NO160577C - Analogifremgangsmaate for fremstilling av antimikrobielt aktive eller beta-laktamaseinhiberende 1-sulfo-2-oksoazetidinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av antimikrobielt aktive eller beta-laktamaseinhiberende 1-sulfo-2-oksoazetidinderivater.Info
- Publication number
- NO160577C NO160577C NO814112A NO814112A NO160577C NO 160577 C NO160577 C NO 160577C NO 814112 A NO814112 A NO 814112A NO 814112 A NO814112 A NO 814112A NO 160577 C NO160577 C NO 160577C
- Authority
- NO
- Norway
- Prior art keywords
- oxoazetime
- inhibitoring
- lactamase
- sulfo
- beta
- Prior art date
Links
- 108090000204 Dipeptidase 1 Proteins 0.000 title 1
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 102000006635 beta-lactamase Human genes 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1980/000297 WO1982001873A1 (fr) | 1980-12-05 | 1980-12-05 | Derives 1-sulfo-2-oxoazetidine et leur procede de preparation |
PCT/JP1981/000103 WO1982003859A1 (fr) | 1980-12-05 | 1981-04-30 | Derives de 1-sulfo-2-oxoazetidine et procede de preparation |
PCT/JP1981/000183 WO1983000689A1 (fr) | 1980-12-05 | 1981-08-21 | Derives de 1-sulfo-2-oxoazetidine et leur procede de preparation |
PCT/JP1981/000252 WO1983001063A1 (fr) | 1980-12-05 | 1981-09-24 | Derives de 1-sulfo-2-oxoazetidine et leur procede de preparation |
Publications (3)
Publication Number | Publication Date |
---|---|
NO814112L NO814112L (no) | 1982-06-07 |
NO160577B NO160577B (no) | 1989-01-23 |
NO160577C true NO160577C (no) | 1989-05-03 |
Family
ID=27466372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO814112A NO160577C (no) | 1980-12-05 | 1981-12-02 | Analogifremgangsmaate for fremstilling av antimikrobielt aktive eller beta-laktamaseinhiberende 1-sulfo-2-oksoazetidinderivater. |
Country Status (28)
Country | Link |
---|---|
US (3) | US4550105A (fr) |
EP (1) | EP0053816B1 (fr) |
AR (1) | AR240171A1 (fr) |
AT (1) | AT378768B (fr) |
AU (1) | AU557689B2 (fr) |
BE (1) | BE891366A (fr) |
BR (1) | BR8107866A (fr) |
CH (1) | CH657610A5 (fr) |
DE (2) | DE3176731D1 (fr) |
DK (1) | DK534481A (fr) |
ES (2) | ES507715A0 (fr) |
FI (1) | FI81085C (fr) |
FR (1) | FR2495613B1 (fr) |
GB (1) | GB2091724B (fr) |
GR (1) | GR77295B (fr) |
IE (1) | IE53314B1 (fr) |
IL (1) | IL64315A (fr) |
IT (1) | IT1139919B (fr) |
LU (1) | LU83819A1 (fr) |
MY (1) | MY8700314A (fr) |
NL (1) | NL8105470A (fr) |
NO (1) | NO160577C (fr) |
NZ (1) | NZ199167A (fr) |
PH (1) | PH25221A (fr) |
PT (1) | PT74088B (fr) |
SE (1) | SE457256B (fr) |
WO (5) | WO1982001873A1 (fr) |
YU (2) | YU43051B (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ205240A (en) * | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Sulphonamide derivatives,being starting materials for producing beta-lactams |
EP0048953B1 (fr) * | 1980-09-29 | 1988-03-09 | E.R. Squibb & Sons, Inc. | Antibiotiques de bêta-lactame |
WO1982001873A1 (fr) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | Derives 1-sulfo-2-oxoazetidine et leur procede de preparation |
US4675397A (en) * | 1980-12-05 | 1987-06-23 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
US4782147A (en) * | 1980-12-05 | 1988-11-01 | Takeda Chemical Industries, Ltd. | 1-sulfo-2-oxoazetidine derivatives and their production |
US4673739A (en) * | 1980-12-05 | 1987-06-16 | Takeda Chemical Industries, Ltd. | 4-carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
US4572801A (en) * | 1981-04-30 | 1986-02-25 | Takeda Chemical Industries, Ltd. | 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production |
EP0187355A1 (fr) * | 1981-09-23 | 1986-07-16 | E.R. Squibb & Sons, Inc. | Procédé de préparation d'antibiotiques bêta-lactames |
GB2151628B (en) * | 1981-10-23 | 1986-05-21 | Roussel Uclaf | Azetidine intermediates |
FR2515182B1 (fr) * | 1981-10-23 | 1986-05-09 | Roussel Uclaf | Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation |
FR2538389B2 (fr) * | 1981-10-23 | 1986-05-16 | Roussel Uclaf | Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine-1-sulfamique, nouveau procede de preparation de produits optiquement actifs, application des nouveaux produits comme medicaments et produits necessaires a leur preparation |
FR2558467B2 (fr) * | 1981-10-23 | 1987-03-20 | Roussel Uclaf | Nouveau produit derive de l'acide 3-amino 2-oxo azetidine 1-sulfamique, son procede de preparation, son application comme medicament et un produit intermediaire necessaire a sa preparation |
IL67451A (en) * | 1981-12-25 | 1987-10-20 | Takeda Chemical Industries Ltd | 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them |
AU564150B2 (en) * | 1982-04-30 | 1987-08-06 | Takeda Chemical Industries Ltd. | 1-sulfo-2-azetidinone derivatives |
JPS58210060A (ja) * | 1982-05-31 | 1983-12-07 | Takeda Chem Ind Ltd | 2−オキソアゼチジン誘導体、その製造法および用途 |
DE3377061D1 (en) * | 1982-06-03 | 1988-07-21 | Hoffmann La Roche | Process for the preparation of 1-sulfo-2-oxoazetidine derivatives |
DE3372768D1 (de) * | 1982-06-03 | 1987-09-03 | Hoffmann La Roche | 1-sulfo-2-oxoazetidine derivatives |
JPS5916888A (ja) * | 1982-07-20 | 1984-01-28 | Takeda Chem Ind Ltd | 1−スルホ−2−アゼチジノン誘導体およびその製造法 |
US4939253A (en) * | 1982-08-04 | 1990-07-03 | E. R. Squibb & Sons, Inc. | 2-oxoazetidin-1-yloxy acetic acids and analogs |
US4681937A (en) * | 1982-09-27 | 1987-07-21 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters |
JPS5982359A (ja) * | 1982-11-02 | 1984-05-12 | Kanegafuchi Chem Ind Co Ltd | 4(R)配位光学活性β−ラクタム化合物の製法 |
US4502994A (en) * | 1982-12-09 | 1985-03-05 | Hoffmann-La Roche Inc. | Enantiomeric synthesis of 3-amino-4-carbamoyloxymethyl-2-azetidonone-1-sulfate |
FR2539128A1 (fr) * | 1983-01-10 | 1984-07-13 | Roussel Uclaf | Nouveaux derives de la 3-amino 2-oxoazetidine comportant en position 1 un radical heterocyclique azote, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation |
US4652651A (en) * | 1983-05-31 | 1987-03-24 | Hoffmann-La Roche Inc. | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage |
US4501697A (en) * | 1983-06-17 | 1985-02-26 | E. R. Squibb & Sons, Inc. | 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts |
US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US4771135A (en) * | 1984-05-22 | 1988-09-13 | Eli Lilly And Company | Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor |
US4918185A (en) * | 1984-05-22 | 1990-04-17 | Eli Lilly And Company | Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor |
US4883869A (en) * | 1984-12-20 | 1989-11-28 | The Upjohn Company | Novel beta-lactams containing amino acid substituents |
US4824537A (en) * | 1985-02-06 | 1989-04-25 | Rikagaku Kenkyusho | Working substances used in laser isotope separation and method of laser isotope separation |
US5006650A (en) * | 1987-02-11 | 1991-04-09 | The Upjohn Company | Novel N-1 substituted beta-lactams as antibiotics |
KR890700586A (ko) * | 1987-02-27 | 1989-04-25 | 로버어트 에이 아마테이지 | 피리돈 카르복실산 또는 산유도체를 함유하는 항균제 베타-락탐 |
