NL8003036A - Pyrido(3,2-e)-as-triazinederivaten, farmaceutisch aanvaardbare zuuradditiezouten daarvan, werkwijze voor de bereiding van dergelijke derivaten, geneesmiddel met als werkzaam bestanddeel een dergelijke derivaat daarin en werkwijze voor de bereiding van dergelijke genees- middelen. - Google Patents
Pyrido(3,2-e)-as-triazinederivaten, farmaceutisch aanvaardbare zuuradditiezouten daarvan, werkwijze voor de bereiding van dergelijke derivaten, geneesmiddel met als werkzaam bestanddeel een dergelijke derivaat daarin en werkwijze voor de bereiding van dergelijke genees- middelen. Download PDFInfo
- Publication number
- NL8003036A NL8003036A NL8003036A NL8003036A NL8003036A NL 8003036 A NL8003036 A NL 8003036A NL 8003036 A NL8003036 A NL 8003036A NL 8003036 A NL8003036 A NL 8003036A NL 8003036 A NL8003036 A NL 8003036A
- Authority
- NL
- Netherlands
- Prior art keywords
- triazine
- formula
- group
- alkyl
- dihydropyrido
- Prior art date
Links
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- 239000002253 acid Substances 0.000 title claims description 28
- 238000000034 method Methods 0.000 title claims description 28
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- 230000008569 process Effects 0.000 title claims description 10
- 230000007721 medicinal effect Effects 0.000 title 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
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- 150000004820 halides Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- UYXAWHWODHRRMR-UHFFFAOYSA-N hexobarbital Chemical compound O=C1N(C)C(=O)NC(=O)C1(C)C1=CCCCC1 UYXAWHWODHRRMR-UHFFFAOYSA-N 0.000 description 1
- 229960002456 hexobarbital Drugs 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 239000003279 phenylacetic acid Substances 0.000 description 1
- 229960003424 phenylacetic acid Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- ATBIAJXSKNPHEI-UHFFFAOYSA-N pyridine-3-carbonyl chloride Chemical compound ClC(=O)C1=CC=CN=C1 ATBIAJXSKNPHEI-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUEE002664 | 1979-05-25 | ||
| HU79EE2664A HU179159B (en) | 1979-05-25 | 1979-05-25 | Process for producing new pyrido-square bracket-3,2-e-square bracket closed-asimmetrical-triasine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8003036A true NL8003036A (nl) | 1980-11-27 |
Family
ID=10995851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8003036A NL8003036A (nl) | 1979-05-25 | 1980-05-27 | Pyrido(3,2-e)-as-triazinederivaten, farmaceutisch aanvaardbare zuuradditiezouten daarvan, werkwijze voor de bereiding van dergelijke derivaten, geneesmiddel met als werkzaam bestanddeel een dergelijke derivaat daarin en werkwijze voor de bereiding van dergelijke genees- middelen. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4320127A (cs) |
| JP (1) | JPS55157585A (cs) |
| AT (1) | AT375371B (cs) |
| AU (1) | AU534540B2 (cs) |
| BE (1) | BE883355A (cs) |
| CH (1) | CH646168A5 (cs) |
| CS (1) | CS244406B2 (cs) |
| DD (1) | DD154489A5 (cs) |
| DE (1) | DE3020137A1 (cs) |
| ES (1) | ES491806A0 (cs) |
| FR (1) | FR2457291A1 (cs) |
| GB (1) | GB2051792B (cs) |
| GR (1) | GR68491B (cs) |
| HU (1) | HU179159B (cs) |
| IT (1) | IT1212416B (cs) |
| NL (1) | NL8003036A (cs) |
| SU (1) | SU982542A3 (cs) |
| YU (1) | YU135780A (cs) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549631A (en) * | 1968-09-27 | 1970-12-22 | American Cyanamid Co | 3,6 - disubstituted - pyrido(3,2-e) - triazines and 3,6 - disubstituted - 1,2 - dihydropyrido(3,2-e)-triazines |
| JPS5469686A (en) * | 1977-11-15 | 1979-06-04 | Omron Tateisi Electronics Co | Input control system |
-
1979
- 1979-05-25 HU HU79EE2664A patent/HU179159B/hu not_active IP Right Cessation
-
1980
- 1980-03-24 GR GR62044A patent/GR68491B/el unknown
- 1980-05-19 BE BE1/9825A patent/BE883355A/fr not_active IP Right Cessation
- 1980-05-20 YU YU01357/80A patent/YU135780A/xx unknown
- 1980-05-20 FR FR8011208A patent/FR2457291A1/fr active Granted
- 1980-05-23 JP JP6796680A patent/JPS55157585A/ja active Pending
- 1980-05-23 AT AT0278180A patent/AT375371B/de not_active IP Right Cessation
- 1980-05-23 IT IT8022280A patent/IT1212416B/it active
- 1980-05-23 DD DD80221352A patent/DD154489A5/de unknown
- 1980-05-23 SU SU802928212A patent/SU982542A3/ru active
- 1980-05-23 ES ES491806A patent/ES491806A0/es active Granted
- 1980-05-23 CH CH404280A patent/CH646168A5/de not_active IP Right Cessation
- 1980-05-23 GB GB8017172A patent/GB2051792B/en not_active Expired
- 1980-05-23 AU AU58711/80A patent/AU534540B2/en not_active Ceased
- 1980-05-23 US US06/152,833 patent/US4320127A/en not_active Expired - Lifetime
- 1980-05-23 CS CS803659A patent/CS244406B2/cs unknown
- 1980-05-27 DE DE19803020137 patent/DE3020137A1/de not_active Withdrawn
- 1980-05-27 NL NL8003036A patent/NL8003036A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CS244406B2 (en) | 1986-07-17 |
| FR2457291A1 (fr) | 1980-12-19 |
| DE3020137A1 (de) | 1981-01-29 |
| ES8106518A1 (es) | 1981-08-01 |
| CS365980A2 (en) | 1985-09-17 |
| SU982542A3 (ru) | 1982-12-15 |
| US4320127A (en) | 1982-03-16 |
| GB2051792B (en) | 1983-06-29 |
| IT8022280A0 (it) | 1980-05-23 |
| ATA278180A (de) | 1983-12-15 |
| AU534540B2 (en) | 1984-02-02 |
| CH646168A5 (de) | 1984-11-15 |
| FR2457291B1 (cs) | 1983-06-10 |
| AU5871180A (en) | 1980-11-27 |
| IT1212416B (it) | 1989-11-22 |
| GR68491B (cs) | 1982-01-07 |
| JPS55157585A (en) | 1980-12-08 |
| DD154489A5 (de) | 1982-03-24 |
| YU135780A (en) | 1983-02-28 |
| AT375371B (de) | 1984-07-25 |
| ES491806A0 (es) | 1981-08-01 |
| GB2051792A (en) | 1981-01-21 |
| HU179159B (en) | 1982-08-28 |
| BE883355A (fr) | 1980-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BT | A notification was added to the application dossier and made available to the public | ||
| BT | A notification was added to the application dossier and made available to the public | ||
| BT | A notification was added to the application dossier and made available to the public | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |