NL1024013C2 - Trapsgewijs (cascade) hydrodynamisch richten in microfluïde kanalen. - Google Patents
Trapsgewijs (cascade) hydrodynamisch richten in microfluïde kanalen. Download PDFInfo
- Publication number
- NL1024013C2 NL1024013C2 NL1024013A NL1024013A NL1024013C2 NL 1024013 C2 NL1024013 C2 NL 1024013C2 NL 1024013 A NL1024013 A NL 1024013A NL 1024013 A NL1024013 A NL 1024013A NL 1024013 C2 NL1024013 C2 NL 1024013C2
- Authority
- NL
- Netherlands
- Prior art keywords
- channels
- fluid
- center channel
- hydraulic diameter
- envelope
- Prior art date
Links
- 239000012530 fluid Substances 0.000 claims description 160
- 238000000034 method Methods 0.000 claims description 36
- 238000004891 communication Methods 0.000 claims description 19
- 238000001514 detection method Methods 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 6
- -1 polytetrafluoroethylene Polymers 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000008685 targeting Effects 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 3
- 229920001971 elastomer Polymers 0.000 claims description 3
- 239000000806 elastomer Substances 0.000 claims description 3
- 229920002492 poly(sulfone) Polymers 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 239000004417 polycarbonate Substances 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- 239000010453 quartz Substances 0.000 claims description 3
- 239000010980 sapphire Substances 0.000 claims description 3
- 229910052594 sapphire Inorganic materials 0.000 claims description 3
- 239000002210 silicon-based material Substances 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims 2
- 239000000758 substrate Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000009792 diffusion process Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000032258 transport Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000020030 perry Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000001712 DNA sequencing Methods 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 230000007257 malfunction Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 238000004557 single molecule detection Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00833—Plastic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00867—Microreactors placed in series, on the same or on different supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23217002 | 2002-08-30 | ||
| US10/232,170 US20040043506A1 (en) | 2002-08-30 | 2002-08-30 | Cascaded hydrodynamic focusing in microfluidic channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL1024013A1 NL1024013A1 (nl) | 2004-03-02 |
| NL1024013C2 true NL1024013C2 (nl) | 2005-07-19 |
Family
ID=22872139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1024013A NL1024013C2 (nl) | 2002-08-30 | 2003-07-28 | Trapsgewijs (cascade) hydrodynamisch richten in microfluïde kanalen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040043506A1 (enExample) |
| JP (1) | JP2004093553A (enExample) |
| KR (1) | KR100508326B1 (enExample) |
| CN (1) | CN1482369A (enExample) |
| DE (1) | DE10334341A1 (enExample) |
| GB (1) | GB2392397B (enExample) |
| NL (1) | NL1024013C2 (enExample) |
| TW (1) | TW200412482A (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
| US7242474B2 (en) * | 2004-07-27 | 2007-07-10 | Cox James A | Cytometer having fluid core stream position control |
| US20090065471A1 (en) * | 2003-02-10 | 2009-03-12 | Faris Sadeg M | Micro-nozzle, nano-nozzle, manufacturing methods therefor, applications therefor |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| WO2004113877A1 (en) * | 2003-06-13 | 2004-12-29 | The General Hospital Corporation | Microfluidic systems for size based removal of red blood cells and platelets from blood |
| JP5138223B2 (ja) | 2003-10-30 | 2013-02-06 | サイトノーム エスティー リミテッド ライアビリティー カンパニー | 流体力学的多層シースフロー構造 |
| EP1776449A4 (en) * | 2004-03-03 | 2009-08-12 | Gen Hospital Corp | MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT |
| US7438792B2 (en) * | 2004-04-20 | 2008-10-21 | The Regents Of The University Of California | Separation system with a sheath-flow supported electrochemical detector |
| WO2006061025A2 (en) * | 2004-12-09 | 2006-06-15 | Inverness Medical Switzerland Gmbh | A method of producing a micro fluidic device and a micro fluidic device |
| US20100089529A1 (en) * | 2005-01-12 | 2010-04-15 | Inverness Medical Switzerland Gmbh | Microfluidic devices and production methods therefor |
| US20070026415A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070026414A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070059680A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for cell enrichment |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20090181421A1 (en) * | 2005-07-29 | 2009-07-16 | Ravi Kapur | Diagnosis of fetal abnormalities using nucleated red blood cells |
| US20070026416A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
| US20070059683A1 (en) * | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| KR101419312B1 (ko) | 2006-09-01 | 2014-07-14 | 도소 가부시키가이샤 | 미소유로 구조 및 그것을 사용한 미소입자 제조 방법 |
| CA2665536C (en) | 2006-10-05 | 2016-02-16 | Massachusetts Institute Of Technology | Multifunctional encoded particles for high-throughput analysis |
| CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
| EP2101917A1 (en) * | 2007-01-10 | 2009-09-23 | Scandinavian Micro Biodevices A/S | A microfluidic device and a microfluidic system and a method of performing a test |
| EP2286125B1 (en) | 2008-05-16 | 2015-07-08 | President and Fellows of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
| EP2294409B1 (en) | 2008-06-17 | 2016-08-10 | The Governing Council Of The University Of Toronto | Device for investigation of a flow conduit |
| US20090318303A1 (en) * | 2008-06-20 | 2009-12-24 | International Business Machines Corporation | Microfluidic selection of library elements |
| HUE031848T2 (en) | 2008-09-20 | 2017-08-28 | Univ Leland Stanford Junior | Non-invasive diagnosis of fetal aneuploidy by sequencing |
| JP2012504764A (ja) | 2008-10-02 | 2012-02-23 | ピクセル メディカル テクノロジーズ リミテッド | 粘弾性フォーカシングに基づく光学的撮像 |
| DK2440941T3 (en) * | 2009-06-10 | 2017-08-28 | Cynvenio Biosystems Inc | Sheath flow devices and methods |
| US8034629B2 (en) * | 2009-06-26 | 2011-10-11 | Massachusetts Institute Of Technology | High precision scanning of encoded hydrogel microparticles |
| US9476101B2 (en) | 2010-06-07 | 2016-10-25 | Firefly Bioworks, Inc. | Scanning multifunctional particles |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| EP4220124A1 (en) | 2013-03-14 | 2023-08-02 | Cytonome/ST, LLC | Hydrodynamic focusing apparatus and methods |
| US9757726B2 (en) | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
| US10371622B2 (en) | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
| BR122016005348B1 (pt) * | 2013-03-14 | 2023-01-24 | Inguran, Llc | Sistema e método de triagem de espermatozoides |
| US10662408B2 (en) | 2013-03-14 | 2020-05-26 | Inguran, Llc | Methods for high throughput sperm sorting |
| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| EP3608022A1 (en) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
| CN103240023B (zh) * | 2013-05-09 | 2015-01-07 | 四川大学 | 一种微手术刀触发液滴融合的方法 |
| EP3022544A4 (en) * | 2013-07-16 | 2017-06-21 | Premium Genetics (UK) Ltd. | Microfluidic chip |
| US8961904B2 (en) * | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| EP3570005A1 (en) | 2013-10-30 | 2019-11-20 | ABS Global, Inc. | Microfluidic system and method with focused energy apparatus |
| US10130950B2 (en) | 2013-11-27 | 2018-11-20 | Bio-Rad Laboratories, Inc. | Microfluidic droplet packing |
| JP2017505920A (ja) * | 2014-01-14 | 2017-02-23 | センター ナショナル デ ラ リシェルシェ サイエンティフィック（シーエヌアールエス） | 流れる汚染物質の分析のためのマイクロ流体デバイス |
| US10307760B2 (en) * | 2014-01-30 | 2019-06-04 | The General Hospital Corporation | Inertio-elastic focusing of particles in microchannels |
