AU8119387A - N9-cyclopentyl-substituted adenine derivatives - Google Patents

N9-cyclopentyl-substituted adenine derivatives

Info

Publication number
AU8119387A
AU8119387A AU81193/87A AU8119387A AU8119387A AU 8119387 A AU8119387 A AU 8119387A AU 81193/87 A AU81193/87 A AU 81193/87A AU 8119387 A AU8119387 A AU 8119387A AU 8119387 A AU8119387 A AU 8119387A
Authority
AU
Australia
Prior art keywords
cyclopentyl
adenine derivatives
substituted adenine
substituted
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU81193/87A
Other versions
AU608258B2 (en
Inventor
Jen Chen
Alan J. Hutchison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU8119387A publication Critical patent/AU8119387A/en
Application granted granted Critical
Publication of AU608258B2 publication Critical patent/AU608258B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU81193/87A 1986-11-14 1987-11-13 N9-cyclopentyl-substituted adenine derivatives Ceased AU608258B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93132786A 1986-11-14 1986-11-14
US931327 1986-11-14

Publications (2)

Publication Number Publication Date
AU8119387A true AU8119387A (en) 1988-05-19
AU608258B2 AU608258B2 (en) 1991-03-28

Family

ID=25460605

Family Applications (1)

Application Number Title Priority Date Filing Date
AU81193/87A Ceased AU608258B2 (en) 1986-11-14 1987-11-13 N9-cyclopentyl-substituted adenine derivatives

Country Status (15)

Country Link
EP (1) EP0267878A1 (en)
JP (1) JPS63135384A (en)
KR (1) KR880006241A (en)
AU (1) AU608258B2 (en)
CA (1) CA1288431C (en)
DD (1) DD273833A5 (en)
DK (1) DK596087A (en)
FI (1) FI874982A (en)
HU (1) HU198489B (en)
IL (1) IL84414A0 (en)
NO (1) NO166184C (en)
NZ (1) NZ222527A (en)
PH (1) PH25044A (en)
PT (1) PT86120B (en)
ZA (1) ZA878527B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU596400B2 (en) * 1986-03-06 1990-05-03 Takeda Chemical Industries Ltd. Carbocyclic purine nucleosides, their production and use
AU621664B2 (en) * 1988-09-27 1992-03-19 Merrell Dow Pharmaceuticals Inc. Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives
AU635209B2 (en) * 1988-06-06 1993-03-18 Steven Albert Benner Oligonucleotide analogs containing sulfur

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US5015739A (en) * 1988-04-22 1991-05-14 Schering Corporation Processes for preparation of cyclopentyl purine derivatives
GB8813148D0 (en) * 1988-06-03 1988-07-06 Glaxo Group Ltd Chemical compounds
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
US5312961A (en) * 1989-02-14 1994-05-17 Elf Sanofi 2-amino-7-hydroxytetralin carboxylalkyl ethers
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
US5514688A (en) * 1990-09-14 1996-05-07 Merrell Dow Pharmaceuticals Inc. Carbocyclic adenosine analogs useful as immunosuppressants
US5470857A (en) * 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
FR2685918B1 (en) * 1992-01-08 1995-06-23 Union Pharma Scient Appl NOVEL ADENOSINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU3961493A (en) * 1992-04-21 1993-11-18 Chiroscience Limited Chiral cyclopentene derivatives and their preparation
US5840923A (en) * 1992-04-21 1998-11-24 Chiroscience Limited Chiral cyclopentene derivatives and their preparation
IT1254915B (en) * 1992-04-24 1995-10-11 Gloria Cristalli ADENOSINE DERIVATIVES FOR ACTIVITY A2 AGONIST
EP0577558A2 (en) * 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclic nucleosides having bicyclic rings, oligonucleotides therefrom, process for their preparation, their use and intermediates
GB9414208D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
WO1996019478A1 (en) * 1994-12-19 1996-06-27 Novartis Ag 6'-substituted carbocyclic nucleosides
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
US6949640B2 (en) * 2000-02-18 2005-09-27 Southern Research Institute Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
GT200500281A (en) 2004-10-22 2006-04-24 Novartis Ag ORGANIC COMPOUNDS.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
SI2013211T1 (en) 2006-04-21 2012-07-31 Novartis Ag Purine derivatives for use as adenosin a2a receptor agonists
GB0607950D0 (en) 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
CN103476415B (en) 2010-11-16 2017-09-22 南加州大学 For the CBP/ catenin antagonists for the Asymmetric division for strengthening adult stem cell
CN105061431B (en) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑N‑（2‑（Methyl mercapto）Ethyl）‑2‑（（3,3,3 trifluoro propyls）It is thio）9H purine and its preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2610985A1 (en) * 1976-03-16 1977-09-29 Byk Gulden Lomberg Chem Fab (1)-Aminopurinyl-(1)-deoxyribofuranuronic acid medicaments - with circulatory, cardiac and metabolic activity
US4345984A (en) * 1981-03-02 1982-08-24 The Procter & Gamble Company Novel prostaglandin analogues and process for making same
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU596400B2 (en) * 1986-03-06 1990-05-03 Takeda Chemical Industries Ltd. Carbocyclic purine nucleosides, their production and use
AU635209B2 (en) * 1988-06-06 1993-03-18 Steven Albert Benner Oligonucleotide analogs containing sulfur
AU621664B2 (en) * 1988-09-27 1992-03-19 Merrell Dow Pharmaceuticals Inc. Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives

Also Published As

Publication number Publication date
NO166184B (en) 1991-03-04
AU608258B2 (en) 1991-03-28
ZA878527B (en) 1988-05-16
DK596087D0 (en) 1987-11-13
KR880006241A (en) 1988-07-22
DK596087A (en) 1988-05-15
NO166184C (en) 1991-06-12
FI874982A0 (en) 1987-11-11
DD273833A5 (en) 1989-11-29
CA1288431C (en) 1991-09-03
JPS63135384A (en) 1988-06-07
NO874749D0 (en) 1987-11-13
PT86120A (en) 1987-12-01
NO874749L (en) 1988-05-16
PH25044A (en) 1991-01-28
IL84414A0 (en) 1988-04-29
EP0267878A1 (en) 1988-05-18
NZ222527A (en) 1990-08-28
HU198489B (en) 1989-10-30
PT86120B (en) 1990-08-31
HUT45057A (en) 1988-05-30
FI874982A (en) 1988-05-15

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