NL1007302C2 - Werkwijze voor de bereiding van een ß-lactam antibioticum. - Google Patents

Werkwijze voor de bereiding van een ß-lactam antibioticum. Download PDF

Info

Publication number
NL1007302C2
NL1007302C2 NL1007302A NL1007302A NL1007302C2 NL 1007302 C2 NL1007302 C2 NL 1007302C2 NL 1007302 A NL1007302 A NL 1007302A NL 1007302 A NL1007302 A NL 1007302A NL 1007302 C2 NL1007302 C2 NL 1007302C2
Authority
NL
Netherlands
Prior art keywords
acylating agent
lactam
reaction
mixture
solution
Prior art date
Application number
NL1007302A
Other languages
English (en)
Dutch (nl)
Inventor
Harold Monro Moody
Theodorus Johannes Godf Dooren
Johanna Christ Wagemans-Smeets
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL1007302A priority Critical patent/NL1007302C2/nl
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to AU95601/98A priority patent/AU9560198A/en
Priority to BR9813079-0A priority patent/BR9813079A/pt
Priority to CNB988122804A priority patent/CN1165626C/zh
Priority to KR10-2000-7004098A priority patent/KR100516271B1/ko
Priority to AT98949243T priority patent/ATE234934T1/de
Priority to PCT/NL1998/000570 priority patent/WO1999020786A1/en
Priority to US09/529,569 priority patent/US6287799B1/en
Priority to ES98949243T priority patent/ES2195400T3/es
Priority to TR2000/00991T priority patent/TR200000991T2/xx
Priority to EP98949243A priority patent/EP1023454B1/en
Priority to IN2240MA1998 priority patent/IN188152B/en
Priority to EG125898A priority patent/EG21235A/xx
Application granted granted Critical
Publication of NL1007302C2 publication Critical patent/NL1007302C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
NL1007302A 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum. NL1007302C2 (nl)

Priority Applications (13)

Application Number Priority Date Filing Date Title
NL1007302A NL1007302C2 (nl) 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum.
ES98949243T ES2195400T3 (es) 1997-10-17 1998-10-01 Procedimiento de preparacion de un antibiotico beta-lactamico.
CNB988122804A CN1165626C (zh) 1997-10-17 1998-10-01 用于制备β-内酰胺抗生素的方法
KR10-2000-7004098A KR100516271B1 (ko) 1997-10-17 1998-10-01 β-락탐 항생제의 제조방법
AT98949243T ATE234934T1 (de) 1997-10-17 1998-10-01 Verfahren zur herstellung von einem beta-laktam antibiotikum
PCT/NL1998/000570 WO1999020786A1 (en) 1997-10-17 1998-10-01 PROCESS FOR THE PREPARATION OF A β-LACTAM ANTIBIOTIC
AU95601/98A AU9560198A (en) 1997-10-17 1998-10-01 Process for the preparation of a beta-lactam antibiotic
BR9813079-0A BR9813079A (pt) 1997-10-17 1998-10-01 Processo para a preparação de um antibiótico beta-lactama
TR2000/00991T TR200000991T2 (tr) 1997-10-17 1998-10-01 Bir beta-laktam antibiyotiğinin hazırlanması için işlem.
EP98949243A EP1023454B1 (en) 1997-10-17 1998-10-01 Process for the preparation of a (beta)-lactam antibiotic
US09/529,569 US6287799B1 (en) 1997-10-17 1998-10-01 Process for the preparation of aβ-lactam antibiotic
IN2240MA1998 IN188152B (ko) 1997-10-17 1998-10-07
EG125898A EG21235A (en) 1997-10-17 1998-10-17 Process for the preparation of a b-lactam antibiotic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1007302A NL1007302C2 (nl) 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1007302 1997-10-17

Publications (1)

Publication Number Publication Date
NL1007302C2 true NL1007302C2 (nl) 1999-04-20

Family

ID=19765855

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1007302A NL1007302C2 (nl) 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum.

