NL8102073A - Nieuw extract uit een plant van het geslacht epimedium sp., werkwijze voor het bereiden van het extract, de immuniteit stimulerend middel, dat het extract als effectieve component omvat en immunotherapie onder toepassing van het extract. - Google Patents
Nieuw extract uit een plant van het geslacht epimedium sp., werkwijze voor het bereiden van het extract, de immuniteit stimulerend middel, dat het extract als effectieve component omvat en immunotherapie onder toepassing van het extract. Download PDFInfo
- Publication number
- NL8102073A NL8102073A NL8102073A NL8102073A NL8102073A NL 8102073 A NL8102073 A NL 8102073A NL 8102073 A NL8102073 A NL 8102073A NL 8102073 A NL8102073 A NL 8102073A NL 8102073 A NL8102073 A NL 8102073A
- Authority
- NL
- Netherlands
- Prior art keywords
- extract
- water
- solvent
- reaction
- molecular weight
- Prior art date
Links
- 239000000284 extract Substances 0.000 title claims description 90
- 241000893536 Epimedium Species 0.000 title claims description 16
- 235000018905 epimedium Nutrition 0.000 title claims description 16
- 238000009169 immunotherapy Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000036039 immunity Effects 0.000 title description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 59
- 239000006286 aqueous extract Substances 0.000 claims description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 33
- 238000000605 extraction Methods 0.000 claims description 22
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 21
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 20
- 239000003960 organic solvent Substances 0.000 claims description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 238000000502 dialysis Methods 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 13
- 150000002605 large molecules Chemical class 0.000 claims description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- 238000005238 degreasing Methods 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
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- 229930182830 galactose Natural products 0.000 claims description 2
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- 241001362411 Epimedium sagittatum Species 0.000 description 2
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- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
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- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
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- XOOMNEFVDUTJPP-UHFFFAOYSA-N naphthalene-1,3-diol Chemical compound C1=CC=CC2=CC(O)=CC(O)=C21 XOOMNEFVDUTJPP-UHFFFAOYSA-N 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5742480 | 1980-04-30 | ||
| JP5742480A JPS56156219A (en) | 1980-04-30 | 1980-04-30 | Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent |
| JP8353980A JPS579719A (en) | 1980-06-20 | 1980-06-20 | Extract from plant of genus epimedium, its preparation and immunological enhancer containing the same as active constituent |
| JP8353980 | 1980-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8102073A true NL8102073A (nl) | 1981-11-16 |
Family
ID=26398465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8102073A NL8102073A (nl) | 1980-04-30 | 1981-04-28 | Nieuw extract uit een plant van het geslacht epimedium sp., werkwijze voor het bereiden van het extract, de immuniteit stimulerend middel, dat het extract als effectieve component omvat en immunotherapie onder toepassing van het extract. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4501736A (enExample) |
| CA (1) | CA1153696A (enExample) |
| CH (1) | CH652028A5 (enExample) |
| DE (1) | DE3116695C2 (enExample) |
| FR (1) | FR2481704A1 (enExample) |
| GB (1) | GB2076002B (enExample) |
| IT (1) | IT1136593B (enExample) |
| NL (1) | NL8102073A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701939A (en) * | 1985-04-01 | 1987-10-20 | General Electric Company | Method and apparatus for obtaining reliable synchronization over a noisy channel |
| US5674496A (en) * | 1993-10-20 | 1997-10-07 | New Mexico Tech Research Foundation | Animal repellent |
| CN1194702C (zh) * | 2002-12-18 | 2005-03-30 | 澳美制药厂有限公司 | 治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 |
| CN100389775C (zh) * | 2003-07-24 | 2008-05-28 | 复旦大学附属华山医院 | 淫羊藿总黄酮提取物在制备延缓免疫衰老药物中的应用 |
| JP6034293B2 (ja) * | 2010-11-05 | 2016-11-30 | ベイジン チョンアン アジュバント バイオテクノロジー カンパニー，リミティド | イカリソウの多糖、その画分、及びワクチンアジュバントとしてのその使用 |
-
1981
- 1981-04-28 DE DE3116695A patent/DE3116695C2/de not_active Expired
- 1981-04-28 NL NL8102073A patent/NL8102073A/nl not_active Application Discontinuation
- 1981-04-29 CA CA000376500A patent/CA1153696A/en not_active Expired
- 1981-04-30 GB GB8113312A patent/GB2076002B/en not_active Expired
- 1981-04-30 CH CH2842/81A patent/CH652028A5/de not_active IP Right Cessation
- 1981-04-30 FR FR8108748A patent/FR2481704A1/fr active Granted
- 1981-04-30 IT IT21484/81A patent/IT1136593B/it active
-
1983
- 1983-08-08 US US06/520,760 patent/US4501736A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1136593B (it) | 1986-09-03 |
| GB2076002A (en) | 1981-11-25 |
| US4501736A (en) | 1985-02-26 |
| DE3116695C2 (de) | 1985-03-07 |
| DE3116695A1 (de) | 1982-02-18 |
| CH652028A5 (de) | 1985-10-31 |
| FR2481704A1 (fr) | 1981-11-06 |
| CA1153696A (en) | 1983-09-13 |
| IT8121484A0 (it) | 1981-04-30 |
| GB2076002B (en) | 1984-06-06 |
| FR2481704B1 (enExample) | 1983-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |