NL8801932A - Tripeptiden nuttig als immunostimulantia en voorts bij de voorkoming van metastasen. - Google Patents
Tripeptiden nuttig als immunostimulantia en voorts bij de voorkoming van metastasen. Download PDFInfo
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- NL8801932A NL8801932A NL8801932A NL8801932A NL8801932A NL 8801932 A NL8801932 A NL 8801932A NL 8801932 A NL8801932 A NL 8801932A NL 8801932 A NL8801932 A NL 8801932A NL 8801932 A NL8801932 A NL 8801932A
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- tripeptides
- arg
- asp
- gly
- salts
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000000650 radiochemotherapeutic effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
- 229910001488 sodium perchlorate Inorganic materials 0.000 description 1
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 108700016958 thymosin fraction 5 Proteins 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21575/87A IT1222437B (it) | 1987-08-04 | 1987-08-04 | Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione |
| IT2157587 | 1987-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8801932A true NL8801932A (nl) | 1989-03-01 |
Family
ID=11183828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8801932A NL8801932A (nl) | 1987-08-04 | 1988-08-03 | Tripeptiden nuttig als immunostimulantia en voorts bij de voorkoming van metastasen. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4929601A (fr) |
| JP (1) | JPS6463593A (fr) |
| AT (1) | ATA195788A (fr) |
| BE (1) | BE1003227A3 (fr) |
| CH (1) | CH678059A5 (fr) |
| DE (1) | DE3826595C2 (fr) |
| FR (1) | FR2621317B1 (fr) |
| GB (1) | GB2207922B (fr) |
| GR (1) | GR1000339B (fr) |
| IE (1) | IE60870B1 (fr) |
| IT (1) | IT1222437B (fr) |
| NL (1) | NL8801932A (fr) |
| SE (1) | SE8802790L (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4156490A (en) * | 1976-05-25 | 1979-05-29 | Prot S.R.L. | Method of hermetically sealing soft-drink bottles and like containers |
| US5827821A (en) * | 1987-12-10 | 1998-10-27 | The Burnham Institute | Conformationally stabilized cell adhesion peptides |
| EP0394326B1 (fr) * | 1987-12-10 | 1996-07-31 | La Jolla Cancer Research Foundation | Methodes pour la production des peptides d'adhesion cellulaire a stabilisation conformationnelle |
| CA1324954C (fr) * | 1988-03-10 | 1993-12-07 | Erkki I. Ruoslahti | Inhibition de la migration cellulaire au moyen de peptides synthetiques |
| US5236903A (en) * | 1988-06-24 | 1993-08-17 | Ichiro Azuma | Polypeptide comprising repeated cell-adhesive core sequences |
| JP2625156B2 (ja) * | 1988-06-24 | 1997-07-02 | 市郎 東 | 細胞接着活性コア配列の繰り返し構造からなるポリペプチド |
| IT1226552B (it) * | 1988-07-29 | 1991-01-24 | Ellem Ind Farmaceutica | Peptidi immunostimolanti. |
| US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5686566A (en) * | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5807828A (en) * | 1989-06-16 | 1998-09-15 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| US5648330A (en) * | 1990-04-06 | 1997-07-15 | La Jolla Cancer Research Foundation | Method and composition for treating vascular graft occlusion |
| DK0527798T3 (da) * | 1990-04-06 | 1997-12-15 | Jolla Cancer Res Found | Fremgangsmåde og sammensætning til behandling af thrombose |
| US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5612311A (en) | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| AU9131091A (en) * | 1990-11-07 | 1992-06-11 | Scripps Research Institute, The | Peptides that inhibit platelet binding of adhesion molecules |
| WO1992017492A1 (fr) * | 1991-04-05 | 1992-10-15 | Genentech, Inc. | INHIBITEURS DE L'AGREGATION PLAQUETTAIRE PRESENTANT UNE SPECIFICITE ELEVEE POUR GP IIbIII¿a? |
| US5639729A (en) * | 1993-08-26 | 1997-06-17 | Immunobiology Research Institute, Inc. | Tripeptides useful in immune and CNS therapy |
| WO2004099237A1 (fr) * | 2003-05-08 | 2004-11-18 | Pentapharm Ag | Tripeptides et leurs derives utilises en cosmetique pour ameliorer la structure de la peau |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743590A (en) * | 1978-07-31 | 1988-05-10 | Debarbieri Augusto | In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound |
| US4508710A (en) * | 1978-07-31 | 1985-04-02 | Proter S.P.A. | In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound |
| HU185263B (en) * | 1981-06-12 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for producing peptides effective on the immuncontroll analogous with the tp5 |
| FR2569111B1 (fr) * | 1984-08-16 | 1987-04-17 | Rhone Poulenc Sante | Nouveaux medicaments contenant des tripeptides |
-
1987
- 1987-08-04 IT IT21575/87A patent/IT1222437B/it active
-
1988
- 1988-08-02 BE BE8800895A patent/BE1003227A3/fr not_active IP Right Cessation
- 1988-08-02 US US07/227,356 patent/US4929601A/en not_active Expired - Fee Related
- 1988-08-02 CH CH2918/88A patent/CH678059A5/it not_active IP Right Cessation
- 1988-08-02 SE SE8802790A patent/SE8802790L/ not_active Application Discontinuation
- 1988-08-03 IE IE236688A patent/IE60870B1/en not_active IP Right Cessation
- 1988-08-03 NL NL8801932A patent/NL8801932A/nl not_active Application Discontinuation
- 1988-08-03 FR FR888810487A patent/FR2621317B1/fr not_active Expired - Fee Related
- 1988-08-03 GB GB8818447A patent/GB2207922B/en not_active Expired - Fee Related
- 1988-08-03 AT AT0195788A patent/ATA195788A/de not_active Application Discontinuation
- 1988-08-03 GR GR880100509A patent/GR1000339B/el unknown
- 1988-08-04 DE DE3826595A patent/DE3826595C2/de not_active Expired - Fee Related
- 1988-08-04 JP JP63197020A patent/JPS6463593A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4929601A (en) | 1990-05-29 |
| CH678059A5 (fr) | 1991-07-31 |
| SE8802790D0 (sv) | 1988-08-02 |
| ATA195788A (de) | 1996-05-15 |
| JPS6463593A (en) | 1989-03-09 |
| IT8721575A0 (it) | 1987-08-04 |
| FR2621317B1 (fr) | 1994-06-17 |
| IE60870B1 (en) | 1994-08-24 |
| GB2207922A (en) | 1989-02-15 |
| GB8818447D0 (en) | 1988-09-07 |
| IE882366L (en) | 1989-02-04 |
| GB2207922B (en) | 1991-02-20 |
| DE3826595C2 (de) | 1994-02-17 |
| IT1222437B (it) | 1990-09-05 |
| GR880100509A (en) | 1989-05-25 |
| BE1003227A3 (fr) | 1992-02-04 |
| FR2621317A1 (fr) | 1989-04-07 |
| SE8802790L (sv) | 1989-02-05 |
| DE3826595A1 (de) | 1989-02-16 |
| GR1000339B (el) | 1992-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | A search report has been drawn up | ||
| BV | The patent application has lapsed |