NL8003003A - Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica. - Google Patents

Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica. Download PDF

Info

Publication number
NL8003003A
NL8003003A NL8003003A NL8003003A NL8003003A NL 8003003 A NL8003003 A NL 8003003A NL 8003003 A NL8003003 A NL 8003003A NL 8003003 A NL8003003 A NL 8003003A NL 8003003 A NL8003003 A NL 8003003A
Authority
NL
Netherlands
Prior art keywords
ceph
pyridiniummethyl
amino
compound
formula
Prior art date
Application number
NL8003003A
Other languages
English (en)
Dutch (nl)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NL8003003A publication Critical patent/NL8003003A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
NL8003003A 1979-05-25 1980-05-23 Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica. NL8003003A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7918428 1979-05-25
GB7918428 1979-05-25

Publications (1)

Publication Number Publication Date
NL8003003A true NL8003003A (nl) 1980-11-27

Family

ID=10505477

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8003003A NL8003003A (nl) 1979-05-25 1980-05-23 Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.

Country Status (10)

Country Link
US (3) US4374983A (el)
JP (2) JPS5612397A (el)
BE (1) BE883453A (el)
CH (1) CH654010A5 (el)
DE (1) DE3019838A1 (el)
FR (1) FR2457295A1 (el)
GB (1) GB2052490B (el)
IT (1) IT1145686B (el)
NL (1) NL8003003A (el)
ZA (1) ZA803093B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
NZ195116A (en) * 1979-10-02 1982-09-07 Glaxo Group Ltd The crystalline bishydrochloride of a certain cephalosporin medicinal preparations
AU557274B2 (en) * 1981-07-17 1986-12-18 Glaxo Group Limited Cephalosporin antibiotics
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
GB2132616B (en) * 1982-12-27 1986-08-06 Lilly Co Eli Improvements in or relating to novel cephalosporin intermediates
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
DE3419014A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 7-amino-3-(3-formamidopyridinium)methyl-3-cephem-4-carboxylat und verwendung zur synthese von ss-lactamantibiotika
JPS6160296A (ja) * 1984-08-30 1986-03-27 Yoshitsuka Seiki:Kk 全自動粉末成形プレス
IL76367A0 (en) * 1984-09-17 1986-01-31 Lilly Co Eli Improved process for cephalsporin intermediates
EP0612750B1 (de) * 1984-11-23 1999-03-03 BIOCHEMIE Gesellschaft m.b.H. Cephalosporinderivative
JPH0649707B2 (ja) * 1985-03-01 1994-06-29 第一製薬株式会社 ３−ピリジニウムメチルセフエム誘導体
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4692518A (en) * 1985-11-06 1987-09-08 Eli Lilly And Company Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound
US4665168A (en) * 1986-04-14 1987-05-12 Eli Lilly And Company Cephalosporin intermediate
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
KR100342600B1 (ko) 2000-03-06 2002-07-04 한미정밀화학주식회사 신규한 티아졸 화합물 및 그의 제조 방법
KR100392409B1 (ko) 2000-03-20 2003-07-22 한미정밀화학주식회사 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB953695A (en) * 1959-08-04 1964-03-25 Nat Res Dev Derivatives of cephalosporin c
BE638034A (el) * 1962-10-03
GB1028563A (en) 1962-12-14 1966-05-04 Glaxo Lab Ltd Antibacterial derivative of 7-aminocephalosporanic acid
GB1052068A (el) * 1963-11-04
US3422099A (en) * 1966-02-18 1969-01-14 Bristol Myers Co 7-(alpha-hydroxy-(2' or 3'-thienyl)-acetamido) cephalosporanic acids and related salts and derivatives
GB1522140A (en) * 1974-12-20 1978-08-23 Glaxo Lab Ltd Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
ZA792581B (en) * 1978-05-26 1981-01-28 Glaxo Group Ltd Cephalosporin antibiotics
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
NZ195116A (en) * 1979-10-02 1982-09-07 Glaxo Group Ltd The crystalline bishydrochloride of a certain cephalosporin medicinal preparations

Also Published As

Publication number Publication date
FR2457295B1 (el) 1983-11-10
BE883453A (fr) 1980-11-24
IT1145686B (it) 1986-11-05
ZA803093B (en) 1981-07-29
FR2457295A1 (fr) 1980-12-19
US4433141A (en) 1984-02-21
CH654010A5 (de) 1986-01-31
DE3019838A1 (de) 1980-12-04
JPH0242085A (ja) 1990-02-13
US4369313A (en) 1983-01-18
US4374983A (en) 1983-02-22
IT8048772A0 (it) 1980-05-23
GB2052490B (en) 1983-09-07
GB2052490A (en) 1981-01-28
JPS5612397A (en) 1981-02-06
JPH0250914B2 (el) 1990-11-05

Similar Documents

Publication Publication Date Title
NL8003003A (nl) Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
US4396620A (en) Cephalosporin quinolinium betaines
CS247081B2 (en) Production method of cefemderivatives
US4402955A (en) Dioximino cephalosporin antibiotics
EP0002605B1 (en) Cephalosporin compounds and formulations containing them for use in the treatment of bacterial infections and the preparation of the cephalosporin compounds
US4450270A (en) Dioximino cephalosporin antibiotics
JPH0228185A (ja) セファロスポリン化合物及びその合成中間体
US4148817A (en) Process and intermediates for preparing cephalosporin antibiotics
JPS59130294A (ja) セフアロスポリン誘導体類およびその製造法
US3892737A (en) Cephalosporins
US4382931A (en) 3'-Substituted quinolinium cephalosporins
EP0238061B1 (en) Cephalosporin derivatives, processes for their preparation and antibacterial agents
JPH0811756B2 (ja) 反応性有機酸誘導体からセファロスポリン化合物の製造方法
EP0266060A2 (en) Cephalosporins, process for their preparation and pharmaceutical compositions containing them
JPS62158290A (ja) 新規セフアロスポリン誘導体
JPH025758B2 (el)
US4139702A (en) Process for preparing cephalosporines
CA1174668A (en) Bis-tetrazoylmethyl substituted cephalosporin antibiotics
JPS62103092A (ja) β−ラクタム誘導体
JPH09100283A (ja) セフェム化合物、その製造法および抗菌組成物
US4631339A (en) 1,3,5-triazepinones
US4223134A (en) Process for preparing cephalosporin antibiotics
US4091214A (en) De-esterification process for cephalosporins
NO743991L (el)
US4514564A (en) 7β-(2'-(1",3",5"-Triazepin-4"-one)-2'-(oxime ether)-acetamido)-3-substituted cephalosporins

Legal Events

Date Code Title Description
BT A notification was added to the application dossier and made available to the public
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed