NO125096B - - Google Patents
Download PDFInfo
- Publication number
- NO125096B NO125096B NO170209A NO17020967A NO125096B NO 125096 B NO125096 B NO 125096B NO 170209 A NO170209 A NO 170209A NO 17020967 A NO17020967 A NO 17020967A NO 125096 B NO125096 B NO 125096B
- Authority
- NO
- Norway
- Prior art keywords
- solution
- iron
- dextran
- heptonic acid
- hydroxide
- Prior art date
Links
- KWMLJOLKUYYJFJ-UHFFFAOYSA-N 2,3,4,5,6,7-Hexahydroxyheptanoic acid Chemical compound OCC(O)C(O)C(O)C(O)C(O)C(O)=O KWMLJOLKUYYJFJ-UHFFFAOYSA-N 0.000 claims description 43
- 229920002307 Dextran Polymers 0.000 claims description 37
- 229920001353 Dextrin Polymers 0.000 claims description 17
- 239000004375 Dextrin Substances 0.000 claims description 17
- 235000019425 dextrin Nutrition 0.000 claims description 17
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical class [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 229960004887 ferric hydroxide Drugs 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 4
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 239000013067 intermediate product Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 106
- 239000000243 solution Substances 0.000 description 70
- 229910052742 iron Inorganic materials 0.000 description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
- 235000019441 ethanol Nutrition 0.000 description 13
- 235000014413 iron hydroxide Nutrition 0.000 description 12
- 230000007062 hydrolysis Effects 0.000 description 11
- 238000006460 hydrolysis reaction Methods 0.000 description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 10
- 230000037396 body weight Effects 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 238000000502 dialysis Methods 0.000 description 6
- 238000001990 intravenous administration Methods 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000000548 hind-foot Anatomy 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 150000002505 iron Chemical class 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000000717 retained effect Effects 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 238000000909 electrodialysis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003957 anion exchange resin Substances 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000000385 dialysis solution Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- -1 iron hydroxide carbohydrate Chemical class 0.000 description 2
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 description 2
- MVZXTUSAYBWAAM-UHFFFAOYSA-N iron;sulfuric acid Chemical compound [Fe].OS(O)(=O)=O MVZXTUSAYBWAAM-UHFFFAOYSA-N 0.000 description 2
- 235000014666 liquid concentrate Nutrition 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 208000022440 X-linked sideroblastic anemia 1 Diseases 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 229960004642 ferric ammonium citrate Drugs 0.000 description 1
- 229940032296 ferric chloride Drugs 0.000 description 1
- 229940044631 ferric chloride hexahydrate Drugs 0.000 description 1
- 229960002413 ferric citrate Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004313 iron ammonium citrate Substances 0.000 description 1
- 235000000011 iron ammonium citrate Nutrition 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- NQXWGWZJXJUMQB-UHFFFAOYSA-K iron trichloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].Cl[Fe+]Cl NQXWGWZJXJUMQB-UHFFFAOYSA-K 0.000 description 1
- WOSISLOTWLGNKT-UHFFFAOYSA-L iron(2+);dichloride;hexahydrate Chemical compound O.O.O.O.O.O.Cl[Fe]Cl WOSISLOTWLGNKT-UHFFFAOYSA-L 0.000 description 1
- LHOWRPZTCLUDOI-UHFFFAOYSA-K iron(3+);triperchlorate Chemical compound [Fe+3].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O LHOWRPZTCLUDOI-UHFFFAOYSA-K 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940066528 trichloroacetate Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electric Clocks (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4746666 | 1966-10-22 | ||
| GB5732366 | 1966-12-21 | ||
| GB37691/67A GB1183940A (en) | 1966-10-22 | 1967-08-16 | Ferric Hydroxide Complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO125096B true NO125096B (xx) | 1972-07-17 |
Family
ID=27259448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO170209A NO125096B (xx) | 1966-10-22 | 1967-10-20 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3536696A (xx) |
| BE (1) | BE705165A (xx) |
| CH (1) | CH476664A (xx) |
| CU (1) | CU33283A (xx) |
| DE (1) | DE1668033C2 (xx) |
| DK (1) | DK129942B (xx) |
| ES (1) | ES346270A1 (xx) |
| FI (1) | FI48475C (xx) |
| FR (2) | FR7079M (xx) |
| GB (1) | GB1183940A (xx) |
| GR (1) | GR35148B (xx) |
| IL (1) | IL28728A (xx) |
| IT (1) | IT1044171B (xx) |
| LU (1) | LU54680A1 (xx) |
| NL (1) | NL154517B (xx) |
| NO (1) | NO125096B (xx) |
| SE (1) | SE344331B (xx) |
| YU (1) | YU34004B (xx) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4056672A (en) * | 1973-03-22 | 1977-11-01 | Astra Lakemedel Aktiebolag | Polymer prepared by cyanhydrin method |
| JPS6039681B2 (ja) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤 |
| US4226983A (en) * | 1977-09-29 | 1980-10-07 | United Kingdom Atomic Energy Authority | Preparation of metal complexes |
| US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
| EP0051707A1 (en) * | 1980-11-12 | 1982-05-19 | Thomas Clemens Usher | Dextran polycarboxylic acids, ferric hydroxide complexes thereof, pharmaceutical compositions containing them and methods for their manufacture |
| US4493826A (en) * | 1982-01-25 | 1985-01-15 | Schering Corporation | Gentamicin-gleptoferron compositions |
| DE3332301A1 (de) * | 1983-09-07 | 1985-03-21 | Algina AG, Zug | Metallsalze und metallmischsalze von polymeren, anionischen carbonsaeuren und/oder ihren schwefelsaeureestern, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und ihre verwendung |
| US4788281A (en) * | 1984-01-04 | 1988-11-29 | Tosoni Anthony L | Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof |
| US5160726A (en) * | 1990-02-15 | 1992-11-03 | Advanced Magnetics Inc. | Filter sterilization for production of colloidal, superparamagnetic MR contrast agents |
| TW293036B (xx) * | 1992-11-27 | 1996-12-11 | Takeda Pharm Industry Co Ltd | |
| DK172860B1 (da) | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| US6703499B1 (en) * | 1999-04-29 | 2004-03-09 | Polydex Pharmaceuticals Ltd. | Process of making carboxylated dextran |
| PT1492821E (pt) * | 2002-04-09 | 2006-12-29 | Pharmacosmos Holding As | Compostos de ferro-dextrina para o tratamento de anemia por deficiência de ferro |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US7964568B2 (en) * | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| KR101905340B1 (ko) | 2006-01-06 | 2018-10-05 | 루이트폴드 파머수티컬스, 인코퍼레이티드 | 철을 투여하기 위한 방법 및 조성물 |
| DE102007025908A1 (de) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
| EP2740470A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Treatment of Coccidiosis with intramuscular triazine composition |
| EP2740469A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | New treatments with triazines |
| WO2017200415A1 (ru) * | 2016-05-20 | 2017-11-23 | Общество с ограниченной ответственностью "ВИК-здоровье животных" | Инъекционная композиция комплекса железо декстрана с витаминами для профилактики и лечения анемий |
| EP3793516B1 (en) * | 2018-05-16 | 2024-01-24 | Ceva Santé Animale | Veterinary compositions and the uses thereof for controlling iron deficiencies in non-human mammals |
| CN113801176B (zh) * | 2021-07-09 | 2023-08-18 | 天津市中升挑战生物科技有限公司 | 一种铁络合物的制备方法及其应用 |
| CN116712455B (zh) * | 2023-06-30 | 2024-04-05 | 重庆汉佩生物科技有限公司 | 一种氟苯尼考与葡庚糖酐铁的组合物 |
| CN116808072B (zh) * | 2023-06-30 | 2024-02-20 | 重庆汉佩生物科技有限公司 | 一种抗虫组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2735866A (en) * | 1956-02-21 | Method for producing glucoheptonic | ||
| US2853495A (en) * | 1954-06-04 | 1958-09-23 | Simon L Ruskin | Preparation of 2, 4-monofurfurylidene sorbitol |
| US2885393A (en) * | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| GB852958A (en) * | 1956-08-07 | 1960-11-02 | Union Starch And Refining Comp | Sequestering composition comprising polyhydroxy carboxylic acids and process of making same |
| AT199794B (de) * | 1957-08-01 | 1958-09-25 | Pharmazeutische Fabrik Montavit Gmbh | Verfahren zur Herstellung eines neuen Eiseninjektionspräparates für medizinische Zwecke |
| GB891769A (en) * | 1958-09-10 | 1962-03-21 | Ohio Commw Eng Co | Carboxymethyl dextran-iron complexes |
| GB891770A (en) * | 1958-09-30 | 1962-03-21 | Ohio Commw Eng Co | Iron carboxymethyl dextran |
| US3022221A (en) * | 1959-04-16 | 1962-02-20 | Chemicals Inc | Iron hydrogenated dextran |
| CH397628A (de) * | 1959-05-08 | 1965-08-31 | Hausmann Ag Labor | Verfahren zur Herstellung von therapeutisch verwendbaren Eisen-(III)-hydroxyd-Polymaltose-Komplexen |
