JPS4944348B1
(xx)
*
|
1969-09-05 |
1974-11-27 |
|
|
US4074042A
(en)
*
|
1975-08-07 |
1978-02-14 |
Research Corporation |
Pseudo-isocytidine
|
US4282349A
(en)
*
|
1976-12-13 |
1981-08-04 |
Board Of Control Of Michigan Technological University |
Crystalline ribofuranosyl halides and other derivatives and methods for producing same
|
US4175123A
(en)
*
|
1976-12-23 |
1979-11-20 |
Bayer Aktiengesellschaft |
Amino-sugar derivatives, process for their preparation and pharmaceutical composition thereof
|
US4438109A
(en)
|
1980-07-25 |
1984-03-20 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Tylosin derivatives
|
US4328336A
(en)
*
|
1980-08-26 |
1982-05-04 |
Icn Pharmaceuticals, Inc. |
9-(β-D-Ribofurandsyl)purine-6-carboxamide and related compounds
|
US4491659A
(en)
*
|
1981-03-30 |
1985-01-01 |
Merck & Co., Inc. |
2,6-Didioxy-3-amine,4-carboxy methylglycoside and related compounds
|
US4663446A
(en)
*
|
1983-06-27 |
1987-05-05 |
Trustees Of The Univ. Of Massachusetts |
N2 (phenyl substituted) deoxy guanosine containing compounds
|
JPS60231690A
(ja)
*
|
1984-05-01 |
1985-11-18 |
Kanto Ishi Pharma Co Ltd |
N―置換ノイラミン酸誘導体
|
JPS6137799A
(ja)
*
|
1984-07-31 |
1986-02-22 |
Suntory Ltd |
エリプチシン誘導体およびその製造法
|
JPH0217199A
(ja)
*
|
1988-07-05 |
1990-01-22 |
Japan Tobacco Inc |
2’−デオキシ−β−アデノシンの製造方法
|
ES2206522T3
(es)
*
|
1994-12-13 |
2004-05-16 |
Taiho Pharmaceutical Co., Ltd. |
Derivados de nucleosido sustituidos en 3'.
|
CA2226363C
(en)
*
|
1996-05-16 |
2001-03-13 |
Taiho Pharmaceutical Co., Ltd. |
D-pentofuranose derivatives and process for preparing the same
|
AU2001259068A1
(en)
*
|
2000-04-13 |
2001-10-30 |
Pharmasset, Ltd. |
3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
EP1294735A2
(en)
*
|
2000-05-26 |
2003-03-26 |
Novirio Pharmaceuticals Limited |
Methods and compositions for treating flaviviruses and pestiviruses
|
US8481712B2
(en)
|
2001-01-22 |
2013-07-09 |
Merck Sharp & Dohme Corp. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
EP2399588B1
(en)
|
2001-01-22 |
2020-04-29 |
Merck Sharp & Dohme Corp. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
US7105499B2
(en)
*
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
US7138376B2
(en)
|
2001-09-28 |
2006-11-21 |
Idenix Pharmaceuticals, Inc. |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
|
US7217815B2
(en)
*
|
2002-01-17 |
2007-05-15 |
Valeant Pharmaceuticals North America |
2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents
|
AU2003232071A1
(en)
*
|
2002-05-06 |
2003-11-17 |
Genelabs Technologies, Inc. |
Nucleoside derivatives for treating hepatitis c virus infection
|
NZ537662A
(en)
|
2002-06-28 |
2007-10-26 |
Idenix Cayman Ltd |
2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
CN100348607C
(zh)
*
|
2002-06-28 |
2007-11-14 |
埃迪尼克斯(开曼)有限公司 |
用于治疗黄病毒科病毒感染的2’和3’-核苷前药
|
JP5087211B2
(ja)
*
|
2002-06-28 |
2012-12-05 |
イデニクス(ケイマン)リミテツド |
フラビウィルス感染治療のための2′および3′−ヌクレオシドプロドラッグ
|
MXPA04012802A
(es)
|
2002-06-28 |
2005-04-19 |
Idenix Cayman Ltd |
Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
US7824851B2
(en)
|
2002-11-15 |
2010-11-02 |
Idenix Pharmaceuticals, Inc. |
2′-branched nucleosides and Flaviviridae mutation
|
WO2004052899A2
(en)
|
2002-12-12 |
2004-06-24 |
Idenix (Cayman) Limited |
Process for the production of 2'-branched nucleosides
|
ITFI20030033A1
(it)
|
2003-02-10 |
2004-08-11 |
Inalco Spa |
Processo per la preparazione di derivati ribofuranosidici
|
AR043006A1
(es)
*
|
2003-02-12 |
2005-07-13 |
Merck & Co Inc |
Proceso para preparar ribonucleosidos ramificados
|
PT1633766T
(pt)
|
2003-05-30 |
2019-06-04 |
Gilead Pharmasset Llc |
Análogos de nucleósido fluorado modificado
|
WO2005123087A2
(en)
|
2004-06-15 |
2005-12-29 |
Merck & Co., Inc. |
C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
WO2006031725A2
(en)
|
2004-09-14 |
2006-03-23 |
Pharmasset, Inc. |
Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
|
JP4516863B2
(ja)
*
|
2005-03-11 |
2010-08-04 |
株式会社ケンウッド |
音声合成装置、音声合成方法及びプログラム
|
EP1879607B1
(en)
*
|
2005-05-02 |
2014-11-12 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
US7470664B2
(en)
*
|
2005-07-20 |
2008-12-30 |
Merck & Co., Inc. |
HCV NS3 protease inhibitors
|
RU2008107972A
(ru)
*
|
2005-08-01 |
2009-09-10 |
Мерк энд Ко., Инк. (US) |
Макроциклические пептиды в качестве ингибиторов ns3-протеазы hcv
|
US7781576B2
(en)
|
2005-12-23 |
2010-08-24 |
Idenix Pharmaceuticals, Inc. |
Process for preparing a synthetic intermediate for preparation of branched nucleosides
|
GB0609492D0
(en)
*
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
GB0612423D0
(en)
*
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
US8377873B2
(en)
*
|
2006-10-24 |
2013-02-19 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
CA2667266C
(en)
*
|
2006-10-24 |
2015-11-24 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
AU2007309544B2
(en)
*
|
2006-10-24 |
2012-05-31 |
Msd Italia S.R.L. |
HCV NS3 protease inhibitors
|
CA2667032A1
(en)
*
|
2006-10-27 |
2008-05-15 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
BRPI0718161A2
(pt)
|
2006-10-27 |
2013-11-26 |
Merck & Co Inc |
Composto, composição farmacêutica, e, uso do composto.
|
GB0625345D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
US8101595B2
(en)
*
|
2006-12-20 |
2012-01-24 |
Istituto di Ricerche di Biologia Molecolare P. Angletti SpA |
Antiviral indoles
|
GB0625349D0
(en)
*
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
WO2008085508A2
(en)
|
2007-01-05 |
2008-07-17 |
Merck & Co., Inc. |
Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
|
GB0709791D0
(en)
*
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
AU2008277440A1
(en)
*
|
2007-07-17 |
2009-01-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Macrocyclic indole derivatives for the treatment of hepatitis C infections
|
CA2699891C
(en)
*
|
2007-07-19 |
2013-10-22 |
Nigel Liverton |
Macrocyclic compounds as antiviral agents
|
GB0718575D0
(en)
*
|
2007-09-24 |
2007-10-31 |
Angeletti P Ist Richerche Bio |
Nucleoside derivatives as inhibitors of viral polymerases
|
CN102014911A
(zh)
*
|
2008-04-28 |
2011-04-13 |
默沙东公司 |
Hcv ns3蛋白酶抑制剂
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
RU2519947C2
(ru)
*
|
2008-07-02 |
2014-06-20 |
Айденикс Фармасьютикалз, Инк. |
Соединения и фармацевтические композиции для лечения вирусных инфекций
|
RS52534B
(en)
|
2008-07-22 |
2013-04-30 |
Merck Sharp & Dohme Corp. |
MACROCYCLIC COMPOUNDS OF HINOXALINE AS HCV NS3 PROTEASE INHIBITORS
|
TW201031675A
(en)
*
|
2008-12-23 |
2010-09-01 |
Pharmasset Inc |
Synthesis of purine nucleosides
|
EP2376514A2
(en)
*
|
2008-12-23 |
2011-10-19 |
Pharmasset, Inc. |
Nucleoside analogs
|
EP2376088B1
(en)
*
|
2008-12-23 |
2017-02-22 |
Gilead Pharmasset LLC |
6-O-Substituted-2-amino-purine nucleoside phosphoramidates
|
WO2010082050A1
(en)
|
2009-01-16 |
2010-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
|
GB0900914D0
(en)
|
2009-01-20 |
2009-03-04 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
WO2011014487A1
(en)
|
2009-07-30 |
2011-02-03 |
Merck Sharp & Dohme Corp. |
Hepatitis c virus ns3 protease inhibitors
|
UY33311A
(es)
|
2010-03-31 |
2011-10-31 |
Pharmasset Inc |
Fosforamidatos de nucleosidos
|
CN102917585A
(zh)
|
2010-04-01 |
2013-02-06 |
埃迪尼克斯医药公司 |
用于治疗病毒感染的化合物和药物组合物
|
CN103209987B
(zh)
|
2010-09-22 |
2017-06-06 |
艾丽奥斯生物制药有限公司 |
取代的核苷酸类似物
|
CA2843324A1
(en)
|
2011-03-31 |
2012-11-15 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
EP2697242B1
(en)
|
2011-04-13 |
2018-10-03 |
Merck Sharp & Dohme Corp. |
