BE1003227A3 - Tripeptides utiles comme immunostimulants de meme que dans la prevention des metastases. - Google Patents

Tripeptides utiles comme immunostimulants de meme que dans la prevention des metastases. Download PDF

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Publication number
BE1003227A3
BE1003227A3 BE8800895A BE8800895A BE1003227A3 BE 1003227 A3 BE1003227 A3 BE 1003227A3 BE 8800895 A BE8800895 A BE 8800895A BE 8800895 A BE8800895 A BE 8800895A BE 1003227 A3 BE1003227 A3 BE 1003227A3
Authority
BE
Belgium
Prior art keywords
immunostimulants
metastases
prevention
well
tripeptides
Prior art date
Application number
BE8800895A
Other languages
English (en)
Inventor
Brunetti Brunetto
Prada Marco
Original Assignee
Ellem Ind Farmaceutica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ellem Ind Farmaceutica filed Critical Ellem Ind Farmaceutica
Application granted granted Critical
Publication of BE1003227A3 publication Critical patent/BE1003227A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des tripeptides de formule générale X-Gly-Y dans laquelle X = L-Arg ou D-Arg, et Y = L-Asp ou D-Asp. Ces tripeptides, possédant des propriétés antimétastatique et 05 immunostimulante, sont actifs non seulement après administration parentérale, mais également après traitement oral. L'invention concerne également un procédé de préparation de ces composés.
BE8800895A 1987-08-04 1988-08-02 Tripeptides utiles comme immunostimulants de meme que dans la prevention des metastases. BE1003227A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21575/87A IT1222437B (it) 1987-08-04 1987-08-04 Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione

Publications (1)

Publication Number Publication Date
BE1003227A3 true BE1003227A3 (fr) 1992-02-04

Family

ID=11183828

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800895A BE1003227A3 (fr) 1987-08-04 1988-08-02 Tripeptides utiles comme immunostimulants de meme que dans la prevention des metastases.

Country Status (13)

Country Link
US (1) US4929601A (fr)
JP (1) JPS6463593A (fr)
AT (1) ATA195788A (fr)
BE (1) BE1003227A3 (fr)
CH (1) CH678059A5 (fr)
DE (1) DE3826595C2 (fr)
FR (1) FR2621317B1 (fr)
GB (1) GB2207922B (fr)
GR (1) GR1000339B (fr)
IE (1) IE60870B1 (fr)
IT (1) IT1222437B (fr)
NL (1) NL8801932A (fr)
SE (1) SE8802790L (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156490A (en) * 1976-05-25 1979-05-29 Prot S.R.L. Method of hermetically sealing soft-drink bottles and like containers
WO1989005150A1 (fr) * 1987-12-10 1989-06-15 La Jolla Cancer Research Foundation Peptides d'adhesion cellulaire a stabilisation conformationnelle
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
CA1324954C (fr) * 1988-03-10 1993-12-07 Erkki I. Ruoslahti Inhibition de la migration cellulaire au moyen de peptides synthetiques
JP2625156B2 (ja) * 1988-06-24 1997-07-02 市郎 東 細胞接着活性コア配列の繰り返し構造からなるポリペプチド
US5236903A (en) * 1988-06-24 1993-08-17 Ichiro Azuma Polypeptide comprising repeated cell-adhesive core sequences
IT1226552B (it) * 1988-07-29 1991-01-24 Ellem Ind Farmaceutica Peptidi immunostimolanti.
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686567A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DE69126871T2 (de) * 1990-04-06 1998-03-12 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
AU9131091A (en) * 1990-11-07 1992-06-11 Scripps Research Institute, The Peptides that inhibit platelet binding of adhesion molecules
JPH06509551A (ja) * 1991-04-05 1994-10-27 ジェネンテク，インコーポレイテッド Ｇｐ　ＩＩ↓ｂＩＩＩ↓ａに対する高い特異性を有する血小板凝集阻害剤
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
RU2346949C2 (ru) 2003-05-08 2009-02-20 Дсм Ип Эссетс Б.В. Трипептиды и их производные для косметического применения для улучшения структуры кожи

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508710A (en) * 1978-07-31 1985-04-02 Proter S.P.A. In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound
US4743590A (en) * 1978-07-31 1988-05-10 Debarbieri Augusto In vitro and in vivo treatment of cancer cells and treatment of viruses with a tripeptide compound
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
FR2569111B1 (fr) * 1984-08-16 1987-04-17 Rhone Poulenc Sante Nouveaux medicaments contenant des tripeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. EXP. MED., vol. 162, août 1985, pages 762-767, The Rockefeller University Press; S.D. WRIGHT et al.: "Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser" *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 82, septembre 1985, pages 5766-5770; R. PYTELA et al.: "A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin" *

Also Published As

Publication number Publication date
NL8801932A (nl) 1989-03-01
IE882366L (en) 1989-02-04
GB2207922B (en) 1991-02-20
IT8721575A0 (it) 1987-08-04
ATA195788A (de) 1996-05-15
GR880100509A (en) 1989-05-25
FR2621317B1 (fr) 1994-06-17
CH678059A5 (fr) 1991-07-31
DE3826595C2 (de) 1994-02-17
GR1000339B (el) 1992-06-25
SE8802790D0 (sv) 1988-08-02
IT1222437B (it) 1990-09-05
JPS6463593A (en) 1989-03-09
GB2207922A (en) 1989-02-15
IE60870B1 (en) 1994-08-24
SE8802790L (sv) 1989-02-05
GB8818447D0 (en) 1988-09-07
FR2621317A1 (fr) 1989-04-07
US4929601A (en) 1990-05-29
DE3826595A1 (de) 1989-02-16

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ELLEM INDUSTRIA FARMACEUTICA S.P.A.

Effective date: 19960831