CA1317298C (fr) * | 1987-03-03 | 1993-05-04 | Upjohn Company (The) | .beta.-lactames antibiotiques activees par des groupes sulfonylaminocar bonyles |
US5015737A (en) * | 1987-07-22 | 1991-05-14 | The Upjohn Company | Therapeutically useful beta-lactams |
US4885362A (en) * | 1988-06-06 | 1989-12-05 | Eli Lilly And Company | Azetidinone intermediates for 1-carba(dethia)caphalosporins |
US5273973A (en) * | 1988-10-24 | 1993-12-28 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl esters |
US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
CA2001203C (fr) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Dithiocarbamoyl quinolones antimicrobiens |
EP0366189A3 (fr) * | 1988-10-24 | 1992-01-02 | Norwich Eaton Pharmaceuticals, Inc. | Lactames-quinolones antimicrobiennes |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
US5491139A (en) * | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
US5093029A (en) * | 1989-08-11 | 1992-03-03 | Atochem North America, Inc. | Breaking emulsions of alkanesulfonyl chlorides in aqueous hydrochloric acid |
AU640481B2 (en) * | 1990-04-18 | 1993-08-26 | Norwich Eaton Pharmaceuticals, Inc. | Penicillan or cephalosporin derivatives of quinolonyl |
US5478846A (en) * | 1990-06-07 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia |
WO1991018603A1 (fr) * | 1990-06-07 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | Derives d'alcanoylarylsulfonamide de piperidinyle-1 |
ES2049638B1 (es) * | 1992-05-13 | 1994-12-16 | Univ Pais Vasco | Procedimiento para la preparacion de compuestos beta-lactamicos homoquirales. |
JPH11503728A (ja) * | 1995-03-31 | 1999-03-30 | シンファー ラボラトリーズ,インコーポレーティッド | システイン・プロテイナーゼ阻害剤として有用な新規な4−置換−3−ペプチジル−アゼチジン−2−オン誘導体 |
US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
US5959123A (en) * | 1996-09-23 | 1999-09-28 | Synphar Laboratories, Inc. | 3,4-Disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators |
US7214364B2 (en) | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
DK2301524T3 (da) * | 2000-12-27 | 2013-07-15 | Gilead Sciences Inc | Inhalerbar aztreonam uden arginin til behandling og forebyggelse af bakterielle lungeinfektioner |
US7138419B2 (en) * | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
WO2003011298A1 (fr) * | 2001-08-03 | 2003-02-13 | Chirologix Pharmaceuticals Inc. | Oxazinones antibacteriennes et procedes d'utilisation et de synthese de celles-ci |
WO2003018565A1 (fr) * | 2001-08-29 | 2003-03-06 | Chirologix Pharmaceuticals Inc. | Procede de synthese d'oxazinones |
US20050005101A1 (en) * | 2003-07-03 | 2005-01-06 | Yenduri Bhargava K. | Kernel cryptographic module signature verification system and method |
NZ583970A (en) | 2007-10-11 | 2011-04-29 | Univ California | Compositions and methods of inhibiting n-acylethanolamine-hydrolyzing acid amidase |
WO2014144547A2 (fr) * | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Dérivés d'amide d'inhibiteurs de l'amidase acide de n-acyléthanolamine à base de lactame |
WO2014144836A2 (fr) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Dérivés de carbamate d'inhibiteurs d'amidase acide de n-acyléthanolamine (naaa) à base de lactame |
WO2015148379A1 (fr) * | 2014-03-24 | 2015-10-01 | Novartis Ag | Composés organiques monobactam pour le traitement d'infections bactériennes |
RU2754180C2 (ru) | 2015-09-23 | 2021-08-30 | Новартис Аг | Соли и твердые формы монобактамного антибиотика |
WO2019026004A2 (fr) | 2017-08-02 | 2019-02-07 | Novartis Ag | Processus chimique de préparation d'antibiotique monobactame et de ses intermédiaires |
CN112225720A (zh) * | 2020-11-10 | 2021-01-15 | 吴仁涛 | 一种噻吩-2-乙酰氯的生产方法 |
CN112480024A (zh) * | 2020-12-11 | 2021-03-12 | 山东金城医药化工有限公司 | 生产氨噻肟酸反式异构体的方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200572A (en) * | 1975-09-03 | 1980-04-29 | Smithkline Corporation | Substituted azetidinones |
JPS6046955B2 (ja) * | 1977-12-30 | 1985-10-18 | 武田薬品工業株式会社 | 抗生物質g−6302 |
JPS5549394A (en) * | 1978-10-03 | 1980-04-09 | Takeda Chem Ind Ltd | Antibiotic substance sb-72310 |
US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
JPS55164672A (en) * | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Azetidine derivative and its preparation |
CA1242188A (fr) * | 1979-06-08 | 1988-09-20 | Takeda Pharmaceutical Company Limited | Derives de 3-methoxy-2-oxoazetidine et leur preparation |
CA1338538C (fr) * | 1979-06-08 | 1996-08-20 | Taisuke Matsuo | Derives de la 1-sulfo-2-oxoazetidine et leur preparation |
ZA81808B (en) * | 1980-02-07 | 1982-02-24 | Squibb & Sons Inc | Beta-lactam antibiotics |
NZ205240A (en) * | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Sulphonamide derivatives,being starting materials for producing beta-lactams |
EP0048953B1 (fr) * | 1980-09-29 | 1988-03-09 | E.R. Squibb & Sons, Inc. | Antibiotiques de bêta-lactame |
WO1982001873A1 (fr) * | 1980-12-05 | 1982-06-10 | Takeda Chemical Industries Ltd | Derives 1-sulfo-2-oxoazetidine et leur procede de preparation |
CA1181075A (fr) * | 1981-07-13 | 1985-01-15 | David M. Floyd | FORME CRISTALLISEE ANHYDRE DE L'ACIDE[3-S-[.alpha. (Z),4.beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL]AMINO ]-4-METHYL-2-OXO-1-AZETIDINESULFONIQUE |
FR2515182B1 (fr) * | 1981-10-23 | 1986-05-09 | Roussel Uclaf | Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation |
US4502994A (en) * | 1982-12-09 | 1985-03-05 | Hoffmann-La Roche Inc. | Enantiomeric synthesis of 3-amino-4-carbamoyloxymethyl-2-azetidonone-1-sulfate |
US4501697A (en) * | 1983-06-17 | 1985-02-26 | E. R. Squibb & Sons, Inc. | 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts |
-
1980
- 1980-12-05 WO PCT/JP1980/000297 patent/WO1982001873A1/fr unknown
-
1981
- 1981-04-30 WO PCT/JP1981/000103 patent/WO1982003859A1/fr unknown
- 1981-08-21 WO PCT/JP1981/000183 patent/WO1983000689A1/fr unknown
- 1981-09-24 WO PCT/JP1981/000252 patent/WO1983001063A1/fr unknown
- 1981-11-19 IL IL64315A patent/IL64315A/xx unknown
- 1981-11-25 AU AU77829/81A patent/AU557689B2/en not_active Ceased
- 1981-12-02 NO NO814112A patent/NO160577C/no unknown
- 1981-12-02 YU YU2810/81A patent/YU43051B/xx unknown
- 1981-12-02 FI FI813852A patent/FI81085C/fi not_active IP Right Cessation
- 1981-12-02 DK DK534481A patent/DK534481A/da not_active Application Discontinuation
- 1981-12-03 BR BR8107866A patent/BR8107866A/pt unknown
- 1981-12-03 US US06/326,937 patent/US4550105A/en not_active Expired - Fee Related
- 1981-12-03 US US06/326,938 patent/US4822788A/en not_active Expired - Fee Related
- 1981-12-04 CH CH7787/81A patent/CH657610A5/de not_active IP Right Cessation
- 1981-12-04 LU LU83819A patent/LU83819A1/fr unknown
- 1981-12-04 AT AT0520881A patent/AT378768B/de not_active IP Right Cessation
- 1981-12-04 IT IT25464/81A patent/IT1139919B/it active
- 1981-12-04 GB GB8136619A patent/GB2091724B/en not_active Expired
- 1981-12-04 SE SE8107274A patent/SE457256B/sv not_active IP Right Cessation
- 1981-12-04 NL NL8105470A patent/NL8105470A/nl not_active Application Discontinuation