2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
JP2014515023A
(ja)
|
2011-04-13 |
2014-06-26 |
メルク・シャープ・アンド・ドーム・コーポレーション |
2’−置換ヌクレオシド誘導体およびウイルス疾患の処置のためのその使用方法
|
JP2014511875A
(ja)
|
2011-04-13 |
2014-05-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
2’−シアノ置換ヌクレオシド誘導体およびウイルス疾患の治療のためのその使用方法
|
US9416154B2
(en)
|
2011-07-13 |
2016-08-16 |
Merck Sharp & Dohme Corp. |
5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
|
EP2731433A4
(en)
|
2011-07-13 |
2014-12-31 |
Merck Sharp & Dohme |
5'-SUBSTITUTED NUCLEOSIDE ANALOGUES AND METHODS OF USE FOR THE TREATMENT OF VIRAL DISEASES
|
AU2012308900A1
(en)
|
2011-09-12 |
2013-05-09 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
EP2755983B1
(en)
|
2011-09-12 |
2017-03-15 |
Idenix Pharmaceuticals LLC. |
Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
|
US8507460B2
(en)
|
2011-10-14 |
2013-08-13 |
Idenix Pharmaceuticals, Inc. |
Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
|
EP2780026B1
(en)
|
2011-11-15 |
2019-10-23 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
AU2012358804B2
(en)
|
2011-12-22 |
2018-04-19 |
Alios Biopharma, Inc. |
Substituted phosphorothioate nucleotide analogs
|
WO2013106344A1
(en)
|
2012-01-12 |
2013-07-18 |
Ligand Pharmaceuticals, Inc. |
2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5'
|
WO2013142124A1
(en)
|
2012-03-21 |
2013-09-26 |
Vertex Pharmaceuticals Incorporated |
Solid forms of a thiophosphoramidate nucleotide prodrug
|
EP2827876A4
(en)
|
2012-03-22 |
2015-10-28 |
Alios Biopharma Inc |
PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
|
MX355708B
(es)
|
2012-05-22 |
2018-04-27 |
Idenix Pharmaceuticals Llc |
Compuestos de d-aminoacidos para enfermedades del higado.
|
US9109001B2
(en)
|
2012-05-22 |
2015-08-18 |
Idenix Pharmaceuticals, Inc. |
3′,5′-cyclic phosphoramidate prodrugs for HCV infection
|
WO2013177195A1
(en)
|
2012-05-22 |
2013-11-28 |
Idenix Pharmaceuticals, Inc. |
3',5'-cyclic phosphate prodrugs for hcv infection
|
EP2861611B1
(en)
|
2012-05-25 |
2016-07-13 |
Janssen Sciences Ireland UC |
Uracyl spirooxetane nucleosides
|
WO2014052638A1
(en)
|
2012-09-27 |
2014-04-03 |
Idenix Pharmaceuticals, Inc. |
Esters and malonates of sate prodrugs
|
CA2887578A1
(en)
|
2012-10-08 |
2014-04-17 |
Idenix Pharamaceuticals, Inc. |
2'-chloro nucleoside analogs for hcv infection
|
US10723754B2
(en)
|
2012-10-22 |
2020-07-28 |
Idenix Pharmaceuticals Llc |
2′,4′-bridged nucleosides for HCV infection
|
EP2935304A1
(en)
|
2012-12-19 |
2015-10-28 |
IDENIX Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
WO2014121417A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
WO2014121418A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
US9339541B2
(en)
|
2013-03-04 |
2016-05-17 |
Merck Sharp & Dohme Corp. |
Thiophosphate nucleosides for the treatment of HCV
|
US9309275B2
(en)
|
2013-03-04 |
2016-04-12 |
Idenix Pharmaceuticals Llc |
3′-deoxy nucleosides for the treatment of HCV
|
EP2970357A1
(en)
|
2013-03-13 |
2016-01-20 |
IDENIX Pharmaceuticals, Inc. |
Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
|
WO2014165542A1
(en)
|
2013-04-01 |
2014-10-09 |
Idenix Pharmaceuticals, Inc. |
2',4'-fluoro nucleosides for the treatment of hcv
|
WO2014169280A2
(en)
|
2013-04-12 |
2014-10-16 |
Achillion Pharmaceuticals, Inc. |
Deuterated nucleoside prodrugs useful for treating hcv
|
EP3004130B1
(en)
|
2013-06-05 |
2019-08-07 |
Idenix Pharmaceuticals LLC. |
1',4'-thio nucleosides for the treatment of hcv
|
US20150037282A1
(en)
|
2013-08-01 |
2015-02-05 |
Idenix Pharmaceuticals, Inc. |
D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
|
EP3131914B1
(en)
|
2014-04-16 |
2023-05-10 |
Idenix Pharmaceuticals LLC |
3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
|