Country Status (13)

Country Link
US (1) US6287799B1 (ko)
EP (1) EP1023454B1 (ko)
KR (1) KR100516271B1 (ko)
CN (1) CN1165626C (ko)
AT (1) ATE234934T1 (ko)
AU (1) AU9560198A (ko)
BR (1) BR9813079A (ko)
EG (1) EG21235A (ko)
ES (1) ES2195400T3 (ko)
IN (1) IN188152B (ko)
NL (1) NL1007302C2 (ko)
TR (1) TR200000991T2 (ko)
WO (1) WO1999020786A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
MX2007007937A (es) * 2004-12-27 2007-08-21 Dsm Ip Assets Bv Procedimiento para la sintesis de cefaclor.
CN102351884B (zh) 2006-05-19 2015-06-17 中化帝斯曼制药有限公司荷兰公司 一种用于结晶头孢羟氨苄的方法
CN101525603B (zh) * 2008-03-04 2013-12-25 中国医药集团总公司四川抗菌素工业研究所 固定化α-氨基酸酯水解酶及其制备与应用
US20140200342A1 (en) 2011-06-23 2014-07-17 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a pencillin g acylase
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
CN103467493B (zh) * 2013-10-16 2016-01-20 华北制药集团先泰药业有限公司 无水氨苄西林的制备方法
CN103757085B (zh) * 2013-11-28 2016-06-15 湖南福来格生物技术有限公司 头孢克洛及其合成方法
CN103937692B (zh) * 2014-04-30 2016-03-23 江南大学 一株丝枝霉菌株及其生产β-葡萄糖苷酶的方法
US20170101660A1 (en) 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
WO1996002663A1 (en) * 1994-07-18 1996-02-01 Gist-Brocades B.V. PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS
WO1996033797A1 (en) * 1995-04-28 1996-10-31 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
WO1997022610A1 (en) * 1995-12-08 1997-06-26 Gist-Brocades B.V. Process for the preparation of an antibiotic

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
WO1996002663A1 (en) * 1994-07-18 1996-02-01 Gist-Brocades B.V. PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS
WO1996033797A1 (en) * 1995-04-28 1996-10-31 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
WO1997022610A1 (en) * 1995-12-08 1997-06-26 Gist-Brocades B.V. Process for the preparation of an antibiotic

Also Published As

Publication number Publication date
AU9560198A (en) 1999-05-10
WO1999020786A1 (en) 1999-04-29
KR100516271B1 (ko) 2005-09-20
TR200000991T2 (tr) 2000-07-21
ES2195400T3 (es) 2003-12-01
EP1023454A1 (en) 2000-08-02
CN1165626C (zh) 2004-09-08
EP1023454B1 (en) 2003-03-19
ATE234934T1 (de) 2003-04-15
EG21235A (en) 2001-03-31
US6287799B1 (en) 2001-09-11
BR9813079A (pt) 2000-08-15
IN188152B (ko) 2002-08-24
CN1282377A (zh) 2001-01-31
KR20010024519A (ko) 2001-03-26

Similar Documents

Publication Publication Date Title
NL1007302C2 (nl) Werkwijze voor de bereiding van een ß-lactam antibioticum.
EP2121960A1 (en) Process for the preparation of beta-lactam compounds
US6048708A (en) Process for preparation of β-lactams at constantly high concentration of reactants
NL1007077C2 (nl) Werkwijze voor de winning van een ß-lactam antibioticum.
KR20010043038A (ko) β-락탐 항생제의 결정화 방법
NL1006266C2 (nl) Werkwijze voor de bereiding van ampicilline.
NL1007076C2 (nl) Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007828C2 (nl) Complexen van beta-lactam antibiotica en 1-naftol.
NL1010506C2 (nl) Werkwijze voor de bereiding van bêta-lactam antibiotica.
NL1007827C2 (nl) Complexen van beta-lactam antibiotica.
EP0730036A1 (en) Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor
US7588913B2 (en) Process for the preparation of cephradine
MXPA00003769A (en) PROCESS FOR THE PREPARATION OF A&bgr;-LACTAM ANTIBIOTIC
NL1006267C2 (nl) Werkwijze voor het afscheiden van een vaste stof.
WO1998056945A1 (en) PROCESS FOR ENZYMATICALLY PREPARING A β-LACTAM ANTIBIOTIC AND THIS ANTIBIOTIC
WO2002020819A2 (en) AN ENZYMATIC PROCESS FOR PREPARING β-LACTAM COMPOUNDS
EP0815256A1 (en) Process for the preparation of a beta-lactam antibiotic
MXPA00010537A (en) A METHOD FOR CRYSTALLIZING A&bgr;-LACTAM ANTIBIOTIC
ITMI960033A1 (it) Procedimento per la sintesi enzimatica di antibiotici b-lattamici in presenza di un inibitore dell'enzima

Legal Events

Date Code Title Description
PD2B A search report has been drawn up
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20020501