| CN103848394A (zh) * | 2014-02-21 | 2014-06-11 | 上海大学 | 基于微流体芯片的多种纳米线阵列水力聚焦组装方法 |
| EP3259579B1 (en) | 2015-02-19 | 2022-09-14 | 1087 Systems, Inc. | Scanning infrared measurement system |
| CN105149019B (zh) * | 2015-06-29 | 2017-04-19 | 清华大学 | 用于二维流体动力聚焦的微流道结构和微流体芯片 |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| WO2017035262A1 (en) * | 2015-08-24 | 2017-03-02 | Gpb Scientific, Llc | Methods and devices for multi-step cell purification and concentration |
| US20170059590A1 (en) | 2015-08-27 | 2017-03-02 | Ativa Medical Corporation | Fluid holding and dispensing micro-feature |
| US11071982B2 (en) | 2015-08-27 | 2021-07-27 | Ativa Medical Corporation | Fluid holding and dispensing micro-feature |
| US9366606B1 (en) | 2015-08-27 | 2016-06-14 | Ativa Medical Corporation | Fluid processing micro-feature devices and methods |
| US20170059459A1 (en) * | 2015-08-27 | 2017-03-02 | Ativa Medical Corporation | Fluid processing micro-feature devices and methods |
| DE102015115343B4 (de) * | 2015-09-11 | 2017-10-26 | Leibniz-Institut für Photonische Technologien e. V. | Anordnung und Verfahren für die Fluidrotation |
| CN108603827A (zh) | 2015-09-11 | 2018-09-28 | 莱布尼茨光电技术研究所 | 用于个体化的患者血液分析的装置 |
| GB201516447D0 (en) * | 2015-09-16 | 2015-10-28 | Sphere Fluidics Ltd | Microfluidic structure |
| US10913039B2 (en) * | 2016-07-06 | 2021-02-09 | Hewlett-Packard Development Company, L.P. | Microfluidic mixer |
| AU2017328510B2 (en) * | 2016-09-15 | 2022-02-24 | Department Of Biotechnology | A multi-dimensional micro fluid focusing device |
| CN107376796B (zh) * | 2017-07-10 | 2019-09-17 | 于志远 | 一种微反应器的加工方法及微反应器 |
| CA3074495A1 (en) | 2017-09-01 | 2019-03-07 | Gpb Scientific, Llc | Methods for preparing therapeutically active cells using microfluidics |
| GB201720627D0 (en) * | 2017-12-11 | 2018-01-24 | Cambridge Entpr Ltd | Fluidic apparatus and methods |
| BR112020023607A2 (pt) | 2018-05-23 | 2021-02-17 | Abs Global, Inc. | sistemas e métodos para focalização de partículas em microcanais |
| CN108896470B (zh) * | 2018-07-31 | 2021-03-16 | 电子科技大学 | 基于led阵列的微流通道旋转细胞相衬成像方法及系统 |
| CN108896471B (zh) * | 2018-07-31 | 2021-03-16 | 电子科技大学 | 基于led阵列微流通道活细胞相衬成像方法及系统 |
| EP4245140A3 (en) | 2019-04-18 | 2024-01-17 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
| US20210033521A1 (en) | 2019-07-30 | 2021-02-04 | Diatron MI PLC | Flow cytometer and method of analysis |
| CN110787846B (zh) * | 2019-11-05 | 2021-04-16 | 华中科技大学 | 一种一步式双层微液滴生成装置及方法 |
| CN112973811B (zh) * | 2019-12-17 | 2022-10-18 | 香港城市大学深圳研究院 | 一种基于层流扩散的血液中外泌体富集微流控芯片 |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| FR3108860B1 (fr) * | 2020-04-07 | 2023-04-21 | Centre Nat Rech Scient | Microreacteurs en saphir |
| KR102134655B1 (ko) * | 2020-04-23 | 2020-07-16 | 농업회사법인 상상텃밭 주식회사 | 용존산소량 및 양액 농도 조절이 가능한 양액 재배 장치 및 방법 |
| JP7633402B2 (ja) | 2020-11-23 | 2025-02-19 | エイビーエス グローバル、インコーポレイテッド | モジュール式フロー・サイトメトリ・システム及びサンプル処理方法 |
| CN113134331B (zh) * | 2021-05-08 | 2021-10-26 | 南开大学 | 反应器、快检尾气二次气溶胶生成因子的系统及方法 |
| US20250128256A1 (en) * | 2022-01-25 | 2025-04-24 | President And Fellows Of Harvard College | Microfluidic devices with autonomous directional valves |
| CN114645986B (zh) * | 2022-03-30 | 2024-04-26 | 深圳麦科田生物医疗技术股份有限公司 | 一种同轴流体液路结构 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000070080A1 (en) * | 1999-05-17 | 2000-11-23 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| US6171865B1 (en) * | 1996-03-29 | 2001-01-09 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159739A (en) * | 1997-03-26 | 2000-12-12 | University Of Washington | Device and method for 3-dimensional alignment of particles in microfabricated flow channels |
| US6540895B1 (en) * | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
| CA2320296A1 (en) * | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
| US6592821B1 (en) * | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
-
