IL26896A - 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones - Google Patents

14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones

Info

Publication number
IL26896A
IL26896A IL26896A IL2689666A IL26896A IL 26896 A IL26896 A IL 26896A IL 26896 A IL26896 A IL 26896A IL 2689666 A IL2689666 A IL 2689666A IL 26896 A IL26896 A IL 26896A
Authority
IL
Israel
Prior art keywords
group
formula
compounds
compound
methyl
Prior art date
Application number
IL26896A
Other languages
English (en)
Hebrew (he)
Original Assignee
Endo Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Lab filed Critical Endo Lab
Publication of IL26896A publication Critical patent/IL26896A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
IL26896A 1966-01-19 1966-11-20 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones IL26896A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52170866A 1966-01-19 1966-01-19
US677727A US3393197A (en) 1966-01-19 1967-10-24 Nu-substituted-14-hydroxydihydronormorphines

Publications (1)

Publication Number Publication Date
IL26896A true IL26896A (en) 1970-11-30

Family

ID=27060549

Family Applications (1)

Application Number Title Priority Date Filing Date
IL26896A IL26896A (en) 1966-01-19 1966-11-20 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones

Country Status (13)

Country Link
US (1) US3393197A (de)
AT (1) AT292206B (de)
CH (1) CH493522A (de)
DE (2) DE1795707C3 (de)
DK (1) DK115631B (de)
ES (1) ES334942A1 (de)
FR (1) FR6112M (de)
GB (1) GB1119270A (de)
IL (1) IL26896A (de)
LU (1) LU52650A1 (de)
NL (2) NL165744C (de)
NO (1) NO120368B (de)
SE (1) SE329402B (de)

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US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
US4218454A (en) * 1977-07-08 1980-08-19 Sri International N-αMethylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives
US4269843A (en) * 1978-05-24 1981-05-26 Sri International N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4282215A (en) * 1980-06-17 1981-08-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4404208A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and tiflamizole
US4404211A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and flurbiprofen
US4407805A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and zomepirac
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
US4407804A (en) * 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and indomethacin
US4404210A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
AU565634B2 (en) * 1982-06-30 1987-09-24 E.I. Du Pont De Nemours And Company Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
US4402962A (en) * 1982-06-30 1983-09-06 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
US4477457A (en) * 1982-10-28 1984-10-16 E. I. Du Pont De Nemours And Company Method for inducing anorexia using nalmetrene
US4478840A (en) * 1983-10-11 1984-10-23 E. I. Du Pont De Nemours And Company Appetite suppressing compositions and methods
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
CA1280695C (en) * 1985-04-29 1991-02-26 Benigno M. Sulit, Jr. Nalbuphine-local anesthetic analgesic composition and method of producing analgesia
DE4132159A1 (de) * 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
JP4040673B2 (ja) * 1994-05-31 2008-01-30 マリンクロッド・ケミカル・インコーポレイテッド ベータ−エピマーが低レベルであるナルブフィンの製造
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
WO2003004030A1 (en) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
ES2292775T3 (es) * 2001-07-06 2008-03-16 Penwest Pharmaceuticals Co. Formulaciones de liberacion prolongada de oximorfona.
EP1429730A4 (de) * 2001-09-26 2010-06-16 Penwest Pharmaceuticals Compan Opioid-formulierungen mit verringertem missbrauchspotenzial
AU2002361742A1 (en) * 2001-12-18 2003-06-30 Alexza Molecular Delivery Corporation Parental analgesic formulations comprising fentanyl and a cannabinoid receptor agonist
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
WO2004108084A2 (en) * 2003-06-04 2004-12-16 Alkermes Controlled Therapeutics, Ii Polymorphic forms of naltrexone
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
AU2004322756B2 (en) 2004-08-12 2011-04-14 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20070093517A1 (en) * 2005-10-24 2007-04-26 Gary Newton Local anesthetic compositions
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
NZ572252A (en) 2006-04-21 2011-09-30 Nektar Therapeutics Stereoselective reduction of a morphinone
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
PL2125824T3 (pl) * 2007-03-23 2014-05-30 SpecGx LLC Ulepszony sposób wytwarzania oksymorfonu z oripawiny
US8309727B2 (en) * 2007-04-16 2012-11-13 Mallinckrodt Llc Opiate reduction utilizing catalytic hydrogen transfer reaction
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
CA2709886C (en) 2007-12-17 2016-10-25 Mallinckrodt Inc. Processes for the production of (+)-"nal" morphinan compounds
WO2017046814A1 (en) * 2015-09-14 2017-03-23 Rusan Pharma Limited A safe and environment friendly process for producing nalbuphine or its pharmaceutically acceptable salts thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320262A (en) * 1964-09-22 1967-05-16 Lewenstein 14 hydroxy morphine and codeine carboxymethyloximes

Also Published As

Publication number Publication date
NL165744C (nl) 1981-05-15
NL165744B (nl) 1980-12-15
DE1670616A1 (de) 1970-09-10
DE1795707C3 (de) 1979-12-20
AT292206B (de) 1971-08-25
DK115631B (da) 1969-10-27
DE1795707B2 (de) 1979-04-19
GB1119270A (en) 1968-07-10
DE1670616B2 (de) 1977-11-10
SE329402B (de) 1970-10-12
CH493522A (de) 1970-07-15
NL7805652A (nl) 1978-09-29
LU52650A1 (de) 1967-02-20
DE1670616C3 (de) 1978-06-29
ES334942A1 (es) 1968-03-01
US3393197A (en) 1968-07-16
NO120368B (de) 1970-10-12
DE1795707A1 (de) 1973-10-11
NL6618022A (de) 1967-07-20
FR6112M (de) 1968-06-17

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