NL165744C - Werkwijze ter bereiding van 14-hydroxy 7,8-dihydronor- morfinederivaten. - Google Patents

Werkwijze ter bereiding van 14-hydroxy 7,8-dihydronor- morfinederivaten.

Info

Publication number
NL165744C
NL165744C NL6618022.A NL6618022A NL165744C NL 165744 C NL165744 C NL 165744C NL 6618022 A NL6618022 A NL 6618022A NL 165744 C NL165744 C NL 165744C
Authority
NL
Netherlands
Prior art keywords
dihydronor
hydroxy
preparing
morphine derivatives
morphine
Prior art date
Application number
NL6618022.A
Other languages
English (en)
Dutch (nl)
Other versions
NL6618022A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
NL165744B (nl
Original Assignee
Endo Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Lab filed Critical Endo Lab
Publication of NL6618022A publication Critical patent/NL6618022A/xx
Publication of NL165744B publication Critical patent/NL165744B/xx
Application granted granted Critical
Publication of NL165744C publication Critical patent/NL165744C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL6618022.A 1966-01-19 1966-12-22 Werkwijze ter bereiding van 14-hydroxy 7,8-dihydronor- morfinederivaten. NL165744C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52170866A 1966-01-19 1966-01-19
US677727A US3393197A (en) 1966-01-19 1967-10-24 Nu-substituted-14-hydroxydihydronormorphines

Publications (3)

Publication Number Publication Date
NL6618022A NL6618022A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1967-07-20
NL165744B NL165744B (nl) 1980-12-15
NL165744C true NL165744C (nl) 1981-05-15

Family

ID=27060549

Family Applications (2)

Application Number Title Priority Date Filing Date
NL6618022.A NL165744C (nl) 1966-01-19 1966-12-22 Werkwijze ter bereiding van 14-hydroxy 7,8-dihydronor- morfinederivaten.
NL7805652A NL7805652A (nl) 1966-01-19 1978-05-24 Werkwijze om farmaceutische preparaten te bereiden met narcoticumantagonistische werking.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL7805652A NL7805652A (nl) 1966-01-19 1978-05-24 Werkwijze om farmaceutische preparaten te bereiden met narcoticumantagonistische werking.

Country Status (13)

Country Link
US (1) US3393197A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT292206B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH493522A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE1670616C3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK115631B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES334942A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR6112M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1119270A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL26896A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU52650A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL165744C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO120368B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE329402B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476757A (en) * 1966-04-18 1969-11-04 Syntex Corp Tetrahydropyranyl and tetrahydrofuranyl ethers of benzomorphans and morphanans
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
US4218454A (en) * 1977-07-08 1980-08-19 Sri International N-αMethylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives
US4269843A (en) * 1978-05-24 1981-05-26 Sri International N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4282215A (en) * 1980-06-17 1981-08-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4404211A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and flurbiprofen
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
US4404210A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
US4407804A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and indomethacin
US4404208A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
US4407805A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and zomepirac
AU565634B2 (en) * 1982-06-30 1987-09-24 E.I. Du Pont De Nemours And Company Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
US4402962A (en) * 1982-06-30 1983-09-06 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
US4477457A (en) * 1982-10-28 1984-10-16 E. I. Du Pont De Nemours And Company Method for inducing anorexia using nalmetrene
US4478840A (en) * 1983-10-11 1984-10-23 E. I. Du Pont De Nemours And Company Appetite suppressing compositions and methods
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
CA1280695C (en) * 1985-04-29 1991-02-26 Benigno M. Sulit, Jr. Nalbuphine-local anesthetic analgesic composition and method of producing analgesia
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
AU699114B2 (en) * 1994-05-31 1998-11-19 Mallinckrodt Chemical, Inc. The preparation of nalbuphine having low levels of beta-epimer
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
JP2005503425A (ja) * 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
AU2002316582B2 (en) * 2001-07-06 2007-03-15 Endo Pharmaceuticals, Inc. Oral administration of 6-hydroxy-oxymorphone for use as an analgesic
ATE376832T1 (de) * 2001-07-06 2007-11-15 Penwest Pharmaceuticals Co Verzögert freisetzende formulierungen von oxymorphon
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
WO2003026743A2 (en) * 2001-09-26 2003-04-03 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
WO2003051367A1 (en) * 2001-12-18 2003-06-26 Alexza Molecular Delivery Corporation Parental analgesic formulations comprising fentanyl and a cannabinoid receptor agonist
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004104492A2 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
CA2527693C (en) * 2003-06-04 2018-09-18 Harry G. Brittain Polymorphic forms of naltrexone
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
AU2004322756B2 (en) 2004-08-12 2011-04-14 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20070093517A1 (en) * 2005-10-24 2007-04-26 Gary Newton Local anesthetic compositions
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
MX2008013594A (es) * 2006-04-21 2009-01-16 Nektar Therapeutics Al Corp Reduccion estereoselectiva de una morfinona.
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
JP2010522189A (ja) * 2007-03-23 2010-07-01 マリンクロッド・インコーポレイテッド オリパビンからのオキシモルホンの改善された調製
ES2423180T3 (es) * 2007-04-16 2013-09-18 Mallinckrodt Llc Nueva reducción de opiáceos mediante reacción de transferencia de hidrógeno catalítica
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
US8067596B2 (en) 2007-12-17 2011-11-29 Mallinckrodt Llc Processes for the production of (+)- “Nal” morphinan compounds
WO2017046814A1 (en) * 2015-09-14 2017-03-23 Rusan Pharma Limited A safe and environment friendly process for producing nalbuphine or its pharmaceutically acceptable salts thereof
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320262A (en) * 1964-09-22 1967-05-16 Lewenstein 14 hydroxy morphine and codeine carboxymethyloximes

Also Published As

Publication number Publication date
DK115631B (da) 1969-10-27
GB1119270A (en) 1968-07-10
DE1795707A1 (de) 1973-10-11
NL6618022A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1967-07-20
DE1670616C3 (de) 1978-06-29
DE1670616B2 (de) 1977-11-10
NL165744B (nl) 1980-12-15
IL26896A (en) 1970-11-30
DE1670616A1 (de) 1970-09-10
CH493522A (de) 1970-07-15
FR6112M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1968-06-17
ES334942A1 (es) 1968-03-01
LU52650A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1967-02-20
US3393197A (en) 1968-07-16
NO120368B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1970-10-12
NL7805652A (nl) 1978-09-29
DE1795707C3 (de) 1979-12-20
DE1795707B2 (de) 1979-04-19
AT292206B (de) 1971-08-25
SE329402B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1970-10-12

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Legal Events

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SNR Assignments of patents or rights arising from examined patent applications

Owner name: E.I. DU PONT DE NEMOURS AND COMPANY

V4 Discontinued because of reaching the maximum lifetime of a patent