2002
- 2002-08-30 US US10/232,170 patent/US20040043506A1/en not_active Abandoned
-
2003
- 2003-05-06 GB GB0310257A patent/GB2392397B/en not_active Expired - Fee Related
- 2003-05-14 TW TW092113087A patent/TW200412482A/zh unknown
- 2003-06-03 JP JP2003158055A patent/JP2004093553A/ja active Pending
- 2003-06-09 KR KR10-2003-0036838A patent/KR100508326B1/ko not_active Expired - Fee Related
- 2003-07-28 DE DE10334341A patent/DE10334341A1/de not_active Withdrawn
- 2003-07-28 NL NL1024013A patent/NL1024013C2/nl not_active IP Right Cessation
- 2003-07-30 CN CNA03152253XA patent/CN1482369A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171865B1 (en) * | 1996-03-29 | 2001-01-09 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
| WO2000070080A1 (en) * | 1999-05-17 | 2000-11-23 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040019869A (ko) | 2004-03-06 |
| NL1024013A1 (nl) | 2004-03-02 |
| TW200412482A (en) | 2004-07-16 |
| GB0310257D0 (en) | 2003-06-11 |
| JP2004093553A (ja) | 2004-03-25 |
| DE10334341A1 (de) | 2004-03-18 |
| GB2392397A (en) | 2004-03-03 |
| HK1060323A1 (en) | 2004-08-06 |
| GB2392397B (en) | 2005-01-19 |
| US20040043506A1 (en) | 2004-03-04 |
| CN1482369A (zh) | 2004-03-17 |
| KR100508326B1 (ko) | 2005-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL1024013C2 (nl) | Trapsgewijs (cascade) hydrodynamisch richten in microfluïde kanalen. | |
| US11027278B2 (en) | Methods for controlling fluid flow in a microfluidic system | |
| Lee et al. | The hydrodynamic focusing effect inside rectangular microchannels | |
| Osborn et al. | Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks | |
| US7069943B2 (en) | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel | |
| Oh et al. | Design of pressure-driven microfluidic networks using electric circuit analogy | |
| Kim et al. | A serial dilution microfluidic device using a ladder network generating logarithmic or linear concentrations | |
| Yamada et al. | Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics | |
| Saias et al. | Design, modeling and characterization of microfluidic architectures for high flow rate, small footprint microfluidic systems | |
| EP3993905B1 (de) | Mikrofluidische vorrichtung und verfahren zum prozessieren und aliquotieren einer probenflüssigkeit | |
| US20150367344A1 (en) | Microfluidic device | |
| Agnihotri et al. | Microvalves for integrated selective droplet generation, splitting and merging on a chip | |
| Zhang et al. | PZT actuator-controlled high-frequency microdroplet generation: Reducing the restrictions of channel size, fluid viscosity, and flow rate | |
| Chen et al. | Generation of dynamic chemical signals with microfluidic C-DACs | |
| Moritani et al. | Generation of uniform-size droplets by multistep hydrodynamic droplet division in microfluidic circuits | |
| US20080160603A1 (en) | Flow stabilization in micro-and nanofluidic devices | |
| KR20020085903A (ko) | 미세 혼합 채널 장치 | |
| US20250065324A1 (en) | Fluidic transistors and uses thereof | |
| JP2004157097A (ja) | 液体制御機構 | |
| Neils et al. | Combinatorial microfluidic devices for cell biology | |
| Sabry | Microfluidics: How can Microfluidics speed up COVID19 vaccine? | |
| Köhler et al. | Microphotometric characterization of fluid segment populations generated in different simple microfluidic networks | |
| Ahmadi et al. | System integration in microfluidics | |
| Khajuria et al. | Investigation of the effect of gravity on fluid flow across a Cu-mica microchannel | |
| Pramuanjaroenkij et al. | The two-phase microchannel flow study of chicken blood on lab-on-a-chip |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AD1A | A request for search or an international type search has been filed | ||
| RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 20050317 |
|
| PD2B | A search report has been drawn up | ||
| VD1 | Lapsed due to non-payment of the annual fee |
Effective date: 20080201 |