ZA803093B - Intermediates for use in the preparation of cephalosporin antibiotics - Google Patents

Intermediates for use in the preparation of cephalosporin antibiotics

Info

Publication number
ZA803093B
ZA803093B ZA00803093A ZA803093A ZA803093B ZA 803093 B ZA803093 B ZA 803093B ZA 00803093 A ZA00803093 A ZA 00803093A ZA 803093 A ZA803093 A ZA 803093A ZA 803093 B ZA803093 B ZA 803093B
Authority
ZA
South Africa
Prior art keywords
intermediates
preparation
cephalosporin antibiotics
cephalosporin
antibiotics
Prior art date
Application number
ZA00803093A
Other languages
English (en)
Inventor
W Jones
J Robinson
T Gane
H Trivedi
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA803093B publication Critical patent/ZA803093B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
ZA00803093A 1979-05-25 1980-05-23 Intermediates for use in the preparation of cephalosporin antibiotics ZA803093B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7918428 1979-05-25

Publications (1)

Publication Number Publication Date
ZA803093B true ZA803093B (en) 1981-07-29

Family

ID=10505477

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00803093A ZA803093B (en) 1979-05-25 1980-05-23 Intermediates for use in the preparation of cephalosporin antibiotics

Country Status (10)

Country Link
US (3) US4374983A (el)
JP (2) JPS5612397A (el)
BE (1) BE883453A (el)
CH (1) CH654010A5 (el)
DE (1) DE3019838A1 (el)
FR (1) FR2457295A1 (el)
GB (1) GB2052490B (el)
IT (1) IT1145686B (el)
NL (1) NL8003003A (el)
ZA (1) ZA803093B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
NZ195116A (en) * 1979-10-02 1982-09-07 Glaxo Group Ltd The crystalline bishydrochloride of a certain cephalosporin medicinal preparations
AU557274B2 (en) * 1981-07-17 1986-12-18 Glaxo Group Limited Cephalosporin antibiotics
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
GB2132616B (en) * 1982-12-27 1986-08-06 Lilly Co Eli Improvements in or relating to novel cephalosporin intermediates
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
DE3419014A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 7-amino-3-(3-formamidopyridinium)methyl-3-cephem-4-carboxylat und verwendung zur synthese von ss-lactamantibiotika
JPS6160296A (ja) * 1984-08-30 1986-03-27 Yoshitsuka Seiki:Kk 全自動粉末成形プレス
IL76367A0 (en) * 1984-09-17 1986-01-31 Lilly Co Eli Improved process for cephalsporin intermediates
EP0612750B1 (de) * 1984-11-23 1999-03-03 BIOCHEMIE Gesellschaft m.b.H. Cephalosporinderivative
JPH0649707B2 (ja) * 1985-03-01 1994-06-29 第一製薬株式会社 ３−ピリジニウムメチルセフエム誘導体
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4692518A (en) * 1985-11-06 1987-09-08 Eli Lilly And Company Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound
US4665168A (en) * 1986-04-14 1987-05-12 Eli Lilly And Company Cephalosporin intermediate
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
KR100342600B1 (ko) 2000-03-06 2002-07-04 한미정밀화학주식회사 신규한 티아졸 화합물 및 그의 제조 방법
KR100392409B1 (ko) 2000-03-20 2003-07-22 한미정밀화학주식회사 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB953695A (en) * 1959-08-04 1964-03-25 Nat Res Dev Derivatives of cephalosporin c
BE638034A (el) * 1962-10-03
GB1028563A (en) 1962-12-14 1966-05-04 Glaxo Lab Ltd Antibacterial derivative of 7-aminocephalosporanic acid
GB1052068A (el) * 1963-11-04
US3422099A (en) * 1966-02-18 1969-01-14 Bristol Myers Co 7-(alpha-hydroxy-(2' or 3'-thienyl)-acetamido) cephalosporanic acids and related salts and derivatives
GB1522140A (en) * 1974-12-20 1978-08-23 Glaxo Lab Ltd Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
ZA792581B (en) * 1978-05-26 1981-01-28 Glaxo Group Ltd Cephalosporin antibiotics
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
NZ195116A (en) * 1979-10-02 1982-09-07 Glaxo Group Ltd The crystalline bishydrochloride of a certain cephalosporin medicinal preparations

Also Published As

Publication number Publication date
FR2457295B1 (el) 1983-11-10
BE883453A (fr) 1980-11-24
IT1145686B (it) 1986-11-05
FR2457295A1 (fr) 1980-12-19
US4433141A (en) 1984-02-21
CH654010A5 (de) 1986-01-31
DE3019838A1 (de) 1980-12-04
JPH0242085A (ja) 1990-02-13
US4369313A (en) 1983-01-18
US4374983A (en) 1983-02-22
NL8003003A (nl) 1980-11-27
IT8048772A0 (it) 1980-05-23
GB2052490B (en) 1983-09-07
GB2052490A (en) 1981-01-28
JPS5612397A (en) 1981-02-06
JPH0250914B2 (el) 1990-11-05

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