NO159796C - Fremgangsmaate ved fremstilling av terapeutisk aktive 2- (fluoralkylthio)substituerte penemer. - Google Patents

Fremgangsmaate ved fremstilling av terapeutisk aktive 2- (fluoralkylthio)substituerte penemer.

Info

Publication number
NO159796C
NO159796C NO823903A NO823903A NO159796C NO 159796 C NO159796 C NO 159796C NO 823903 A NO823903 A NO 823903A NO 823903 A NO823903 A NO 823903A NO 159796 C NO159796 C NO 159796C
Authority
NO
Norway
Prior art keywords
fluoralkylthio
procedure
preparation
therapeutic active
penems
Prior art date
Application number
NO823903A
Other languages
English (en)
Norwegian (no)
Other versions
NO159796B (no
NO823903L (no
Inventor
Viyyoor M Girijavallabhan
Stuart W Mccombie
Ashit K Ganguly
Patrick Anthony Pinto
Richard William Versace
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO823903L publication Critical patent/NO823903L/no
Publication of NO159796B publication Critical patent/NO159796B/no
Publication of NO159796C publication Critical patent/NO159796C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO823903A 1981-11-25 1982-11-22 Fremgangsmaate ved fremstilling av terapeutisk aktive 2- (fluoralkylthio)substituerte penemer. NO159796C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/324,931 US4411906A (en) 1981-11-25 1981-11-25 (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates

Publications (3)

Publication Number Publication Date
NO823903L NO823903L (no) 1983-05-26
NO159796B NO159796B (no) 1988-10-31
NO159796C true NO159796C (no) 1989-02-08

Family

ID=23265741

Family Applications (1)

Application Number Title Priority Date Filing Date
NO823903A NO159796C (no) 1981-11-25 1982-11-22 Fremgangsmaate ved fremstilling av terapeutisk aktive 2- (fluoralkylthio)substituerte penemer.

Country Status (22)

Country Link
US (2) US4411906A (fr)
EP (1) EP0080162B1 (fr)
JP (1) JPS5892683A (fr)
KR (1) KR890005148B1 (fr)
AT (1) ATE20666T1 (fr)
AU (1) AU560838B2 (fr)
CA (1) CA1207753A (fr)
DE (1) DE3271955D1 (fr)
DK (1) DK153553C (fr)
FI (1) FI76091C (fr)
HK (1) HK56889A (fr)
HU (1) HU190044B (fr)
IE (1) IE54219B1 (fr)
IL (1) IL67327A0 (fr)
MY (1) MY8700708A (fr)
NO (1) NO159796C (fr)
NZ (1) NZ202574A (fr)
OA (1) OA07255A (fr)
PH (1) PH19647A (fr)
PT (1) PT75878B (fr)
SG (1) SG88388G (fr)
ZA (1) ZA828602B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
EP0091576B1 (fr) * 1982-03-26 1987-07-29 Hoechst Uk Limited Dérivés du 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane
DE3382761T2 (de) * 1982-11-29 1995-03-09 Schering Corp Verfahren zur Herstellung von Penem-Verbindungen.
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
WO1999036098A1 (fr) * 1998-01-13 1999-07-22 Suntory Limited Composition antibacterienne contenant des antibiotiques et destinee a l'administration topique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (fr) * 1978-02-02 1986-01-08 Ciba-Geigy Ag Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
US4614738A (en) * 1983-03-25 1986-09-30 Schering Corporation 2-(N-heterocycloaliphaticthio)penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems

Also Published As

Publication number Publication date
FI76091B (fi) 1988-05-31
AU560838B2 (en) 1987-04-16
DK153553B (da) 1988-07-25
HK56889A (en) 1989-07-21
FI76091C (fi) 1988-09-09
DE3271955D1 (en) 1986-08-14
SG88388G (en) 1989-06-16
IE54219B1 (en) 1989-07-19
DK153553C (da) 1988-12-19
PT75878B (en) 1986-01-15
MY8700708A (en) 1987-12-31
IL67327A0 (en) 1983-03-31
US4411906A (en) 1983-10-25
KR890005148B1 (ko) 1989-12-14
FI823997L (fi) 1983-05-26
OA07255A (fr) 1984-04-30
NO159796B (no) 1988-10-31
HU190044B (en) 1986-08-28
EP0080162B1 (fr) 1986-07-09
IE822765L (en) 1983-05-25
DK519382A (da) 1983-05-26
EP0080162A1 (fr) 1983-06-01
FI823997A0 (fi) 1982-11-22
PT75878A (en) 1982-12-01
US4814442A (en) 1989-03-21
KR840002403A (ko) 1984-07-02
JPS5892683A (ja) 1983-06-02
PH19647A (en) 1986-06-04
AU9078782A (en) 1983-06-02
CA1207753A (fr) 1986-07-15
ATE20666T1 (de) 1986-07-15
NZ202574A (en) 1986-06-11
ZA828602B (en) 1983-09-28
NO823903L (no) 1983-05-26

Similar Documents

Publication Publication Date Title
NO165543C (no) Analogifremgangsmaate for fremst av terapeutisk aktiv (4r,5s,6s,8r,2's,-4's)-3- 4-(dimethylamino-carbonyl)-pyrrolidinhylthio -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo- 3,2,0 hept-2-en-7-on-2-carboxylsyre i krystallinsk form.
NO161439C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-imidazolylderivater av bicykliske forbindelser.
NO161117C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive cefalosporinderivater.
NO159796C (no) Fremgangsmaate ved fremstilling av terapeutisk aktive 2- (fluoralkylthio)substituerte penemer.
NO158060C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonforbindelser.
NO158534C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenoksyalkylkarboksylsyrederivater.
ES2113938T3 (es) Isomeros opticos de 7-(3-(1,1-dialquilmetil-1-amino)-1-pirrolidinil)-quinolonas y naftiridonas utilizados como agentes antibacterianos.
NO167573C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive (5r, 6s,)-6-((r)-1-hydroksyetyl)-2-azacykloalkyltio-2-penem-3-karboksyl-syrederivater.
DK440187D0 (da) (5r,6s,8r)-6-(1-hydroxyethyl)-2-(3r-pyrrolidin-2-on-3-yl)-thiopenem-3-carboxylsyre
FI905912A0 (fi) Menetelmä farmaseuttisesti käyttökelpoisten 6-(1-hydroksietyyli)-3-(substituoitu tio)-7-okso-1-atsabisyklo/3.2.0/hept-2-eeni-2-karboksyylihappojohdannaisten valmistamiseksi
ES2029794T3 (es) Procedimiento de preparacion de antibioticos de 2-(1-oxo-3-tiolanil)-2-penem.
NO158300C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa-substituerte ureidobenzylpenicillan-syrederivater.
NO165399C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive (5r,6s)-6-((r)-1-hydroksyetyl)-penem-derivater.
NO175368C (no) Mellomprodukter for fremstilling av terapeutisk aktive diastereomere 5R,6S-6-(1R-hydroksyetyl)-2-(cis-1-okso-3-tiolanyltio)-2-penem-3-karboksylsyrer
NO832870L (no) Fremgangsmaate for fremstilling av penicillansyrederivater som er egnet som utgangsmateriale ved fremstilling av antibakterielle penicillinderivater
NO157103C (no) Analogifremgangsmÿte for fremstilling av terapeutisk virksomme dicykliske forbindelser.
NO911040L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte imidazol-forbindelser.
NO154230C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktiv (+)-(4r,6s)-(e)-6-(2-(4'-fluor-3-3', 5-trimethyl-(1,1'-bifenyl)-2-yl)-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-on.
NO159856C (no) Analogifremgangsm te for fremstilling av terapeutisk aktive salter av penicillansyre-1,1-dioksyd.
NO172583C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktiv penicillansyre-derivater