| US3070506A (en) * | 1960-04-04 | 1962-12-25 | American Cyanamid Co | Process of preparing hematinic for parenteral administration |
| US3100202A (en) * | 1960-06-17 | 1963-08-06 | Muller Arthur | Process for preparing an iron hydroxide polyisomaltose complex and the resulting product |
| US3151107A (en) * | 1960-12-22 | 1964-09-29 | Central Pharmacal Company | Water-soluble iron complexes of carboxymethyl dextran |
| US3076798A (en) * | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| FR2823M (xx) * | 1962-11-08 | 1964-11-06 | Ct De Lyophilisation Pharma |
-
1967
- 1967-08-16 GB GB37691/67A patent/GB1183940A/en not_active Expired
- 1967-10-04 IL IL28728A patent/IL28728A/en unknown
- 1967-10-12 NL NL676713890A patent/NL154517B/xx not_active IP Right Cessation
- 1967-10-16 BE BE705165D patent/BE705165A/xx not_active IP Right Cessation
- 1967-10-16 US US675343A patent/US3536696A/en not_active Expired - Lifetime
- 1967-10-16 LU LU54680A patent/LU54680A1/xx unknown
- 1967-10-18 GR GR670135148A patent/GR35148B/el unknown
- 1967-10-19 DE DE1668033A patent/DE1668033C2/de not_active Expired
- 1967-10-19 CH CH1461267A patent/CH476664A/fr not_active IP Right Cessation
- 1967-10-20 IT IT21830/67A patent/IT1044171B/it active
- 1967-10-20 ES ES346270A patent/ES346270A1/es not_active Expired
- 1967-10-20 CU CU33283A patent/CU33283A/es unknown
- 1967-10-20 FR FR125164A patent/FR7079M/fr not_active Expired
- 1967-10-20 NO NO170209A patent/NO125096B/no unknown
- 1967-10-20 FR FR1577238D patent/FR1577238A/fr not_active Expired
- 1967-10-20 SE SE14428/67A patent/SE344331B/xx unknown
- 1967-10-20 DK DK524767AA patent/DK129942B/da not_active IP Right Cessation
- 1967-10-21 YU YU2064/67A patent/YU34004B/xx unknown
- 1967-10-21 FI FI672843A patent/FI48475C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| CU20626L (es) | 1968-11-11 |
| GR35148B (el) | 1968-08-21 |
| SE344331B (xx) | 1972-04-10 |
| YU206467A (en) | 1978-05-15 |
| CU33283A (es) | 1968-11-11 |
| NL154517B (nl) | 1977-09-15 |
| NL6713890A (xx) | 1968-04-23 |
| FR1577238A (xx) | 1969-08-08 |
| BE705165A (xx) | 1968-04-16 |
| CH476664A (fr) | 1969-08-15 |
| FI48475C (fi) | 1974-10-10 |
| FR7079M (xx) | 1969-06-30 |
| GB1183940A (en) | 1970-03-11 |
| US3536696A (en) | 1970-10-27 |
| ES346270A1 (es) | 1969-04-16 |
| LU54680A1 (xx) | 1968-05-08 |
| DK129942C (xx) | 1975-05-12 |
| YU34004B (en) | 1978-10-31 |
| IT1044171B (it) | 1980-03-20 |
| DE1668033C2 (de) | 1983-02-10 |
| IL28728A (en) | 1971-10-20 |
| FI48475B (xx) | 1974-07-01 |
| DE1668033A1 (de) | 1971-05-13 |
| DK129942B (da) | 1974-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO125096B (xx) | ||
| JP5289413B2 (ja) | 水溶性鉄−炭水化物複合体、その製法、及びそれを含有する薬剤 | |
| US2820740A (en) | Therapeutic preparations of iron | |
| US8993748B2 (en) | Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars | |
| KR20120016063A (ko) | 안정한 철 올리고당 화합물 | |
| JP4558198B2 (ja) | 鉄欠乏症の予防または治療のための治療組成物の成分として用いる鉄−デキストラン化合物、および前記鉄−デキストラン化合物の製造法 | |
| US3928135A (en) | Process for the production of glucose polymers | |
| JP4520748B2 (ja) | 鉄欠乏性貧血の治療のための鉄デキストリン化合物 | |
| US4788281A (en) | Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof | |
| US3928581A (en) | Certain polymer-iron complexes for treatment of iron deficiency | |
| CN103040730A (zh) | 蔗糖铁注射液及其制备方法 | |
| US3639588A (en) | Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids | |
| US3686397A (en) | Parenteral iron preparations | |
| USRE24642E (en) | Therapeutic preparations of iron | |
| US2591133A (en) | Method of producing gelatin derivative | |
| US3100202A (en) | Process for preparing an iron hydroxide polyisomaltose complex and the resulting product | |
| GB2094142A (en) | Injectable solution containing theophylline and a basic amino acid | |
| US3666749A (en) | Iron dextran complex and process for making same | |
| US3151107A (en) | Water-soluble iron complexes of carboxymethyl dextran | |
| IL24513A (en) | Iron-containing therapeutic preparations | |
| US3487046A (en) | Novel pyrazolidone derivatives substituted on the 4 position with a phenolhcho-polyamine ion exchange resin | |
| US3208995A (en) | Method of depolymerizing alginic acid salts and esters by reaction with no2 | |
| CN113559058A (zh) | 吉西他滨氨基酸注射液 | |
| USRE27240E (en) | Therapeutic preparation of iron | |
| EA033807B1 (ru) | Комплексы гидроксида железа(iii) с сиропами из активированной глюкозы и способ их получения |