NO161116C - Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater.

Info

Publication number
NO161116C
NO161116C NO833722A NO833722A NO161116C NO 161116 C NO161116 C NO 161116C NO 833722 A NO833722 A NO 833722A NO 833722 A NO833722 A NO 833722A NO 161116 C NO161116 C NO 161116C
Authority
NO
Norway
Prior art keywords
preparation
hydroxyalkyl
alkyl
hydrogen
purine derivatives
Prior art date
Application number
NO833722A
Other languages
English (en)
Norwegian (no)
Other versions
NO161116B (no
NO833722L (no
Inventor
Howard John Schaeffer
Thomas Anthony Krenitsky
Lilla Marie Beauchamp
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/434,384 external-priority patent/US4544634A/en
Priority claimed from US06/434,395 external-priority patent/US4609662A/en
Priority claimed from GB838320309A external-priority patent/GB8320309D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO833722L publication Critical patent/NO833722L/no
Publication of NO161116B publication Critical patent/NO161116B/no
Publication of NO161116C publication Critical patent/NO161116C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO833722A 1982-10-14 1983-10-13 Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater. NO161116C (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43439382A 1982-10-14 1982-10-14
US43439482A 1982-10-14 1982-10-14
US06/434,384 US4544634A (en) 1982-10-14 1982-10-14 Method of producing acyclovir
US06/434,395 US4609662A (en) 1982-10-14 1982-10-14 Method for using purine derivatives
GB838320309A GB8320309D0 (en) 1983-07-28 1983-07-28 Antiviral compounds

Publications (3)

Publication Number Publication Date
NO833722L NO833722L (no) 1984-04-16
NO161116B NO161116B (no) 1989-03-28
NO161116C true NO161116C (no) 1989-07-05

Family

ID=27516520

Family Applications (1)

Application Number Title Priority Date Filing Date
NO833722A NO161116C (no) 1982-10-14 1983-10-13 Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater.

Country Status (19)

Country Link
EP (2) EP0108285B1 (de)
JP (1) JPS5989682A (de)
KR (1) KR890001487B1 (de)
AT (2) ATE33653T1 (de)
AU (1) AU573540B2 (de)
CA (1) CA1308714C (de)
CS (1) CS244697B2 (de)
DE (2) DE3376326D1 (de)
DK (1) DK472683A (de)
FI (1) FI74468C (de)
GB (2) GB2130204B (de)
GR (1) GR79681B (de)
IE (1) IE56416B1 (de)
MC (1) MC1551A1 (de)
NO (1) NO161116C (de)
NZ (1) NZ205955A (de)
PL (1) PL143208B1 (de)
PT (2) PT77494B (de)
ZW (1) ZW22283A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250688A (en) * 1984-09-20 1993-10-05 Beecham Group P.L.C. Purine derivatives
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
DK163985A (da) * 1984-04-13 1985-10-14 Wellcome Found Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
EP0203736B1 (de) * 1985-05-02 1989-11-23 The Wellcome Foundation Limited Antivirale Verbindungen
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
EP0289229B1 (de) * 1987-04-24 1992-01-29 The Wellcome Foundation Limited Antivirale Mischungen
DE3889248T2 (de) * 1987-05-04 1994-11-17 Kemijski Inst Verfahren zu Herstellung von Purinverbindungen.
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
EP0363320A3 (de) * 1988-10-06 1991-11-21 Ciba-Geigy Ag Substituierte 9H-Purine
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
JP2788084B2 (ja) * 1988-12-19 1998-08-20 ザ ウエルカム フアウンデーシヨン リミテツド 抗ウイルス化合物
DE3941658A1 (de) * 1989-12-16 1991-06-20 Hoechst Ag Verfahren zur herstellung von 2-acylamino-9-acyl-6-halogen-purin
US6110923A (en) * 1994-06-22 2000-08-29 Biochem Pharma Inc. Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
ZA83626B (en) * 1982-02-01 1983-12-28 Syntex Inc Substituted 9-(1 or 3-monoacyloxy or 1, 3-diacyloxy-2-propoxy-methyl purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Also Published As

Publication number Publication date
PL244141A1 (en) 1985-06-18
CA1308714C (en) 1992-10-13
CS244697B2 (en) 1986-08-14
FI833730A (fi) 1984-04-15
EP0108285A3 (en) 1985-05-15
GB8327513D0 (en) 1983-11-16
PT79813B (en) 1986-10-28
MC1551A1 (fr) 1984-08-31
JPH0549674B2 (de) 1993-07-26
IE832409L (en) 1984-04-14
DE3376325D1 (en) 1988-05-26
EP0108285B1 (de) 1988-04-20
AU573540B2 (en) 1988-06-16
NZ205955A (en) 1988-02-29
JPS5989682A (ja) 1984-05-23
ATE33653T1 (de) 1988-05-15
FI833730A0 (fi) 1983-10-13
DK472683A (da) 1984-04-15
ZW22283A1 (en) 1985-05-22
PT77494B (en) 1986-08-14
DK472683D0 (da) 1983-10-13
EP0108285A2 (de) 1984-05-16
PT77494A (en) 1983-11-01
NO161116B (no) 1989-03-28
FI74468C (fi) 1988-02-08
ATE33654T1 (de) 1988-05-15
KR840006483A (ko) 1984-11-30
PL143208B1 (en) 1988-01-30
IE56416B1 (en) 1991-07-31
FI74468B (fi) 1987-10-30
GR79681B (de) 1984-10-31
EP0158847B1 (de) 1988-04-20
DE3376326D1 (en) 1988-05-26
GB2151222B (en) 1987-02-25
GB8421849D0 (en) 1984-10-03
AU2016383A (en) 1984-04-19
GB2130204A (en) 1984-05-31
NO833722L (no) 1984-04-16
KR890001487B1 (ko) 1989-05-04
PT79813A (en) 1985-02-01
GB2151222A (en) 1985-07-17
EP0158847A1 (de) 1985-10-23
GB2130204B (en) 1986-03-05

Similar Documents

Publication Publication Date Title
NO161116C (no) Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater.
GB2104070B (en) Purines