NL8201650A - Semisynthetische bereiding van humane insuline. - Google Patents

Semisynthetische bereiding van humane insuline. Download PDF

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Publication number
NL8201650A
NL8201650A NL8201650A NL8201650A NL8201650A NL 8201650 A NL8201650 A NL 8201650A NL 8201650 A NL8201650 A NL 8201650A NL 8201650 A NL8201650 A NL 8201650A NL 8201650 A NL8201650 A NL 8201650A
Authority
NL
Netherlands
Prior art keywords
insulin
human insulin
amino acid
ester
coupling
Prior art date
Application number
NL8201650A
Other languages
English (en)
Dutch (nl)
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Priority to NL8201650A priority Critical patent/NL8201650A/nl
Priority to ZA832602A priority patent/ZA832602B/xx
Priority to DK198301616A priority patent/DK173007B1/da
Priority to AT83200530T priority patent/ATE42203T1/de
Priority to EP83200530A priority patent/EP0092280B1/en
Priority to DE8383200530T priority patent/DE3379640D1/de
Priority to IL68397A priority patent/IL68397A/xx
Priority to AU13554/83A priority patent/AU554050B2/en
Priority to JP58069862A priority patent/JPS58189149A/ja
Priority to PL1983241575A priority patent/PL143571B1/pl
Priority to CA000426236A priority patent/CA1202587A/en
Priority to SU833582755A priority patent/SU1232148A3/ru
Priority to ES521674A priority patent/ES8405760A1/es
Priority to HU831392A priority patent/HU189268B/hu
Publication of NL8201650A publication Critical patent/NL8201650A/nl
Priority to US06/767,481 priority patent/US4840897A/en
Priority to JP4290556A priority patent/JPH0735399B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NL8201650A 1982-04-21 1982-04-21 Semisynthetische bereiding van humane insuline. NL8201650A (nl)

Priority Applications (16)

Application Number Priority Date Filing Date Title
NL8201650A NL8201650A (nl) 1982-04-21 1982-04-21 Semisynthetische bereiding van humane insuline.
ZA832602A ZA832602B (en) 1982-04-21 1983-04-13 Semi-synthetic preparation of human insulin
DK198301616A DK173007B1 (da) 1982-04-21 1983-04-13 Fremgangsmåde til semisyntetisk fremstilling af humaninsulin og modificeret humaninsulin til brug ved fremgangsmåden
AT83200530T ATE42203T1 (de) 1982-04-21 1983-04-14 Semi-synthetisches verfahren zur herstellung von insulin.
EP83200530A EP0092280B1 (en) 1982-04-21 1983-04-14 Semi-synthetic preparation of human insulin
DE8383200530T DE3379640D1 (en) 1982-04-21 1983-04-14 Semi-synthetic preparation of human insulin
IL68397A IL68397A (en) 1982-04-21 1983-04-14 Semi-synthetic preparation of human insulin and a modified human insulin
AU13554/83A AU554050B2 (en) 1982-04-21 1983-04-15 Semi-synthetic preparation of human insulin 0
JP58069862A JPS58189149A (ja) 1982-04-21 1983-04-20 ヒトインシユリンの半合成方法
PL1983241575A PL143571B1 (en) 1982-04-21 1983-04-20 Method of obtaining semi-synthetic human insulin
CA000426236A CA1202587A (en) 1982-04-21 1983-04-20 Semi-synthetic preparation of human insulin
SU833582755A SU1232148A3 (ru) 1982-04-21 1983-04-20 Способ получени инсулина человека
ES521674A ES8405760A1 (es) 1982-04-21 1983-04-20 Metodo para la preparacion de insulina humana semisintetica.
HU831392A HU189268B (en) 1982-04-21 1983-04-21 Process for the semisynthetic preparation of humane insuline
US06/767,481 US4840897A (en) 1982-04-21 1985-08-20 Modified human insulin and its use as starting material for the preparation of human insulin
JP4290556A JPH0735399B2 (ja) 1982-04-21 1992-10-28 変性ヒトインシュリン

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8201650 1982-04-21
NL8201650A NL8201650A (nl) 1982-04-21 1982-04-21 Semisynthetische bereiding van humane insuline.

Publications (1)

Publication Number Publication Date
NL8201650A true NL8201650A (nl) 1983-11-16

Family

ID=19839621

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8201650A NL8201650A (nl) 1982-04-21 1982-04-21 Semisynthetische bereiding van humane insuline.

Country Status (15)

Country Link
US (1) US4840897A (ru)
EP (1) EP0092280B1 (ru)
JP (2) JPS58189149A (ru)
AT (1) ATE42203T1 (ru)
AU (1) AU554050B2 (ru)
CA (1) CA1202587A (ru)
DE (1) DE3379640D1 (ru)
DK (1) DK173007B1 (ru)
ES (1) ES8405760A1 (ru)
HU (1) HU189268B (ru)
IL (1) IL68397A (ru)
NL (1) NL8201650A (ru)
PL (1) PL143571B1 (ru)
SU (1) SU1232148A3 (ru)
ZA (1) ZA832602B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK309184D0 (da) * 1984-06-25 1984-06-25 Nordisk Insulinlab Fremgangsmaade til isolering af insulin eller insulinlignende materiale fra en fermenteringsvaeske
CN113956326B (zh) * 2021-09-15 2024-05-28 河南工业大学 一种短肽单体，结构自愈型肽基水凝胶及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten

Also Published As

Publication number Publication date
HU189268B (en) 1986-06-30
AU554050B2 (en) 1986-08-07
CA1202587A (en) 1986-04-01
JPH0533993B2 (ru) 1993-05-20
PL241575A1 (en) 1983-12-19
AU1355483A (en) 1983-10-27
JPS58189149A (ja) 1983-11-04
ATE42203T1 (de) 1989-05-15
ES521674A0 (es) 1984-06-16
EP0092280B1 (en) 1989-04-19
IL68397A0 (en) 1983-07-31
ZA832602B (en) 1984-01-25
ES8405760A1 (es) 1984-06-16
DK161683A (da) 1983-10-22
PL143571B1 (en) 1988-02-29
IL68397A (en) 1986-01-31
JPH05339290A (ja) 1993-12-21
US4840897A (en) 1989-06-20
SU1232148A3 (ru) 1986-05-15
JPH0735399B2 (ja) 1995-04-19
EP0092280A1 (en) 1983-10-26
DK161683D0 (da) 1983-04-13
DK173007B1 (da) 1999-11-08
DE3379640D1 (en) 1989-05-24

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Legal Events

Date Code Title Description
A1B A search report has been drawn up
A85 Still pending on 85-01-01
BV The patent application has lapsed