- 1981-12-04 PT PT74088A patent/PT74088B/pt unknown
- 1981-12-04 IE IE2860/81A patent/IE53314B1/en unknown
- 1981-12-04 FR FR8122775A patent/FR2495613B1/fr not_active Expired
- 1981-12-04 GR GR66689A patent/GR77295B/el unknown
- 1981-12-04 DE DE8181110155T patent/DE3176731D1/de not_active Expired
- 1981-12-04 ES ES507715A patent/ES507715A0/es active Granted
- 1981-12-04 BE BE206752A patent/BE891366A/fr not_active IP Right Cessation
- 1981-12-04 NZ NZ199167A patent/NZ199167A/en unknown
- 1981-12-04 DE DE19813148021 patent/DE3148021A1/de not_active Withdrawn
- 1981-12-04 EP EP81110155A patent/EP0053816B1/fr not_active Expired
- 1981-12-05 WO PCT/JP1981/000369 patent/WO1982002043A1/fr unknown
- 1981-12-07 PH PH26590A patent/PH25221A/en unknown
-
1982
- 1982-10-06 ES ES516254A patent/ES8400400A1/es not_active Expired
-
1983
- 1983-05-19 AR AR293082A patent/AR240171A1/es active
- 1983-06-30 YU YU01429/83A patent/YU142983A/xx unknown
-
1985
- 1985-06-05 US US06/741,741 patent/US4665067A/en not_active Expired - Fee Related
-
1987
- 1987-12-30 MY MY314/87A patent/MY8700314A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO160577C (no) | Analogifremgangsmaate for fremstilling av antimikrobielt aktive eller beta-laktamaseinhiberende 1-sulfo-2-oksoazetidinderivater. | |
NO159531C (no) | Analogifremgangsmaate for fremstilling av farmasoeytisk aktive karbostyrilderivater. | |
NO166327C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater. | |
NO154905C (no) | Fremgangsmaate for fremstilling av preparater for behandling av melanomer. | |
NO163691C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive n-acryl-piperazinalkanamider. | |
NO163668C (no) | Fremgangsmaate for fremstilling av immunogent kompleks. | |
NO156864B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater. | |
NO160521C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 13alfa- alkylgonaner. | |
NO159667C (no) | Fremgangsmaate for fremstilling av kikhostetoksid. | |
NO157739C (no) | Analogifremgangsmaate for fremstilling av antimikrobielle naftyridin- og kinolin-forbindelser. | |
NO158183C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolylfenylamidiner. | |
NO153496C (no) | Analogifremgangsmaate for fremstilling av fysiologisk aktive indolizin-derivater. | |
NO155051C (no) | Fremgangsmaate for fremstilling av alfa-klorerte klorformiaer. | |
NO159528C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive aminoguanidinderivater. | |
NO152649C (no) | Analogifremgangsmaate for fremstilling av farmasoeytisk aktive fenylalkylaminer. | |
NO821904L (no) | Fremgangsmaate for fremstilling av farmasoeytisk aktive kinolinderivater. | |
NO155840C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive taurin-derivater. | |
NO160079C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-derivater. | |
IT7825477A0 (it) | Procedimento per la preparazione di film poliolefinici termosaldabili. | |
NO158948C (no) | Fremgangsmaate for fremstilling av enzymet kolesterase. | |
NO158739C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-piperazinopyrimidinderivater. | |
NO832659L (no) | Fremgangsmaate for fremstilling av antimikrobielle forbindelser. | |
NO147716C (no) | Analogifremgangsmaate for fremstilling av antibakterielle erytromycylaminderivater. | |
NO812701L (no) | Fremgangsmaate for fremstilling av antibakterielle timetyl-cefalosporiner. | |
NO162018C (no) | Fremgangsmaate for fremstilling av 4-metyl-5-alkyltiometylimidazoler. |