) * 2000-02-18 2001-08-23 Southern Research Institute METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
PL2013211T3 (pl) 2006-04-21 2012-08-31 Novartis Ag Pochodne puryny do zastosowania jako agoniści receptora adenozyny A2A
GB0607950D0 (en) 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
KR102077871B1 (ko) * 2010-11-16 2020-02-14 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제
CN105061431B (zh) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2610985A1 (de) * 1976-03-16 1977-09-29 Byk Gulden Lomberg Chem Fab Arzneimittel enthaltend beta-d-1 (6-amino-9h-purin-9-yl)-1-deoxyribofuranuronsaeurederivate
US4345984A (en) * 1981-03-02 1982-08-24 The Procter & Gamble Company Novel prostaglandin analogues and process for making same
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines

Also Published As

Publication number Publication date
PT86120A (en) 1987-12-01
PT86120B (pt) 1990-08-31
FI874982A (fi) 1988-05-15
CA1288431C (en) 1991-09-03
PH25044A (en) 1991-01-28
NO874749L (no) 1988-05-16
NZ222527A (en) 1990-08-28
FI874982A0 (fi) 1987-11-11
AU608258B2 (en) 1991-03-28
ZA878527B (en) 1988-05-16
EP0267878A1 (en) 1988-05-18
DK596087A (da) 1988-05-15
JPS63135384A (ja) 1988-06-07
NO166184B (no) 1991-03-04
NO874749D0 (no) 1987-11-13
DK596087D0 (da) 1987-11-13
HUT45057A (en) 1988-05-30
AU8119387A (en) 1988-05-19
DD273833A5 (de) 1989-11-29
KR880006241A (ko) 1988-07-22
IL84414A0 (en) 1988-04-29
HU198489B (en) 1989-10-30

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