NO161674C - Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater. - Google Patents
Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater.Info
- Publication number
- NO161674C NO161674C NO830110A NO830110A NO161674C NO 161674 C NO161674 C NO 161674C NO 830110 A NO830110 A NO 830110A NO 830110 A NO830110 A NO 830110A NO 161674 C NO161674 C NO 161674C
- Authority
- NO
- Norway
- Prior art keywords
- triazolo
- preparation
- derivatives
- tthalazine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8201273 | 1982-01-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO830110L NO830110L (no) | 1983-07-19 |
| NO161674B NO161674B (no) | 1989-06-05 |
| NO161674C true NO161674C (no) | 1989-09-13 |
Family
ID=10527683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO830110A NO161674C (no) | 1982-01-18 | 1983-01-14 | Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4788186A (fi) |
| EP (1) | EP0085840B1 (fi) |
| JP (1) | JPS58124786A (fi) |
| KR (1) | KR890000184B1 (fi) |
| AT (1) | ATE22562T1 (fi) |
| AU (1) | AU564026B2 (fi) |
| CA (1) | CA1214168A (fi) |
| DE (1) | DE3366494D1 (fi) |
| DK (1) | DK163145C (fi) |
| ES (1) | ES531458A0 (fi) |
| FI (1) | FI81350C (fi) |
| GR (1) | GR78442B (fi) |
| HU (1) | HU193033B (fi) |
| IE (1) | IE55032B1 (fi) |
| IL (1) | IL67697A (fi) |
| NO (1) | NO161674C (fi) |
| NZ (1) | NZ203021A (fi) |
| PH (1) | PH21834A (fi) |
| PT (1) | PT76107A (fi) |
| ZA (1) | ZA83224B (fi) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| US6465462B1 (en) | 1996-07-25 | 2002-10-15 | Merck Sharp & Dohme Ltd. | Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAα5 receptor subtype |
| CN1251589A (zh) * | 1996-07-25 | 2000-04-26 | 默克·夏普-道姆公司 | 为gaba受体配位体的取代的三唑并哒嗪衍生物 |
| JP4672820B2 (ja) | 1997-05-08 | 2011-04-20 | メルク シャープ エンド ドーム リミテッド | ＧＡＢＡα５リガンドとしての置換１，２，４−トリアゾロ［３，４−ａ］フタラジン誘導体 |
| ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
| GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9723999D0 (en) | 1997-11-13 | 1998-01-14 | Merck Sharp & Dohme | Therapeutic use |
| GB9726701D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| WO1999025353A1 (en) * | 1997-11-13 | 1999-05-27 | Merck Sharp & Dohme Limited | Therapeutic uses of triazolo-pyridazine derivatives |
| GB9726699D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| GB9726702D0 (en) * | 1997-12-18 | 1998-02-18 | Merck Sharp & Dohme | Therapeutic use |
| US6110915A (en) * | 1997-12-18 | 2000-08-29 | Merck & Co., Inc. | Antiemetic use of triazolo-pyridazine derivatives |
| WO1999036423A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9801202D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801234D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801210D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GEP20032868B (en) | 1998-01-21 | 2003-01-27 | Merck Sharp & Dohme | Triazolo-Pyridazine Derivatives as Ligands for Gaba Receptors, Methods for Their Production, Pharmaceutical Compositions Containing the Same for Treatment and/or Prevention of disorders of Central Nervous System |
| GB9801397D0 (en) * | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
| HUP0100647A3 (en) * | 1998-02-25 | 2003-03-28 | Merck Sharp & Dohme Ltd Hoddes | Substituted 1,2,4-triazolo[3,4-a]pyridazine and its pharmaceutical use |
| BR9908155A (pt) | 1998-02-25 | 2000-10-31 | Merck Sharp & Dohme | Composto, composição farmacêutica, uso do composto, e, processo para intensificar cognição em um sujeito sofrendo de cognição diminuìda |
| GB9824897D0 (en) | 1998-11-12 | 1999-01-06 | Merck Sharp & Dohme | Therapeutic compounds |
| EP1129094A2 (en) | 1998-11-12 | 2001-09-05 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
| GB9929569D0 (en) * | 1999-12-14 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| GB0028583D0 (en) | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
| JP2004527531A (ja) * | 2001-04-10 | 2004-09-09 | メルク エンド カムパニー インコーポレーテッド | 癌を治療する方法 |
| WO2002083140A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20060142178A1 (en) * | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
