AT292206B - Verfahren zur Herstellung von neuen N-substituierten 14-Hydroxydihydronormorphin-Verbindungen - Google Patents

Verfahren zur Herstellung von neuen N-substituierten 14-Hydroxydihydronormorphin-Verbindungen

Info

Publication number
AT292206B
AT292206B AT1135867A AT1135867A AT292206B AT 292206 B AT292206 B AT 292206B AT 1135867 A AT1135867 A AT 1135867A AT 1135867 A AT1135867 A AT 1135867A AT 292206 B AT292206 B AT 292206B
Authority
AT
Austria
Prior art keywords
hydroxydihydronormorphine
substituted
compounds
preparation
new
Prior art date
Application number
AT1135867A
Other languages
English (en)
Original Assignee
Endo Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Lab filed Critical Endo Lab
Application granted granted Critical
Publication of AT292206B publication Critical patent/AT292206B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT1135867A 1966-01-19 1966-12-23 Verfahren zur Herstellung von neuen N-substituierten 14-Hydroxydihydronormorphin-Verbindungen AT292206B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52170866A 1966-01-19 1966-01-19
US677727A US3393197A (en) 1966-01-19 1967-10-24 Nu-substituted-14-hydroxydihydronormorphines

Publications (1)

Publication Number Publication Date
AT292206B true AT292206B (de) 1971-08-25

Family

ID=27060549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT1135867A AT292206B (de) 1966-01-19 1966-12-23 Verfahren zur Herstellung von neuen N-substituierten 14-Hydroxydihydronormorphin-Verbindungen

Country Status (13)

Country Link
US (1) US3393197A (de)
AT (1) AT292206B (de)
CH (1) CH493522A (de)
DE (2) DE1670616C3 (de)
DK (1) DK115631B (de)
ES (1) ES334942A1 (de)
FR (1) FR6112M (de)
GB (1) GB1119270A (de)
IL (1) IL26896A (de)
LU (1) LU52650A1 (de)
NL (2) NL165744C (de)
NO (1) NO120368B (de)
SE (1) SE329402B (de)

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US4218454A (en) * 1977-07-08 1980-08-19 Sri International N-αMethylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives
US4269843A (en) * 1978-05-24 1981-05-26 Sri International N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives
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US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4282215A (en) * 1980-06-17 1981-08-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4404210A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
US4407804A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and indomethacin
US4404208A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
US4407805A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and zomepirac
US4404211A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and flurbiprofen
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
US4402962A (en) * 1982-06-30 1983-09-06 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
AU565634B2 (en) * 1982-06-30 1987-09-24 E.I. Du Pont De Nemours And Company Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
US4477457A (en) * 1982-10-28 1984-10-16 E. I. Du Pont De Nemours And Company Method for inducing anorexia using nalmetrene
US4478840A (en) * 1983-10-11 1984-10-23 E. I. Du Pont De Nemours And Company Appetite suppressing compositions and methods
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
CA1280695C (en) * 1985-04-29 1991-02-26 Benigno M. Sulit, Jr. Nalbuphine-local anesthetic analgesic composition and method of producing analgesia
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
NZ287243A (en) * 1994-05-31 1997-12-19 Mallinckrodt Chemical Inc Process for production of nalbuphine form alpha-noroxymorphol
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20030138508A1 (en) * 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
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US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
EP1392262A1 (de) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US7276250B2 (en) * 2001-07-06 2007-10-02 Penwest Pharmaceuticals Company Sustained release formulations of oxymorphone
CA2452872A1 (en) * 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic
CA2459976A1 (en) * 2001-09-26 2003-04-03 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625334B9 (de) 2003-05-21 2012-07-25 Alexza Pharmaceuticals, Inc. Schlag gezündete unabhängige heizeinheit
WO2004108084A2 (en) 2003-06-04 2004-12-16 Alkermes Controlled Therapeutics, Ii Polymorphic forms of naltrexone
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7581540B2 (en) 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
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US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
JP5586223B2 (ja) * 2006-04-21 2014-09-10 ネクター セラピューティクス モルヒノンの立体選択的還元
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
CA2681740A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
MX2009010931A (es) * 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
US8067596B2 (en) 2007-12-17 2011-11-29 Mallinckrodt Llc Processes for the production of (+)- “Nal” morphinan compounds
WO2017046814A1 (en) * 2015-09-14 2017-03-23 Rusan Pharma Limited A safe and environment friendly process for producing nalbuphine or its pharmaceutically acceptable salts thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320262A (en) * 1964-09-22 1967-05-16 Lewenstein 14 hydroxy morphine and codeine carboxymethyloximes

Also Published As

Publication number Publication date
DE1670616B2 (de) 1977-11-10
NL7805652A (nl) 1978-09-29
NL165744B (nl) 1980-12-15
FR6112M (de) 1968-06-17
DE1670616C3 (de) 1978-06-29
DE1795707B2 (de) 1979-04-19
NL6618022A (de) 1967-07-20
ES334942A1 (es) 1968-03-01
GB1119270A (en) 1968-07-10
NO120368B (de) 1970-10-12
DE1795707C3 (de) 1979-12-20
DE1795707A1 (de) 1973-10-11
CH493522A (de) 1970-07-15
DE1670616A1 (de) 1970-09-10
SE329402B (de) 1970-10-12
IL26896A (en) 1970-11-30
NL165744C (nl) 1981-05-15
DK115631B (da) 1969-10-27
LU52650A1 (de) 1967-02-20
US3393197A (en) 1968-07-16

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ELA Expired due to lapse of time