|
JPS4944348B1
(https=)
*
|
1969-09-05 |
1974-11-27 |
|
|
|
US4074042A
(en)
*
|
1975-08-07 |
1978-02-14 |
Research Corporation |
Pseudo-isocytidine
|
|
US4282349A
(en)
*
|
1976-12-13 |
1981-08-04 |
Board Of Control Of Michigan Technological University |
Crystalline ribofuranosyl halides and other derivatives and methods for producing same
|
|
US4175123A
(en)
*
|
1976-12-23 |
1979-11-20 |
Bayer Aktiengesellschaft |
Amino-sugar derivatives, process for their preparation and pharmaceutical composition thereof
|
|
US4438109A
(en)
|
1980-07-25 |
1984-03-20 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Tylosin derivatives
|
|
US4328336A
(en)
*
|
1980-08-26 |
1982-05-04 |
Icn Pharmaceuticals, Inc. |
9-(β-D-Ribofurandsyl)purine-6-carboxamide and related compounds
|
|
US4491659A
(en)
*
|
1981-03-30 |
1985-01-01 |
Merck & Co., Inc. |
2,6-Didioxy-3-amine,4-carboxy methylglycoside and related compounds
|
|
US4663446A
(en)
*
|
1983-06-27 |
1987-05-05 |
Trustees Of The Univ. Of Massachusetts |
N2 (phenyl substituted) deoxy guanosine containing compounds
|
|
JPS60231690A
(ja)
*
|
1984-05-01 |
1985-11-18 |
Kanto Ishi Pharma Co Ltd |
N―置換ノイラミン酸誘導体
|
|
JPS6137799A
(ja)
*
|
1984-07-31 |
1986-02-22 |
Suntory Ltd |
エリプチシン誘導体およびその製造法
|
|
JPH0217199A
(ja)
*
|
1988-07-05 |
1990-01-22 |
Japan Tobacco Inc |
2’−デオキシ−β−アデノシンの製造方法
|
|
DE69531729T2
(de)
*
|
1994-12-13 |
2004-08-05 |
Taiho Pharmaceutical Co. Ltd. |
3'-substuierte nukleosidderivate
|
|
DE69719673T2
(de)
*
|
1996-05-16 |
2003-12-18 |
Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo |
D-pentofuranose-derivate und verfahren zu ihrer herstellung
|
|
EP1964569A3
(en)
*
|
2000-04-13 |
2009-07-22 |
Pharmasset, Inc. |
3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
KR20080021797A
(ko)
|
2000-05-26 |
2008-03-07 |
이데닉스(케이만)리미티드 |
플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
|
|
WO2002057425A2
(en)
*
|
2001-01-22 |
2002-07-25 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
US8481712B2
(en)
|
2001-01-22 |
2013-07-09 |
Merck Sharp & Dohme Corp. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
US7105499B2
(en)
*
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
AU2002330154A1
(en)
|
2001-09-28 |
2003-04-07 |
Centre National De La Recherche Scientifique |
Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
|
|
US7217815B2
(en)
*
|
2002-01-17 |
2007-05-15 |
Valeant Pharmaceuticals North America |
2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents
|
|
AU2003232071A1
(en)
*
|
2002-05-06 |
2003-11-17 |
Genelabs Technologies, Inc. |
Nucleoside derivatives for treating hepatitis c virus infection
|
|
PL374781A1
(en)
|
2002-06-28 |
2005-10-31 |
Idenix (Cayman) Limited |
2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
MXPA04012779A
(es)
*
|
2002-06-28 |
2005-08-19 |
Idenix Cayman Ltd |
Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.
|
|
BR0312271A
(pt)
*
|
2002-06-28 |
2007-11-06 |
Idenix Cayman Ltd |
compostos, composições e seus usos para o tratamento de infecções por flaviviridae
|
|
NZ537662A
(en)
|
2002-06-28 |
2007-10-26 |
Idenix Cayman Ltd |
2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
|
HUE033832T2
(en)
|
2002-11-15 |
2018-01-29 |
Idenix Pharmaceuticals Llc |
2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
|
|
RU2005121904A
(ru)
|
2002-12-12 |
2006-01-20 |
Айденикс (Кайман) Лимитед (Ky) |
Способ получения 2`-разветвленных нуклеозидов
|
|
ITFI20030033A1
(it)
*
|
2003-02-10 |
2004-08-11 |
Inalco Spa |
Processo per la preparazione di derivati ribofuranosidici
|
|
AR043006A1
(es)
*
|
2003-02-12 |
2005-07-13 |
Merck & Co Inc |
Proceso para preparar ribonucleosidos ramificados
|
|
EP2345657A1
(en)
|
2003-05-30 |
2011-07-20 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
|
AU2005254057B2
(en)
|
2004-06-15 |
2011-02-17 |
Isis Pharmaceuticals, Inc. |
C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
AU2005285045B2
(en)
|
2004-09-14 |
2011-10-13 |
Gilead Sciences, Inc. |
Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
|
|
JP4516863B2
(ja)
*
|
2005-03-11 |
2010-08-04 |
株式会社ケンウッド |
音声合成装置、音声合成方法及びプログラム
|
|
CA2606195C
(en)
*
|
2005-05-02 |
2015-03-31 |
Merck And Co., Inc. |
Hcv ns3 protease inhibitors
|
|
AR057456A1
(es)
*
|
2005-07-20 |
2007-12-05 |
Merck & Co Inc |
Inhibidores de la proteasa ns3 del vhc
|
|
NZ565269A
(en)
*
|
2005-08-01 |
2010-03-26 |
Merck & Co Inc |
Macrocyclic peptides as HCV NS3 protease inhibitors
|
|
EP1976382B1
(en)
|
2005-12-23 |
2013-04-24 |
IDENIX Pharmaceuticals, Inc. |
Process for preparing a synthetic intermediate for preparation of branched nucleosides
|
|
GB0609492D0
(en)
*
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
GB0612423D0
(en)
*
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
AU2007309488B2
(en)
*
|
2006-10-24 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
|
AU2007309546A1
(en)
*
|
2006-10-24 |
2008-05-02 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
HCV NS3 protease inhibitors
|
|
CA2667146C
(en)
*
|
2006-10-24 |
2016-01-19 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
US8377874B2
(en)
*
|
2006-10-27 |
2013-02-19 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
|
BRPI0718161A2
(pt)
*
|
2006-10-27 |
2013-11-26 |
Merck & Co Inc |
Composto, composição farmacêutica, e, uso do composto.
|
|
CA2672250C
(en)
*
|
2006-12-20 |
2013-04-30 |
Ian Stansfield |
Antiviral indoles
|
|
GB0625345D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
GB0625349D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
|
AU2007342367B2
(en)
|
2007-01-05 |
2012-12-06 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
GB0709791D0
(en)
*
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
JP2010533699A
(ja)
*
|
2007-07-17 |
2010-10-28 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
C型肝炎感染症の治療のための大環状インドール誘導体
|
|
AU2008277377B2
(en)
*
|
2007-07-19 |
2013-08-01 |
Msd Italia S.R.L. |
Macrocyclic compounds as antiviral agents
|
|
GB0718575D0
(en)
*
|
2007-09-24 |
2007-10-31 |
Angeletti P Ist Richerche Bio |
Nucleoside derivatives as inhibitors of viral polymerases
|
|
WO2009134624A1
(en)
*
|
2008-04-28 |
2009-11-05 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
KR20110065440A
(ko)
*
|
2008-07-02 |
2011-06-15 |
아이데닉스 파마슈티칼스, 인코포레이티드 |
바이러스 감염의 치료를 위한 화합물 및 제약 조성물
|
|
EA019327B1
(ru)
|
2008-07-22 |
2014-02-28 |
Мерк Шарп Энд Домэ Корп. |
Макроциклическое хиноксалиновое соединение в качестве ингибитора протеазы вгс ns3
|
|
PT2376088T
(pt)
*
|
2008-12-23 |
2017-05-02 |
Gilead Pharmasset Llc |
Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
|
|
KR20110098849A
(ko)
*
|
2008-12-23 |
2011-09-01 |
파마셋 인코포레이티드 |
뉴클레오시드 유사체
|
|
SG194404A1
(en)
*
|
2008-12-23 |
2013-11-29 |
Gilead Pharmasset Llc |
Synthesis of purine nucleosides
|
|
WO2010082050A1
(en)
|
2009-01-16 |
2010-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
|
|
GB0900914D0
(en)
|
2009-01-20 |
2009-03-04 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
US8828930B2
(en)
|
2009-07-30 |
2014-09-09 |
Merck Sharp & Dohme Corp. |
Hepatitis C virus NS3 protease inhibitors
|
|
PT2609923T
(pt)
|
2010-03-31 |
2017-08-30 |
Gilead Pharmasset Llc |
Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
|
|
MX2012011222A
(es)
|
2010-04-01 |
2013-01-18 |
Centre Nat Rech Scient |
Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales.
|
|
BR112013005872A2
(pt)
|
2010-09-22 |
2019-09-24 |
Alios Biopharma Inc |
compostos, composição farmacêutica e respectivos usos
|
|
EP2691409B1
(en)
|
2011-03-31 |
2018-02-21 |
Idenix Pharmaceuticals LLC. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
WO2012142093A2
(en)
|
2011-04-13 |
2012-10-18 |
Merck Sharp & Dohme Corp. |
2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
|
WO2012142075A1
(en)
|
2011-04-13 |
2012-10-18 |
Merck Sharp & Dohme Corp. |
2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
|
BR112013026345A2
(pt)
|
2011-04-13 |
2019-04-24 |
Merck Sharp & Dohe Corp. |
composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv
|
|
WO2013009737A1
(en)
|
2011-07-13 |
2013-01-17 |
Merck Sharp & Dohme Corp. |
5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
|
|
US9416154B2
(en)
|
2011-07-13 |
2016-08-16 |
Merck Sharp & Dohme Corp. |
5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
|
EP2755985B1
(en)
|
2011-09-12 |
2017-11-01 |
Idenix Pharmaceuticals LLC |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
TW201329096A
(zh)
|
2011-09-12 |
2013-07-16 |
Idenix Pharmaceuticals Inc |
經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
|
|
US8507460B2
(en)
|
2011-10-14 |
2013-08-13 |
Idenix Pharmaceuticals, Inc. |
Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
|
|
EP2780026B1
(en)
|
2011-11-15 |
2019-10-23 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
EP2794630A4
(en)
|
2011-12-22 |
2015-04-01 |
Alios Biopharma Inc |
SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
|
|
WO2013106344A1
(en)
|
2012-01-12 |
2013-07-18 |
Ligand Pharmaceuticals, Inc. |
2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5'
|
|
WO2013142124A1
(en)
|
2012-03-21 |
2013-09-26 |
Vertex Pharmaceuticals Incorporated |
Solid forms of a thiophosphoramidate nucleotide prodrug
|
|
US9012427B2
(en)
|
2012-03-22 |
2015-04-21 |
Alios Biopharma, Inc. |
Pharmaceutical combinations comprising a thionucleotide analog
|
|
US9296778B2
(en)
|
2012-05-22 |
2016-03-29 |
Idenix Pharmaceuticals, Inc. |
3′,5′-cyclic phosphate prodrugs for HCV infection
|
|
WO2013177188A1
(en)
|
2012-05-22 |
2013-11-28 |
Idenix Pharmaceuticals, Inc. |
3',5'-cyclic phosphoramidate prodrugs for hcv infection
|
|
CA2873315A1
(en)
|
2012-05-22 |
2013-11-28 |
Idenix Pharamaceuticals, Inc. |
D-amino acid compounds for liver disease
|
|
SG11201407336PA
(en)
|
2012-05-25 |
2015-03-30 |
Janssen Sciences Ireland Uc |
Uracyl spirooxetane nucleosides
|
|
WO2014052638A1
(en)
|
2012-09-27 |
2014-04-03 |
Idenix Pharmaceuticals, Inc. |
Esters and malonates of sate prodrugs
|
|
KR102001280B1
(ko)
|
2012-10-08 |
2019-07-17 |
아이데닉스 파마슈티칼스 엘엘씨 |
Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체
|
|
WO2014066239A1
(en)
|
2012-10-22 |
2014-05-01 |
Idenix Pharmaceuticals, Inc. |
2',4'-bridged nucleosides for hcv infection
|
|
EP2935304A1
(en)
|
2012-12-19 |
2015-10-28 |
IDENIX Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
|
WO2014121417A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
|
WO2014121418A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
|
US9309275B2
(en)
|
2013-03-04 |
2016-04-12 |
Idenix Pharmaceuticals Llc |
3′-deoxy nucleosides for the treatment of HCV
|
|
US9339541B2
(en)
|
2013-03-04 |
2016-05-17 |
Merck Sharp & Dohme Corp. |
Thiophosphate nucleosides for the treatment of HCV
|
|
WO2014160484A1
(en)
|
2013-03-13 |
2014-10-02 |
Idenix Pharmaceuticals, Inc. |
Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
|
|
EP2981542B1
(en)
|
2013-04-01 |
2021-09-15 |
Idenix Pharmaceuticals LLC |
2',4'-fluoro nucleosides for the treatment of hcv
|
|
AU2014250762A1
(en)
|
2013-04-12 |
2015-10-29 |
Achillion Pharmaceuticals, Inc. |
Highly active nucleoside derivative for the treatment of HCV
|
|
US10005779B2
(en)
|
2013-06-05 |
2018-06-26 |
Idenix Pharmaceuticals Llc |
1′,4′-thio nucleosides for the treatment of HCV
|
|
WO2015017713A1
(en)
|
2013-08-01 |
2015-02-05 |
Idenix Pharmaceuticals, Inc. |
D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
|
|
WO2015161137A1
(en)
|
2014-04-16 |
2015-10-22 |
Idenix Pharmaceuticals, Inc. |
3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
|