| US20050054647A1 (en) * | 2002-12-27 | 2005-03-10 | Detlev Schuppan | New pharmaceutical combination |
| NZ553160A (en) | 2004-09-02 | 2010-08-27 | Nycomed Gmbh | Anilino-substituted triazolophthalazine derivatives having PDE2 inhibitory activity |
| AU2006204454B2 (en) | 2005-01-05 | 2011-11-10 | Takeda Gmbh | Triazolophthalazines as PDE2-inhibitors |
| WO2006072612A2 (en) | 2005-01-05 | 2006-07-13 | Nycomed Gmbh | Triazolophthalazines as pde2- inhibitors |
| CN102791715B (zh) | 2009-12-31 | 2016-04-27 | 卡洛斯三世国家癌症研究中心基金会 | 用作激酶抑制剂的三环化合物 |
| CN103694244B (zh) * | 2014-01-09 | 2016-03-30 | 郑州大学 | 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途 |
| CN104016986B (zh) * | 2014-03-13 | 2016-02-03 | 郑州大学 | 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途 |
| EP4279074A1 (en) * | 2022-05-19 | 2023-11-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Azolo compounds for treatment of fibrotic diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB629177A (en) * | 1945-12-21 | 1949-09-14 | Ciba Ltd | Manufacture of new hydrazine compounds and derivatives thereof |
| US2484029A (en) * | 1945-12-21 | 1949-10-11 | Ciba Pharm Prod Inc | Hydrazine derivatives of pyridazine compounds |
| JPS5132598A (en) * | 1974-09-13 | 1976-03-19 | Eisai Co Ltd | Toriazoro * 3 44 ee * futarajinjudotai no goseiho |
| JPS603080B2 (ja) * | 1976-08-10 | 1985-01-25 | 三菱化学株式会社 | Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類 |
| GR70309B (fi) * | 1979-10-29 | 1982-09-08 | Dow Chemical Co |
-
1983
- 1983-01-12 PH PH28380A patent/PH21834A/en unknown
- 1983-01-12 FI FI830100A patent/FI81350C/fi not_active IP Right Cessation
- 1983-01-13 CA CA000419398A patent/CA1214168A/en not_active Expired
- 1983-01-13 ZA ZA83224A patent/ZA83224B/xx unknown
- 1983-01-13 NZ NZ203021A patent/NZ203021A/en unknown
- 1983-01-13 EP EP83100232A patent/EP0085840B1/en not_active Expired
- 1983-01-13 DE DE8383100232T patent/DE3366494D1/de not_active Expired
- 1983-01-13 AT AT83100232T patent/ATE22562T1/de not_active IP Right Cessation
- 1983-01-13 GR GR70257A patent/GR78442B/el unknown
- 1983-01-14 NO NO830110A patent/NO161674C/no unknown
- 1983-01-17 IL IL67697A patent/IL67697A/xx unknown
- 1983-01-17 HU HU83141A patent/HU193033B/hu not_active IP Right Cessation
- 1983-01-17 IE IE82/83A patent/IE55032B1/en not_active IP Right Cessation
- 1983-01-18 JP JP58005413A patent/JPS58124786A/ja active Granted
- 1983-01-18 PT PT76107A patent/PT76107A/pt unknown
- 1983-01-18 KR KR1019830000174A patent/KR890000184B1/ko not_active IP Right Cessation
- 1983-01-18 AU AU10550/83A patent/AU564026B2/en not_active Ceased
- 1983-01-18 DK DK017983A patent/DK163145C/da not_active IP Right Cessation
-
1984
- 1984-04-10 ES ES531458A patent/ES531458A0/es active Granted
-
1987
- 1987-10-20 US US07/112,015 patent/US4788186A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ203021A (en) | 1986-05-09 |
| KR890000184B1 (ko) | 1989-03-09 |
| AU564026B2 (en) | 1987-07-30 |
| EP0085840A1 (en) | 1983-08-17 |
| ZA83224B (en) | 1983-10-26 |
| JPH048428B2 (fi) | 1992-02-17 |
| DK163145B (da) | 1992-01-27 |
| PH21834A (en) | 1988-03-17 |
| EP0085840B1 (en) | 1986-10-01 |
| HU193033B (en) | 1987-08-28 |
| NO830110L (no) | 1983-07-19 |
| ATE22562T1 (de) | 1986-10-15 |
| CA1214168A (en) | 1986-11-18 |
| US4788186A (en) | 1988-11-29 |
| IL67697A0 (en) | 1983-05-15 |
| ES8601995A1 (es) | 1985-11-01 |
| GR78442B (fi) | 1984-09-27 |
| DK17983A (da) | 1983-07-19 |
| FI830100A0 (fi) | 1983-01-12 |
| NO161674B (no) | 1989-06-05 |
| DE3366494D1 (de) | 1986-11-06 |
| FI81350C (fi) | 1990-10-10 |
| JPS58124786A (ja) | 1983-07-25 |
| DK163145C (da) | 1992-06-22 |
| ES531458A0 (es) | 1985-11-01 |
| IE55032B1 (en) | 1990-05-09 |
| AU1055083A (en) | 1983-07-28 |
| FI81350B (fi) | 1990-06-29 |
| FI830100L (fi) | 1983-07-19 |
| DK17983D0 (da) | 1983-01-18 |
| IE830082L (en) | 1983-07-18 |
| KR840003254A (ko) | 1984-08-20 |
| PT76107A (en) | 1983-02-01 |
| IL67697A (en) | 1990-02-09 |
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