NL8304224A - Gesubstitueerde pyrazolochinolinen, werkwijze ter bereiding daarvan, farmaceutische preparaten, die deze verbindingen bevatten en de therapeutische toepassing daarvan. - Google Patents
Gesubstitueerde pyrazolochinolinen, werkwijze ter bereiding daarvan, farmaceutische preparaten, die deze verbindingen bevatten en de therapeutische toepassing daarvan. Download PDFInfo
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- NL8304224A NL8304224A NL8304224A NL8304224A NL8304224A NL 8304224 A NL8304224 A NL 8304224A NL 8304224 A NL8304224 A NL 8304224A NL 8304224 A NL8304224 A NL 8304224A NL 8304224 A NL8304224 A NL 8304224A
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- Prior art keywords
- compounds
- salts
- formula
- compound
- lower alkoxy
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 150000002902 organometallic compounds Chemical class 0.000 description 1
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- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
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- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
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- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- IISWOHCLTBUICM-UHFFFAOYSA-N quinolin-3-ylhydrazine Chemical compound C1=CC=CC2=CC(NN)=CN=C21 IISWOHCLTBUICM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/447,825 US4524146A (en) | 1982-12-08 | 1982-12-08 | Certain -2-heterocycle substituted pyrazoloquinolines |
| US44782582 | 1982-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8304224A true NL8304224A (nl) | 1984-07-02 |
Family
ID=23777905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8304224A NL8304224A (nl) | 1982-12-08 | 1983-12-07 | Gesubstitueerde pyrazolochinolinen, werkwijze ter bereiding daarvan, farmaceutische preparaten, die deze verbindingen bevatten en de therapeutische toepassing daarvan. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4524146A (de) |
| JP (1) | JPS59110694A (de) |
| BE (1) | BE898383A (de) |
| CH (1) | CH656127A5 (de) |
| DE (1) | DE3343922A1 (de) |
| FR (1) | FR2537584B1 (de) |
| GB (1) | GB2131801B (de) |
| IT (1) | IT1205349B (de) |
| NL (1) | NL8304224A (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549833B1 (fr) * | 1983-07-26 | 1985-11-08 | Roussel Uclaf | Derives de la pyrazolo /4,3-c/ cinnolin-3-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et produits intermediaires |
| CA1263651A (en) * | 1984-07-09 | 1989-12-05 | Ciba-Geigy Ag | Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives |
| US4602014A (en) * | 1984-07-09 | 1986-07-22 | Ciba-Geigy Corporation | Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators |
| PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
| JPS61112075A (ja) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| US4591589A (en) * | 1985-01-16 | 1986-05-27 | Roussel Uclaf | 2-aryl pyrazolo[4,3-c]cinnolin-3-ones |
| US4758427A (en) * | 1985-08-08 | 1988-07-19 | Ciba-Geigy Corporation | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US4831013A (en) * | 1986-03-20 | 1989-05-16 | Ciba-Geigy Corporation | 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof |
| US4826854A (en) * | 1986-11-25 | 1989-05-02 | Ciba-Geigy Corporation | Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives |
| US5192768A (en) * | 1990-09-14 | 1993-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Pyrazoloquinoline derivatives |
| US5334595A (en) * | 1992-10-23 | 1994-08-02 | Sterling Winthrop Inc. | Pyrazoloquinolones as anticancer agents |
| AR006520A1 (es) * | 1996-03-20 | 1999-09-08 | Astra Pharma Prod | Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion. |
| AU6019900A (en) * | 1999-11-24 | 2001-06-04 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
| US7863266B2 (en) * | 2007-06-08 | 2011-01-04 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
| WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2009079A1 (de) * | 1968-05-22 | 1970-01-30 | Sandoz Sa | |
| US4312870A (en) * | 1979-06-21 | 1982-01-26 | Ciba-Geigy Corporation | Pyrazoloquinolines |
| ATE8629T1 (de) * | 1979-06-21 | 1984-08-15 | Ciba-Geigy Ag | Pyrazolochinoline, verfahren zu ihrer herstellung, und pharmazeutische praeparate enthaltend diese verbindungen. |
-
1982
- 1982-12-08 US US06/447,825 patent/US4524146A/en not_active Expired - Lifetime
-
1983
- 1983-11-14 CH CH6117/83A patent/CH656127A5/de not_active IP Right Cessation
- 1983-12-02 GB GB08332274A patent/GB2131801B/en not_active Expired
- 1983-12-05 JP JP58228616A patent/JPS59110694A/ja active Pending
- 1983-12-05 DE DE19833343922 patent/DE3343922A1/de not_active Ceased
- 1983-12-06 IT IT49450/83A patent/IT1205349B/it active
- 1983-12-06 FR FR8319492A patent/FR2537584B1/fr not_active Expired
- 1983-12-06 BE BE0/211989A patent/BE898383A/fr not_active IP Right Cessation
- 1983-12-07 NL NL8304224A patent/NL8304224A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB8332274D0 (en) | 1984-01-11 |
| GB2131801B (en) | 1986-01-22 |
| IT8349450A0 (it) | 1983-12-06 |
| DE3343922A1 (de) | 1984-06-28 |
| FR2537584A1 (fr) | 1984-06-15 |
| FR2537584B1 (fr) | 1987-01-16 |
| US4524146A (en) | 1985-06-18 |
| JPS59110694A (ja) | 1984-06-26 |
| CH656127A5 (de) | 1986-06-13 |
| IT1205349B (it) | 1989-03-15 |
| BE898383A (fr) | 1984-06-06 |
| GB2131801A (en) | 1984-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BV | The patent application has lapsed |